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The map label for this gene is aphA [H]

Identifier: 222526921

GI number: 222526921

Start: 4611494

End: 4612549

Strand: Reverse

Name: aphA [H]

Synonym: Chy400_3699

Alternate gene names: 222526921

Gene position: 4612549-4611494 (Counterclockwise)

Preceding gene: 222526929

Following gene: 222526920

Centisome position: 87.54

GC content: 60.98

Gene sequence:

>1056_bases
ATGAACATCTTTCTGAGTGCTGACCATCACCATCACAACCCGCCGTTCGAGATACTCGACGGTCGTGTCGTGCCCTATGC
CGAAACACCGCAGCGGGTCGCGATCATCCTGGCTGCACTGGCAGAGGCAGGTTTTGCACCGCCGATTGTAGCGTCACCTG
CTACCATTGCCGATCTGGCGGCAATCCATACCGCTGACTACCTGGAGTATCTGGCTAATGGCAGCGCACGCTGGCAGGCT
GCCGGATTGTCGGCGCCAGTCTTCCCATCGGCATGGCCATTGCCGGGGTTACGGTTGCGCAGCGACTGCCCGCAGGCGGC
TGCCGGACGCTACACCTTTGACCTGAGCGCCCCCATCACCGCCGGCACTTTCACCGCTGCCTGTTCGGCGGCGGGAGCAG
CGTTGGCCGGCGCGGCGGCATTGCTCGCCGGTAATACTAGTGCGTATGCCCTCTGCCGTCCGCCGGGCCACCACGCTGCG
GCGGCGATGGCCGGTGGCTACTGCTACCTGAATAACGCTGCGCTGGCTGCCGACTACCTGGCACGTAGCCAGACGAGCGG
TGATGCAACGTGGGCATTGCGTTCACCGACTGTTGCTGTGCTCGACATTGACTATCACCACGGCAACGGCACCCAGAGCA
TCTTCTACGAACGCAATGATGTGCTGACCGTCTCGCTCCATGCCGATCCGGCTTACGAATATCCGTACTACCTCGGCTAC
GCCGACGAGCGCGGGGCCGGGGCCGGTGAAGGGTACAACCTCAATTTCCCGCTACCGGCAGGGATTGATGATGCCGGTTA
TCTCAAAGCGCTCGATCAGGCATTGCAGGCGATTGCCGATTACGGCCCGCGCTACCTGGTGGTTTCTGCCGGCTTCGATA
CTTTTGCCGGCGACCCCCTGGGCGGGTTTGCACTGATCACCGAAGCATATCGAACGATTGGTCGATCAATTACCCAACTC
GGTCTGCCAACACTGATTGTGCAAGAGGGTGGTTATGCGCTCGAAGCCCTGGGTGCCAATGTCGTGGCATTGCTACAAGG
AGTTTCCACAGCATGA

Upstream 100 bases:

>100_bases
CCTATCTCCTATCTCCTATCTCCTATCTCCTATCTCCTATCTCCTATTTCCTATTTCCTCTTTCCTCTCTCCTCCCCCCA
AGTTGCGTTACAATATAGCT

Downstream 100 bases:

>100_bases
TCAACGATAATTCACTCGACCAGCCACAACCGTCGCTGACGCCGGGGTGGGGCTGGCGTGATCTGTTCATTACCCTGTTA
GTCATCGGAGTTGGCGGCTC

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MNIFLSADHHHHNPPFEILDGRVVPYAETPQRVAIILAALAEAGFAPPIVASPATIADLAAIHTADYLEYLANGSARWQA
AGLSAPVFPSAWPLPGLRLRSDCPQAAAGRYTFDLSAPITAGTFTAACSAAGAALAGAAALLAGNTSAYALCRPPGHHAA
AAMAGGYCYLNNAALAADYLARSQTSGDATWALRSPTVAVLDIDYHHGNGTQSIFYERNDVLTVSLHADPAYEYPYYLGY
ADERGAGAGEGYNLNFPLPAGIDDAGYLKALDQALQAIADYGPRYLVVSAGFDTFAGDPLGGFALITEAYRTIGRSITQL
GLPTLIVQEGGYALEALGANVVALLQGVSTA

Sequences:

>Translated_351_residues
MNIFLSADHHHHNPPFEILDGRVVPYAETPQRVAIILAALAEAGFAPPIVASPATIADLAAIHTADYLEYLANGSARWQA
AGLSAPVFPSAWPLPGLRLRSDCPQAAAGRYTFDLSAPITAGTFTAACSAAGAALAGAAALLAGNTSAYALCRPPGHHAA
AAMAGGYCYLNNAALAADYLARSQTSGDATWALRSPTVAVLDIDYHHGNGTQSIFYERNDVLTVSLHADPAYEYPYYLGY
ADERGAGAGEGYNLNFPLPAGIDDAGYLKALDQALQAIADYGPRYLVVSAGFDTFAGDPLGGFALITEAYRTIGRSITQL
GLPTLIVQEGGYALEALGANVVALLQGVSTA
>Mature_351_residues
MNIFLSADHHHHNPPFEILDGRVVPYAETPQRVAIILAALAEAGFAPPIVASPATIADLAAIHTADYLEYLANGSARWQA
AGLSAPVFPSAWPLPGLRLRSDCPQAAAGRYTFDLSAPITAGTFTAACSAAGAALAGAAALLAGNTSAYALCRPPGHHAA
AAMAGGYCYLNNAALAADYLARSQTSGDATWALRSPTVAVLDIDYHHGNGTQSIFYERNDVLTVSLHADPAYEYPYYLGY
ADERGAGAGEGYNLNFPLPAGIDDAGYLKALDQALQAIADYGPRYLVVSAGFDTFAGDPLGGFALITEAYRTIGRSITQL
GLPTLIVQEGGYALEALGANVVALLQGVSTA

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=335, Percent_Identity=32.5373134328358, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI17158039, Length=222, Percent_Identity=34.6846846846847, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI30795204, Length=222, Percent_Identity=34.6846846846847, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI30795202, Length=222, Percent_Identity=34.6846846846847, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI148539870, Length=200, Percent_Identity=34.5, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI169234807, Length=200, Percent_Identity=34.5, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI13128862, Length=316, Percent_Identity=28.1645569620253, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI153085395, Length=200, Percent_Identity=36, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI8923769, Length=317, Percent_Identity=27.1293375394322, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI20070354, Length=233, Percent_Identity=34.7639484978541, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI13128860, Length=232, Percent_Identity=29.7413793103448, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI62750347, Length=222, Percent_Identity=34.6846846846847, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI62750349, Length=222, Percent_Identity=34.6846846846847, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI293336691, Length=205, Percent_Identity=31.7073170731707, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI262073088, Length=219, Percent_Identity=29.6803652968037, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI226529806, Length=231, Percent_Identity=30.7359307359307, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI262073092, Length=255, Percent_Identity=25.4901960784314, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17540334, Length=342, Percent_Identity=30.9941520467836, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI193206283, Length=342, Percent_Identity=30.9941520467836, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17540332, Length=342, Percent_Identity=30.9941520467836, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI193209491, Length=333, Percent_Identity=29.4294294294294, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17534739, Length=325, Percent_Identity=28.6153846153846, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17508561, Length=333, Percent_Identity=28.5285285285285, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17537347, Length=234, Percent_Identity=29.9145299145299, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17561978, Length=285, Percent_Identity=26.3157894736842, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI25154020, Length=217, Percent_Identity=28.110599078341, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI25154022, Length=185, Percent_Identity=28.1081081081081, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324307, Length=350, Percent_Identity=28, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6323999, Length=313, Percent_Identity=28.1150159744409, Blast_Score=119, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6321244, Length=284, Percent_Identity=28.8732394366197, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24642144, Length=226, Percent_Identity=37.6106194690265, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24644244, Length=316, Percent_Identity=30.379746835443, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24642142, Length=226, Percent_Identity=37.6106194690265, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24642146, Length=226, Percent_Identity=37.6106194690265, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI281360899, Length=225, Percent_Identity=37.7777777777778, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI281360801, Length=227, Percent_Identity=34.8017621145374, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24641720, Length=227, Percent_Identity=34.8017621145374, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI281360799, Length=227, Percent_Identity=34.8017621145374, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24657891, Length=235, Percent_Identity=30.2127659574468, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24649807, Length=210, Percent_Identity=29.0476190476191, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 36459; Mature: 36459

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIFLSADHHHHNPPFEILDGRVVPYAETPQRVAIILAALAEAGFAPPIVASPATIADLA
CEEEEECCCCCCCCCHHEECCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
AIHTADYLEYLANGSARWQAAGLSAPVFPSAWPLPGLRLRSDCPQAAAGRYTFDLSAPIT
HHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHCCCEEEEECCCCC
AGTFTAACSAAGAALAGAAALLAGNTSAYALCRPPGHHAAAAMAGGYCYLNNAALAADYL
CCHHHHHHHHHHHHHHHHHHEEECCCCEEEEECCCCCHHHHHHCCCEEEECCCHHHHHHH
ARSQTSGDATWALRSPTVAVLDIDYHHGNGTQSIFYERNDVLTVSLHADPAYEYPYYLGY
HHCCCCCCEEEEECCCEEEEEEEEEECCCCCCEEEEECCCEEEEEEECCCCCCCCEEEEC
ADERGAGAGEGYNLNFPLPAGIDDAGYLKALDQALQAIADYGPRYLVVSAGFDTFAGDPL
CCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCC
GGFALITEAYRTIGRSITQLGLPTLIVQEGGYALEALGANVVALLQGVSTA
CHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEHHCCHHHHHHHHCCCC
>Mature Secondary Structure
MNIFLSADHHHHNPPFEILDGRVVPYAETPQRVAIILAALAEAGFAPPIVASPATIADLA
CEEEEECCCCCCCCCHHEECCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
AIHTADYLEYLANGSARWQAAGLSAPVFPSAWPLPGLRLRSDCPQAAAGRYTFDLSAPIT
HHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHCCCEEEEECCCCC
AGTFTAACSAAGAALAGAAALLAGNTSAYALCRPPGHHAAAAMAGGYCYLNNAALAADYL
CCHHHHHHHHHHHHHHHHHHEEECCCCEEEEECCCCCHHHHHHCCCEEEECCCHHHHHHH
ARSQTSGDATWALRSPTVAVLDIDYHHGNGTQSIFYERNDVLTVSLHADPAYEYPYYLGY
HHCCCCCCEEEEECCCEEEEEEEEEECCCCCCEEEEECCCEEEEEEECCCCCCCCEEEEC
ADERGAGAGEGYNLNFPLPAGIDDAGYLKALDQALQAIADYGPRYLVVSAGFDTFAGDPL
CCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCC
GGFALITEAYRTIGRSITQLGLPTLIVQEGGYALEALGANVVALLQGVSTA
CHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEHHCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]