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The map label for this gene is lon [H]

Identifier: 222526350

GI number: 222526350

Start: 3853872

End: 3856349

Strand: Direct

Name: lon [H]

Synonym: Chy400_3116

Alternate gene names: 222526350

Gene position: 3853872-3856349 (Clockwise)

Preceding gene: 222526349

Following gene: 222526351

Centisome position: 73.14

GC content: 56.86

Gene sequence:

>2478_bases
ATGAATGAACCAATGTCTCTCTTTGACGATCTGCCTGAAGAGCAGGATGACCTGCACGAAGAGCCAGAACGCCGTCTCCC
GATGGTGGTGCTCGGCGAAATGGTCATCATGCCCCATATGACCATCCCGCTCCAGGTACCGCAGGGGAAGTCGTACCGTG
CGATGGAGCGAGCGTGGGAAGAAGATCGTGATGTTTTGTTGATCTTTGTGCGCGAGAATCAGCTCGAAGGATACAAGAGC
AACCAGCCGCAGAATCTACCGCCGATTGGGGTTATTGCGCAGTTGCAGGAGTTTGCCAAGTTGCCCGATGGCACAGCCCG
TGTAATCCTTGAAGGCCAGCAGCGGGCACAGATTATCGAAGCGATCCAGATTACACCCTTCTATCGGGTGCGTTGCCGAC
CAATCTTTGATCCACCGGTCGGGGGGATCGAGGTCGAAGCCCTGATGGAGACGGTGAAGCAGCAGGTTGATGAATTCGTC
GAGCATCTCGGTGAGGTGCCCCAGGAGGCGGTGCAGTTTGTGCATCGCATTGATCGCGCCGGTCATCTGGCCGATATTGT
GACCTGGGGGCCGGCATTCGATTTCAAGGACCGGCTTGAGATCCTCAATACGCTTGATCCGGTCGAGCGCCTGCGCAAGG
CTTACCTGGTGCTGGCACGACAGTTGGAGCTGCTGAAGCTGCGCGTCAAGATTCAGCAGGATACCCGCGAGGTACTCGAC
CAGAGTCAGCGTGAGTATTTCCTGCGCGAGCAGTTGCGGGTTATTCGCCGTGAGTTGGGTGAAGATGAAGATGGCGATGA
TCCGATTGACGAGCTGCGGCGCAGGATTCACGAGATGAACGCTCCAGAGTATGTGAAGAATCAGGCGCTGCACGAGTTGA
AGCGGCTGTCCCAGCAGGGGATGCACAGCCCTGAAGCAGGCGTGATTCGGACCTACCTCGACTGGATTCTCTCGCTGCCC
TGGGCTGATGAGGAGTTGCCAGAGATCAGCATTACTGAGGCCAAAAAGGTGCTCGACGAAGATCACTATGGCCTCGAAAA
GGTCAAAGAGCGTATTCTTGAATACCTGGCTGTGCTTAAACTGGCCGGTAATAAGATGCGCGGTCCCATCCTCTGCTTTG
TCGGCCCGCCCGGTGTAGGTAAGACCAGCCTGGGGCGCAGCATTGCCCGTGCGTTGGGCCGCAAATTTGTCCGTACCAGC
CTCGGTGGCGTGCGCGATGAGGCTGAGATCCGCGGTCATCGCCGCACCTATATCGGCGCGTTGCCCGGTCGGATCATCCA
GGCCATGAAGACGGCTAAATCGCGGAGTCCGGTCTACATTCTTGATGAAGTTGACAAGATTGGTATCGATTTCCGCGGCG
ATCCAACCTCGGCATTGTTAGAGGTACTCGATCCAGAGCAGAACAACGCATTTAGCGATCATTACCTTGAATTGCCGTTC
GATCTCAGTAAGGTTATCTTCATTGCCACGGCGAACCAGCTTGAACCAATCCCGCTGCCGCTCCGTGATCGCATGGAGAT
CATCGAGATCAGTGGCTACACCGAAGACGAGAAGATGGAGATCGCACGCGGTTTCCTGATTCCCAAGCAGCGCGAGTTCC
ATGGGCTGCGTGAGGATCAGATCGAGTTTACCGATGGCGCCATCATCAAGCTGATTCGCGAATACACCCGCGAGGCTGGT
GTGCGTGGCCTTGAGCGCGAGATCGCCAGTCTGTGCCGTAAAGTGGCGCGTAAGGTGGCCGAACAAAGCGAAGCAACCGA
TGGCTCGGTGCAGAAGTTTGTGATTGATGAGGCTGCCGTGCTGGAATATCTTGGTCCCGAGCGCTTCACCTTCGGTCTGG
TCGAGGAGAAAGACGAGGTTGGGGTCGCGACCGGTGTGGCCTGGACGAGCGCCGGTGGTGATATTCTCAATATCGAGGTG
TTGCCGTTCAAGGGCAAGGGCCAGCTTCAACTCACCGGTCAGCTCGGTGAGGTTATGAAGGAGAGCGCGCAGGCTGCGGT
GAGCTACGTTCGCTCACGTGCTGCCGACTTCGGGATTGATCCGGCGATCTTTGAAGAAACCAATATTCACATTCACATCC
CAGAGGGTTCAGTCCCGAAGGATGGTCCATCCGCCGGTATTACGCTGACCACCGCGCTGATCAGTGCGCTGACCGGCACC
CCCGTGCGCCGCGATGTGGCGATGACCGGTGAGGTCACTCTGCGCGGAAAGGTCTTGCCTATCGGTGGACTGAAAGAGAA
GACGCTGGCCGCGCATCGGGCCGGTATTCGTACCTTTATCTTGCCGAAGGAAAACGCGAAGGATATTAGTGAACTGCCAG
AAAAGGTGCGGCGGGAACTGAATCTAATCCCGGTCTCCTCGATGGACGAGGTGCTGCAAATTGCGCTGAGTCGGATGCCG
ACTGCAAACAATCAGGTCAGCGGGCCGCATCATCAAAATAATCGCGGTCAACCCTCGCCAACCCCAGCCGGTGCATAG

Upstream 100 bases:

>100_bases
CGGTTGTACGAACGACAATTTTTGCAGCCAATACCGGCAACGGCTGCTGTGTAAATAGTGTGAGTAACGTTCCTCATAGA
ACGTAGGAGATAAAACTACT

Downstream 100 bases:

>100_bases
GTAAAGCGTTGATGGTTCTGCGGTGACAATACAACCGCAGAACCATACTCTATTCATACCCAGGCTTTGCATATGATATT
CACACCGCAGCAGTGGCAAG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 825; Mature: 825

Protein sequence:

>825_residues
MNEPMSLFDDLPEEQDDLHEEPERRLPMVVLGEMVIMPHMTIPLQVPQGKSYRAMERAWEEDRDVLLIFVRENQLEGYKS
NQPQNLPPIGVIAQLQEFAKLPDGTARVILEGQQRAQIIEAIQITPFYRVRCRPIFDPPVGGIEVEALMETVKQQVDEFV
EHLGEVPQEAVQFVHRIDRAGHLADIVTWGPAFDFKDRLEILNTLDPVERLRKAYLVLARQLELLKLRVKIQQDTREVLD
QSQREYFLREQLRVIRRELGEDEDGDDPIDELRRRIHEMNAPEYVKNQALHELKRLSQQGMHSPEAGVIRTYLDWILSLP
WADEELPEISITEAKKVLDEDHYGLEKVKERILEYLAVLKLAGNKMRGPILCFVGPPGVGKTSLGRSIARALGRKFVRTS
LGGVRDEAEIRGHRRTYIGALPGRIIQAMKTAKSRSPVYILDEVDKIGIDFRGDPTSALLEVLDPEQNNAFSDHYLELPF
DLSKVIFIATANQLEPIPLPLRDRMEIIEISGYTEDEKMEIARGFLIPKQREFHGLREDQIEFTDGAIIKLIREYTREAG
VRGLEREIASLCRKVARKVAEQSEATDGSVQKFVIDEAAVLEYLGPERFTFGLVEEKDEVGVATGVAWTSAGGDILNIEV
LPFKGKGQLQLTGQLGEVMKESAQAAVSYVRSRAADFGIDPAIFEETNIHIHIPEGSVPKDGPSAGITLTTALISALTGT
PVRRDVAMTGEVTLRGKVLPIGGLKEKTLAAHRAGIRTFILPKENAKDISELPEKVRRELNLIPVSSMDEVLQIALSRMP
TANNQVSGPHHQNNRGQPSPTPAGA

Sequences:

>Translated_825_residues
MNEPMSLFDDLPEEQDDLHEEPERRLPMVVLGEMVIMPHMTIPLQVPQGKSYRAMERAWEEDRDVLLIFVRENQLEGYKS
NQPQNLPPIGVIAQLQEFAKLPDGTARVILEGQQRAQIIEAIQITPFYRVRCRPIFDPPVGGIEVEALMETVKQQVDEFV
EHLGEVPQEAVQFVHRIDRAGHLADIVTWGPAFDFKDRLEILNTLDPVERLRKAYLVLARQLELLKLRVKIQQDTREVLD
QSQREYFLREQLRVIRRELGEDEDGDDPIDELRRRIHEMNAPEYVKNQALHELKRLSQQGMHSPEAGVIRTYLDWILSLP
WADEELPEISITEAKKVLDEDHYGLEKVKERILEYLAVLKLAGNKMRGPILCFVGPPGVGKTSLGRSIARALGRKFVRTS
LGGVRDEAEIRGHRRTYIGALPGRIIQAMKTAKSRSPVYILDEVDKIGIDFRGDPTSALLEVLDPEQNNAFSDHYLELPF
DLSKVIFIATANQLEPIPLPLRDRMEIIEISGYTEDEKMEIARGFLIPKQREFHGLREDQIEFTDGAIIKLIREYTREAG
VRGLEREIASLCRKVARKVAEQSEATDGSVQKFVIDEAAVLEYLGPERFTFGLVEEKDEVGVATGVAWTSAGGDILNIEV
LPFKGKGQLQLTGQLGEVMKESAQAAVSYVRSRAADFGIDPAIFEETNIHIHIPEGSVPKDGPSAGITLTTALISALTGT
PVRRDVAMTGEVTLRGKVLPIGGLKEKTLAAHRAGIRTFILPKENAKDISELPEKVRRELNLIPVSSMDEVLQIALSRMP
TANNQVSGPHHQNNRGQPSPTPAGA
>Mature_825_residues
MNEPMSLFDDLPEEQDDLHEEPERRLPMVVLGEMVIMPHMTIPLQVPQGKSYRAMERAWEEDRDVLLIFVRENQLEGYKS
NQPQNLPPIGVIAQLQEFAKLPDGTARVILEGQQRAQIIEAIQITPFYRVRCRPIFDPPVGGIEVEALMETVKQQVDEFV
EHLGEVPQEAVQFVHRIDRAGHLADIVTWGPAFDFKDRLEILNTLDPVERLRKAYLVLARQLELLKLRVKIQQDTREVLD
QSQREYFLREQLRVIRRELGEDEDGDDPIDELRRRIHEMNAPEYVKNQALHELKRLSQQGMHSPEAGVIRTYLDWILSLP
WADEELPEISITEAKKVLDEDHYGLEKVKERILEYLAVLKLAGNKMRGPILCFVGPPGVGKTSLGRSIARALGRKFVRTS
LGGVRDEAEIRGHRRTYIGALPGRIIQAMKTAKSRSPVYILDEVDKIGIDFRGDPTSALLEVLDPEQNNAFSDHYLELPF
DLSKVIFIATANQLEPIPLPLRDRMEIIEISGYTEDEKMEIARGFLIPKQREFHGLREDQIEFTDGAIIKLIREYTREAG
VRGLEREIASLCRKVARKVAEQSEATDGSVQKFVIDEAAVLEYLGPERFTFGLVEEKDEVGVATGVAWTSAGGDILNIEV
LPFKGKGQLQLTGQLGEVMKESAQAAVSYVRSRAADFGIDPAIFEETNIHIHIPEGSVPKDGPSAGITLTTALISALTGT
PVRRDVAMTGEVTLRGKVLPIGGLKEKTLAAHRAGIRTFILPKENAKDISELPEKVRRELNLIPVSSMDEVLQIALSRMP
TANNQVSGPHHQNNRGQPSPTPAGA

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=850, Percent_Identity=39.1764705882353, Blast_Score=552, Evalue=1e-157,
Organism=Homo sapiens, GI21396489, Length=637, Percent_Identity=44.8979591836735, Blast_Score=536, Evalue=1e-152,
Organism=Escherichia coli, GI1786643, Length=793, Percent_Identity=46.6582597730139, Blast_Score=725, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=708, Percent_Identity=40.5367231638418, Blast_Score=508, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17556486, Length=543, Percent_Identity=41.804788213628, Blast_Score=457, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6319449, Length=667, Percent_Identity=42.7286356821589, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI221513036, Length=679, Percent_Identity=43.298969072165, Blast_Score=540, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24666867, Length=679, Percent_Identity=43.298969072165, Blast_Score=539, Evalue=1e-153,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 92697; Mature: 92697

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEPMSLFDDLPEEQDDLHEEPERRLPMVVLGEMVIMPHMTIPLQVPQGKSYRAMERAWE
CCCCHHHHHCCCCCHHHHHCCHHHCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHC
EDRDVLLIFVRENQLEGYKSNQPQNLPPIGVIAQLQEFAKLPDGTARVILEGQQRAQIIE
CCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHH
AIQITPFYRVRCRPIFDPPVGGIEVEALMETVKQQVDEFVEHLGEVPQEAVQFVHRIDRA
HHHCCCEEEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHC
GHLADIVTWGPAFDFKDRLEILNTLDPVERLRKAYLVLARQLELLKLRVKIQQDTREVLD
CCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QSQREYFLREQLRVIRRELGEDEDGDDPIDELRRRIHEMNAPEYVKNQALHELKRLSQQG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
MHSPEAGVIRTYLDWILSLPWADEELPEISITEAKKVLDEDHYGLEKVKERILEYLAVLK
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LAGNKMRGPILCFVGPPGVGKTSLGRSIARALGRKFVRTSLGGVRDEAEIRGHRRTYIGA
HCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHC
LPGRIIQAMKTAKSRSPVYILDEVDKIGIDFRGDPTSALLEVLDPEQNNAFSDHYLELPF
CHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEECCC
DLSKVIFIATANQLEPIPLPLRDRMEIIEISGYTEDEKMEIARGFLIPKQREFHGLREDQ
CCCCEEEEEECCCCCCCCCCHHCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHCCCCCCC
IEFTDGAIIKLIREYTREAGVRGLEREIASLCRKVARKVAEQSEATDGSVQKFVIDEAAV
EECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LEYLGPERFTFGLVEEKDEVGVATGVAWTSAGGDILNIEVLPFKGKGQLQLTGQLGEVMK
HHHCCCCCEEECCCCCCCCCCEEECCEEECCCCCEEEEEEEEECCCCCEEECHHHHHHHH
ESAQAAVSYVRSRAADFGIDPAIFEETNIHIHIPEGSVPKDGPSAGITLTTALISALTGT
HHHHHHHHHHHHHHHCCCCCCHHEECCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCC
PVRRDVAMTGEVTLRGKVLPIGGLKEKTLAAHRAGIRTFILPKENAKDISELPEKVRREL
CCCCCEEEECCEEEEEEEEECCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHC
NLIPVSSMDEVLQIALSRMPTANNQVSGPHHQNNRGQPSPTPAGA
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNEPMSLFDDLPEEQDDLHEEPERRLPMVVLGEMVIMPHMTIPLQVPQGKSYRAMERAWE
CCCCHHHHHCCCCCHHHHHCCHHHCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHC
EDRDVLLIFVRENQLEGYKSNQPQNLPPIGVIAQLQEFAKLPDGTARVILEGQQRAQIIE
CCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHH
AIQITPFYRVRCRPIFDPPVGGIEVEALMETVKQQVDEFVEHLGEVPQEAVQFVHRIDRA
HHHCCCEEEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHC
GHLADIVTWGPAFDFKDRLEILNTLDPVERLRKAYLVLARQLELLKLRVKIQQDTREVLD
CCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QSQREYFLREQLRVIRRELGEDEDGDDPIDELRRRIHEMNAPEYVKNQALHELKRLSQQG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
MHSPEAGVIRTYLDWILSLPWADEELPEISITEAKKVLDEDHYGLEKVKERILEYLAVLK
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LAGNKMRGPILCFVGPPGVGKTSLGRSIARALGRKFVRTSLGGVRDEAEIRGHRRTYIGA
HCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHC
LPGRIIQAMKTAKSRSPVYILDEVDKIGIDFRGDPTSALLEVLDPEQNNAFSDHYLELPF
CHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEECCC
DLSKVIFIATANQLEPIPLPLRDRMEIIEISGYTEDEKMEIARGFLIPKQREFHGLREDQ
CCCCEEEEEECCCCCCCCCCHHCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHCCCCCCC
IEFTDGAIIKLIREYTREAGVRGLEREIASLCRKVARKVAEQSEATDGSVQKFVIDEAAV
EECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LEYLGPERFTFGLVEEKDEVGVATGVAWTSAGGDILNIEVLPFKGKGQLQLTGQLGEVMK
HHHCCCCCEEECCCCCCCCCCEEECCEEECCCCCEEEEEEEEECCCCCEEECHHHHHHHH
ESAQAAVSYVRSRAADFGIDPAIFEETNIHIHIPEGSVPKDGPSAGITLTTALISALTGT
HHHHHHHHHHHHHHHCCCCCCHHEECCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCC
PVRRDVAMTGEVTLRGKVLPIGGLKEKTLAAHRAGIRTFILPKENAKDISELPEKVRREL
CCCCCEEEECCEEEEEEEEECCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHC
NLIPVSSMDEVLQIALSRMPTANNQVSGPHHQNNRGQPSPTPAGA
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA