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The map label for this gene is era [H]

Identifier: 225630483

GI number: 225630483

Start: 793584

End: 794468

Strand: Reverse

Name: era [H]

Synonym: WRi_007330

Alternate gene names: 225630483

Gene position: 794468-793584 (Counterclockwise)

Preceding gene: 225630484

Following gene: 225630482

Centisome position: 54.95

GC content: 35.14

Gene sequence:

>885_bases
GTGAAAGAACAAAAATGCTTATTTGTAACCATAGCTGGCTTACCAAATGCTGGGAAGTCTACATTAATTAACAGCATCAT
AGGCAAGAAAATTGCAATTGTCACCCCTAAAGTGCAAACAACAAGGACGCAAATAAGGGGTGTTGCAACATGCAACAACA
CACAAGTTGTCTTTACTGACTCCCCAGGAATTTTCTCAGCAGAAACAAAACTTGAAAAAGCTTTAGTCAAATCTGCATGG
TCGGCAGTTAAGGATAGTGACATCACTTTGTTGCTTGTTGATGTAAGCAATTATTTGAAAAATATAGAAAGAATTAAGAC
TATATTTATGCGGCTGCAGCGCACAAAAGGCAGATGCATTTTGGTTATCAATAAAACTGATTTGGTAAAAAGGCCTGAAT
TAAAGATGGCGCATGAGCATCTGAATTTGCTTTATAAATTTGAAAAGGTTTTTATGATATCAGCATTAAAGAATGATGGA
CTTTCTGATTTGATGAATTACTTGTCTGAAGTTGCATCGGTGAGCCCCTGGTTTTATGAAGAAGATCAAATAACCGATTC
CTCGACAAATTTTTTATCAGCAGAAATTACGAGAGAAAAATTATTCTTGAACTTGCGTGAAGAATTGCCATACTCTACAG
CTGTTATAACTGAACAATTTGAGGAAAAAAAAGATAAGAGTTTAGTCATCAAACAGATCATATTTGTGTTGAAAGATAGT
CATAAAAAAATAGTACTAGGAAAAGATGGCAGTAATATTAAAAAAATTAATATCGAAGCGCGTGCTGAACTAGAAAAATT
ATTTGAGTGCAAGGTACACCTCTTTTTATTTGTGAAAGTGCGACCTTGGATCGACCGTCCGGAGGAGTATATAGGCAATG
CTTAA

Upstream 100 bases:

>100_bases
TTTTTTTCCTTTTTGCATGCTAACCAAAAAGGGTTCTGTCATCCTTCTTGTCATATAAGTAGCTTGACGCGGGCATTCAG
TTTTCTTTATAATTTTCTTT

Downstream 100 bases:

>100_bases
TTCTTTATTGGTATTTGATATTGAAACTATACCAGATGTAAATTCCTGCAAAAATTTACTCAATATTAGTGATGATAGTA
GTGTAGAAGAGAAGAGGGAT

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MKEQKCLFVTIAGLPNAGKSTLINSIIGKKIAIVTPKVQTTRTQIRGVATCNNTQVVFTDSPGIFSAETKLEKALVKSAW
SAVKDSDITLLLVDVSNYLKNIERIKTIFMRLQRTKGRCILVINKTDLVKRPELKMAHEHLNLLYKFEKVFMISALKNDG
LSDLMNYLSEVASVSPWFYEEDQITDSSTNFLSAEITREKLFLNLREELPYSTAVITEQFEEKKDKSLVIKQIIFVLKDS
HKKIVLGKDGSNIKKINIEARAELEKLFECKVHLFLFVKVRPWIDRPEEYIGNA

Sequences:

>Translated_294_residues
MKEQKCLFVTIAGLPNAGKSTLINSIIGKKIAIVTPKVQTTRTQIRGVATCNNTQVVFTDSPGIFSAETKLEKALVKSAW
SAVKDSDITLLLVDVSNYLKNIERIKTIFMRLQRTKGRCILVINKTDLVKRPELKMAHEHLNLLYKFEKVFMISALKNDG
LSDLMNYLSEVASVSPWFYEEDQITDSSTNFLSAEITREKLFLNLREELPYSTAVITEQFEEKKDKSLVIKQIIFVLKDS
HKKIVLGKDGSNIKKINIEARAELEKLFECKVHLFLFVKVRPWIDRPEEYIGNA
>Mature_294_residues
MKEQKCLFVTIAGLPNAGKSTLINSIIGKKIAIVTPKVQTTRTQIRGVATCNNTQVVFTDSPGIFSAETKLEKALVKSAW
SAVKDSDITLLLVDVSNYLKNIERIKTIFMRLQRTKGRCILVINKTDLVKRPELKMAHEHLNLLYKFEKVFMISALKNDG
LSDLMNYLSEVASVSPWFYEEDQITDSSTNFLSAEITREKLFLNLREELPYSTAVITEQFEEKKDKSLVIKQIIFVLKDS
HKKIVLGKDGSNIKKINIEARAELEKLFECKVHLFLFVKVRPWIDRPEEYIGNA

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=324, Percent_Identity=31.4814814814815, Blast_Score=130, Evalue=1e-30,
Organism=Escherichia coli, GI1788919, Length=287, Percent_Identity=34.1463414634146, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI2367268, Length=169, Percent_Identity=28.4023668639053, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24646434, Length=309, Percent_Identity=26.8608414239482, Blast_Score=101, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 33545; Mature: 33545

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEQKCLFVTIAGLPNAGKSTLINSIIGKKIAIVTPKVQTTRTQIRGVATCNNTQVVFTD
CCCCEEEEEEEECCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHEEEEEECCCEEEEEC
SPGIFSAETKLEKALVKSAWSAVKDSDITLLLVDVSNYLKNIERIKTIFMRLQRTKGRCI
CCCCEEHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEE
LVINKTDLVKRPELKMAHEHLNLLYKFEKVFMISALKNDGLSDLMNYLSEVASVSPWFYE
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEC
EDQITDSSTNFLSAEITREKLFLNLREELPYSTAVITEQFEEKKDKSLVIKQIIFVLKDS
CCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HKKIVLGKDGSNIKKINIEARAELEKLFECKVHLFLFVKVRPWIDRPEEYIGNA
CCEEEEECCCCCEEEEEEHHHHHHHHHHHHEEEEEEEEEECCCCCCCHHHCCCC
>Mature Secondary Structure
MKEQKCLFVTIAGLPNAGKSTLINSIIGKKIAIVTPKVQTTRTQIRGVATCNNTQVVFTD
CCCCEEEEEEEECCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHEEEEEECCCEEEEEC
SPGIFSAETKLEKALVKSAWSAVKDSDITLLLVDVSNYLKNIERIKTIFMRLQRTKGRCI
CCCCEEHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEE
LVINKTDLVKRPELKMAHEHLNLLYKFEKVFMISALKNDGLSDLMNYLSEVASVSPWFYE
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEC
EDQITDSSTNFLSAEITREKLFLNLREELPYSTAVITEQFEEKKDKSLVIKQIIFVLKDS
CCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HKKIVLGKDGSNIKKINIEARAELEKLFECKVHLFLFVKVRPWIDRPEEYIGNA
CCEEEEECCCCCEEEEEEHHHHHHHHHHHHEEEEEEEEEECCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA