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The map label for this gene is accA [C]

Identifier: 222526534

GI number: 222526534

Start: 4112558

End: 4114135

Strand: Reverse

Name: accA [C]

Synonym: Chy400_3301

Alternate gene names: 222526534

Gene position: 4114135-4112558 (Counterclockwise)

Preceding gene: 222526546

Following gene: 222526533

Centisome position: 78.08

GC content: 59.19

Gene sequence:

>1578_bases
ATGACTCAACAAGAGCTGGCCCGACAAGCACCGCCAACGATGCGTGCTCGCATTGAATCCCTGCGCCAGTACCGGCAGCG
CCTGGAACAGGGCGGTGGCCCAGACCGTATCGCACGCCAGCATCAAGCCGGTAAACTGACTGCCCGCGAACGTATTCACC
TGCTGATTGAACCGGAAACGTTTCAGGAACTCTTCCTCTTTGCCCGTCACCGCTGTACCGCCTTTGGCATGGCCGACAAG
GAGATACCGGCTGAAGGCGTCATCACCGGTTGTGGCAGTGTTGATGGCCGCCAGGTCTTTGTTGCCGCTCAGGACTTTAC
CGTTGCCGGCGGCTCGGTCGGCGAGATGCACGCCGATAAGATCTGTCAGACGATGGATCTCGCGTTCAAATGCGGTTCGC
CGTTTATCACCATCAACGATAGCGGCGGTGCTCGCATCCAGGAGGGCATTGATGCCCTCAGTGGCTATGGTCGCATCTTC
TACCGCAACGTCCTGCTCTCCGGAGTAGTACCCCAAATCGCCATTATCGCCGGGCCATGCGCGGGCGGTGCCGCCTATTC
GCCGGCTTTGATGGACTTCATCATCATGGTGCGGGGCAGCGAGATGTTCATCACCGGCCCGGAAGTACTCAAACAAGTGA
CCGGCGAACACGTCACCGGTGACGAACTCGGCGGCCCTGAAGCTCAAGTACGTAGCGGCGTTGCCCATTTCATTGCTGAG
AACGATGTGGAAGCAATTGCAATCTGCAAGCGACTGCTGAGTTTCCTACCGGCGAACAACCTCGAAGACCCACCTGATCG
CGGTGACGGCGAACTGCGCCTGTTCAACGATCCGGTGCTCGACACCATCATCCCCGCTGATCCACGTGAACCATACGATG
TCATACCCATCATCAAGCGGATCGTTGATGATGGGGACTTTCTCGAAGTCCAGCGTGGCTTCGCCGACAACGCCGTAATC
GGGTTTGCCCGCATCGACGGCAGTACCGTTGGAATTGTTGCCAATCAGCCGATGGTGATGGCAGGAGTACTCGATATTGA
CGCTTCGGATAAGATAGCGCGTTTTGTCCGTTTTTGCAACGCCTTCAACATTCCACTCATCACATTTATTGACGTCCCAG
GCTTCCTGCCCGGCGTTGCCCAGGAACGCGGCGGCATCATTCGGCACGGCGCGAAGATGCTCTTCGCCTACTCCGCCGCA
ACCACACCGAAAATATCAATCATCCTGCGCAAAGCCTACGGCGGCGCCTACCTGGCCATGTGCGGCAAAGACCTGGGGGC
GGATCGGGTAGCCGCCTGGCCAGGCGCCGAAATCGCGGTCATGGGGCCAGAGGGCGCGGTTAACATCATCTACCGCGACC
AGATCAAGCAGGCGGACGACCCGGCTGCGGCGCGTGCCGAATTTGTACGCCAGTACCGGGCTGAGTTTGCCTCACCCTAC
GTCGGTGCCGGTCGCAACCTTATCGATAGCATCATTGCCCCCAGCGAAACCCGCCGCTACCTCAGCCTGGCCCTGGCCTC
GCTGCGCACCAAACGTGAGTTCCGTCCGCAAAAGAAGCACGGCCTGGTTCCGCTCTAA

Upstream 100 bases:

>100_bases
TTCTGTACATCCCCCACAGCGCTCAACCCTGACACCGATGTTCACTCCCTGCATAGACAGCGCCAGGCGAGTGAAGCAAT
GAATCCAAGGGAGGGTTGCG

Downstream 100 bases:

>100_bases
ATCTCAAAGGAGAGTCTATGGTCGATCCTGGCGCTAATCCGCTCCTGACCGGCTTGCAGATCGCGATTACCGGTATAAGC
ATCGTCTTCATCGTGTTAAT

Product: carboxyl transferase

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MTQQELARQAPPTMRARIESLRQYRQRLEQGGGPDRIARQHQAGKLTARERIHLLIEPETFQELFLFARHRCTAFGMADK
EIPAEGVITGCGSVDGRQVFVAAQDFTVAGGSVGEMHADKICQTMDLAFKCGSPFITINDSGGARIQEGIDALSGYGRIF
YRNVLLSGVVPQIAIIAGPCAGGAAYSPALMDFIIMVRGSEMFITGPEVLKQVTGEHVTGDELGGPEAQVRSGVAHFIAE
NDVEAIAICKRLLSFLPANNLEDPPDRGDGELRLFNDPVLDTIIPADPREPYDVIPIIKRIVDDGDFLEVQRGFADNAVI
GFARIDGSTVGIVANQPMVMAGVLDIDASDKIARFVRFCNAFNIPLITFIDVPGFLPGVAQERGGIIRHGAKMLFAYSAA
TTPKISIILRKAYGGAYLAMCGKDLGADRVAAWPGAEIAVMGPEGAVNIIYRDQIKQADDPAAARAEFVRQYRAEFASPY
VGAGRNLIDSIIAPSETRRYLSLALASLRTKREFRPQKKHGLVPL

Sequences:

>Translated_525_residues
MTQQELARQAPPTMRARIESLRQYRQRLEQGGGPDRIARQHQAGKLTARERIHLLIEPETFQELFLFARHRCTAFGMADK
EIPAEGVITGCGSVDGRQVFVAAQDFTVAGGSVGEMHADKICQTMDLAFKCGSPFITINDSGGARIQEGIDALSGYGRIF
YRNVLLSGVVPQIAIIAGPCAGGAAYSPALMDFIIMVRGSEMFITGPEVLKQVTGEHVTGDELGGPEAQVRSGVAHFIAE
NDVEAIAICKRLLSFLPANNLEDPPDRGDGELRLFNDPVLDTIIPADPREPYDVIPIIKRIVDDGDFLEVQRGFADNAVI
GFARIDGSTVGIVANQPMVMAGVLDIDASDKIARFVRFCNAFNIPLITFIDVPGFLPGVAQERGGIIRHGAKMLFAYSAA
TTPKISIILRKAYGGAYLAMCGKDLGADRVAAWPGAEIAVMGPEGAVNIIYRDQIKQADDPAAARAEFVRQYRAEFASPY
VGAGRNLIDSIIAPSETRRYLSLALASLRTKREFRPQKKHGLVPL
>Mature_524_residues
TQQELARQAPPTMRARIESLRQYRQRLEQGGGPDRIARQHQAGKLTARERIHLLIEPETFQELFLFARHRCTAFGMADKE
IPAEGVITGCGSVDGRQVFVAAQDFTVAGGSVGEMHADKICQTMDLAFKCGSPFITINDSGGARIQEGIDALSGYGRIFY
RNVLLSGVVPQIAIIAGPCAGGAAYSPALMDFIIMVRGSEMFITGPEVLKQVTGEHVTGDELGGPEAQVRSGVAHFIAEN
DVEAIAICKRLLSFLPANNLEDPPDRGDGELRLFNDPVLDTIIPADPREPYDVIPIIKRIVDDGDFLEVQRGFADNAVIG
FARIDGSTVGIVANQPMVMAGVLDIDASDKIARFVRFCNAFNIPLITFIDVPGFLPGVAQERGGIIRHGAKMLFAYSAAT
TPKISIILRKAYGGAYLAMCGKDLGADRVAAWPGAEIAVMGPEGAVNIIYRDQIKQADDPAAARAEFVRQYRAEFASPYV
GAGRNLIDSIIAPSETRRYLSLALASLRTKREFRPQKKHGLVPL

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=513, Percent_Identity=52.046783625731, Blast_Score=507, Evalue=1e-143,
Organism=Homo sapiens, GI295821216, Length=533, Percent_Identity=50.093808630394, Blast_Score=495, Evalue=1e-140,
Organism=Homo sapiens, GI11545863, Length=518, Percent_Identity=33.7837837837838, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI134142062, Length=416, Percent_Identity=24.0384615384615, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI38679971, Length=402, Percent_Identity=23.8805970149254, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI38679974, Length=402, Percent_Identity=23.8805970149254, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI38679977, Length=402, Percent_Identity=23.8805970149254, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI38679967, Length=402, Percent_Identity=23.8805970149254, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI38679960, Length=402, Percent_Identity=23.8805970149254, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786382, Length=189, Percent_Identity=28.5714285714286, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI25147362, Length=509, Percent_Identity=50.6876227897839, Blast_Score=507, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI25147359, Length=509, Percent_Identity=50.6876227897839, Blast_Score=506, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17552936, Length=524, Percent_Identity=31.8702290076336, Blast_Score=251, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI71997163, Length=309, Percent_Identity=27.831715210356, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323863, Length=356, Percent_Identity=22.752808988764, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24586065, Length=525, Percent_Identity=33.1428571428571, Blast_Score=247, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 56924; Mature: 56793

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQELARQAPPTMRARIESLRQYRQRLEQGGGPDRIARQHQAGKLTARERIHLLIEPET
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEEECCHH
FQELFLFARHRCTAFGMADKEIPAEGVITGCGSVDGRQVFVAAQDFTVAGGSVGEMHADK
HHHHHHHHHHHHHEECCCCCCCCCCCEEECCCCCCCCEEEEEECCEEECCCCCCHHHHHH
ICQTMDLAFKCGSPFITINDSGGARIQEGIDALSGYGRIFYRNVLLSGVVPQIAIIAGPC
HHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCC
AGGAAYSPALMDFIIMVRGSEMFITGPEVLKQVTGEHVTGDELGGPEAQVRSGVAHFIAE
CCCCCCHHHHHHHHHHEECCEEEEECHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHC
NDVEAIAICKRLLSFLPANNLEDPPDRGDGELRLFNDPVLDTIIPADPREPYDVIPIIKR
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCHHHCCCCCCCCCCHHHHHHHH
IVDDGDFLEVQRGFADNAVIGFARIDGSTVGIVANQPMVMAGVLDIDASDKIARFVRFCN
HHCCCCHHHHHHCCCCCCEEEEEEECCCEEEEEECCCEEEEEEEECCCHHHHHHHHHHHC
AFNIPLITFIDVPGFLPGVAQERGGIIRHGAKMLFAYSAATTPKISIILRKAYGGAYLAM
CCCCCEEEEECCCCCCCCHHHHCCCHHHHCCCEEEEECCCCCCEEEEEEEECCCCEEEEE
CGKDLGADRVAAWPGAEIAVMGPEGAVNIIYRDQIKQADDPAAARAEFVRQYRAEFASPY
CCCCCCCCCEECCCCCEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCC
VGAGRNLIDSIIAPSETRRYLSLALASLRTKREFRPQKKHGLVPL
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC
>Mature Secondary Structure 
TQQELARQAPPTMRARIESLRQYRQRLEQGGGPDRIARQHQAGKLTARERIHLLIEPET
CHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEEECCHH
FQELFLFARHRCTAFGMADKEIPAEGVITGCGSVDGRQVFVAAQDFTVAGGSVGEMHADK
HHHHHHHHHHHHHEECCCCCCCCCCCEEECCCCCCCCEEEEEECCEEECCCCCCHHHHHH
ICQTMDLAFKCGSPFITINDSGGARIQEGIDALSGYGRIFYRNVLLSGVVPQIAIIAGPC
HHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCC
AGGAAYSPALMDFIIMVRGSEMFITGPEVLKQVTGEHVTGDELGGPEAQVRSGVAHFIAE
CCCCCCHHHHHHHHHHEECCEEEEECHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHC
NDVEAIAICKRLLSFLPANNLEDPPDRGDGELRLFNDPVLDTIIPADPREPYDVIPIIKR
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCHHHCCCCCCCCCCHHHHHHHH
IVDDGDFLEVQRGFADNAVIGFARIDGSTVGIVANQPMVMAGVLDIDASDKIARFVRFCN
HHCCCCHHHHHHCCCCCCEEEEEEECCCEEEEEECCCEEEEEEEECCCHHHHHHHHHHHC
AFNIPLITFIDVPGFLPGVAQERGGIIRHGAKMLFAYSAATTPKISIILRKAYGGAYLAM
CCCCCEEEEECCCCCCCCHHHHCCCHHHHCCCEEEEECCCCCCEEEEEEEECCCCEEEEE
CGKDLGADRVAAWPGAEIAVMGPEGAVNIIYRDQIKQADDPAAARAEFVRQYRAEFASPY
CCCCCCCCCEECCCCCEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCC
VGAGRNLIDSIIAPSETRRYLSLALASLRTKREFRPQKKHGLVPL
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]