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The map label for this gene is lon [H]

Identifier: 225630253

GI number: 225630253

Start: 507101

End: 509554

Strand: Reverse

Name: lon [H]

Synonym: WRi_004670

Alternate gene names: 225630253

Gene position: 509554-507101 (Counterclockwise)

Preceding gene: 225630254

Following gene: 225630251

Centisome position: 35.24

GC content: 36.27

Gene sequence:

>2454_bases
ATGAACATTGAACGTGCTGTAAGCTCTAGTTTTACTGCATTGCCAGTATTACCTTTAAGAGATGTAGTAATTTTTCCAAA
TATAATGGTGCCTTTATTCATAGGCAGAGAAAAATCTGTTAATGCACTAGAGTATGCAATAAGTAGTAGTAATCACCAAA
ATGAGATTTTTCTTGTAGCACAGAAAGATGGCTCTGTTGATAATCCAGAGCCTGAAGATCTTTATGAAGTAGGTGTGTTA
GCAAGCATTGTACAACCGTTAATAAAATTACCTGACAATGCAGTAAAAGTTATAATCCGGGGGATAAGAAGGGGAAGAGT
TGTAGAATATATTAGCTCTCATACTTTATTACAAGCCAGGGTAGAGTTAGACAATTATTATAAAGAAGATGAAGACAATA
TTGATTTAGAAGCTTTAAGGCGGTCTGTTGTAGACGCGTTCGATAGCTGGTGTAAGCTAAACAAGAAAAATCAACCCGAG
GTTGCCATTAACTCCATTGATCAAATCAAAGAAGTTGATCAACTTGTAGACACGGTAGCTTCACATTTAAATATAAAAGT
ATCAGATAAACAAAGTATACTTGAGGCTTATGACCCAGAAGAGCGTTTAAAAAAAGCTTTTGCTTTTATTGAGAGAGAAA
TGAGTATTTTGAACGCACAAAACCGTTTATATAAGACAATTAAATCGCAAGTTGAAAGCACTCAGAAAGTTTACTACCTT
AACGAGCAATTGAAAGCTATACAGAAAGAATTAGGCGAATTTGAGAATGGTGATGAAGGGAATATACTCAATGAATTTGA
AAAAAAGATAAATGAAACAAAGCTTTCTCAGGAAGCAAGAGAGAAAGCTATAACTGATTTGAAGAGATACAAGAAAATGA
ATCCCATTTCTCCTGAAGCTACAGTTATATCTAGTTACTTGCATTGGTTGCTTGAGTTGCCATGGGGAAAGTACAAAGAT
GCAAAAATTAACTTAAATGCAGCTAAGAAAATCTTAGATGAAAATCATTATGGCATAGAGAAAGTAAAAGATAGAATAAT
AGAATTTTTAGCGGTATTAAAAAGAGTAAAAGAGATAAAAGGTCCTATACTTTGCTTAGTTGGACCGCCAGGTGTTGGTA
AAACTTCTTTAGCTAAGTCTATGGCAAGAGCAGTAGGAAGAGATTTTGTTCGCATAGCTCTTGGTGGTGTGCGTGATGAG
TCTGAGATACGAGGGCATAGGAAAACTTATATTGGCTCAATGCCTGGTAAAATCATTCAACACATGAAAAAAGCTAATTC
ATGCAACCCGCTTTTTCTGCTTGATGAAATAGATAAGATGGGTTCTGATTCGCGTGGCGATCCTGCATCTGCATTACTTG
AGGTTTTAGATACTGAGCACAATAAACACTTTACGGATCATTACTTGGAAGTTGAGTTTGATCTTTCAAGTGTAATGTTT
GTAGCTACGGCAAACAGCTTAAATTTACCACATCCTTTGCGTGATAGGATGGAAATTATACAATTGTCTGGTTATACTGA
AGATGAAAAAATCAGTATTGCTACACACCACCTTATTCCGAAGTTAAAGAAGGAGCATGGTTTGTATCAGAAGGAATGGG
ACATAACTAATGAGGCGTTATACGAGTTGATACGTTTATATACACGTGAAAGTGGTGTGCGGAGTATGGAAAGGGAGCTT
GCAAAGCTCATGAGAAAGGCAGTTAAAGAAATATTGACTGATAAAAATAAGAAAATATCCGTAGGGGTTGACAATTTACA
AGATTATTTAGGGGTACGTAAATATACCTTTGGCATTGCGGAAAATGAGAGTTTAGTAGGAATAGTAACTGGGCTCGCCT
ATACTGAAACAGGTGGTGATATTTTGATGATAGAATCAGTCCTAATTCCGGGCAAGGGAGAAATAAAATACACAGGAAAG
CTTGGAGAGGTTATGCAAGAATCTATAAAAGCTGCGTATAGTTATATTCGATCGAATTGTTTATTTTTTGGTATAAAGCC
CGAAAAATTCCAAAATAATGATATACATTTGCATGTACCTGAGGGTGCTGTACCAAAAGATGGCCCTTCTGCTGGCGGCG
CGGTATGTACGTCTATTGTTTCTCTTATGACGAATATACCAGTTAACAAAAATGTTGCTATGACAGGCGAAGTGACATTG
CGTGGTAGAGTTTTAGCTATTGGGGGCTTAAGAGAAAAATTGCTTGCAGCGCTCAGAGGATCAATCAAAACTGTGATTAT
ACCAAGTGAAAATGAGAAAGATATGCAAGAGATTCCGGCAAGCATCAAAGAGGGGATCAACGTAGTTTTTGCTAAGAATA
TTGATGAAGTTATGAAAGTTGCTTTAATGCACCCTACTACTCCAATTGATGGTGATGATAATCAAAATAGTGTGCCTTCC
TCTATAGAAAATAAAGATGATACTTTTCCTATGTCGGAAACATTGAAGCATTAG

Upstream 100 bases:

>100_bases
AGTAATCACTAAGAAAATGGTAGAATTAGGAAAAGCAACGGTTAATCATAATAACAATGGCAATGTTATAACGGTTAATG
ATTAATTTGAGGCATATATT

Downstream 100 bases:

>100_bases
ATTAAGAAAATATTATACAATCTCCACTTCTTTTTTATCCGGCAAAAACCCACCAACTTGCGCATTCCATAGGGTCTTAT
ACATTCCGTTTTTATCAAGA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 817; Mature: 817

Protein sequence:

>817_residues
MNIERAVSSSFTALPVLPLRDVVIFPNIMVPLFIGREKSVNALEYAISSSNHQNEIFLVAQKDGSVDNPEPEDLYEVGVL
ASIVQPLIKLPDNAVKVIIRGIRRGRVVEYISSHTLLQARVELDNYYKEDEDNIDLEALRRSVVDAFDSWCKLNKKNQPE
VAINSIDQIKEVDQLVDTVASHLNIKVSDKQSILEAYDPEERLKKAFAFIEREMSILNAQNRLYKTIKSQVESTQKVYYL
NEQLKAIQKELGEFENGDEGNILNEFEKKINETKLSQEAREKAITDLKRYKKMNPISPEATVISSYLHWLLELPWGKYKD
AKINLNAAKKILDENHYGIEKVKDRIIEFLAVLKRVKEIKGPILCLVGPPGVGKTSLAKSMARAVGRDFVRIALGGVRDE
SEIRGHRKTYIGSMPGKIIQHMKKANSCNPLFLLDEIDKMGSDSRGDPASALLEVLDTEHNKHFTDHYLEVEFDLSSVMF
VATANSLNLPHPLRDRMEIIQLSGYTEDEKISIATHHLIPKLKKEHGLYQKEWDITNEALYELIRLYTRESGVRSMEREL
AKLMRKAVKEILTDKNKKISVGVDNLQDYLGVRKYTFGIAENESLVGIVTGLAYTETGGDILMIESVLIPGKGEIKYTGK
LGEVMQESIKAAYSYIRSNCLFFGIKPEKFQNNDIHLHVPEGAVPKDGPSAGGAVCTSIVSLMTNIPVNKNVAMTGEVTL
RGRVLAIGGLREKLLAALRGSIKTVIIPSENEKDMQEIPASIKEGINVVFAKNIDEVMKVALMHPTTPIDGDDNQNSVPS
SIENKDDTFPMSETLKH

Sequences:

>Translated_817_residues
MNIERAVSSSFTALPVLPLRDVVIFPNIMVPLFIGREKSVNALEYAISSSNHQNEIFLVAQKDGSVDNPEPEDLYEVGVL
ASIVQPLIKLPDNAVKVIIRGIRRGRVVEYISSHTLLQARVELDNYYKEDEDNIDLEALRRSVVDAFDSWCKLNKKNQPE
VAINSIDQIKEVDQLVDTVASHLNIKVSDKQSILEAYDPEERLKKAFAFIEREMSILNAQNRLYKTIKSQVESTQKVYYL
NEQLKAIQKELGEFENGDEGNILNEFEKKINETKLSQEAREKAITDLKRYKKMNPISPEATVISSYLHWLLELPWGKYKD
AKINLNAAKKILDENHYGIEKVKDRIIEFLAVLKRVKEIKGPILCLVGPPGVGKTSLAKSMARAVGRDFVRIALGGVRDE
SEIRGHRKTYIGSMPGKIIQHMKKANSCNPLFLLDEIDKMGSDSRGDPASALLEVLDTEHNKHFTDHYLEVEFDLSSVMF
VATANSLNLPHPLRDRMEIIQLSGYTEDEKISIATHHLIPKLKKEHGLYQKEWDITNEALYELIRLYTRESGVRSMEREL
AKLMRKAVKEILTDKNKKISVGVDNLQDYLGVRKYTFGIAENESLVGIVTGLAYTETGGDILMIESVLIPGKGEIKYTGK
LGEVMQESIKAAYSYIRSNCLFFGIKPEKFQNNDIHLHVPEGAVPKDGPSAGGAVCTSIVSLMTNIPVNKNVAMTGEVTL
RGRVLAIGGLREKLLAALRGSIKTVIIPSENEKDMQEIPASIKEGINVVFAKNIDEVMKVALMHPTTPIDGDDNQNSVPS
SIENKDDTFPMSETLKH
>Mature_817_residues
MNIERAVSSSFTALPVLPLRDVVIFPNIMVPLFIGREKSVNALEYAISSSNHQNEIFLVAQKDGSVDNPEPEDLYEVGVL
ASIVQPLIKLPDNAVKVIIRGIRRGRVVEYISSHTLLQARVELDNYYKEDEDNIDLEALRRSVVDAFDSWCKLNKKNQPE
VAINSIDQIKEVDQLVDTVASHLNIKVSDKQSILEAYDPEERLKKAFAFIEREMSILNAQNRLYKTIKSQVESTQKVYYL
NEQLKAIQKELGEFENGDEGNILNEFEKKINETKLSQEAREKAITDLKRYKKMNPISPEATVISSYLHWLLELPWGKYKD
AKINLNAAKKILDENHYGIEKVKDRIIEFLAVLKRVKEIKGPILCLVGPPGVGKTSLAKSMARAVGRDFVRIALGGVRDE
SEIRGHRKTYIGSMPGKIIQHMKKANSCNPLFLLDEIDKMGSDSRGDPASALLEVLDTEHNKHFTDHYLEVEFDLSSVMF
VATANSLNLPHPLRDRMEIIQLSGYTEDEKISIATHHLIPKLKKEHGLYQKEWDITNEALYELIRLYTRESGVRSMEREL
AKLMRKAVKEILTDKNKKISVGVDNLQDYLGVRKYTFGIAENESLVGIVTGLAYTETGGDILMIESVLIPGKGEIKYTGK
LGEVMQESIKAAYSYIRSNCLFFGIKPEKFQNNDIHLHVPEGAVPKDGPSAGGAVCTSIVSLMTNIPVNKNVAMTGEVTL
RGRVLAIGGLREKLLAALRGSIKTVIIPSENEKDMQEIPASIKEGINVVFAKNIDEVMKVALMHPTTPIDGDDNQNSVPS
SIENKDDTFPMSETLKH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=618, Percent_Identity=40.7766990291262, Blast_Score=506, Evalue=1e-143,
Organism=Homo sapiens, GI31377667, Length=658, Percent_Identity=41.7933130699088, Blast_Score=494, Evalue=1e-139,
Organism=Escherichia coli, GI1786643, Length=785, Percent_Identity=53.8853503184713, Blast_Score=842, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=650, Percent_Identity=40, Blast_Score=467, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17556486, Length=546, Percent_Identity=38.8278388278388, Blast_Score=409, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6319449, Length=715, Percent_Identity=38.3216783216783, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24666867, Length=656, Percent_Identity=40.2439024390244, Blast_Score=485, Evalue=1e-137,
Organism=Drosophila melanogaster, GI221513036, Length=656, Percent_Identity=40.2439024390244, Blast_Score=485, Evalue=1e-137,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 91677; Mature: 91677

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIERAVSSSFTALPVLPLRDVVIFPNIMVPLFIGREKSVNALEYAISSSNHQNEIFLVA
CCCHHHHHCCCCEECCCCCCCHHCCCCHHHHHEECCCCCCHHHHHHHCCCCCCCEEEEEE
QKDGSVDNPEPEDLYEVGVLASIVQPLIKLPDNAVKVIIRGIRRGRVVEYISSHTLLQAR
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
VELDNYYKEDEDNIDLEALRRSVVDAFDSWCKLNKKNQPEVAINSIDQIKEVDQLVDTVA
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SHLNIKVSDKQSILEAYDPEERLKKAFAFIEREMSILNAQNRLYKTIKSQVESTQKVYYL
HHCEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NEQLKAIQKELGEFENGDEGNILNEFEKKINETKLSQEAREKAITDLKRYKKMNPISPEA
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
TVISSYLHWLLELPWGKYKDAKINLNAAKKILDENHYGIEKVKDRIIEFLAVLKRVKEIK
HHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GPILCLVGPPGVGKTSLAKSMARAVGRDFVRIALGGVRDESEIRGHRKTYIGSMPGKIIQ
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHCCCCHHHHH
HMKKANSCNPLFLLDEIDKMGSDSRGDPASALLEVLDTEHNKHFTDHYLEVEFDLSSVMF
HHHHCCCCCCEEEHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECHHHEEE
VATANSLNLPHPLRDRMEIIQLSGYTEDEKISIATHHLIPKLKKEHGLYQKEWDITNEAL
EEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHCCCCHHHH
YELIRLYTRESGVRSMERELAKLMRKAVKEILTDKNKKISVGVDNLQDYLGVRKYTFGIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHEEECC
ENESLVGIVTGLAYTETGGDILMIESVLIPGKGEIKYTGKLGEVMQESIKAAYSYIRSNC
CCCCEEEEEECCEEECCCCCEEEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHCCC
LFFGIKPEKFQNNDIHLHVPEGAVPKDGPSAGGAVCTSIVSLMTNIPVNKNVAMTGEVTL
EEEECCHHCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEE
RGRVLAIGGLREKLLAALRGSIKTVIIPSENEKDMQEIPASIKEGINVVFAKNIDEVMKV
CCEEEEECCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCHHHHHHH
ALMHPTTPIDGDDNQNSVPSSIENKDDTFPMSETLKH
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCC
>Mature Secondary Structure
MNIERAVSSSFTALPVLPLRDVVIFPNIMVPLFIGREKSVNALEYAISSSNHQNEIFLVA
CCCHHHHHCCCCEECCCCCCCHHCCCCHHHHHEECCCCCCHHHHHHHCCCCCCCEEEEEE
QKDGSVDNPEPEDLYEVGVLASIVQPLIKLPDNAVKVIIRGIRRGRVVEYISSHTLLQAR
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
VELDNYYKEDEDNIDLEALRRSVVDAFDSWCKLNKKNQPEVAINSIDQIKEVDQLVDTVA
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SHLNIKVSDKQSILEAYDPEERLKKAFAFIEREMSILNAQNRLYKTIKSQVESTQKVYYL
HHCEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NEQLKAIQKELGEFENGDEGNILNEFEKKINETKLSQEAREKAITDLKRYKKMNPISPEA
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
TVISSYLHWLLELPWGKYKDAKINLNAAKKILDENHYGIEKVKDRIIEFLAVLKRVKEIK
HHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GPILCLVGPPGVGKTSLAKSMARAVGRDFVRIALGGVRDESEIRGHRKTYIGSMPGKIIQ
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHCCCCHHHHH
HMKKANSCNPLFLLDEIDKMGSDSRGDPASALLEVLDTEHNKHFTDHYLEVEFDLSSVMF
HHHHCCCCCCEEEHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECHHHEEE
VATANSLNLPHPLRDRMEIIQLSGYTEDEKISIATHHLIPKLKKEHGLYQKEWDITNEAL
EEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHCCCCHHHH
YELIRLYTRESGVRSMERELAKLMRKAVKEILTDKNKKISVGVDNLQDYLGVRKYTFGIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHEEECC
ENESLVGIVTGLAYTETGGDILMIESVLIPGKGEIKYTGKLGEVMQESIKAAYSYIRSNC
CCCCEEEEEECCEEECCCCCEEEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHCCC
LFFGIKPEKFQNNDIHLHVPEGAVPKDGPSAGGAVCTSIVSLMTNIPVNKNVAMTGEVTL
EEEECCHHCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEE
RGRVLAIGGLREKLLAALRGSIKTVIIPSENEKDMQEIPASIKEGINVVFAKNIDEVMKV
CCEEEEECCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCHHHHHHH
ALMHPTTPIDGDDNQNSVPSSIENKDDTFPMSETLKH
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA