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The map label for this gene is argD [H]

Identifier: 222527161

GI number: 222527161

Start: 4895544

End: 4896731

Strand: Direct

Name: argD [H]

Synonym: Chy400_3943

Alternate gene names: 222527161

Gene position: 4895544-4896731 (Clockwise)

Preceding gene: 222527160

Following gene: 222527162

Centisome position: 92.91

GC content: 61.2

Gene sequence:

>1188_bases
ATGATCAATACGCTGAGCACAAATGCCGAGATTATTGCGCAAGAAGCGCTCTACACCAGTGGCTTGTATCCAAAGCGGCC
ACTGGCAATCGTGCGCGGGGAAGGGGCGCGCCTGTACGATGCGGATGGCCGGGTCTACATCGATTGTGTCGGTGGTCAGG
GTGCGGCCAATCTCGGCCACTGCCACCCGGCTATCGTCGCAGCGATTCGCGAACAGGCAGAGCGGCTCATCAGTTGTCCC
GAAATCTTTCCCAACGATGTCCGGGCAGCATATCTGGCCGAATTAGCGGCGGTCGTACCATTCCCCTCGCGTATCTTCCT
CTGCAACAGCGGGGCAGAAGCGGTTGAAGCAGCTTTGAAATTTGCGCGGCTTTTGACAGGTCGGCCTGGCGTCGTTGCAA
CCATGCGCGGCTTCCATGGCCGTACCATGGGGGCGCTCAGTGCCACCTGGGAGAGCAAGTACCGCGAACCATTTTTACCC
CTGGTGCCGGAATTCAGCCATGTGCCTTACGGAAACGTGGAAGCGTTGCGAGCCGCTATCGGCCCACAGACGGCTGCGGT
GCTGATCGAACCGGTGCAGGGAGAGGGTGGGGTGCGACCGGCGCCGCCCGGCTATCTGGCAGAAGTCGCCACCATCTGCG
CTGCGAATGGCACGTTGTTGTTGGTTGATGAAGTACAGACTGGCTTTGGGCGAACCGGCAAGCTGTTTGCGATTGAGCAT
AGTGGCGTCACGCCTGATATGCTCATCCTTGCCAAGAGCATTGCTGCCGGGGTACCAATGGGTGCCGTGGTCATCCACGA
ACGTCACGGCGCACTACCACCGGGAACCCATGGCTCAACCTTTGGGGGCAACCCTCTGGCCTGTGCTGCGGCCCGGGCCG
CCCTGCACGTGTATCAGAGCGAACGGATACCTGAGCAGGCGGCGGCCAAAGGGGCATGGCTGCTACAAACACTGCGCGAC
CTGCGCCTGCCGTCGGTTCGCGAAGTCCGGGGATTGGGCCTGTTAGTCGGTCTTGAGCTGAAAAGTCGCTCCCAGCCCGC
CATCGCAGCGCTGATCGACCACGGCGTCCTGGCCCTACCGGCGGGACCCAATGTCTTGCGGCTGCTACCACCGCTGGTTA
TCGAGCAGGCCGACCTGGAACGGGTGGTAACAGCCATTGAAGCGGTACTGAGTACCGAAGAGAGATAG

Upstream 100 bases:

>100_bases
TGGCCACTGGTCAGTAATGCGCTGGCCCAGGCCGGGATTACGGTCGCCGAATAGCATGCCTCATAGCTTCAATGAGTCAC
ACAAGGGTAAGGATGTCGTG

Downstream 100 bases:

>100_bases
GGCAAGTGGCAGGCTGCACATTACCGTTACGCACCTGGTAGTGCGCAGCTTGCCGGGAACAACTCTGCGCTGAGCGCTGA
CACCGCGTCCACCGTGCTGC

Product: acetylornithine and succinylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MINTLSTNAEIIAQEALYTSGLYPKRPLAIVRGEGARLYDADGRVYIDCVGGQGAANLGHCHPAIVAAIREQAERLISCP
EIFPNDVRAAYLAELAAVVPFPSRIFLCNSGAEAVEAALKFARLLTGRPGVVATMRGFHGRTMGALSATWESKYREPFLP
LVPEFSHVPYGNVEALRAAIGPQTAAVLIEPVQGEGGVRPAPPGYLAEVATICAANGTLLLVDEVQTGFGRTGKLFAIEH
SGVTPDMLILAKSIAAGVPMGAVVIHERHGALPPGTHGSTFGGNPLACAAARAALHVYQSERIPEQAAAKGAWLLQTLRD
LRLPSVREVRGLGLLVGLELKSRSQPAIAALIDHGVLALPAGPNVLRLLPPLVIEQADLERVVTAIEAVLSTEER

Sequences:

>Translated_395_residues
MINTLSTNAEIIAQEALYTSGLYPKRPLAIVRGEGARLYDADGRVYIDCVGGQGAANLGHCHPAIVAAIREQAERLISCP
EIFPNDVRAAYLAELAAVVPFPSRIFLCNSGAEAVEAALKFARLLTGRPGVVATMRGFHGRTMGALSATWESKYREPFLP
LVPEFSHVPYGNVEALRAAIGPQTAAVLIEPVQGEGGVRPAPPGYLAEVATICAANGTLLLVDEVQTGFGRTGKLFAIEH
SGVTPDMLILAKSIAAGVPMGAVVIHERHGALPPGTHGSTFGGNPLACAAARAALHVYQSERIPEQAAAKGAWLLQTLRD
LRLPSVREVRGLGLLVGLELKSRSQPAIAALIDHGVLALPAGPNVLRLLPPLVIEQADLERVVTAIEAVLSTEER
>Mature_395_residues
MINTLSTNAEIIAQEALYTSGLYPKRPLAIVRGEGARLYDADGRVYIDCVGGQGAANLGHCHPAIVAAIREQAERLISCP
EIFPNDVRAAYLAELAAVVPFPSRIFLCNSGAEAVEAALKFARLLTGRPGVVATMRGFHGRTMGALSATWESKYREPFLP
LVPEFSHVPYGNVEALRAAIGPQTAAVLIEPVQGEGGVRPAPPGYLAEVATICAANGTLLLVDEVQTGFGRTGKLFAIEH
SGVTPDMLILAKSIAAGVPMGAVVIHERHGALPPGTHGSTFGGNPLACAAARAALHVYQSERIPEQAAAKGAWLLQTLRD
LRLPSVREVRGLGLLVGLELKSRSQPAIAALIDHGVLALPAGPNVLRLLPPLVIEQADLERVVTAIEAVLSTEER

Specific function: Involved in both the arginine and lysine biosynthetic pathways [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=401, Percent_Identity=35.1620947630923, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI284507298, Length=299, Percent_Identity=36.4548494983278, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI24119277, Length=420, Percent_Identity=29.5238095238095, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI13994255, Length=363, Percent_Identity=31.404958677686, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI37574042, Length=423, Percent_Identity=26.9503546099291, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI226442705, Length=423, Percent_Identity=26.0047281323877, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI226442709, Length=387, Percent_Identity=26.8733850129199, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI188536080, Length=403, Percent_Identity=24.8138957816377, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI38679950, Length=403, Percent_Identity=24.8138957816377, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI38679946, Length=403, Percent_Identity=24.8138957816377, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI145693181, Length=376, Percent_Identity=42.2872340425532, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1789759, Length=364, Percent_Identity=39.2857142857143, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1788044, Length=393, Percent_Identity=39.1857506361323, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI1789016, Length=414, Percent_Identity=33.5748792270531, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI1787560, Length=391, Percent_Identity=36.3171355498721, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI1786991, Length=423, Percent_Identity=33.096926713948, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1786349, Length=284, Percent_Identity=35.2112676056338, Blast_Score=131, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI25144271, Length=393, Percent_Identity=34.6055979643766, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI32564660, Length=423, Percent_Identity=33.096926713948, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI25144274, Length=261, Percent_Identity=37.9310344827586, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI71992977, Length=428, Percent_Identity=28.0373831775701, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71981843, Length=180, Percent_Identity=30.5555555555556, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17541228, Length=423, Percent_Identity=24.113475177305, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323470, Length=415, Percent_Identity=36.6265060240964, Blast_Score=236, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6324432, Length=405, Percent_Identity=35.3086419753086, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6324386, Length=450, Percent_Identity=25.7777777777778, Blast_Score=109, Evalue=6e-25,
Organism=Drosophila melanogaster, GI21357415, Length=393, Percent_Identity=35.6234096692112, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI28574759, Length=419, Percent_Identity=31.980906921241, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI161085790, Length=424, Percent_Identity=31.3679245283019, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI21356575, Length=417, Percent_Identity=30.9352517985612, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI281366494, Length=421, Percent_Identity=25.8907363420428, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667139, Length=421, Percent_Identity=25.8907363420428, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667143, Length=421, Percent_Identity=25.8907363420428, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 41650; Mature: 41650

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINTLSTNAEIIAQEALYTSGLYPKRPLAIVRGEGARLYDADGRVYIDCVGGQGAANLGH
CCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCCEEEEEEECCCCCCCCCC
CHPAIVAAIREQAERLISCPEIFPNDVRAAYLAELAAVVPFPSRIFLCNSGAEAVEAALK
HHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHH
FARLLTGRPGVVATMRGFHGRTMGALSATWESKYREPFLPLVPEFSHVPYGNVEALRAAI
HHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHH
GPQTAAVLIEPVQGEGGVRPAPPGYLAEVATICAANGTLLLVDEVQTGFGRTGKLFAIEH
CCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEC
SGVTPDMLILAKSIAAGVPMGAVVIHERHGALPPGTHGSTFGGNPLACAAARAALHVYQS
CCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ERIPEQAAAKGAWLLQTLRDLRLPSVREVRGLGLLVGLELKSRSQPAIAALIDHGVLALP
HCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEEEEECCCCCCHHHHHHCCCEEEEC
AGPNVLRLLPPLVIEQADLERVVTAIEAVLSTEER
CCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MINTLSTNAEIIAQEALYTSGLYPKRPLAIVRGEGARLYDADGRVYIDCVGGQGAANLGH
CCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCCEEEEEEECCCCCCCCCC
CHPAIVAAIREQAERLISCPEIFPNDVRAAYLAELAAVVPFPSRIFLCNSGAEAVEAALK
HHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHH
FARLLTGRPGVVATMRGFHGRTMGALSATWESKYREPFLPLVPEFSHVPYGNVEALRAAI
HHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHH
GPQTAAVLIEPVQGEGGVRPAPPGYLAEVATICAANGTLLLVDEVQTGFGRTGKLFAIEH
CCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEC
SGVTPDMLILAKSIAAGVPMGAVVIHERHGALPPGTHGSTFGGNPLACAAARAALHVYQS
CCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ERIPEQAAAKGAWLLQTLRDLRLPSVREVRGLGLLVGLELKSRSQPAIAALIDHGVLALP
HCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEEEEECCCCCCHHHHHHCCCEEEEC
AGPNVLRLLPPLVIEQADLERVVTAIEAVLSTEER
CCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11489859 [H]