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The map label for this gene is galK

Identifier: 222527216

GI number: 222527216

Start: 4944122

End: 4945294

Strand: Direct

Name: galK

Synonym: Chy400_4000

Alternate gene names: 222527216

Gene position: 4944122-4945294 (Clockwise)

Preceding gene: 222527214

Following gene: 222527217

Centisome position: 93.84

GC content: 60.36

Gene sequence:

>1173_bases
ATGTACGAATTATCTACACTGTACGCTGCATTTGAGCAGTACTTCGGTCATCCACCAACCCGCATCGCTCGCGCTCCTGG
TCGGGTGAATTTGATCGGTGAGCACACCGATTACAACGATGGTTTTGTCTTCCCGATGGCGCTGGATCGCGCCACCTATG
TGGCGGCCCGGCCACGCAACGATCAGATTGTGCGGGTGTTTAGTATAAAGTTCCGCGACGAGGATCAGTTCGATTTACAG
CAGATTGTGCGCGATGAGCGCCGGCAGTGGGTGAATTATATTCGCGGTGTGGCAAAAGGGTTACTGGCCCGTGATTTGCC
GCTGCGTGGTGCCGATTTAATGATCGATAGCGATGTCCCGGCGGGGAGTGGTCTCTCGTCGTCGGCGGCACTGGAGGTGG
CGGTTGGGTATACGTTTCAACTGCTGAACAATATCAACCTGCTCGGTGAGGAGCTGGCGCTGGTGGCGCAGGGCGCGGAG
CATACGTTTGTTGGGGTCAAGTGTGGGATTATGGATCAGTTGATCGCTGCCCTGGGTGAAGCCGGCCATGCGCTGCTGAT
CGACTGCCGCGACTTGAGTTATCGTCCGGTGCCGATTCCCGCCGAAGCGCGGGTAGTCGTGTGCGATAGCGGTGTACGCC
ATCGCCTGGCCGGTTCCGAGTACAATCAGCGCCGCGCCGGTTGCGAAGAAGCGGTGCGCCTGCTCAAGCCGGCGTTGGGG
AAGATTCAGGCGCTGCGTGATGTGCGTTCGAGCGATCTGGCTATGTACGGTCACCTGTTGCCGCCCGATTTGCTGCCGCT
GGCCCGCCATGTGGTGAGCGAAAATGAACGCACGCTGGCGGCTGCCGAGGCGCTGGCTGCCGGTGATCTGGTGAAGATGG
GCCAGTTGATGGTCGCTTCGCACGTAAGCTTGCGCGACGACTATCGGGTGAGTGTGCGCGAACTCGATACGCTCGTCGAT
CTGGCGCTGGCCGCACCGGGTTGCTTCGGCAGTCGCATGACCGGCGGTGGCTTCGGTGGTAGCACAGTGTCGCTGGTAGC
CGCCGATCACGTTGATGCGTTCGTGGCAGCGATGGTAGACGGCTATGCCATTCGTACCGGACGCAAACTGCAACCGCTGG
TCTGCACCGCCGGCGCCGGGGTGTCGTGTGTCTACGCCAGCGAAGAGGAATAG

Upstream 100 bases:

>100_bases
TCCTATCTCCTATCTCCTATTTCCTCAAAAAGTGATATAGTACGCAAGACAACACAAAGCGCTCGTATCACTCGCGGGGT
GTTCCTGCTGGAGTAAGGTT

Downstream 100 bases:

>100_bases
GGTCTCGCCCTGCGGATGGTTCGCCTGCGCGAGGCAAGCCGGTAGGGCGGCCATCCGCCGGTGGTGCGGAATCGCCACGG
GGCAGGCAGGTGCGATTCAG

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MYELSTLYAAFEQYFGHPPTRIARAPGRVNLIGEHTDYNDGFVFPMALDRATYVAARPRNDQIVRVFSIKFRDEDQFDLQ
QIVRDERRQWVNYIRGVAKGLLARDLPLRGADLMIDSDVPAGSGLSSSAALEVAVGYTFQLLNNINLLGEELALVAQGAE
HTFVGVKCGIMDQLIAALGEAGHALLIDCRDLSYRPVPIPAEARVVVCDSGVRHRLAGSEYNQRRAGCEEAVRLLKPALG
KIQALRDVRSSDLAMYGHLLPPDLLPLARHVVSENERTLAAAEALAAGDLVKMGQLMVASHVSLRDDYRVSVRELDTLVD
LALAAPGCFGSRMTGGGFGGSTVSLVAADHVDAFVAAMVDGYAIRTGRKLQPLVCTAGAGVSCVYASEEE

Sequences:

>Translated_390_residues
MYELSTLYAAFEQYFGHPPTRIARAPGRVNLIGEHTDYNDGFVFPMALDRATYVAARPRNDQIVRVFSIKFRDEDQFDLQ
QIVRDERRQWVNYIRGVAKGLLARDLPLRGADLMIDSDVPAGSGLSSSAALEVAVGYTFQLLNNINLLGEELALVAQGAE
HTFVGVKCGIMDQLIAALGEAGHALLIDCRDLSYRPVPIPAEARVVVCDSGVRHRLAGSEYNQRRAGCEEAVRLLKPALG
KIQALRDVRSSDLAMYGHLLPPDLLPLARHVVSENERTLAAAEALAAGDLVKMGQLMVASHVSLRDDYRVSVRELDTLVD
LALAAPGCFGSRMTGGGFGGSTVSLVAADHVDAFVAAMVDGYAIRTGRKLQPLVCTAGAGVSCVYASEEE
>Mature_390_residues
MYELSTLYAAFEQYFGHPPTRIARAPGRVNLIGEHTDYNDGFVFPMALDRATYVAARPRNDQIVRVFSIKFRDEDQFDLQ
QIVRDERRQWVNYIRGVAKGLLARDLPLRGADLMIDSDVPAGSGLSSSAALEVAVGYTFQLLNNINLLGEELALVAQGAE
HTFVGVKCGIMDQLIAALGEAGHALLIDCRDLSYRPVPIPAEARVVVCDSGVRHRLAGSEYNQRRAGCEEAVRLLKPALG
KIQALRDVRSSDLAMYGHLLPPDLLPLARHVVSENERTLAAAEALAAGDLVKMGQLMVASHVSLRDDYRVSVRELDTLVD
LALAAPGCFGSRMTGGGFGGSTVSLVAADHVDAFVAAMVDGYAIRTGRKLQPLVCTAGAGVSCVYASEEE

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily

Homologues:

Organism=Homo sapiens, GI4503895, Length=350, Percent_Identity=48.2857142857143, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI48527957, Length=429, Percent_Identity=30.3030303030303, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI4503897, Length=429, Percent_Identity=30.3030303030303, Blast_Score=138, Evalue=8e-33,
Organism=Escherichia coli, GI1786972, Length=373, Percent_Identity=47.1849865951743, Blast_Score=330, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI71989053, Length=409, Percent_Identity=30.5623471882641, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320212, Length=242, Percent_Identity=31.8181818181818, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319494, Length=254, Percent_Identity=31.8897637795276, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24661292, Length=430, Percent_Identity=28.3720930232558, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21355577, Length=430, Percent_Identity=28.3720930232558, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24661285, Length=430, Percent_Identity=28.3720930232558, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GAL1_CHLAA (A9WB97)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001637279.1
- ProteinModelPortal:   A9WB97
- SMR:   A9WB97
- GeneID:   5825520
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_3712
- HOGENOM:   HBG725121
- OMA:   YNDGFVM
- ProtClustDB:   CLSK974997
- GO:   GO:0005737
- HAMAP:   MF_00246
- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000530
- PRINTS:   PR00473
- PRINTS:   PR00959
- TIGRFAMs:   TIGR00131

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.6

Molecular weight: Translated: 42183; Mature: 42183

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00106 GALACTOKINASE; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYELSTLYAAFEQYFGHPPTRIARAPGRVNLIGEHTDYNDGFVFPMALDRATYVAARPRN
CCCHHHHHHHHHHHHCCCCHHHHCCCCCEEEEECCCCCCCCEEEEEECCCEEEEEECCCC
DQIVRVFSIKFRDEDQFDLQQIVRDERRQWVNYIRGVAKGLLARDLPLRGADLMIDSDVP
CCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCC
AGSGLSSSAALEVAVGYTFQLLNNINLLGEELALVAQGAEHTFVGVKCGIMDQLIAALGE
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCC
AGHALLIDCRDLSYRPVPIPAEARVVVCDSGVRHRLAGSEYNQRRAGCEEAVRLLKPALG
CCCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHCCCCHHHHHCCHHHHHHHHHHHHH
KIQALRDVRSSDLAMYGHLLPPDLLPLARHVVSENERTLAAAEALAAGDLVKMGQLMVAS
HHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HVSLRDDYRVSVRELDTLVDLALAAPGCFGSRMTGGGFGGSTVSLVAADHVDAFVAAMVD
HCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHC
GYAIRTGRKLQPLVCTAGAGVSCVYASEEE
CEEEECCCCCCCEEEECCCCEEEEEECCCC
>Mature Secondary Structure
MYELSTLYAAFEQYFGHPPTRIARAPGRVNLIGEHTDYNDGFVFPMALDRATYVAARPRN
CCCHHHHHHHHHHHHCCCCHHHHCCCCCEEEEECCCCCCCCEEEEEECCCEEEEEECCCC
DQIVRVFSIKFRDEDQFDLQQIVRDERRQWVNYIRGVAKGLLARDLPLRGADLMIDSDVP
CCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCC
AGSGLSSSAALEVAVGYTFQLLNNINLLGEELALVAQGAEHTFVGVKCGIMDQLIAALGE
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCC
AGHALLIDCRDLSYRPVPIPAEARVVVCDSGVRHRLAGSEYNQRRAGCEEAVRLLKPALG
CCCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHCCCCHHHHHCCHHHHHHHHHHHHH
KIQALRDVRSSDLAMYGHLLPPDLLPLARHVVSENERTLAAAEALAAGDLVKMGQLMVAS
HHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HVSLRDDYRVSVRELDTLVDLALAAPGCFGSRMTGGGFGGSTVSLVAADHVDAFVAAMVD
HCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHC
GYAIRTGRKLQPLVCTAGAGVSCVYASEEE
CEEEECCCCCCCEEEECCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA