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The map label for this gene is ccmA

Identifier: 225630147

GI number: 225630147

Start: 360017

End: 360640

Strand: Direct

Name: ccmA

Synonym: WRi_003300

Alternate gene names: 225630147

Gene position: 360017-360640 (Clockwise)

Preceding gene: 225630144

Following gene: 225630148

Centisome position: 24.9

GC content: 36.06

Gene sequence:

>624_bases
ATGCTTGAATGTGAAAATTTATCCTGCACTCGTAATAATAAGGTACTATTTAAGAATCTCAGTTTTAAAGCTGAGCTAAA
ATCAAAGATTCTAATCACTGGTCCAAATGGTAGTGGTAAAACCAGCTTAATTAGAAGTTTATCTGGACTTTTACCACCGG
TATCAGGCAATATAAGGCACTGTGGAAAAGATATATATGATGATCCAAAATCCTATATATCTTCTATGGTCTATATAGGC
CATAAGAATGCCTGTAAAGATAGCTTAACTGTTGCTCAAAACGTAGAATTCTGGGCAGGAATACGAAATACTAGAGAATT
GATTGTGGCAGCTATTTGTTGCTTGCAGTTGCAACCTGTACTTAATATTAGATATGGCGAACTTTCTGCAGGCTGGAAAA
GGAGAGTTGCGCTTGCTCGCCTCTTGATTTCTAATGCAAACGTTTGGCTGATAGATGAACCATTTTGTAATCTTGATAGT
GCAACGTGTGAATTAGTGCTGAACTTAATCTCAATACGCTCTGAGCAAAATGGTATAGTAATTATTACAGGGCATAGCTC
TACAGAGCAATTGTGTGATTTTACAACGATTGATATACGTAATTTCAATAGACTTCTTGTATAG

Upstream 100 bases:

>100_bases
AATTGATACATAGAGAAGGCGGACAGAAAGGATTTTGGGAGCTGTTTGTAAAGCTCAGGCTTCAACTCAAGGTAAACATA
AGGGAAAGGGCAGATAATCC

Downstream 100 bases:

>100_bases
TTTTTGGCAACAACCGCTAGAAATAAAAAACTTACTTGACAAACTCCGCCAGCCTCCTTATCATGAAACTGAAGCTATTT
ATTTATCTTCTCTGTACAGA

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MLECENLSCTRNNKVLFKNLSFKAELKSKILITGPNGSGKTSLIRSLSGLLPPVSGNIRHCGKDIYDDPKSYISSMVYIG
HKNACKDSLTVAQNVEFWAGIRNTRELIVAAICCLQLQPVLNIRYGELSAGWKRRVALARLLISNANVWLIDEPFCNLDS
ATCELVLNLISIRSEQNGIVIITGHSSTEQLCDFTTIDIRNFNRLLV

Sequences:

>Translated_207_residues
MLECENLSCTRNNKVLFKNLSFKAELKSKILITGPNGSGKTSLIRSLSGLLPPVSGNIRHCGKDIYDDPKSYISSMVYIG
HKNACKDSLTVAQNVEFWAGIRNTRELIVAAICCLQLQPVLNIRYGELSAGWKRRVALARLLISNANVWLIDEPFCNLDS
ATCELVLNLISIRSEQNGIVIITGHSSTEQLCDFTTIDIRNFNRLLV
>Mature_207_residues
MLECENLSCTRNNKVLFKNLSFKAELKSKILITGPNGSGKTSLIRSLSGLLPPVSGNIRHCGKDIYDDPKSYISSMVYIG
HKNACKDSLTVAQNVEFWAGIRNTRELIVAAICCLQLQPVLNIRYGELSAGWKRRVALARLLISNANVWLIDEPFCNLDS
ATCELVLNLISIRSEQNGIVIITGHSSTEQLCDFTTIDIRNFNRLLV

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI27436953, Length=195, Percent_Identity=26.1538461538462, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI27477115, Length=201, Percent_Identity=26.3681592039801, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI116734710, Length=160, Percent_Identity=26.875, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI46592971, Length=190, Percent_Identity=27.8947368421053, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI46592915, Length=190, Percent_Identity=27.8947368421053, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI46592964, Length=190, Percent_Identity=27.8947368421053, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI46592956, Length=190, Percent_Identity=27.8947368421053, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI46592978, Length=190, Percent_Identity=27.8947368421053, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI6005701, Length=195, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI46592898, Length=190, Percent_Identity=27.8947368421053, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI153792144, Length=197, Percent_Identity=23.8578680203046, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI21536376, Length=162, Percent_Identity=27.1604938271605, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI215820660, Length=188, Percent_Identity=28.1914893617021, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI20143975, Length=188, Percent_Identity=28.1914893617021, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI30795238, Length=164, Percent_Identity=29.2682926829268, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI11967969, Length=220, Percent_Identity=28.1818181818182, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI27881501, Length=164, Percent_Identity=29.2682926829268, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI87082064, Length=186, Percent_Identity=36.5591397849462, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1786253, Length=183, Percent_Identity=31.1475409836066, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI87081782, Length=199, Percent_Identity=26.1306532663317, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1790467, Length=166, Percent_Identity=27.710843373494, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788761, Length=168, Percent_Identity=29.7619047619048, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1790544, Length=211, Percent_Identity=26.5402843601896, Blast_Score=67, Evalue=6e-13,
Organism=Escherichia coli, GI87081834, Length=190, Percent_Identity=30, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI87082267, Length=137, Percent_Identity=31.3868613138686, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1786654, Length=206, Percent_Identity=25.2427184466019, Blast_Score=61, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71983523, Length=174, Percent_Identity=28.1609195402299, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71983516, Length=174, Percent_Identity=28.1609195402299, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71983510, Length=174, Percent_Identity=28.1609195402299, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71992290, Length=193, Percent_Identity=25.9067357512953, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI115533608, Length=194, Percent_Identity=25.7731958762887, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320874, Length=196, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19920532, Length=181, Percent_Identity=29.2817679558011, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24580930, Length=181, Percent_Identity=29.2817679558011, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28574533, Length=208, Percent_Identity=29.8076923076923, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24643674, Length=194, Percent_Identity=25.2577319587629, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28574744, Length=166, Percent_Identity=28.3132530120482, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28574150, Length=192, Percent_Identity=27.0833333333333, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI116007328, Length=192, Percent_Identity=27.0833333333333, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMA_WOLPM (Q73HX8)

Other databases:

- EMBL:   AE017196
- RefSeq:   NP_966201.1
- ProteinModelPortal:   Q73HX8
- SMR:   Q73HX8
- EnsemblBacteria:   EBWOLT00000004346
- GeneID:   2738963
- GenomeReviews:   AE017196_GR
- KEGG:   wol:WD0411
- TIGR:   WD_0411
- GeneTree:   EBGT00050000030885
- HOGENOM:   HBG758042
- OMA:   NIWIIDE
- PhylomeDB:   Q73HX8
- ProtClustDB:   PRK13539
- BioCyc:   WPIP955:WD_0411-MONOMER
- HAMAP:   MF_01707
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593
- PANTHER:   PTHR19222:SF5
- SMART:   SM00382
- TIGRFAMs:   TIGR01189

Pfam domain/function: PF00005 ABC_tran

EC number: =3.6.3.41

Molecular weight: Translated: 23014; Mature: 23014

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51243 CCMA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLECENLSCTRNNKVLFKNLSFKAELKSKILITGPNGSGKTSLIRSLSGLLPPVSGNIRH
CCCCCCCCCCCCCEEEEECCCEEEECCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCHHH
CGKDIYDDPKSYISSMVYIGHKNACKDSLTVAQNVEFWAGIRNTRELIVAAICCLQLQPV
CCCHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHCCHH
LNIRYGELSAGWKRRVALARLLISNANVWLIDEPFCNLDSATCELVLNLISIRSEQNGIV
HEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEE
IITGHSSTEQLCDFTTIDIRNFNRLLV
EEECCCCHHHHHCEEEEECCCCCCCCC
>Mature Secondary Structure
MLECENLSCTRNNKVLFKNLSFKAELKSKILITGPNGSGKTSLIRSLSGLLPPVSGNIRH
CCCCCCCCCCCCCEEEEECCCEEEECCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCHHH
CGKDIYDDPKSYISSMVYIGHKNACKDSLTVAQNVEFWAGIRNTRELIVAAICCLQLQPV
CCCHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHCCHH
LNIRYGELSAGWKRRVALARLLISNANVWLIDEPFCNLDSATCELVLNLISIRSEQNGIV
HEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEE
IITGHSSTEQLCDFTTIDIRNFNRLLV
EEECCCCHHHHHCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA