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The map label for this gene is trx [H]

Identifier: 225630597

GI number: 225630597

Start: 935005

End: 935328

Strand: Reverse

Name: trx [H]

Synonym: WRi_008660

Alternate gene names: 225630597

Gene position: 935328-935005 (Counterclockwise)

Preceding gene: 225630598

Following gene: 225630596

Centisome position: 64.69

GC content: 37.35

Gene sequence:

>324_bases
ATGAGTGATGATATTACATCGGTAAATGATCAAAATTTCAAATCTGAAGTCACTGACTATAAAGGGTTCGTGCTGGTAGA
TTTTTGGGCAGAATGGTGTGGGCCATGCAAAAGTCTAATGCCACGTATAGAACAATTGGCTAAGGATAGAAAAGGCAAGA
TTAAGATCTGCAAATTCGACATAGATGAAGGGACTGAAGTGCCAAGTAAGTATGGAGTGCAATCTATACCCACTTTAATC
ATATTTCAAGATGGTAAGGAAATTGCACGCAAAATTGGTGCAACAAATGATTTGTCAAGTTGGGTTGATAGTGAAATAAG
CTAA

Upstream 100 bases:

>100_bases
GTGCAAAACACTTTAGGGCAATTTTTCAAGCTCTGCGGTAAGAATTTAGTTGATTAACTGCTAATAGATACGCTATATTT
TACAAAAATTTAGGTATTTT

Downstream 100 bases:

>100_bases
TAGACAAATTTGCTTTTGTGTGTATTATAAATATTGATAAAAGGGATTGTAGCTCAGTCGGTTAGAGCAGTTCGCTCATA
ACGAATTGGTCGTAGGTTCG

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MSDDITSVNDQNFKSEVTDYKGFVLVDFWAEWCGPCKSLMPRIEQLAKDRKGKIKICKFDIDEGTEVPSKYGVQSIPTLI
IFQDGKEIARKIGATNDLSSWVDSEIS

Sequences:

>Translated_107_residues
MSDDITSVNDQNFKSEVTDYKGFVLVDFWAEWCGPCKSLMPRIEQLAKDRKGKIKICKFDIDEGTEVPSKYGVQSIPTLI
IFQDGKEIARKIGATNDLSSWVDSEIS
>Mature_106_residues
SDDITSVNDQNFKSEVTDYKGFVLVDFWAEWCGPCKSLMPRIEQLAKDRKGKIKICKFDIDEGTEVPSKYGVQSIPTLII
FQDGKEIARKIGATNDLSSWVDSEIS

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361657, Length=86, Percent_Identity=43.0232558139535, Blast_Score=75, Evalue=1e-14,
Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=35.8695652173913, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI5031973, Length=85, Percent_Identity=36.4705882352941, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082331, Length=109, Percent_Identity=39.4495412844037, Blast_Score=100, Evalue=2e-23,
Organism=Escherichia coli, GI1788936, Length=85, Percent_Identity=36.4705882352941, Blast_Score=77, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI212646193, Length=94, Percent_Identity=38.2978723404255, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71980562, Length=98, Percent_Identity=35.7142857142857, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=74, Percent_Identity=41.8918918918919, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17549970, Length=80, Percent_Identity=38.75, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=73, Percent_Identity=39.7260273972603, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=87, Percent_Identity=39.0804597701149, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=87, Percent_Identity=39.0804597701149, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=104, Percent_Identity=35.5769230769231, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17554386, Length=105, Percent_Identity=35.2380952380952, Blast_Score=61, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=72, Percent_Identity=45.8333333333333, Blast_Score=73, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=73, Percent_Identity=42.4657534246575, Blast_Score=72, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573567, Length=98, Percent_Identity=33.6734693877551, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21358065, Length=98, Percent_Identity=38.7755102040816, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664269, Length=98, Percent_Identity=33.6734693877551, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17530795, Length=105, Percent_Identity=32.3809523809524, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24639826, Length=75, Percent_Identity=32, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19921434, Length=86, Percent_Identity=34.8837209302326, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17648013, Length=73, Percent_Identity=31.5068493150685, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24583090, Length=73, Percent_Identity=31.5068493150685, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12067; Mature: 11936

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDITSVNDQNFKSEVTDYKGFVLVDFWAEWCGPCKSLMPRIEQLAKDRKGKIKICKFD
CCCCCCCCCCCCHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
IDEGTEVPSKYGVQSIPTLIIFQDGKEIARKIGATNDLSSWVDSEIS
CCCCCCCCCCCCCCCCCEEEEEECCHHHHHHCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
SDDITSVNDQNFKSEVTDYKGFVLVDFWAEWCGPCKSLMPRIEQLAKDRKGKIKICKFD
CCCCCCCCCCCHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
IDEGTEVPSKYGVQSIPTLIIFQDGKEIARKIGATNDLSSWVDSEIS
CCCCCCCCCCCCCCCCCEEEEEECCHHHHHHCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]