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The map label for this gene is lpd [H]

Identifier: 222526310

GI number: 222526310

Start: 3794811

End: 3796223

Strand: Direct

Name: lpd [H]

Synonym: Chy400_3076

Alternate gene names: 222526310

Gene position: 3794811-3796223 (Clockwise)

Preceding gene: 222526309

Following gene: 222526311

Centisome position: 72.02

GC content: 57.54

Gene sequence:

>1413_bases
GTGAGTGAGCAAGTATACGATCTCGTGGTACTTGGTTCAGGGCCGGGCGGGTACGTTGCTGCCATCCGTGCTGCCCAACT
GGGTATGAAGACAGCGATTGTTGAGGTGAATGCCCTGGGTGGCGTGTGTCTGAACATCGGCTGTATCCCAACCAAAGCAC
TCTTGCACAGCGCCGATCTGCTTGAAGAGGTGAAGGAGGCGAAGCGTTTCGGCATTACCGTTGAGAACGTCGCCTTTGAG
CTGGCCGGGGCAATGAAGCACAAAGATACGGTCGTCAAGCAGAGCACCGATGGCGTGGCATTTTTAATGAAGAAAAATAA
GATTGAGGTAGTGGCCGGTCGGGGCCGGCTAATTGGTCGCGGTCAGGTGCATGTGCAGTTAAACGAAGGTGGTGAGCGGG
TTCTGGCGGCCAAACATATTATTGTCGCTACCGGTGGTCGGCCACGTCCCTTCCCCGGTATTCCCTTCGATGGCGAGCGG
GTGCTCTCTTCGACCGATATGCTTACCTTGAAAACGGTACCGTCCAGTCTGCTGGCTATCGGTGCCGGAGCCATCGGGGT
TGAATTCGCCTCGATGTTCCGTTCGTTCGGCAGTGATGTGACGATTGTTGAAGCCTTACCCCGCATTGTGCCGAATGAAG
ACGAAGAGGTCAGTGCTGAGTTGACCAAGGCGTTCCAGCGCCGAGGGATCAAGACGCTGGCCGGGGCAAAGGTCGAAGGG
GTGGATGTTGGCGGCGAGAAAGTGGTGGTGACCGTGGTTGATAGCTCTGGCAAGCCACAGCAGATTGCCGTCGAGAAGTT
GCTGGTCTCGATTGGCATCGCTCCCAACACCGAGAATATCGGCCTGGAGGAGGTCGGTGTCAAGGTAAACAATCGCGGTT
TCATCGAGACCGACGGTTTCCTGCGAACCAGTGCCGAGGGTGTCTATGCCATCGGTGATTGTACCGCCAATACCCCCTGG
CTGGCGCACAAGGCCAGCGCCGAGGGGATTCTGGCCGCCGAACATATCGCCGGTCATCACGTGACGCCGATTGACTACGG
GAAGATTGCTGCCTGTACCTACTGCAACCCTGAAATTGCCAGTGTTGGTTTGACCGAGGCAAAGGCACGCGAGCGTGGTT
ACCAGGTGAAGGTGGGCAAGTTCCCCTTCTCGGCCAACGGCAAAGCGCGGGTGCTCGGTCAGACCCGGTTTGGTTTCATC
AAGCTGGTTGCCGATGCCCAGTACGATGAGATTTTGGGTGTGCATATGATCGGCCCGCGGGTCACCGAAATGATCGCCGA
AGGTGGCATTGCCCTCAGCCACGAAGCAACCGGTGAGAGCATGATGCAGACGATCCATGCTCACCCGACGCTGTACGAGG
CGATTGGTGAGGCTGCCCATGCGCTGGTGCACGGTGCGCCGATCCATCTGTAA

Upstream 100 bases:

>100_bases
TACCTGCGCGATTGCCTATCATTTCAATGCTGTTGTATCTTTTGGTAACGGCATCTGAGTGTTGCGTTGTCGTGATCAGA
TGAGATGAAAGGATAGTTCC

Downstream 100 bases:

>100_bases
TCCACGCCGGGCATTGGTCAAGAGACGTTACGTTAGAATTGCGTATTTTTACCCTGAATAAAGCGGTTTTTTGTGCCGGA
GTGCACTATCATAGACTGTG

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MSEQVYDLVVLGSGPGGYVAAIRAAQLGMKTAIVEVNALGGVCLNIGCIPTKALLHSADLLEEVKEAKRFGITVENVAFE
LAGAMKHKDTVVKQSTDGVAFLMKKNKIEVVAGRGRLIGRGQVHVQLNEGGERVLAAKHIIVATGGRPRPFPGIPFDGER
VLSSTDMLTLKTVPSSLLAIGAGAIGVEFASMFRSFGSDVTIVEALPRIVPNEDEEVSAELTKAFQRRGIKTLAGAKVEG
VDVGGEKVVVTVVDSSGKPQQIAVEKLLVSIGIAPNTENIGLEEVGVKVNNRGFIETDGFLRTSAEGVYAIGDCTANTPW
LAHKASAEGILAAEHIAGHHVTPIDYGKIAACTYCNPEIASVGLTEAKARERGYQVKVGKFPFSANGKARVLGQTRFGFI
KLVADAQYDEILGVHMIGPRVTEMIAEGGIALSHEATGESMMQTIHAHPTLYEAIGEAAHALVHGAPIHL

Sequences:

>Translated_470_residues
MSEQVYDLVVLGSGPGGYVAAIRAAQLGMKTAIVEVNALGGVCLNIGCIPTKALLHSADLLEEVKEAKRFGITVENVAFE
LAGAMKHKDTVVKQSTDGVAFLMKKNKIEVVAGRGRLIGRGQVHVQLNEGGERVLAAKHIIVATGGRPRPFPGIPFDGER
VLSSTDMLTLKTVPSSLLAIGAGAIGVEFASMFRSFGSDVTIVEALPRIVPNEDEEVSAELTKAFQRRGIKTLAGAKVEG
VDVGGEKVVVTVVDSSGKPQQIAVEKLLVSIGIAPNTENIGLEEVGVKVNNRGFIETDGFLRTSAEGVYAIGDCTANTPW
LAHKASAEGILAAEHIAGHHVTPIDYGKIAACTYCNPEIASVGLTEAKARERGYQVKVGKFPFSANGKARVLGQTRFGFI
KLVADAQYDEILGVHMIGPRVTEMIAEGGIALSHEATGESMMQTIHAHPTLYEAIGEAAHALVHGAPIHL
>Mature_469_residues
SEQVYDLVVLGSGPGGYVAAIRAAQLGMKTAIVEVNALGGVCLNIGCIPTKALLHSADLLEEVKEAKRFGITVENVAFEL
AGAMKHKDTVVKQSTDGVAFLMKKNKIEVVAGRGRLIGRGQVHVQLNEGGERVLAAKHIIVATGGRPRPFPGIPFDGERV
LSSTDMLTLKTVPSSLLAIGAGAIGVEFASMFRSFGSDVTIVEALPRIVPNEDEEVSAELTKAFQRRGIKTLAGAKVEGV
DVGGEKVVVTVVDSSGKPQQIAVEKLLVSIGIAPNTENIGLEEVGVKVNNRGFIETDGFLRTSAEGVYAIGDCTANTPWL
AHKASAEGILAAEHIAGHHVTPIDYGKIAACTYCNPEIASVGLTEAKARERGYQVKVGKFPFSANGKARVLGQTRFGFIK
LVADAQYDEILGVHMIGPRVTEMIAEGGIALSHEATGESMMQTIHAHPTLYEAIGEAAHALVHGAPIHL

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=470, Percent_Identity=42.3404255319149, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI50301238, Length=466, Percent_Identity=27.0386266094421, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI33519430, Length=468, Percent_Identity=26.4957264957265, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI33519428, Length=468, Percent_Identity=26.4957264957265, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI33519426, Length=468, Percent_Identity=26.4957264957265, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI148277065, Length=468, Percent_Identity=26.4957264957265, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI148277071, Length=468, Percent_Identity=26.4957264957265, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI291045266, Length=461, Percent_Identity=25.3796095444685, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI22035672, Length=476, Percent_Identity=29.2016806722689, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI291045268, Length=454, Percent_Identity=24.4493392070485, Blast_Score=119, Evalue=5e-27,
Organism=Escherichia coli, GI1786307, Length=466, Percent_Identity=37.5536480686695, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI87082354, Length=458, Percent_Identity=28.3842794759825, Blast_Score=192, Evalue=6e-50,
Organism=Escherichia coli, GI87081717, Length=466, Percent_Identity=30.0429184549356, Blast_Score=181, Evalue=8e-47,
Organism=Escherichia coli, GI1789915, Length=435, Percent_Identity=30.3448275862069, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI32565766, Length=471, Percent_Identity=42.2505307855626, Blast_Score=332, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=26.3713080168776, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71983429, Length=436, Percent_Identity=27.5229357798165, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI71983419, Length=436, Percent_Identity=27.5229357798165, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI71982272, Length=494, Percent_Identity=25.9109311740891, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17559934, Length=198, Percent_Identity=29.2929292929293, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=468, Percent_Identity=40.8119658119658, Blast_Score=313, Evalue=3e-86,
Organism=Saccharomyces cerevisiae, GI6325240, Length=479, Percent_Identity=30.6889352818372, Blast_Score=183, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=28.5407725321888, Blast_Score=167, Evalue=4e-42,
Organism=Drosophila melanogaster, GI21358499, Length=469, Percent_Identity=42.4307036247335, Blast_Score=347, Evalue=8e-96,
Organism=Drosophila melanogaster, GI24640553, Length=467, Percent_Identity=29.1220556745182, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24640551, Length=467, Percent_Identity=28.2655246252677, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24640549, Length=468, Percent_Identity=29.0598290598291, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI17737741, Length=467, Percent_Identity=27.8372591006424, Blast_Score=136, Evalue=3e-32,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49558; Mature: 49427

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQVYDLVVLGSGPGGYVAAIRAAQLGMKTAIVEVNALGGVCLNIGCIPTKALLHSADL
CCCCEEEEEEEECCCCCHHHHHHHHHCCCEEEEEEEECCCCEEEEECCCCHHHHHHHHHH
LEEVKEAKRFGITVENVAFELAGAMKHKDTVVKQSTDGVAFLMKKNKIEVVAGRGRLIGR
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHCCCCCCEEEEEECCCEEEEECCCEEEEC
GQVHVQLNEGGERVLAAKHIIVATGGRPRPFPGIPFDGERVLSSTDMLTLKTVPSSLLAI
CEEEEEECCCCCEEEEEEEEEEEECCCCCCCCCCCCCCHHHHCCCCEEEEECCCHHHHHH
GAGAIGVEFASMFRSFGSDVTIVEALPRIVPNEDEEVSAELTKAFQRRGIKTLAGAKVEG
CCCHHHHHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHCCCEEEE
VDVGGEKVVVTVVDSSGKPQQIAVEKLLVSIGIAPNTENIGLEEVGVKVNNRGFIETDGF
EECCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCEEECCCCEEECCCC
LRTSAEGVYAIGDCTANTPWLAHKASAEGILAAEHIAGHHVTPIDYGKIAACTYCNPEIA
EEECCCCEEEEECCCCCCCCEEECCCCCCEEEEHHHCCCCCCCCCCCCEEEEEECCCHHH
SVGLTEAKARERGYQVKVGKFPFSANGKARVLGQTRFGFIKLVADAQYDEILGVHMIGPR
HCCCHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCEEEEEEECCCHHHEEEEEECCHH
VTEMIAEGGIALSHEATGESMMQTIHAHPTLYEAIGEAAHALVHGAPIHL
HHHHHHCCCEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SEQVYDLVVLGSGPGGYVAAIRAAQLGMKTAIVEVNALGGVCLNIGCIPTKALLHSADL
CCCEEEEEEEECCCCCHHHHHHHHHCCCEEEEEEEECCCCEEEEECCCCHHHHHHHHHH
LEEVKEAKRFGITVENVAFELAGAMKHKDTVVKQSTDGVAFLMKKNKIEVVAGRGRLIGR
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHCCCCCCEEEEEECCCEEEEECCCEEEEC
GQVHVQLNEGGERVLAAKHIIVATGGRPRPFPGIPFDGERVLSSTDMLTLKTVPSSLLAI
CEEEEEECCCCCEEEEEEEEEEEECCCCCCCCCCCCCCHHHHCCCCEEEEECCCHHHHHH
GAGAIGVEFASMFRSFGSDVTIVEALPRIVPNEDEEVSAELTKAFQRRGIKTLAGAKVEG
CCCHHHHHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHCCCEEEE
VDVGGEKVVVTVVDSSGKPQQIAVEKLLVSIGIAPNTENIGLEEVGVKVNNRGFIETDGF
EECCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCEEECCCCEEECCCC
LRTSAEGVYAIGDCTANTPWLAHKASAEGILAAEHIAGHHVTPIDYGKIAACTYCNPEIA
EEECCCCEEEEECCCCCCCCEEECCCCCCEEEEHHHCCCCCCCCCCCCEEEEEECCCHHH
SVGLTEAKARERGYQVKVGKFPFSANGKARVLGQTRFGFIKLVADAQYDEILGVHMIGPR
HCCCHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCEEEEEEECCCHHHEEEEEECCHH
VTEMIAEGGIALSHEATGESMMQTIHAHPTLYEAIGEAAHALVHGAPIHL
HHHHHHCCCEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]