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The map label for this gene is phhA [H]

Identifier: 222526264

GI number: 222526264

Start: 3737821

End: 3738552

Strand: Direct

Name: phhA [H]

Synonym: Chy400_3030

Alternate gene names: 222526264

Gene position: 3737821-3738552 (Clockwise)

Preceding gene: 222526263

Following gene: 222526265

Centisome position: 70.94

GC content: 56.56

Gene sequence:

>732_bases
ATGACAACCATTGCTCCGCCCGCGATGCCTGCCTACACTGAAGAAGACCATCTGGTTTGGGCAACACTCTGTGCACGCCA
GGTTCCCCGGCTTGATCGGTACGCCTGTCGGCTCTTCCGCGAAGGGTTTCGTAAACTCAATCTCGATTTGCAGCGTCTCC
CCGATCCGGTACAGGTAAGCGAACGGCTGGCCGCGATGACCGGCTGGACGTTGTGTGACGCTCAAAACGAGTATCTCAAT
CCCACCGAATGGTTCGAGCATATCGCCGAACGACGTTTTCCGGTCACCAATTACATTCGGCGCATGGACGAGCTTGATTT
CACACCGCTCCCCGATCTGTTCCACGAGTACATCGGTCATCTGGCGTTTTTCACCGATCAGCGGTTTGCCGATATTGCCC
AGGCGTTTGGGCCGCTCTACTTTGCCGGCGATGAACGGCAGCGGCTCGAAATTGCCCGTCTCTGGTGGTACAGTATCGAG
TTTGGCCTGATCCGCGAAGATGGTGAGTTACGCGCCTTTGGTGCCGGTCTGCTGTCGTCGATTGGTGAACTCGACCACGC
CTTCGCCCCCGATACGCCGCGAGTACCCTTCGATATTCGACGGGTTGCCAATACACCAGGGGCGGCCTATTCGATGCATG
AAACCTACTTCATCCTTGAGGATTTAGAGCACGTTGCGGCTATTTTGCGCGATTACGCTGCAATGGAAGGACTGCCGCCG
GTGCAGATCTGA

Upstream 100 bases:

>100_bases
AGAGTTAGGGTTCTTCTAAGTGGTAAGCGAACGGTGAGTATTGGGCGATACTCGCCGTTCGTTGACGATTCAGTAGCATA
CAATACAAGGGGGTATTGTC

Downstream 100 bases:

>100_bases
TACAGGACCGGTGAGGAATCTGTACCGGGGTCTGTCCTCTTAGTTAGTGAAGGTGGTGACTTCGCCTGCTCCACCTGGAA
AGATGGTGTTGGACATGTTA

Product: aromatic amino acid hydroxylase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MTTIAPPAMPAYTEEDHLVWATLCARQVPRLDRYACRLFREGFRKLNLDLQRLPDPVQVSERLAAMTGWTLCDAQNEYLN
PTEWFEHIAERRFPVTNYIRRMDELDFTPLPDLFHEYIGHLAFFTDQRFADIAQAFGPLYFAGDERQRLEIARLWWYSIE
FGLIREDGELRAFGAGLLSSIGELDHAFAPDTPRVPFDIRRVANTPGAAYSMHETYFILEDLEHVAAILRDYAAMEGLPP
VQI

Sequences:

>Translated_243_residues
MTTIAPPAMPAYTEEDHLVWATLCARQVPRLDRYACRLFREGFRKLNLDLQRLPDPVQVSERLAAMTGWTLCDAQNEYLN
PTEWFEHIAERRFPVTNYIRRMDELDFTPLPDLFHEYIGHLAFFTDQRFADIAQAFGPLYFAGDERQRLEIARLWWYSIE
FGLIREDGELRAFGAGLLSSIGELDHAFAPDTPRVPFDIRRVANTPGAAYSMHETYFILEDLEHVAAILRDYAAMEGLPP
VQI
>Mature_242_residues
TTIAPPAMPAYTEEDHLVWATLCARQVPRLDRYACRLFREGFRKLNLDLQRLPDPVQVSERLAAMTGWTLCDAQNEYLNP
TEWFEHIAERRFPVTNYIRRMDELDFTPLPDLFHEYIGHLAFFTDQRFADIAQAFGPLYFAGDERQRLEIARLWWYSIEF
GLIREDGELRAFGAGLLSSIGELDHAFAPDTPRVPFDIRRVANTPGAAYSMHETYFILEDLEHVAAILRDYAAMEGLPPV
QI

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI31795563, Length=227, Percent_Identity=32.15859030837, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI4759248, Length=231, Percent_Identity=29.8701298701299, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI4557819, Length=227, Percent_Identity=26.8722466960352, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI88900503, Length=193, Percent_Identity=31.6062176165803, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI88900505, Length=193, Percent_Identity=31.6062176165803, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI88900501, Length=193, Percent_Identity=31.6062176165803, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71980736, Length=234, Percent_Identity=29.9145299145299, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17531391, Length=233, Percent_Identity=31.3304721030043, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI115532103, Length=236, Percent_Identity=28.8135593220339, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI115533973, Length=236, Percent_Identity=28.8135593220339, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71980731, Length=151, Percent_Identity=25.8278145695364, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17136776, Length=212, Percent_Identity=30.6603773584906, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI17136774, Length=212, Percent_Identity=30.6603773584906, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI62472054, Length=193, Percent_Identity=31.6062176165803, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24660393, Length=193, Percent_Identity=31.6062176165803, Blast_Score=97, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24654994, Length=206, Percent_Identity=29.126213592233, Blast_Score=95, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 28114; Mature: 27983

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIAPPAMPAYTEEDHLVWATLCARQVPRLDRYACRLFREGFRKLNLDLQRLPDPVQVS
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHCCCHHHHH
ERLAAMTGWTLCDAQNEYLNPTEWFEHIAERRFPVTNYIRRMDELDFTPLPDLFHEYIGH
HHHHHHHCCHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
LAFFTDQRFADIAQAFGPLYFAGDERQRLEIARLWWYSIEFGLIREDGELRAFGAGLLSS
HHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHH
IGELDHAFAPDTPRVPFDIRRVANTPGAAYSMHETYFILEDLEHVAAILRDYAAMEGLPP
HHHHHHHCCCCCCCCCHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VQI
CCC
>Mature Secondary Structure 
TTIAPPAMPAYTEEDHLVWATLCARQVPRLDRYACRLFREGFRKLNLDLQRLPDPVQVS
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHCCCHHHHH
ERLAAMTGWTLCDAQNEYLNPTEWFEHIAERRFPVTNYIRRMDELDFTPLPDLFHEYIGH
HHHHHHHCCHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
LAFFTDQRFADIAQAFGPLYFAGDERQRLEIARLWWYSIEFGLIREDGELRAFGAGLLSS
HHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHH
IGELDHAFAPDTPRVPFDIRRVANTPGAAYSMHETYFILEDLEHVAAILRDYAAMEGLPP
HHHHHHHCCCCCCCCCHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VQI
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1655752; 14500782; 12096915 [H]