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The map label for this gene is sdhA [H]

Identifier: 225630126

GI number: 225630126

Start: 329416

End: 331215

Strand: Reverse

Name: sdhA [H]

Synonym: WRi_003080

Alternate gene names: 225630126

Gene position: 331215-329416 (Counterclockwise)

Preceding gene: 225630127

Following gene: 225630120

Centisome position: 22.91

GC content: 42.94

Gene sequence:

>1800_bases
ATGGATAAGTCAGCGTATGAGATCATAGAACATGAGTATGACGTGGTAGTAGTAGGTGCAGGTGGAGCAGGGCTCAGAGC
AACGCTTGGGATGGCTGCAACTAATTTTTCAGTTGCCTGCATTTCTAAAATTTTCCCTACACGAAGTCATACAGTTGCAG
CACAAGGCGGAATTAGTGCAGCTTTAGGTAATATCGGTGAAGACGATTGGCGCTGGCATGCATATGACACAATAAAAGGT
TCAGACTGGCTTGGTGATCAAGATGCAATAGAATATATGTGTAAAAACGCTGCTAAAGCTGTTATTGAACTTGAAAATTT
TGGCGTACCTTTTTCTCGTACAGAAGATGGCAAAATATACCAGCGCTCTTTTGGTGGAATGACAACTCACTTTGGTAAAG
GAAAATCAGCGCAGCGCACTTGTGCGGCAGCAGATAAAACTGGGCACGCAATCCTTCACACTCTATATCAGCAGTGTCTT
AAATTCAACGCTGAATTTTTTGTTGAATACTTTGTGATTGATTTAATTATGGATAGCGAAACATGCTGCGGAGTTCTTGC
TTGGTCGCTATGCGACGGCACATTACATAGATTTCGCGCGCATAGGGTGGTGCTAGCAACAGGTGGATATGGACGTGTTT
ATTTCTCTGCAACAAGTGCGCATACCTGCACAGGTGATGGTAACGGCATGGTAGTAAGGGCTGGATTACCACTTGAAGAT
ATGGAATTTGTACAATTTCATCCAACAGGAATATATGGCTCAGGGTGCTTGATGACAGAAGGATGCCGTGGCGAAGGGGG
ATATCTCGTTAATTCTCAGGGCGAAAAGTTTATGGAACGTTACGCACCAAAAGCAAAAGATTTAGCTTCCCGTGATGTGG
TAAGTCGTGCAATAACAATTGAAATTAGAGAGGGAAGGGGAGTTGGGCCGAAAAAAGATTACATGTATTTAACTATAGCG
CATCTTGATCCGGAAGTAATAAAACTCAGATTGCCGGGCATTAGCGAAACCGCAAGAACTTTTGCTGGAGTTGATGTCAC
TAAAGATCCAATACCGGTCATTCCGACTGTTCACTATAACATGGGTGGCATTCCAACCAATTATTATGGAGAAGTGATCA
CGCTGAAGCAAGGTAAGGAAGAAGTGGTAGATGGACTATTTGCAATTGGAGAAGCTGCGTGTGTCTCTGTGCACGGTGCA
AATCGACTTGGCTCTAACTCGCTTCTTGATCTTGTGGTTTTTGGTAGAGCTGCAGCGCTCAGAGCAAAAGAGAAGCTAAA
ATCCGGTACACCACATAAAAAATTGCATTCAGACTGCACAGACTGGATAGTAGATAGGTTTAATAAAATGCGATTTGCCT
CCGGTGGGCTAAAAGTAGCAAAAATACGCAGCGAAATGCAGAACACTATGCAAAAGTACGCATCAGTGTTCCGTGTTGCT
GAAGTTTTAGAAGAAGGCAAAAAAGCTATAAAAAAGGTAGCAAAAATGATGCCTGATATTTCACTTGAGGATCACAGTAT
GATGTGGAATAGTGATTTAGTTGAAGCACTGGAGCTTGCTAACATGATCCCACAAGCGGTTATTACCATGGAATGCGCAG
CTAATCGCGAGGAAAGCAGAGGTGCCCATGCTCGTGAAGACTTTCCTGAACGTGATGACAAAAACTGGATGAAGCACACT
ATAGCGTGGCTTGAAGAAAAGAAAGGGCAAATTAACGTAAAAATTGATTATAAAAAAGTGGCTGAAAAAACTCTGAGCGG
TGAGATTGATTTCATAGCGCCAGAGAAGAGGGTTTACTAG

Upstream 100 bases:

>100_bases
GTTAGCGCCGCGGCGGCATGACGTCTTAACTATAGAAAACTTGTATAGATTTTTTCTACTTCTGTGATATCATAAGCCTG
TAATGATAAAATAAGTAAAT

Downstream 100 bases:

>100_bases
TTACACTATCCCTACACAATTTTTCAACGAGTTCATATATTGATATGGCACTCATTTTAGTGTCTGGAGGACTCTCAGTA
TGCTCTGATTGATTTGGTGA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 599

Protein sequence:

>599_residues
MDKSAYEIIEHEYDVVVVGAGGAGLRATLGMAATNFSVACISKIFPTRSHTVAAQGGISAALGNIGEDDWRWHAYDTIKG
SDWLGDQDAIEYMCKNAAKAVIELENFGVPFSRTEDGKIYQRSFGGMTTHFGKGKSAQRTCAAADKTGHAILHTLYQQCL
KFNAEFFVEYFVIDLIMDSETCCGVLAWSLCDGTLHRFRAHRVVLATGGYGRVYFSATSAHTCTGDGNGMVVRAGLPLED
MEFVQFHPTGIYGSGCLMTEGCRGEGGYLVNSQGEKFMERYAPKAKDLASRDVVSRAITIEIREGRGVGPKKDYMYLTIA
HLDPEVIKLRLPGISETARTFAGVDVTKDPIPVIPTVHYNMGGIPTNYYGEVITLKQGKEEVVDGLFAIGEAACVSVHGA
NRLGSNSLLDLVVFGRAAALRAKEKLKSGTPHKKLHSDCTDWIVDRFNKMRFASGGLKVAKIRSEMQNTMQKYASVFRVA
EVLEEGKKAIKKVAKMMPDISLEDHSMMWNSDLVEALELANMIPQAVITMECAANREESRGAHAREDFPERDDKNWMKHT
IAWLEEKKGQINVKIDYKKVAEKTLSGEIDFIAPEKRVY

Sequences:

>Translated_599_residues
MDKSAYEIIEHEYDVVVVGAGGAGLRATLGMAATNFSVACISKIFPTRSHTVAAQGGISAALGNIGEDDWRWHAYDTIKG
SDWLGDQDAIEYMCKNAAKAVIELENFGVPFSRTEDGKIYQRSFGGMTTHFGKGKSAQRTCAAADKTGHAILHTLYQQCL
KFNAEFFVEYFVIDLIMDSETCCGVLAWSLCDGTLHRFRAHRVVLATGGYGRVYFSATSAHTCTGDGNGMVVRAGLPLED
MEFVQFHPTGIYGSGCLMTEGCRGEGGYLVNSQGEKFMERYAPKAKDLASRDVVSRAITIEIREGRGVGPKKDYMYLTIA
HLDPEVIKLRLPGISETARTFAGVDVTKDPIPVIPTVHYNMGGIPTNYYGEVITLKQGKEEVVDGLFAIGEAACVSVHGA
NRLGSNSLLDLVVFGRAAALRAKEKLKSGTPHKKLHSDCTDWIVDRFNKMRFASGGLKVAKIRSEMQNTMQKYASVFRVA
EVLEEGKKAIKKVAKMMPDISLEDHSMMWNSDLVEALELANMIPQAVITMECAANREESRGAHAREDFPERDDKNWMKHT
IAWLEEKKGQINVKIDYKKVAEKTLSGEIDFIAPEKRVY
>Mature_599_residues
MDKSAYEIIEHEYDVVVVGAGGAGLRATLGMAATNFSVACISKIFPTRSHTVAAQGGISAALGNIGEDDWRWHAYDTIKG
SDWLGDQDAIEYMCKNAAKAVIELENFGVPFSRTEDGKIYQRSFGGMTTHFGKGKSAQRTCAAADKTGHAILHTLYQQCL
KFNAEFFVEYFVIDLIMDSETCCGVLAWSLCDGTLHRFRAHRVVLATGGYGRVYFSATSAHTCTGDGNGMVVRAGLPLED
MEFVQFHPTGIYGSGCLMTEGCRGEGGYLVNSQGEKFMERYAPKAKDLASRDVVSRAITIEIREGRGVGPKKDYMYLTIA
HLDPEVIKLRLPGISETARTFAGVDVTKDPIPVIPTVHYNMGGIPTNYYGEVITLKQGKEEVVDGLFAIGEAACVSVHGA
NRLGSNSLLDLVVFGRAAALRAKEKLKSGTPHKKLHSDCTDWIVDRFNKMRFASGGLKVAKIRSEMQNTMQKYASVFRVA
EVLEEGKKAIKKVAKMMPDISLEDHSMMWNSDLVEALELANMIPQAVITMECAANREESRGAHAREDFPERDDKNWMKHT
IAWLEEKKGQINVKIDYKKVAEKTLSGEIDFIAPEKRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=614, Percent_Identity=57.4918566775244, Blast_Score=716, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=553, Percent_Identity=54.249547920434, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1790597, Length=578, Percent_Identity=40.4844290657439, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1788928, Length=554, Percent_Identity=31.5884476534296, Blast_Score=229, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17550100, Length=618, Percent_Identity=57.6051779935275, Blast_Score=707, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=616, Percent_Identity=56.3311688311688, Blast_Score=690, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=597, Percent_Identity=63.1490787269682, Blast_Score=779, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=597, Percent_Identity=63.3165829145729, Blast_Score=765, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320788, Length=489, Percent_Identity=27.4028629856851, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17137288, Length=612, Percent_Identity=59.640522875817, Blast_Score=746, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=612, Percent_Identity=59.640522875817, Blast_Score=746, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=612, Percent_Identity=59.640522875817, Blast_Score=746, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=617, Percent_Identity=54.7811993517018, Blast_Score=680, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66055; Mature: 66055

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKSAYEIIEHEYDVVVVGAGGAGLRATLGMAATNFSVACISKIFPTRSHTVAAQGGISA
CCCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCCHHH
ALGNIGEDDWRWHAYDTIKGSDWLGDQDAIEYMCKNAAKAVIELENFGVPFSRTEDGKIY
HHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCH
QRSFGGMTTHFGKGKSAQRTCAAADKTGHAILHTLYQQCLKFNAEFFVEYFVIDLIMDSE
HHHCCCCEEECCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
TCCGVLAWSLCDGTLHRFRAHRVVLATGGYGRVYFSATSAHTCTGDGNGMVVRAGLPLED
HHHHHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEEECCCEEEECCCCCEEEECCCCCCC
MEFVQFHPTGIYGSGCLMTEGCRGEGGYLVNSQGEKFMERYAPKAKDLASRDVVSRAITI
CCEEEEECCCEECCCCEEECCCCCCCCEEECCCCHHHHHHHCCCHHHHHHHHHHCEEEEE
EIREGRGVGPKKDYMYLTIAHLDPEVIKLRLPGISETARTFAGVDVTKDPIPVIPTVHYN
EEECCCCCCCCCCEEEEEEEECCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCEEECC
MGGIPTNYYGEVITLKQGKEEVVDGLFAIGEAACVSVHGANRLGSNSLLDLVVFGRAAAL
CCCCCCCCCCCEEEECCCHHHHHHHHHHHCCHHEEEEECCCCCCCCHHHHHHHHHHHHHH
RAKEKLKSGTPHKKLHSDCTDWIVDRFNKMRFASGGLKVAKIRSEMQNTMQKYASVFRVA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
EVLEEGKKAIKKVAKMMPDISLEDHSMMWNSDLVEALELANMIPQAVITMECAANREESR
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEHHHHCCCCHHC
GAHAREDFPERDDKNWMKHTIAWLEEKKGQINVKIDYKKVAEKTLSGEIDFIAPEKRVY
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHCCCEEEECCCCCCC
>Mature Secondary Structure
MDKSAYEIIEHEYDVVVVGAGGAGLRATLGMAATNFSVACISKIFPTRSHTVAAQGGISA
CCCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCCHHH
ALGNIGEDDWRWHAYDTIKGSDWLGDQDAIEYMCKNAAKAVIELENFGVPFSRTEDGKIY
HHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCH
QRSFGGMTTHFGKGKSAQRTCAAADKTGHAILHTLYQQCLKFNAEFFVEYFVIDLIMDSE
HHHCCCCEEECCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
TCCGVLAWSLCDGTLHRFRAHRVVLATGGYGRVYFSATSAHTCTGDGNGMVVRAGLPLED
HHHHHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEEECCCEEEECCCCCEEEECCCCCCC
MEFVQFHPTGIYGSGCLMTEGCRGEGGYLVNSQGEKFMERYAPKAKDLASRDVVSRAITI
CCEEEEECCCEECCCCEEECCCCCCCCEEECCCCHHHHHHHCCCHHHHHHHHHHCEEEEE
EIREGRGVGPKKDYMYLTIAHLDPEVIKLRLPGISETARTFAGVDVTKDPIPVIPTVHYN
EEECCCCCCCCCCEEEEEEEECCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCEEECC
MGGIPTNYYGEVITLKQGKEEVVDGLFAIGEAACVSVHGANRLGSNSLLDLVVFGRAAAL
CCCCCCCCCCCEEEECCCHHHHHHHHHHHCCHHEEEEECCCCCCCCHHHHHHHHHHHHHH
RAKEKLKSGTPHKKLHSDCTDWIVDRFNKMRFASGGLKVAKIRSEMQNTMQKYASVFRVA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
EVLEEGKKAIKKVAKMMPDISLEDHSMMWNSDLVEALELANMIPQAVITMECAANREESR
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEHHHHCCCCHHC
GAHAREDFPERDDKNWMKHTIAWLEEKKGQINVKIDYKKVAEKTLSGEIDFIAPEKRVY
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA