Click here to switch to the map view.

The map label for this gene is nuoD

Identifier: 225630184

GI number: 225630184

Start: 407581

End: 408753

Strand: Direct

Name: nuoD

Synonym: WRi_003800

Alternate gene names: 225630184

Gene position: 407581-408753 (Clockwise)

Preceding gene: 225630178

Following gene: 225630190

Centisome position: 28.19

GC content: 40.49

Gene sequence:

>1173_bases
ATGCCCGATCTAAAGACAATGATGTTAAATTTTGGACCTCAGCACCCAGCTGCACATGGAGTGTTGCGTCTTGTTTTAGA
GATGGATGGTGAAGTGATCGAGAGGGCAGATCCCCATATTGGGCTTTTGCACCGCGGTACTGAAAAATTAATAGAACATA
AAACGTATCTTCAAGCTTTGCCTTATTTTGATCGCCTTGATTACGTATCACCAATGTCACAAGAGCATGCATATTCACTT
TGTGTGGAGAAATTGTTGCAATGTGAAGTGCCAATTAGGGCAAAGTATTTACGTGTCTTGTTTTGTGAACTGACGAGAAT
ACTAAATCATTTACTGAACGTTTCTTCTCAAGCACTTGATGTTGGAGCAATGACCCCTCTTTTATGGCTCTTTGAAGAAA
GAGAAAAAATACTGGAATTTTACGAAAGAGCTTCAGGTGCAAGGTTTCACGCAGCTTACATCAGGCCAGGTGGAATTGCA
GCAGATGTTCCAGAAGATTTGATTGAGGATATTGCAAAGTTTATAGAGCAATTTCCAAAATATATAGACGATGTTGATGA
ACTTTTAACAGAAAATAGGATATGGAAGCAACGCACTGTAGGAATTAGTGAAATATCAATTAAACAGGCACTTGATTGGG
GCTTTAGTGGCCCAATGTTGCGCGCTGCTGGGCTTGCTTGGGATTTGCGAAAAAGCCAGCCATATGAGATATATGATCAA
CTAGATTTTGATATACCGATCGGCCAAAATGGCGACTGTTATGACCGTTATCTAGTTAGAATGGCAGAGATTAGGCAATC
TATCAGTTTGGTGAAGCAGTGCATAGAGAAAATGCCTGAAGGGCAAATAAAAACTGAAGATAGAAAAATTTCTCCACCGT
CAAGAGCAGAGATGAAAAAATCTATGGAAGCTCTGATTCACCATTTTAAGCTCTATTCAGAAGGATATCACGTACCAGAA
GGTGAGGCTTACGCAGTTGTTGAGGCACCAAAAGGTGAGTTTGGAGTGTATATAGTTTCAGATGGTACCAATAGACCTTA
TAGGTGCCGAATAAGAGCACCTGGCTTTGCGCATTTACAAGCCTTAGACTTTATGGCAAAAGGACACATGCTTGCTGACG
TTGCAGCAATTATTGGCTCACTCGATATAGTTTTTGGTGAGATTGATAGGTAA

Upstream 100 bases:

>100_bases
TTTTTGTTTCTATTGAATGATAGTTGTAGCCTATGCAAGAAGTTTATTGACTTTGAGCGCACTTTAGCCTATACAATTTT
AATATCTTAAACTACTGGAC

Downstream 100 bases:

>100_bases
TCATTGGTACCCGTTCAGGCAATGGCGTCATGCAAGTAGCTGACACATAACTGTACGAACATTTGTTTGCAAAGGCAGTA
TGTTAAGTGTTATAGCCGAT

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MPDLKTMMLNFGPQHPAAHGVLRLVLEMDGEVIERADPHIGLLHRGTEKLIEHKTYLQALPYFDRLDYVSPMSQEHAYSL
CVEKLLQCEVPIRAKYLRVLFCELTRILNHLLNVSSQALDVGAMTPLLWLFEEREKILEFYERASGARFHAAYIRPGGIA
ADVPEDLIEDIAKFIEQFPKYIDDVDELLTENRIWKQRTVGISEISIKQALDWGFSGPMLRAAGLAWDLRKSQPYEIYDQ
LDFDIPIGQNGDCYDRYLVRMAEIRQSISLVKQCIEKMPEGQIKTEDRKISPPSRAEMKKSMEALIHHFKLYSEGYHVPE
GEAYAVVEAPKGEFGVYIVSDGTNRPYRCRIRAPGFAHLQALDFMAKGHMLADVAAIIGSLDIVFGEIDR

Sequences:

>Translated_390_residues
MPDLKTMMLNFGPQHPAAHGVLRLVLEMDGEVIERADPHIGLLHRGTEKLIEHKTYLQALPYFDRLDYVSPMSQEHAYSL
CVEKLLQCEVPIRAKYLRVLFCELTRILNHLLNVSSQALDVGAMTPLLWLFEEREKILEFYERASGARFHAAYIRPGGIA
ADVPEDLIEDIAKFIEQFPKYIDDVDELLTENRIWKQRTVGISEISIKQALDWGFSGPMLRAAGLAWDLRKSQPYEIYDQ
LDFDIPIGQNGDCYDRYLVRMAEIRQSISLVKQCIEKMPEGQIKTEDRKISPPSRAEMKKSMEALIHHFKLYSEGYHVPE
GEAYAVVEAPKGEFGVYIVSDGTNRPYRCRIRAPGFAHLQALDFMAKGHMLADVAAIIGSLDIVFGEIDR
>Mature_389_residues
PDLKTMMLNFGPQHPAAHGVLRLVLEMDGEVIERADPHIGLLHRGTEKLIEHKTYLQALPYFDRLDYVSPMSQEHAYSLC
VEKLLQCEVPIRAKYLRVLFCELTRILNHLLNVSSQALDVGAMTPLLWLFEEREKILEFYERASGARFHAAYIRPGGIAA
DVPEDLIEDIAKFIEQFPKYIDDVDELLTENRIWKQRTVGISEISIKQALDWGFSGPMLRAAGLAWDLRKSQPYEIYDQL
DFDIPIGQNGDCYDRYLVRMAEIRQSISLVKQCIEKMPEGQIKTEDRKISPPSRAEMKKSMEALIHHFKLYSEGYHVPEG
EAYAVVEAPKGEFGVYIVSDGTNRPYRCRIRAPGFAHLQALDFMAKGHMLADVAAIIGSLDIVFGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=387, Percent_Identity=66.1498708010336, Blast_Score=561, Evalue=1e-160,
Organism=Homo sapiens, GI260898743, Length=381, Percent_Identity=65.6167979002625, Blast_Score=546, Evalue=1e-155,
Organism=Escherichia coli, GI145693162, Length=385, Percent_Identity=40, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI1789076, Length=390, Percent_Identity=27.1794871794872, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI1788832, Length=380, Percent_Identity=26.8421052631579, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17555284, Length=388, Percent_Identity=62.3711340206186, Blast_Score=539, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17568379, Length=388, Percent_Identity=61.8556701030928, Blast_Score=536, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24638644, Length=388, Percent_Identity=65.7216494845361, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI221459469, Length=387, Percent_Identity=62.015503875969, Blast_Score=537, Evalue=1e-153,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_WOLPM (Q73HJ8)

Other databases:

- EMBL:   AE017196
- RefSeq:   NP_966333.1
- HSSP:   Q56220
- ProteinModelPortal:   Q73HJ8
- SMR:   Q73HJ8
- EnsemblBacteria:   EBWOLT00000003735
- GeneID:   2738075
- GenomeReviews:   AE017196_GR
- KEGG:   wol:WD0560
- TIGR:   WD_0560
- GeneTree:   EBGT00050000031239
- HOGENOM:   HBG459705
- OMA:   GVFIQGN
- PhylomeDB:   Q73HJ8
- ProtClustDB:   PRK06075
- BioCyc:   WPIP955:WD_0560-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 44512; Mature: 44381

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00535 COMPLEX1_49K; PS00503 PECTINESTERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDLKTMMLNFGPQHPAAHGVLRLVLEMDGEVIERADPHIGLLHRGTEKLIEHKTYLQAL
CCCHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHCCCCEEHHHCCHHHHHHHHHHHHHC
PYFDRLDYVSPMSQEHAYSLCVEKLLQCEVPIRAKYLRVLFCELTRILNHLLNVSSQALD
CHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VGAMTPLLWLFEEREKILEFYERASGARFHAAYIRPGGIAADVPEDLIEDIAKFIEQFPK
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
YIDDVDELLTENRIWKQRTVGISEISIKQALDWGFSGPMLRAAGLAWDLRKSQPYEIYDQ
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHCCHHCCCCCCCCCHHHC
LDFDIPIGQNGDCYDRYLVRMAEIRQSISLVKQCIEKMPEGQIKTEDRKISPPSRAEMKK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHH
SMEALIHHFKLYSEGYHVPEGEAYAVVEAPKGEFGVYIVSDGTNRPYRCRIRAPGFAHLQ
HHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCCCHHHHH
ALDFMAKGHMLADVAAIIGSLDIVFGEIDR
HHHHHHHCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PDLKTMMLNFGPQHPAAHGVLRLVLEMDGEVIERADPHIGLLHRGTEKLIEHKTYLQAL
CCHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHCCCCEEHHHCCHHHHHHHHHHHHHC
PYFDRLDYVSPMSQEHAYSLCVEKLLQCEVPIRAKYLRVLFCELTRILNHLLNVSSQALD
CHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VGAMTPLLWLFEEREKILEFYERASGARFHAAYIRPGGIAADVPEDLIEDIAKFIEQFPK
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
YIDDVDELLTENRIWKQRTVGISEISIKQALDWGFSGPMLRAAGLAWDLRKSQPYEIYDQ
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHCCHHCCCCCCCCCHHHC
LDFDIPIGQNGDCYDRYLVRMAEIRQSISLVKQCIEKMPEGQIKTEDRKISPPSRAEMKK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHH
SMEALIHHFKLYSEGYHVPEGEAYAVVEAPKGEFGVYIVSDGTNRPYRCRIRAPGFAHLQ
HHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCCCHHHHH
ALDFMAKGHMLADVAAIIGSLDIVFGEIDR
HHHHHHHCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA