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The map label for this gene is glcD [H]

Identifier: 222525549

GI number: 222525549

Start: 2907426

End: 2908874

Strand: Direct

Name: glcD [H]

Synonym: Chy400_2298

Alternate gene names: 222525549

Gene position: 2907426-2908874 (Clockwise)

Preceding gene: 222525545

Following gene: 222525550

Centisome position: 55.18

GC content: 57.07

Gene sequence:

>1449_bases
ATGAACCGTGCTGAACTAATCGCAGAGCTTGAGCGTATCCTCGGCCCACGCGGTGTTGTGGCTAACCCTGATGCGTTGCT
TACCTACGACGCCGATGGCTGTGTGATGGATACGCACGAGCCGCACGTAGTGACCTTGCCAACCAGTGCCGAGCAGGTGG
CGGCGATTGTCCGGCTGGCTGCGCGTGCTGGTATGCCGATTGTTCCCCGTGGCGCCGGTACCGGTCTGGCCGGTGGTGCT
ACACCAATGCAGGGTGGCATCGTTATCTCCACCGCTCGCATGGACAAGATTTTGCAGGTTGATACTGCCAATGGGCGCGT
GCTCTGCCAGCCCGGTGTGATTAACTGGGAGCTGTCACAGTATCTGAAGCCGTTTGGCTATCAATTTGCTCCCGATCCCT
CTTCTCAGAAAGCCTGTACGATTGGTGGGAATATTGCCAATAATTCGGGCGGCCCACACTGCCTGAAATACGGGATTACC
GCTAGCCACGTGCTGGCCGTGCAGGTTGTGTTGCCCGATGGTTCGATTGTCTGGACGGGTGATGGCAGTGCGCATACCCC
CGGTTACGATCTGACCGGTGTGATCACCGGTTCGGAAGGTACTATCGGTTTTGTCACTGCTGCCTGGTTGAGGCTCACCC
GCCTGCCCGAAGCGGTGCGGGTTGTGCTCGCTCTGTTCCCTGACATTGCCGGTGCCTCGAATACCGTTTCGCAGGTGATT
GCCAGTGGTTTATTACCGGCAGCGCTTGAAATCATGGATCGCCTGGCGATTAAAGCAGTGAATGATATGTACCGGCTGGG
TCTGCCCGAAGCAGCCGGTGCTGCTCTGCTGATTGAGGTGGATGGTGTCGAAGACGGCCTTGATGAGCTGTTGAACGATG
TGACAGCGATTTGCTGGCGCAACGGGGCCATCGATGTACGCCCGGCCCGTACTCTGGCTGAGCAGAATCAGGTTTGGGCT
GCGCGCAAAAATGCCTTTGGCGCGATGGGACGCCTCGCCCCAACCTACTATTTGGTTGATACGGTTGTGCCGCGCACGAA
GTTGCCCCAAACCATGGACGAAGTGGGTCGCATTTCGCGTGAATTCCGGCTGCCGATTGCCAATGTCTTCCATGCCGGCG
ATGGCAATCTCCATCCCATTATTCTCTTTGATCGCCGTGACCGCTCACAGAATCAGCGTGCGCTAGAGGCAGCGACCAGT
GTGATGCAGGTGAGTATTGATTTTGGCGGGGTGATCAGCGGCGAGCATGGGATTGGGGTCGAAAAGCAGGATTATATGAC
GCTGCTCTTCTCGACCGATGATCTGGCTGCGATGGCCGGTCTGCATCAGAGTTTCGATCCGCACGATTTGTTTAATCCCG
GCAAGGTGTTTCCCAAAGGCCGTGGTTGTGGTGAACTGGCAGCGTTGCGACGTTCGGGTGTGGCCTGGAGTGCTTTGAAA
TCGAGTTAA

Upstream 100 bases:

>100_bases
ACCGCATTTATGGTATACTACATACATAACCAGTCACTTCTGAAAGTATTTCCTATTAAAACCCCACAGGGTGCGGCCCG
GCTGGCCGCAGGAGTGCGGA

Downstream 100 bases:

>100_bases
CGCAGATGAATGACGGATCATTGCTTGCTGATCTGACAGCGCTGGTTGGTGAACAATACGTAGTTGATCATCCCACTGGG
TACGCAATCTACGGTCAATC

Product: D-lactate dehydrogenase

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MNRAELIAELERILGPRGVVANPDALLTYDADGCVMDTHEPHVVTLPTSAEQVAAIVRLAARAGMPIVPRGAGTGLAGGA
TPMQGGIVISTARMDKILQVDTANGRVLCQPGVINWELSQYLKPFGYQFAPDPSSQKACTIGGNIANNSGGPHCLKYGIT
ASHVLAVQVVLPDGSIVWTGDGSAHTPGYDLTGVITGSEGTIGFVTAAWLRLTRLPEAVRVVLALFPDIAGASNTVSQVI
ASGLLPAALEIMDRLAIKAVNDMYRLGLPEAAGAALLIEVDGVEDGLDELLNDVTAICWRNGAIDVRPARTLAEQNQVWA
ARKNAFGAMGRLAPTYYLVDTVVPRTKLPQTMDEVGRISREFRLPIANVFHAGDGNLHPIILFDRRDRSQNQRALEAATS
VMQVSIDFGGVISGEHGIGVEKQDYMTLLFSTDDLAAMAGLHQSFDPHDLFNPGKVFPKGRGCGELAALRRSGVAWSALK
SS

Sequences:

>Translated_482_residues
MNRAELIAELERILGPRGVVANPDALLTYDADGCVMDTHEPHVVTLPTSAEQVAAIVRLAARAGMPIVPRGAGTGLAGGA
TPMQGGIVISTARMDKILQVDTANGRVLCQPGVINWELSQYLKPFGYQFAPDPSSQKACTIGGNIANNSGGPHCLKYGIT
ASHVLAVQVVLPDGSIVWTGDGSAHTPGYDLTGVITGSEGTIGFVTAAWLRLTRLPEAVRVVLALFPDIAGASNTVSQVI
ASGLLPAALEIMDRLAIKAVNDMYRLGLPEAAGAALLIEVDGVEDGLDELLNDVTAICWRNGAIDVRPARTLAEQNQVWA
ARKNAFGAMGRLAPTYYLVDTVVPRTKLPQTMDEVGRISREFRLPIANVFHAGDGNLHPIILFDRRDRSQNQRALEAATS
VMQVSIDFGGVISGEHGIGVEKQDYMTLLFSTDDLAAMAGLHQSFDPHDLFNPGKVFPKGRGCGELAALRRSGVAWSALK
SS
>Mature_482_residues
MNRAELIAELERILGPRGVVANPDALLTYDADGCVMDTHEPHVVTLPTSAEQVAAIVRLAARAGMPIVPRGAGTGLAGGA
TPMQGGIVISTARMDKILQVDTANGRVLCQPGVINWELSQYLKPFGYQFAPDPSSQKACTIGGNIANNSGGPHCLKYGIT
ASHVLAVQVVLPDGSIVWTGDGSAHTPGYDLTGVITGSEGTIGFVTAAWLRLTRLPEAVRVVLALFPDIAGASNTVSQVI
ASGLLPAALEIMDRLAIKAVNDMYRLGLPEAAGAALLIEVDGVEDGLDELLNDVTAICWRNGAIDVRPARTLAEQNQVWA
ARKNAFGAMGRLAPTYYLVDTVVPRTKLPQTMDEVGRISREFRLPIANVFHAGDGNLHPIILFDRRDRSQNQRALEAATS
VMQVSIDFGGVISGEHGIGVEKQDYMTLLFSTDDLAAMAGLHQSFDPHDLFNPGKVFPKGRGCGELAALRRSGVAWSALK
SS

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=432, Percent_Identity=32.1759259259259, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI37595754, Length=455, Percent_Identity=30.5494505494506, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI119964728, Length=457, Percent_Identity=29.7592997811816, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI4501993, Length=460, Percent_Identity=23.0434782608696, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1789351, Length=452, Percent_Identity=42.0353982300885, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1787977, Length=498, Percent_Identity=30.1204819277108, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI48994907, Length=488, Percent_Identity=21.9262295081967, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71992373, Length=465, Percent_Identity=28.6021505376344, Blast_Score=194, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI71992381, Length=465, Percent_Identity=27.0967741935484, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI71992392, Length=385, Percent_Identity=28.051948051948, Blast_Score=155, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17534361, Length=434, Percent_Identity=28.3410138248848, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17556096, Length=453, Percent_Identity=23.841059602649, Blast_Score=101, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320027, Length=472, Percent_Identity=26.0593220338983, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6320764, Length=480, Percent_Identity=26.0416666666667, Blast_Score=150, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6320023, Length=462, Percent_Identity=28.1385281385281, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI18921117, Length=473, Percent_Identity=27.2727272727273, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24639277, Length=473, Percent_Identity=27.2727272727273, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24639275, Length=473, Percent_Identity=27.2727272727273, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24653753, Length=217, Percent_Identity=28.110599078341, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 51141; Mature: 51141

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRAELIAELERILGPRGVVANPDALLTYDADGCVMDTHEPHVVTLPTSAEQVAAIVRLA
CCHHHHHHHHHHHHCCCCEEECCCEEEEECCCCCEECCCCCEEEECCCCHHHHHHHHHHH
ARAGMPIVPRGAGTGLAGGATPMQGGIVISTARMDKILQVDTANGRVLCQPGVINWELSQ
HHCCCCEEECCCCCCCCCCCCCCCCCEEEEEHHCCCEEEEECCCCEEEECCCCCCEEHHH
YLKPFGYQFAPDPSSQKACTIGGNIANNSGGPHCLKYGITASHVLAVQVVLPDGSIVWTG
HHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEECCCEEEEEEEEEEECCCCEEECC
DGSAHTPGYDLTGVITGSEGTIGFVTAAWLRLTRLPEAVRVVLALFPDIAGASNTVSQVI
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHHHHH
ASGLLPAALEIMDRLAIKAVNDMYRLGLPEAAGAALLIEVDGVEDGLDELLNDVTAICWR
HHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHC
NGAIDVRPARTLAEQNQVWAARKNAFGAMGRLAPTYYLVDTVVPRTKLPQTMDEVGRISR
CCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCCCCCCHHHHHHHHHHHH
EFRLPIANVFHAGDGNLHPIILFDRRDRSQNQRALEAATSVMQVSIDFGGVISGEHGIGV
HHCCCHHHEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHEEEEECCCCEECCCCCCCC
EKQDYMTLLFSTDDLAAMAGLHQSFDPHDLFNPGKVFPKGRGCGELAALRRSGVAWSALK
CCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHC
SS
CC
>Mature Secondary Structure
MNRAELIAELERILGPRGVVANPDALLTYDADGCVMDTHEPHVVTLPTSAEQVAAIVRLA
CCHHHHHHHHHHHHCCCCEEECCCEEEEECCCCCEECCCCCEEEECCCCHHHHHHHHHHH
ARAGMPIVPRGAGTGLAGGATPMQGGIVISTARMDKILQVDTANGRVLCQPGVINWELSQ
HHCCCCEEECCCCCCCCCCCCCCCCCEEEEEHHCCCEEEEECCCCEEEECCCCCCEEHHH
YLKPFGYQFAPDPSSQKACTIGGNIANNSGGPHCLKYGITASHVLAVQVVLPDGSIVWTG
HHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEECCCEEEEEEEEEEECCCCEEECC
DGSAHTPGYDLTGVITGSEGTIGFVTAAWLRLTRLPEAVRVVLALFPDIAGASNTVSQVI
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHHHHH
ASGLLPAALEIMDRLAIKAVNDMYRLGLPEAAGAALLIEVDGVEDGLDELLNDVTAICWR
HHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHC
NGAIDVRPARTLAEQNQVWAARKNAFGAMGRLAPTYYLVDTVVPRTKLPQTMDEVGRISR
CCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCCCCCCHHHHHHHHHHHH
EFRLPIANVFHAGDGNLHPIILFDRRDRSQNQRALEAATSVMQVSIDFGGVISGEHGIGV
HHCCCHHHEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHEEEEECCCCEECCCCCCCC
EKQDYMTLLFSTDDLAAMAGLHQSFDPHDLFNPGKVFPKGRGCGELAALRRSGVAWSALK
CCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHC
SS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]