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The map label for this gene is panC

Identifier: 222525628

GI number: 222525628

Start: 3005507

End: 3006352

Strand: Reverse

Name: panC

Synonym: Chy400_2379

Alternate gene names: 222525628

Gene position: 3006352-3005507 (Counterclockwise)

Preceding gene: 222525629

Following gene: 222525627

Centisome position: 57.06

GC content: 58.98

Gene sequence:

>846_bases
ATGAAAGTCCTACACACAGTCGCCGAATTTCGACAGGCACGGGCGGCGTTTGATGTCCTGGGGTTCGTGCCGACGATGGG
GTATTTGCATCAGGGACATCTGGCGCTGGTTGAACAGGCCCGTCGCGAATGCCCGGCAGTAGCGGTGAGTATCTTTGTCA
ATCCAACGCAGTTTGGCCCTAACGAGGACTATGCCCGCTATCCACGCGATACTAACCGCGATCTGGCGCTGCTCGAAGCA
GCCGGTGTTGATCTGGTATTTATCCCTTCGGTCGAAGAGATGTATCCGCCCGGATTCGGCACCTATGTCATTCAGCCTGC
CGCTGATGAGGTGCTGGAAGGGGCGGCCCGACCCGGCCATTTTCGGGGTGTCGCGACCGTTGTCTGTAAGCTGTTTAATA
TTGTGCAGCCGACCAAGAGCTACTTCGGGCAGAAGGATGCCCAACAGACGGTTGTAGTGCGTCAGATGGTTCGCGATCTA
AATCTCCCGGTTGAGATTGTGATTGTACCGACGGTACGCGAACCTGATGGTCTGGCGCTCAGTAGTCGTAACGTCTATTT
GAACGCCGAACAGCGAGCCGCCGCACCGGTGCTCTACCGGGCACTGCGCACCGCTGCCGAACGCTACGCTGCCGGTGAGC
GTGACGCCGAGACGCTGCGAGCAGTGATGCGAAGTGTGCTCGCCGGGGAGCCGCTGGCCCGACCGGATTACGTTAGCGTG
GCCCATCCGCTCACGTTGCGTGAACTGGATCGGATTGGTGCGGACGGTGCTTTGTTGTCGATGGCCGTGCGCTTCGACCA
GGTGCGCCTGATCGACAACTGGCTGTTGGAAGGGGAAGGAAAATAG

Upstream 100 bases:

>100_bases
TCGCGGGATGAGGGTGAGCAGAGACTCAGAAATGCCACATTGTTATTGATGATGGGTGCGATCAGGCTCAACGTTGAGCA
AGACAACGAGGAAACATGCT

Downstream 100 bases:

>100_bases
ACGATAGTGAGCGGGTTGACCCTCACCCCCGGCCCCTCTCCCGCGGCGCGGGAGAGGGGAGATGAGAGGTTTGATTCAGG
GCTTCCTGATGCGGTAGACG

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MKVLHTVAEFRQARAAFDVLGFVPTMGYLHQGHLALVEQARRECPAVAVSIFVNPTQFGPNEDYARYPRDTNRDLALLEA
AGVDLVFIPSVEEMYPPGFGTYVIQPAADEVLEGAARPGHFRGVATVVCKLFNIVQPTKSYFGQKDAQQTVVVRQMVRDL
NLPVEIVIVPTVREPDGLALSSRNVYLNAEQRAAAPVLYRALRTAAERYAAGERDAETLRAVMRSVLAGEPLARPDYVSV
AHPLTLRELDRIGADGALLSMAVRFDQVRLIDNWLLEGEGK

Sequences:

>Translated_281_residues
MKVLHTVAEFRQARAAFDVLGFVPTMGYLHQGHLALVEQARRECPAVAVSIFVNPTQFGPNEDYARYPRDTNRDLALLEA
AGVDLVFIPSVEEMYPPGFGTYVIQPAADEVLEGAARPGHFRGVATVVCKLFNIVQPTKSYFGQKDAQQTVVVRQMVRDL
NLPVEIVIVPTVREPDGLALSSRNVYLNAEQRAAAPVLYRALRTAAERYAAGERDAETLRAVMRSVLAGEPLARPDYVSV
AHPLTLRELDRIGADGALLSMAVRFDQVRLIDNWLLEGEGK
>Mature_281_residues
MKVLHTVAEFRQARAAFDVLGFVPTMGYLHQGHLALVEQARRECPAVAVSIFVNPTQFGPNEDYARYPRDTNRDLALLEA
AGVDLVFIPSVEEMYPPGFGTYVIQPAADEVLEGAARPGHFRGVATVVCKLFNIVQPTKSYFGQKDAQQTVVVRQMVRDL
NLPVEIVIVPTVREPDGLALSSRNVYLNAEQRAAAPVLYRALRTAAERYAAGERDAETLRAVMRSVLAGEPLARPDYVSV
AHPLTLRELDRIGADGALLSMAVRFDQVRLIDNWLLEGEGK

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=271, Percent_Identity=46.8634686346863, Blast_Score=228, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6322046, Length=307, Percent_Identity=40.7166123778502, Blast_Score=191, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_CHLAA (A9WFR6)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001635805.1
- ProteinModelPortal:   A9WFR6
- SMR:   A9WFR6
- GeneID:   5826667
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_2207
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- ProtClustDB:   PRK00380
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31012; Mature: 31012

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: ACT_SITE 33-33 BINDING 57-57 BINDING 57-57 BINDING 149-149 BINDING 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLHTVAEFRQARAAFDVLGFVPTMGYLHQGHLALVEQARRECPAVAVSIFVNPTQFGP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEEEECCCCCCC
NEDYARYPRDTNRDLALLEAAGVDLVFIPSVEEMYPPGFGTYVIQPAADEVLEGAARPGH
CCCHHHCCCCCCCCEEEEEECCCCEEEECCHHHHCCCCCCCEEECCCHHHHHHCCCCCCC
FRGVATVVCKLFNIVQPTKSYFGQKDAQQTVVVRQMVRDLNLPVEIVIVPTVREPDGLAL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEE
SSRNVYLNAEQRAAAPVLYRALRTAAERYAAGERDAETLRAVMRSVLAGEPLARPDYVSV
ECCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHH
AHPLTLRELDRIGADGALLSMAVRFDQVRLIDNWLLEGEGK
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKVLHTVAEFRQARAAFDVLGFVPTMGYLHQGHLALVEQARRECPAVAVSIFVNPTQFGP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEEEECCCCCCC
NEDYARYPRDTNRDLALLEAAGVDLVFIPSVEEMYPPGFGTYVIQPAADEVLEGAARPGH
CCCHHHCCCCCCCCEEEEEECCCCEEEECCHHHHCCCCCCCEEECCCHHHHHHCCCCCCC
FRGVATVVCKLFNIVQPTKSYFGQKDAQQTVVVRQMVRDLNLPVEIVIVPTVREPDGLAL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEE
SSRNVYLNAEQRAAAPVLYRALRTAAERYAAGERDAETLRAVMRSVLAGEPLARPDYVSV
ECCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHH
AHPLTLRELDRIGADGALLSMAVRFDQVRLIDNWLLEGEGK
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA