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The map label for this gene is adh [H]

Identifier: 222526277

GI number: 222526277

Start: 3753145

End: 3754170

Strand: Direct

Name: adh [H]

Synonym: Chy400_3043

Alternate gene names: 222526277

Gene position: 3753145-3754170 (Clockwise)

Preceding gene: 222526276

Following gene: 222526279

Centisome position: 71.23

GC content: 52.14

Gene sequence:

>1026_bases
ATGAAAACAATGAAAGCCGCTGTGGTTCACGACTTCCATCAACCATTGCGCATCGAGGAAGTTCCCAAGCCGGAGCCGGG
TTTTGGTGAGATTGTAGTCAAGATCGAGGCATCGGGACTCTGTCATACAGATATACACGCAGCGCATGGTGATTGGCCGG
TAAAACCAAAACTCCCATTCATTCCGGGGCACGAAGGAATAGGCATTGTTGAAAGCGTCGGTGCAGGGGTAACTAACGTA
AAGGAAGGTGATCGTGTTGCAATCCCCTGGCTGGGGTACGCCTGTGGCGAGTGTAAATATTGTGCTTCTGGATGGGAGAC
GCTTTGTGAGCGTCAACTGAATACTGGCTATTTCCTTGATGGGGCGCATGCTCAGTATGCAAAAGCGTATGCGAAGTATG
TGGGTATTGTTCCGGCTGGGGTTTCTGCCCTTGACGCCGCACCGTTAACCTGTGCTGGCGTTACCACGTACAAAGCTGTT
AAGGTCTCCGGAGCTCGTCCCTCGGAGCTGGTAGCTATCTTTGGTGTTGGTGGATTAGGTCATCTGGCATTGCAGTATGC
CAGAATCGCCGGGGCCACGGTAGCGGCTATTGATCTCCTGGATGAGCGATTACAGACAGCACGCGAACTTGGTGCCGATA
TTACCATCAATGCCAGCACCCAGGACCCCATTGAAGAATTGAAGAAGTGGGGCGGTGCTGATGCAGCCATCTGTTTAGCT
GTTTCACCGAAGGCTTTTGAGCAGGCTTATCGATCATTGCGACGTGGCGGGCGACTGGTTTTCGTTGGGCTTCCGGCTGA
TAACATGATTCAGTTGCCAATCTTCGAGACAGTGCTCAACGGTATTCATGTCATGGGTTCGATTGTTGGAACCCGCGCCG
ACCTGGCAGAAACATTTGCGTTACATGCCGCGGGCAAGACGCGAGTGCTCTTTGAGACGCGAAAGCTGGATCAGGTAAAT
GAAGCTTTCGAGGAGGTTGAGCACGGACGTAATAAGGCGCCACGAATCGTCTTCTCCGAATTTTAA

Upstream 100 bases:

>100_bases
ATGGTCAATAAGTTTTTGCTTAAAACAATGACATAAGTTGCCATTTGGGAATACTGGATAGCAATAAGGATAACTCAGGT
TCACGAGAGGAGGAAGACCA

Downstream 100 bases:

>100_bases
TGCAATGCATGGTATGAAGCGGGGCTTTGATGTTCATGTCCCGCTTCGACTACGTCTGATGTCGATGTTCAGCCTACCAT
GATCTCTGTTCTGGTCTCTT

Product: alcohol dehydrogenase GroES domain-containing protein

Products: NA

Alternate protein names: ADH [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKTMKAAVVHDFHQPLRIEEVPKPEPGFGEIVVKIEASGLCHTDIHAAHGDWPVKPKLPFIPGHEGIGIVESVGAGVTNV
KEGDRVAIPWLGYACGECKYCASGWETLCERQLNTGYFLDGAHAQYAKAYAKYVGIVPAGVSALDAAPLTCAGVTTYKAV
KVSGARPSELVAIFGVGGLGHLALQYARIAGATVAAIDLLDERLQTARELGADITINASTQDPIEELKKWGGADAAICLA
VSPKAFEQAYRSLRRGGRLVFVGLPADNMIQLPIFETVLNGIHVMGSIVGTRADLAETFALHAAGKTRVLFETRKLDQVN
EAFEEVEHGRNKAPRIVFSEF

Sequences:

>Translated_341_residues
MKTMKAAVVHDFHQPLRIEEVPKPEPGFGEIVVKIEASGLCHTDIHAAHGDWPVKPKLPFIPGHEGIGIVESVGAGVTNV
KEGDRVAIPWLGYACGECKYCASGWETLCERQLNTGYFLDGAHAQYAKAYAKYVGIVPAGVSALDAAPLTCAGVTTYKAV
KVSGARPSELVAIFGVGGLGHLALQYARIAGATVAAIDLLDERLQTARELGADITINASTQDPIEELKKWGGADAAICLA
VSPKAFEQAYRSLRRGGRLVFVGLPADNMIQLPIFETVLNGIHVMGSIVGTRADLAETFALHAAGKTRVLFETRKLDQVN
EAFEEVEHGRNKAPRIVFSEF
>Mature_341_residues
MKTMKAAVVHDFHQPLRIEEVPKPEPGFGEIVVKIEASGLCHTDIHAAHGDWPVKPKLPFIPGHEGIGIVESVGAGVTNV
KEGDRVAIPWLGYACGECKYCASGWETLCERQLNTGYFLDGAHAQYAKAYAKYVGIVPAGVSALDAAPLTCAGVTTYKAV
KVSGARPSELVAIFGVGGLGHLALQYARIAGATVAAIDLLDERLQTARELGADITINASTQDPIEELKKWGGADAAICLA
VSPKAFEQAYRSLRRGGRLVFVGLPADNMIQLPIFETVLNGIHVMGSIVGTRADLAETFALHAAGKTRVLFETRKLDQVN
EAFEEVEHGRNKAPRIVFSEF

Specific function: Active with primary alcohols, including methanol [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=375, Percent_Identity=31.7333333333333, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI4501929, Length=375, Percent_Identity=31.2, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI34577061, Length=375, Percent_Identity=30.9333333333333, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI71565154, Length=247, Percent_Identity=34.8178137651822, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI71565152, Length=374, Percent_Identity=29.4117647058824, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI262073058, Length=246, Percent_Identity=34.5528455284553, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI4501939, Length=368, Percent_Identity=30.4347826086957, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI156523966, Length=368, Percent_Identity=30.4347826086957, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI71743840, Length=246, Percent_Identity=34.5528455284553, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI156627571, Length=332, Percent_Identity=27.4096385542169, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI194239674, Length=356, Percent_Identity=23.876404494382, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI13236495, Length=356, Percent_Identity=23.876404494382, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI87081918, Length=337, Percent_Identity=45.9940652818991, Blast_Score=238, Evalue=4e-64,
Organism=Escherichia coli, GI1786518, Length=340, Percent_Identity=29.1176470588235, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI87082125, Length=277, Percent_Identity=32.4909747292419, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1788073, Length=267, Percent_Identity=30.7116104868914, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1787863, Length=295, Percent_Identity=30.5084745762712, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1790045, Length=290, Percent_Identity=28.6206896551724, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1786552, Length=366, Percent_Identity=29.7814207650273, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87082401, Length=344, Percent_Identity=26.1627906976744, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788075, Length=270, Percent_Identity=30, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI226510992, Length=287, Percent_Identity=30.6620209059233, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788407, Length=224, Percent_Identity=33.0357142857143, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786825, Length=307, Percent_Identity=29.6416938110749, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790718, Length=271, Percent_Identity=27.6752767527675, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71988145, Length=337, Percent_Identity=34.7181008902077, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17562584, Length=332, Percent_Identity=34.3373493975904, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17562582, Length=339, Percent_Identity=34.2182890855457, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17562876, Length=327, Percent_Identity=31.4984709480122, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17562878, Length=337, Percent_Identity=32.0474777448071, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI25146526, Length=238, Percent_Identity=32.3529411764706, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71997431, Length=240, Percent_Identity=31.6666666666667, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17565904, Length=211, Percent_Identity=30.3317535545024, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324486, Length=333, Percent_Identity=36.9369369369369, Blast_Score=215, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6323729, Length=333, Percent_Identity=35.4354354354354, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6323961, Length=333, Percent_Identity=36.6366366366366, Blast_Score=211, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6319621, Length=333, Percent_Identity=37.2372372372372, Blast_Score=209, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6320033, Length=363, Percent_Identity=30.3030303030303, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6323980, Length=332, Percent_Identity=28.6144578313253, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6319949, Length=337, Percent_Identity=28.7833827893175, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322619, Length=352, Percent_Identity=29.2613636363636, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=343, Percent_Identity=29.1545189504373, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=224, Percent_Identity=27.2321428571429, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737895, Length=366, Percent_Identity=27.5956284153005, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17737897, Length=347, Percent_Identity=29.971181556196, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17137530, Length=352, Percent_Identity=29.5454545454545, Blast_Score=95, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36539; Mature: 36539

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTMKAAVVHDFHQPLRIEEVPKPEPGFGEIVVKIEASGLCHTDIHAAHGDWPVKPKLPF
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEECCCCCCCCCCCCCCCCCC
IPGHEGIGIVESVGAGVTNVKEGDRVAIPWLGYACGECKYCASGWETLCERQLNTGYFLD
CCCCCCCCHHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEC
GAHAQYAKAYAKYVGIVPAGVSALDAAPLTCAGVTTYKAVKVSGARPSELVAIFGVGGLG
CCHHHHHHHHHHHHCCCCCCCHHHCCCCCEECCCCEEEEEEECCCCCCCEEEEEECCCHH
HLALQYARIAGATVAAIDLLDERLQTARELGADITINASTQDPIEELKKWGGADAAICLA
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHCCCCCEEEEEE
VSPKAFEQAYRSLRRGGRLVFVGLPADNMIQLPIFETVLNGIHVMGSIVGTRADLAETFA
ECHHHHHHHHHHHHCCCEEEEEECCCCCEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LHAAGKTRVLFETRKLDQVNEAFEEVEHGRNKAPRIVFSEF
HHCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure
MKTMKAAVVHDFHQPLRIEEVPKPEPGFGEIVVKIEASGLCHTDIHAAHGDWPVKPKLPF
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEECCCCCCCCCCCCCCCCCC
IPGHEGIGIVESVGAGVTNVKEGDRVAIPWLGYACGECKYCASGWETLCERQLNTGYFLD
CCCCCCCCHHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEC
GAHAQYAKAYAKYVGIVPAGVSALDAAPLTCAGVTTYKAVKVSGARPSELVAIFGVGGLG
CCHHHHHHHHHHHHCCCCCCCHHHCCCCCEECCCCEEEEEEECCCCCCCEEEEEECCCHH
HLALQYARIAGATVAAIDLLDERLQTARELGADITINASTQDPIEELKKWGGADAAICLA
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHCCCCCEEEEEE
VSPKAFEQAYRSLRRGGRLVFVGLPADNMIQLPIFETVLNGIHVMGSIVGTRADLAETFA
ECHHHHHHHHHHHHCCCEEEEEECCCCCEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LHAAGKTRVLFETRKLDQVNEAFEEVEHGRNKAPRIVFSEF
HHCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8049268 [H]