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The map label for this gene is adhA [H]

Identifier: 222525704

GI number: 222525704

Start: 3098585

End: 3099571

Strand: Direct

Name: adhA [H]

Synonym: Chy400_2455

Alternate gene names: 222525704

Gene position: 3098585-3099571 (Clockwise)

Preceding gene: 222525701

Following gene: 222525707

Centisome position: 58.81

GC content: 59.98

Gene sequence:

>987_bases
ATGCGCGCAATGGTCTTCACCGCACCTGGTCAACCGCTCGAATACCGTGATCTTCCGGTGCCAACACCACAGCCCGAAGA
GGTCTTGATTCGGGTTGAGGCGTGTGCTGTCTGTCGTACCGATCTTCATATTATCGATGGGGAATTACCAGCGCCGAACC
TGCCACTTGTTCCAGGTCATCAAATTGTCGGTACTATCGAGCGTCTCGGCGAGCGGGTCACACGCTGGACGGTTGGGCAA
CGGGTTGGGGTGCCCTGGCTGGGCTGGACGTGTGGCGAGTGCCGTTTTTGCCGTGATGGGCGCGAAAATCTTTGCGATCA
GGCGCAGTTTACCGGCTATACCCGACCCGGCGGCTTTGCCGAATATACCGTTGCCGATCAACGTTTCTGCTTTGCTCTAC
CCACCGACTACGACGCAACCGCAGTTGCACCGTTGCTCTGCGCTGGTCTGATCGGATATCGGGCACTCCGCCTGGCCGGT
ACTGGCGAGCGACTGGGTATCTACGGCTTCGGTGCCGCAGCACACCTGATGACGCAGGTTGCACGCTGGCAGGGTCGCGA
AGTCTTCGCCTTCACCCGTCCCGGTGATACTGAAGGGCAACGTTTTGCCCGCGAATTAGGCGCAGTCTGGGCCGGCAGTT
CAACCGAGCTGCCGCCGGTGCCACTCGATGCCGCAATCATCTTTGCCCCGGTAGGCGATCTCGTTCCGTATGCGTTACGT
GCCGTCGAGAAAGGGGGCGTTGTCGTCTGTGGCGGCATTCATATGAGCCAGATTCCTGCCTTCGCCTACGAATTGCTGTG
GGGCGAGCGCGTATTGCGCTCGGTCGCCAACCTAACCCGTGAGGACGGCGAGGCATTCCTGCAGATCGCGCCACAAATCC
CGGTGCGGACAACCGTCCAGACCTTTCCACTCACCGAACTGAACACAGCCCTGAACGCACTCCGCCAGGGGAAGTTACAG
GGTGCCGCCGTGATCCAGATTTCGTAA

Upstream 100 bases:

>100_bases
ATGCACGCTGCACGGATGAACGCGATGACCTTAGTTATACTGCAATCATGTATGACCGATCAACATCCCGGTTAATTCAG
TTCTCTTCTGGAGGCACGCC

Downstream 100 bases:

>100_bases
GGGGTGGGGCGATCAGGTGAATGGTTGCGTAGAATCTATCTTCGCAGACGACAGGGGAGCGCATTGGATGAGAACCCTGC
CGGGTATGCTATATCTACAT

Product: zinc-binding alcohol dehydrogenase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MRAMVFTAPGQPLEYRDLPVPTPQPEEVLIRVEACAVCRTDLHIIDGELPAPNLPLVPGHQIVGTIERLGERVTRWTVGQ
RVGVPWLGWTCGECRFCRDGRENLCDQAQFTGYTRPGGFAEYTVADQRFCFALPTDYDATAVAPLLCAGLIGYRALRLAG
TGERLGIYGFGAAAHLMTQVARWQGREVFAFTRPGDTEGQRFARELGAVWAGSSTELPPVPLDAAIIFAPVGDLVPYALR
AVEKGGVVVCGGIHMSQIPAFAYELLWGERVLRSVANLTREDGEAFLQIAPQIPVRTTVQTFPLTELNTALNALRQGKLQ
GAAVIQIS

Sequences:

>Translated_328_residues
MRAMVFTAPGQPLEYRDLPVPTPQPEEVLIRVEACAVCRTDLHIIDGELPAPNLPLVPGHQIVGTIERLGERVTRWTVGQ
RVGVPWLGWTCGECRFCRDGRENLCDQAQFTGYTRPGGFAEYTVADQRFCFALPTDYDATAVAPLLCAGLIGYRALRLAG
TGERLGIYGFGAAAHLMTQVARWQGREVFAFTRPGDTEGQRFARELGAVWAGSSTELPPVPLDAAIIFAPVGDLVPYALR
AVEKGGVVVCGGIHMSQIPAFAYELLWGERVLRSVANLTREDGEAFLQIAPQIPVRTTVQTFPLTELNTALNALRQGKLQ
GAAVIQIS
>Mature_328_residues
MRAMVFTAPGQPLEYRDLPVPTPQPEEVLIRVEACAVCRTDLHIIDGELPAPNLPLVPGHQIVGTIERLGERVTRWTVGQ
RVGVPWLGWTCGECRFCRDGRENLCDQAQFTGYTRPGGFAEYTVADQRFCFALPTDYDATAVAPLLCAGLIGYRALRLAG
TGERLGIYGFGAAAHLMTQVARWQGREVFAFTRPGDTEGQRFARELGAVWAGSSTELPPVPLDAAIIFAPVGDLVPYALR
AVEKGGVVVCGGIHMSQIPAFAYELLWGERVLRSVANLTREDGEAFLQIAPQIPVRTTVQTFPLTELNTALNALRQGKLQ
GAAVIQIS

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=110, Percent_Identity=36.3636363636364, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI4501933, Length=233, Percent_Identity=26.6094420600858, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI71743840, Length=193, Percent_Identity=27.979274611399, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI262073058, Length=193, Percent_Identity=27.979274611399, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI34577061, Length=235, Percent_Identity=27.2340425531915, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4501929, Length=235, Percent_Identity=26.3829787234043, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI194239674, Length=214, Percent_Identity=28.5046728971963, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI13236495, Length=214, Percent_Identity=28.5046728971963, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI194239676, Length=214, Percent_Identity=28.5046728971963, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI156627571, Length=217, Percent_Identity=28.110599078341, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI71565152, Length=179, Percent_Identity=27.3743016759777, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87081918, Length=348, Percent_Identity=30.4597701149425, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI87082401, Length=315, Percent_Identity=29.2063492063492, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1786518, Length=222, Percent_Identity=36.036036036036, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1787863, Length=224, Percent_Identity=29.0178571428571, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790045, Length=210, Percent_Identity=29.5238095238095, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788073, Length=200, Percent_Identity=30.5, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786552, Length=233, Percent_Identity=31.7596566523605, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI226510992, Length=174, Percent_Identity=31.0344827586207, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788075, Length=220, Percent_Identity=27.7272727272727, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786825, Length=215, Percent_Identity=25.1162790697674, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788407, Length=199, Percent_Identity=31.1557788944724, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87082125, Length=191, Percent_Identity=27.7486910994764, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=341, Percent_Identity=26.6862170087977, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17562582, Length=342, Percent_Identity=28.0701754385965, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71988145, Length=193, Percent_Identity=30.5699481865285, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17562876, Length=262, Percent_Identity=26.3358778625954, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=208, Percent_Identity=28.3653846153846, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=196, Percent_Identity=30.1020408163265, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=198, Percent_Identity=29.7979797979798, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=344, Percent_Identity=30.8139534883721, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323961, Length=202, Percent_Identity=39.1089108910891, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6324486, Length=194, Percent_Identity=38.1443298969072, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6319621, Length=350, Percent_Identity=29.4285714285714, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323980, Length=199, Percent_Identity=32.6633165829146, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6319949, Length=186, Percent_Identity=32.258064516129, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6320033, Length=200, Percent_Identity=28.5, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=188, Percent_Identity=30.3191489361702, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6319257, Length=186, Percent_Identity=29.0322580645161, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737895, Length=110, Percent_Identity=35.4545454545455, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17737897, Length=209, Percent_Identity=31.1004784688995, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137530, Length=207, Percent_Identity=30.9178743961353, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35686; Mature: 35686

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAMVFTAPGQPLEYRDLPVPTPQPEEVLIRVEACAVCRTDLHIIDGELPAPNLPLVPGH
CCEEEEECCCCCCCCCCCCCCCCCCHHHEEEEHHHHHHHCCCEEECCCCCCCCCCCCCCH
QIVGTIERLGERVTRWTVGQRVGVPWLGWTCGECRFCRDGRENLCDQAQFTGYTRPGGFA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCE
EYTVADQRFCFALPTDYDATAVAPLLCAGLIGYRALRLAGTGERLGIYGFGAAAHLMTQV
EEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHEEEECCCCEEEEEECCHHHHHHHHH
ARWQGREVFAFTRPGDTEGQRFARELGAVWAGSSTELPPVPLDAAIIFAPVGDLVPYALR
HHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECHHHHHHHHHH
AVEKGGVVVCGGIHMSQIPAFAYELLWGERVLRSVANLTREDGEAFLQIAPQIPVRTTVQ
HHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEE
TFPLTELNTALNALRQGKLQGAAVIQIS
ECCCHHHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MRAMVFTAPGQPLEYRDLPVPTPQPEEVLIRVEACAVCRTDLHIIDGELPAPNLPLVPGH
CCEEEEECCCCCCCCCCCCCCCCCCHHHEEEEHHHHHHHCCCEEECCCCCCCCCCCCCCH
QIVGTIERLGERVTRWTVGQRVGVPWLGWTCGECRFCRDGRENLCDQAQFTGYTRPGGFA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCE
EYTVADQRFCFALPTDYDATAVAPLLCAGLIGYRALRLAGTGERLGIYGFGAAAHLMTQV
EEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHEEEECCCCEEEEEECCHHHHHHHHH
ARWQGREVFAFTRPGDTEGQRFARELGAVWAGSSTELPPVPLDAAIIFAPVGDLVPYALR
HHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECHHHHHHHHHH
AVEKGGVVVCGGIHMSQIPAFAYELLWGERVLRSVANLTREDGEAFLQIAPQIPVRTTVQ
HHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEE
TFPLTELNTALNALRQGKLQGAAVIQIS
ECCCHHHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]