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The map label for this gene is proC [H]

Identifier: 222525663

GI number: 222525663

Start: 3041561

End: 3042379

Strand: Reverse

Name: proC [H]

Synonym: Chy400_2414

Alternate gene names: 222525663

Gene position: 3042379-3041561 (Counterclockwise)

Preceding gene: 222525664

Following gene: 222525662

Centisome position: 57.74

GC content: 61.17

Gene sequence:

>819_bases
ATGCTCTCAGATTTACCAATTGCCGTTATTGGGGCCGGCGCGATGGGCGAAGCAATTATCGGTGGCCTGTTGCGCAACGA
GCTGGTTGCCGCCGATCAGATTTTAGCCAGCCATCCCCGCGAAGACCGCCGGCGCGAACTGAGCCATCACTACGGCATTC
AGACCACGCACGATAATCTGGCCGCTGCCCAATGGGGACGGGTGGTCATCTTCGCCGTCAAGCCGCAACAGTTACGCCGG
GTGCTGCCACCACTGCGCGGCGCCCTGCGCGACGACGATCTGGCGATTTCGGTCATCGCCGGCGCTACCATCGCCTCGTT
TGCCGAGGCGCTTGACCATCAGGCCGTTGTGCGCAGTATGCCCAACACTCCCGCCCAAATCGGTTGTGGAATGACGGTGT
GGACTGCGGCACCGGCAGTGAATGAGCGTCAGCGCGGCTGGGCAGCCACTGTGTTGGGTGCGCTCGGTCGTGAATTGTTT
GTCGATAACGAGACCTATCTCGATATGGCAACCGCGATCAATGGCACCGGGCCGGCGTATGTCTTCCTGATGATGGAAGC
GATGATCGATGCCGGTGTTCACCTTGGCCTGTCGCGGCGGATTGCCGAAGAGCTGGTACAACAGACGATGCTCGGCTCGG
TGCAATACGCCATTCAGAGCGGTTTGCATCCGGCACAGTTGCGCAATGCGGTCACCTCTCCCGGTGGCACCAGCGCCGCC
GCGTTGAGTGAGCTTGAGCGCGGTGGTCTGCGCACTGTCCTGGCCGATGCCATTTGGGCGGCTTATCGGCGGTCGGTTGA
ATTGGGAAGGAATGGTTAG

Upstream 100 bases:

>100_bases
CCTCTTCCCCATCCATCCCGTGGTATCATATTCCCCAGAACAGACATGGTTTGCCGTCCAACGGCAAACAGGTAAAGCAC
TAGCTACAGGTACAACAACT

Downstream 100 bases:

>100_bases
ATGGCGGTGAGCTACGCGCGGGCGCGCTTAACAACCGAAGACGACCGTCGCTACCGGGCCTTTGTCGAGCAGTTCAAGCT
GCAACGCAAAAATCAGAAAG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MLSDLPIAVIGAGAMGEAIIGGLLRNELVAADQILASHPREDRRRELSHHYGIQTTHDNLAAAQWGRVVIFAVKPQQLRR
VLPPLRGALRDDDLAISVIAGATIASFAEALDHQAVVRSMPNTPAQIGCGMTVWTAAPAVNERQRGWAATVLGALGRELF
VDNETYLDMATAINGTGPAYVFLMMEAMIDAGVHLGLSRRIAEELVQQTMLGSVQYAIQSGLHPAQLRNAVTSPGGTSAA
ALSELERGGLRTVLADAIWAAYRRSVELGRNG

Sequences:

>Translated_272_residues
MLSDLPIAVIGAGAMGEAIIGGLLRNELVAADQILASHPREDRRRELSHHYGIQTTHDNLAAAQWGRVVIFAVKPQQLRR
VLPPLRGALRDDDLAISVIAGATIASFAEALDHQAVVRSMPNTPAQIGCGMTVWTAAPAVNERQRGWAATVLGALGRELF
VDNETYLDMATAINGTGPAYVFLMMEAMIDAGVHLGLSRRIAEELVQQTMLGSVQYAIQSGLHPAQLRNAVTSPGGTSAA
ALSELERGGLRTVLADAIWAAYRRSVELGRNG
>Mature_272_residues
MLSDLPIAVIGAGAMGEAIIGGLLRNELVAADQILASHPREDRRRELSHHYGIQTTHDNLAAAQWGRVVIFAVKPQQLRR
VLPPLRGALRDDDLAISVIAGATIASFAEALDHQAVVRSMPNTPAQIGCGMTVWTAAPAVNERQRGWAATVLGALGRELF
VDNETYLDMATAINGTGPAYVFLMMEAMIDAGVHLGLSRRIAEELVQQTMLGSVQYAIQSGLHPAQLRNAVTSPGGTSAA
ALSELERGGLRTVLADAIWAAYRRSVELGRNG

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=268, Percent_Identity=35.8208955223881, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI24797097, Length=269, Percent_Identity=32.7137546468402, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI24797095, Length=269, Percent_Identity=32.7137546468402, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI21361454, Length=269, Percent_Identity=30.8550185873606, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1786585, Length=266, Percent_Identity=33.8345864661654, Blast_Score=154, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17569021, Length=263, Percent_Identity=36.1216730038023, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17540664, Length=290, Percent_Identity=27.5862068965517, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320861, Length=286, Percent_Identity=29.020979020979, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=35.6060606060606, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24648116, Length=281, Percent_Identity=35.2313167259786, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=39.0532544378698, Blast_Score=121, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29016; Mature: 29016

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00962 RIBOSOMAL_S2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSDLPIAVIGAGAMGEAIIGGLLRNELVAADQILASHPREDRRRELSHHYGIQTTHDNL
CCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCH
AAAQWGRVVIFAVKPQQLRRVLPPLRGALRDDDLAISVIAGATIASFAEALDHQAVVRSM
HHHCCCCEEEEEECHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHC
PNTPAQIGCGMTVWTAAPAVNERQRGWAATVLGALGRELFVDNETYLDMATAINGTGPAY
CCCCHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHCCCCCHHH
VFLMMEAMIDAGVHLGLSRRIAEELVQQTMLGSVQYAIQSGLHPAQLRNAVTSPGGTSAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHH
ALSELERGGLRTVLADAIWAAYRRSVELGRNG
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLSDLPIAVIGAGAMGEAIIGGLLRNELVAADQILASHPREDRRRELSHHYGIQTTHDNL
CCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCH
AAAQWGRVVIFAVKPQQLRRVLPPLRGALRDDDLAISVIAGATIASFAEALDHQAVVRSM
HHHCCCCEEEEEECHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHC
PNTPAQIGCGMTVWTAAPAVNERQRGWAATVLGALGRELFVDNETYLDMATAINGTGPAY
CCCCHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHCCCCCHHH
VFLMMEAMIDAGVHLGLSRRIAEELVQQTMLGSVQYAIQSGLHPAQLRNAVTSPGGTSAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHH
ALSELERGGLRTVLADAIWAAYRRSVELGRNG
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]