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The map label for this gene is hcrA [H]

Identifier: 222526485

GI number: 222526485

Start: 4053091

End: 4055373

Strand: Reverse

Name: hcrA [H]

Synonym: Chy400_3252

Alternate gene names: 222526485

Gene position: 4055373-4053091 (Counterclockwise)

Preceding gene: 222526486

Following gene: 222526482

Centisome position: 76.97

GC content: 62.59

Gene sequence:

>2283_bases
ATGACACAACAAGCCCCGCATCGCTACCTTGGCAAAGCGCGTAAATTAGTCGATGGCGTCGAGAAGGTGACCGGTCGTGC
CCGTTACGCCGGAGATGTTTCCCTGCCGGGTATGCTGCACGGCAAGCTGGCCCTCAGCCTGTTCGCCCATGCCCGAATTA
CCCGGATCGATACTGCGGCGGCGCTGAAGATTCCCGGCGTGGTCGCGGTATTGACTGCCGACGATCTACCCACACGCAAT
CGGCAGCCCTCATCACGACAGACGACAACCCTCGCCAGAGAGGTTGTTCGCTACCGTGGTGAACCGGTTGCGCTGGTTCT
GGCCACCAGTCTGGCGGCTGCCGAGGATGGTGTGGCTGCCTTGCAGATCGATTATGAACCGTTGCCGGCACCGGTTACTG
CGGAAGCCGCCCTCGATCCGGCGGCACCGGTGATTTGGCCGCAAGGCGCGCCGAAGGCCGACACCGATTTAACTGCGGCC
CACGCCGCCGTGGCCCGTGGCGAAGAGCAGAGTGACCACGTCGCCTCGAACATCCATGAACAGAAACGCTTCAGTCGGGG
TGATGCCCTGGCGGCGCTCGCCACTGCTGAGGTGGTGGTCGCAGGCACCTATCGAACGGCGATAGTCCACCAGGGCTACC
TGGAACCGCACGCCGTAGTCGCCGATATCGAACCGATCCGCAAACACATTACCCTGTACACCAGCACGCAGGGGCAGTTT
GGGGTTCGCGATGAAGTCGCTCGTTTGCTTGGACTGCGGACAAGTCAGGTAACGGTGGTACCGATGACGGTCGGCGGTGG
GTTTGGCGCCAAATACGGCATTCTCGATCCACTGGCTGCCGCTGCTGCGCTGGCCGTTGGGCGTCCGGTACGGATCGTCC
TTGACCGCAGTGAAGACTTTCTGACCACCACCCCCTCACCGGCCAGTACCATCACGATCAAACTGGGGGCAACTCGTGAA
GGAGTCCTCACGGCAATAGTGGCCGAGATGGTGATCGACAACGGCGTCTACCCCTTCACGCTGGGCGGCATCATGAGCAC
GCTACTCGGCGGCTACTACCGCTGCCCCAACGTCCAGATTGATGTGGTTGAAGTCCTCACCCACAAACCCCAGGCCGGCG
CATACCGTGCGCCGGGGGCACCGCAAGTTACGTTCGCGCTCGAGTCGAGCATTGACGAGCTGGCTCGCCGTCTGGAGCTT
GATCCGCTTGAGCTACGCTTGCGAAACGCAGCGACGACCGGCGACCCGATGGGCAACAACGACCCGTGGCCGTCGATGGG
GCTACGGCAGGTGCTGGAAGCCGCGGCCAACCATCCGCTCTGGCGCGAGCGCACACCGGGCAGCGGAGTCGGCCTGGCGA
TTGGCGGCTGGCCGTGTGGGATGTCACCCGCCGCAGCCGTTTGTCGGGTTGACACCGATGGGATCGTGCGCGTCCACGTC
GGCTCGGTTGACATTTCAGGTGTCAACAGCAGCTTCGTGCTGGTGGCGGCGGAGATTCTGGGTGTACCACCCGAACAGGT
CGAGATTGTGGCCGGTGATACCCGCAGCGGGCCGTTTGCCGGGCCGAGTGGCGGCAGTCAGATCACGTACAGTGTTGCCG
GTGCGGTAGCTGCGGCGGCCCAGGAAGCCCGGCGGCAGCTTCTGGAGGTTGCTGCTGATATGTTGGAAGCCCGCATTGAC
GATCTCGACCTGCGTGATGGCGCTATCCATGTCCGGGGCTTACCTGGACGCACACTGCCAATTGGCGAGGTTGCCCGGCG
TGCTCAGGAACAGCAGGGCGGGCCGGGACCTATTGTCGGTGAAGGACGAACAGCACCCGCCGAAAATGCTCCCGGCTTTG
TCGCGCATATTGTGCAGGTCACGGTAGACAACGAAACCGGACGAGTGCAACCGTTGCGGTATGTCGCAATCCAGGATGTC
GGGTTTCCGCTCAACCCGCTGATGGTGGAAGGCCAGATTCACGGTGGTGCCGTGCAGGGAATTGGTTGGGGGTTGCACGA
AGCACTCCGCTACGACGAAAATGGCGAGCTATTGACGGCCAGTCTTATGGATTACACCCTGCCACGTGCGGCAGATGTGC
CGTCGATTGAAACTGTTCTGGTCACCAATCCGGCACCCAACGGGCCGTTTGGCGCACGTGGTGTTGGCGAGCCACCGATC
ACCGCCGGGGCAGCAGCGCTCGCCAATGCGATTCGCGATGCCACCGGTGCCCGTATCTACGAACTGCCGATGCGCGATGA
AGTGGTGTGGCGGGCAATGCAGAAGGGTGTCAACAAGCAATAG

Upstream 100 bases:

>100_bases
GGTATGTATGCAGCACAGGCAGCCGCTTGTGCTGCTTCGTTATCCCACACTCACATTATGGTACGATAGACGGGGAGAGG
TTCACAGAGGAGTTACAAGC

Downstream 100 bases:

>100_bases
TTCCTGAATCTACAAGTGACAAATGATCGGGGTATGGTTGTTCACCATACCCCGATCAATACTTGCGGTAAGACTCATGC
AGTGTCAGTAAGCCTACACA

Product: Xanthine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 760; Mature: 759

Protein sequence:

>760_residues
MTQQAPHRYLGKARKLVDGVEKVTGRARYAGDVSLPGMLHGKLALSLFAHARITRIDTAAALKIPGVVAVLTADDLPTRN
RQPSSRQTTTLAREVVRYRGEPVALVLATSLAAAEDGVAALQIDYEPLPAPVTAEAALDPAAPVIWPQGAPKADTDLTAA
HAAVARGEEQSDHVASNIHEQKRFSRGDALAALATAEVVVAGTYRTAIVHQGYLEPHAVVADIEPIRKHITLYTSTQGQF
GVRDEVARLLGLRTSQVTVVPMTVGGGFGAKYGILDPLAAAAALAVGRPVRIVLDRSEDFLTTTPSPASTITIKLGATRE
GVLTAIVAEMVIDNGVYPFTLGGIMSTLLGGYYRCPNVQIDVVEVLTHKPQAGAYRAPGAPQVTFALESSIDELARRLEL
DPLELRLRNAATTGDPMGNNDPWPSMGLRQVLEAAANHPLWRERTPGSGVGLAIGGWPCGMSPAAAVCRVDTDGIVRVHV
GSVDISGVNSSFVLVAAEILGVPPEQVEIVAGDTRSGPFAGPSGGSQITYSVAGAVAAAAQEARRQLLEVAADMLEARID
DLDLRDGAIHVRGLPGRTLPIGEVARRAQEQQGGPGPIVGEGRTAPAENAPGFVAHIVQVTVDNETGRVQPLRYVAIQDV
GFPLNPLMVEGQIHGGAVQGIGWGLHEALRYDENGELLTASLMDYTLPRAADVPSIETVLVTNPAPNGPFGARGVGEPPI
TAGAAALANAIRDATGARIYELPMRDEVVWRAMQKGVNKQ

Sequences:

>Translated_760_residues
MTQQAPHRYLGKARKLVDGVEKVTGRARYAGDVSLPGMLHGKLALSLFAHARITRIDTAAALKIPGVVAVLTADDLPTRN
RQPSSRQTTTLAREVVRYRGEPVALVLATSLAAAEDGVAALQIDYEPLPAPVTAEAALDPAAPVIWPQGAPKADTDLTAA
HAAVARGEEQSDHVASNIHEQKRFSRGDALAALATAEVVVAGTYRTAIVHQGYLEPHAVVADIEPIRKHITLYTSTQGQF
GVRDEVARLLGLRTSQVTVVPMTVGGGFGAKYGILDPLAAAAALAVGRPVRIVLDRSEDFLTTTPSPASTITIKLGATRE
GVLTAIVAEMVIDNGVYPFTLGGIMSTLLGGYYRCPNVQIDVVEVLTHKPQAGAYRAPGAPQVTFALESSIDELARRLEL
DPLELRLRNAATTGDPMGNNDPWPSMGLRQVLEAAANHPLWRERTPGSGVGLAIGGWPCGMSPAAAVCRVDTDGIVRVHV
GSVDISGVNSSFVLVAAEILGVPPEQVEIVAGDTRSGPFAGPSGGSQITYSVAGAVAAAAQEARRQLLEVAADMLEARID
DLDLRDGAIHVRGLPGRTLPIGEVARRAQEQQGGPGPIVGEGRTAPAENAPGFVAHIVQVTVDNETGRVQPLRYVAIQDV
GFPLNPLMVEGQIHGGAVQGIGWGLHEALRYDENGELLTASLMDYTLPRAADVPSIETVLVTNPAPNGPFGARGVGEPPI
TAGAAALANAIRDATGARIYELPMRDEVVWRAMQKGVNKQ
>Mature_759_residues
TQQAPHRYLGKARKLVDGVEKVTGRARYAGDVSLPGMLHGKLALSLFAHARITRIDTAAALKIPGVVAVLTADDLPTRNR
QPSSRQTTTLAREVVRYRGEPVALVLATSLAAAEDGVAALQIDYEPLPAPVTAEAALDPAAPVIWPQGAPKADTDLTAAH
AAVARGEEQSDHVASNIHEQKRFSRGDALAALATAEVVVAGTYRTAIVHQGYLEPHAVVADIEPIRKHITLYTSTQGQFG
VRDEVARLLGLRTSQVTVVPMTVGGGFGAKYGILDPLAAAAALAVGRPVRIVLDRSEDFLTTTPSPASTITIKLGATREG
VLTAIVAEMVIDNGVYPFTLGGIMSTLLGGYYRCPNVQIDVVEVLTHKPQAGAYRAPGAPQVTFALESSIDELARRLELD
PLELRLRNAATTGDPMGNNDPWPSMGLRQVLEAAANHPLWRERTPGSGVGLAIGGWPCGMSPAAAVCRVDTDGIVRVHVG
SVDISGVNSSFVLVAAEILGVPPEQVEIVAGDTRSGPFAGPSGGSQITYSVAGAVAAAAQEARRQLLEVAADMLEARIDD
LDLRDGAIHVRGLPGRTLPIGEVARRAQEQQGGPGPIVGEGRTAPAENAPGFVAHIVQVTVDNETGRVQPLRYVAIQDVG
FPLNPLMVEGQIHGGAVQGIGWGLHEALRYDENGELLTASLMDYTLPRAADVPSIETVLVTNPAPNGPFGARGVGEPPIT
AGAAALANAIRDATGARIYELPMRDEVVWRAMQKGVNKQ

Specific function: Catalyzes reductive dehydroxylation of 4-hydroxybenzoyl- CoA. Reaction is not reversible [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To xanthine oxidases [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=770, Percent_Identity=25.7142857142857, Blast_Score=179, Evalue=1e-44,
Organism=Homo sapiens, GI71773480, Length=778, Percent_Identity=25.3213367609255, Blast_Score=159, Evalue=6e-39,
Organism=Escherichia coli, GI1789230, Length=768, Percent_Identity=32.1614583333333, Blast_Score=308, Evalue=9e-85,
Organism=Escherichia coli, GI1789246, Length=796, Percent_Identity=29.6482412060301, Blast_Score=281, Evalue=1e-76,
Organism=Escherichia coli, GI1786478, Length=769, Percent_Identity=28.3485045513654, Blast_Score=191, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17540638, Length=778, Percent_Identity=25.5784061696658, Blast_Score=167, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17539860, Length=752, Percent_Identity=22.8723404255319, Blast_Score=109, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI32566215, Length=533, Percent_Identity=23.827392120075, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17737937, Length=774, Percent_Identity=27.2609819121447, Blast_Score=175, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24647193, Length=756, Percent_Identity=26.1904761904762, Blast_Score=156, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24647195, Length=742, Percent_Identity=24.1239892183288, Blast_Score=126, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24647197, Length=750, Percent_Identity=24.2666666666667, Blast_Score=125, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017607
- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.3.99.20 [H]

Molecular weight: Translated: 79890; Mature: 79759

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQAPHRYLGKARKLVDGVEKVTGRARYAGDVSLPGMLHGKLALSLFAHARITRIDTAA
CCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHEEECCHH
ALKIPGVVAVLTADDLPTRNRQPSSRQTTTLAREVVRYRGEPVALVLATSLAAAEDGVAA
EEECCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCEEE
LQIDYEPLPAPVTAEAALDPAAPVIWPQGAPKADTDLTAAHAAVARGEEQSDHVASNIHE
EEEECCCCCCCCCHHHCCCCCCCEECCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHH
QKRFSRGDALAALATAEVVVAGTYRTAIVHQGYLEPHAVVADIEPIRKHITLYTSTQGQF
HHHHCCCCHHHHHHHEEEEEECCHHEEEEECCCCCCCCEEECHHHHHCEEEEEECCCCCC
GVRDEVARLLGLRTSQVTVVPMTVGGGFGAKYGILDPLAAAAALAVGRPVRIVLDRSEDF
CCHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCC
LTTTPSPASTITIKLGATREGVLTAIVAEMVIDNGVYPFTLGGIMSTLLGGYYRCPNVQI
EEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCEEECCCCEE
DVVEVLTHKPQAGAYRAPGAPQVTFALESSIDELARRLELDPLELRLRNAATTGDPMGNN
EHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCCCCC
DPWPSMGLRQVLEAAANHPLWRERTPGSGVGLAIGGWPCGMSPAAAVCRVDTDGIVRVHV
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCHHHEEEEECCCCEEEEEE
GSVDISGVNSSFVLVAAEILGVPPEQVEIVAGDTRSGPFAGPSGGSQITYSVAGAVAAAA
CCEEECCCCCCHHEEEHHHHCCCHHHEEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHH
QEARRQLLEVAADMLEARIDDLDLRDGAIHVRGLPGRTLPIGEVARRAQEQQGGPGPIVG
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCC
EGRTAPAENAPGFVAHIVQVTVDNETGRVQPLRYVAIQDVGFPLNPLMVEGQIHGGAVQG
CCCCCCCCCCCCCEEEEEEEEEECCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCEEEC
IGWGLHEALRYDENGELLTASLMDYTLPRAADVPSIETVLVTNPAPNGPFGARGVGEPPI
CCHHHHHHHCCCCCCCEEEEHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCC
TAGAAALANAIRDATGARIYELPMRDEVVWRAMQKGVNKQ
HHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TQQAPHRYLGKARKLVDGVEKVTGRARYAGDVSLPGMLHGKLALSLFAHARITRIDTAA
CCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHEEECCHH
ALKIPGVVAVLTADDLPTRNRQPSSRQTTTLAREVVRYRGEPVALVLATSLAAAEDGVAA
EEECCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCEEE
LQIDYEPLPAPVTAEAALDPAAPVIWPQGAPKADTDLTAAHAAVARGEEQSDHVASNIHE
EEEECCCCCCCCCHHHCCCCCCCEECCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHH
QKRFSRGDALAALATAEVVVAGTYRTAIVHQGYLEPHAVVADIEPIRKHITLYTSTQGQF
HHHHCCCCHHHHHHHEEEEEECCHHEEEEECCCCCCCCEEECHHHHHCEEEEEECCCCCC
GVRDEVARLLGLRTSQVTVVPMTVGGGFGAKYGILDPLAAAAALAVGRPVRIVLDRSEDF
CCHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCC
LTTTPSPASTITIKLGATREGVLTAIVAEMVIDNGVYPFTLGGIMSTLLGGYYRCPNVQI
EEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCEEECCCCEE
DVVEVLTHKPQAGAYRAPGAPQVTFALESSIDELARRLELDPLELRLRNAATTGDPMGNN
EHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCCCCC
DPWPSMGLRQVLEAAANHPLWRERTPGSGVGLAIGGWPCGMSPAAAVCRVDTDGIVRVHV
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCHHHEEEEECCCCEEEEEE
GSVDISGVNSSFVLVAAEILGVPPEQVEIVAGDTRSGPFAGPSGGSQITYSVAGAVAAAA
CCEEECCCCCCHHEEEHHHHCCCHHHEEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHH
QEARRQLLEVAADMLEARIDDLDLRDGAIHVRGLPGRTLPIGEVARRAQEQQGGPGPIVG
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCC
EGRTAPAENAPGFVAHIVQVTVDNETGRVQPLRYVAIQDVGFPLNPLMVEGQIHGGAVQG
CCCCCCCCCCCCCEEEEEEEEEECCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCEEEC
IGWGLHEALRYDENGELLTASLMDYTLPRAADVPSIETVLVTNPAPNGPFGARGVGEPPI
CCHHHHHHHCCCCCCCEEEEHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCC
TAGAAALANAIRDATGARIYELPMRDEVVWRAMQKGVNKQ
HHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9490068 [H]