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The map label for this gene is wecC [H]

Identifier: 222525526

GI number: 222525526

Start: 2879325

End: 2880647

Strand: Direct

Name: wecC [H]

Synonym: Chy400_2275

Alternate gene names: 222525526

Gene position: 2879325-2880647 (Clockwise)

Preceding gene: 222525525

Following gene: 222525527

Centisome position: 54.65

GC content: 55.1

Gene sequence:

>1323_bases
ATGTTCCACGAATTGATGAATCGCATCCACGGCCGCACTGCAAAAGTCGGTGTGATTGGATTAGGGTATGTCGGGTTACC
GCTCGCCGAGCGTGCCGGGCGAGTTGGGTTTTCCGTGCTTGGTTTTGATGTCAGTCCAATGCGTGTCGCGCAGGTCAATC
GCGGCGAGAGCTACATTGGCGACGTATCCAGTGATGCGTTAGCGACTCTGCGCGAAGCGGGTCGGATTGAGGCAACAACC
GATGTTCGTCGGATGGCCGAATGTGATATTTTGGTCATCTGCGTTCCCACCCCGCTCAACGCAACGCGCGAACCGGATAT
GCGCTTTGTCGAAGCGGCGAGTGAAAATGTCGCCGCCAGCATTCGACCCGGTCAACTGGTGATTCTGGAAAGTACTACCT
ACCCTGGTACCACCCGTGAACTGATCATGCCCCGGATCGAGCGCTCCGGCTTGAAGGTTGGCGAACAGATTTTTCTGGCG
TTCTCACCCGAACGCATCGATCCCGGTCAGACGAGTAGCAAGGGTTACAGCGTTGAGAATACGCCGAAGGTGGTGGGGGG
TGTGACACCACACTGCACTGAACTGGCCGGTGCCTTCTACGGCTATATCACCAGTCGGGTGGTGCCGGTTAGCTCGCCGG
ATGTTGCCGAGCTAACGAAGCTGTTCGAGAACATCTTTCGCGCCGTCAATATTGCGTTGGTCAACGAACTGGCGTTGCTC
TGCGACCGAATGGGCATTGATGTCTGGGAAGTGATCGATGCCGCTGCGACCAAGCCCTACGGCTTTATGAAGTTTACCCC
TGGGCCAGGGCTGGGTGGTCACTGTATCCCTATCGATCCGTTCTACCTGACGTGGAAGGCGCGGGCGTATGATCTGACGA
CCCGGTTTATTGAGCTGGCCGGTGAAATCAACAGTCAAATGCCACGGCACGTTCACGATCTGGTTGTACGGGCGCTTAAT
CGTGCCCGTAAGCCACTGAACGGGAGTACTATCCTGTTGCTTGGGATTGCCTACAAACCGGATGTCGATGATTATCGCGA
ATCACCGGCATTTAAGGTCTACGATCTGCTGACTGCCGACGGCGCAACGGTGATTCCCTGCGATCCGCACATTACCCAAT
TTGAGCTGCACGATGGTCGGTGTATGCAAACAGTGCCATTAACTGACGAGTTGCTCCGTCAGTGTGATTGCGCGGTCATT
ATCACCAATCATCGTGCGTTTGACTACGAGCGGATCGTGACATTGGCTCCGGCAATCGTGGATACACGCAACGCAACCCG
CAACATTCAGGGTGAGTTACGAACAAAGATTACAGTATTGTAG

Upstream 100 bases:

>100_bases
TTGGGCTGATGGCAGTGAACTGGGTTTGGGGTCGCCGTAAAAAACCTCGCCTATAATATCAAATCGTACATTCCAGAGAT
ATTATGGAGACGACACCATC

Downstream 100 bases:

>100_bases
TCTGAACGCCGGTATGCCAATCATCATTGATTCACCCGGTGTTGGCATAACGGTAGTACGGAACGATGGGGAGTGACGAG
GAGGGATACCGTGCAGCGTG

Product: nucleotide sugar dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MFHELMNRIHGRTAKVGVIGLGYVGLPLAERAGRVGFSVLGFDVSPMRVAQVNRGESYIGDVSSDALATLREAGRIEATT
DVRRMAECDILVICVPTPLNATREPDMRFVEAASENVAASIRPGQLVILESTTYPGTTRELIMPRIERSGLKVGEQIFLA
FSPERIDPGQTSSKGYSVENTPKVVGGVTPHCTELAGAFYGYITSRVVPVSSPDVAELTKLFENIFRAVNIALVNELALL
CDRMGIDVWEVIDAAATKPYGFMKFTPGPGLGGHCIPIDPFYLTWKARAYDLTTRFIELAGEINSQMPRHVHDLVVRALN
RARKPLNGSTILLLGIAYKPDVDDYRESPAFKVYDLLTADGATVIPCDPHITQFELHDGRCMQTVPLTDELLRQCDCAVI
ITNHRAFDYERIVTLAPAIVDTRNATRNIQGELRTKITVL

Sequences:

>Translated_440_residues
MFHELMNRIHGRTAKVGVIGLGYVGLPLAERAGRVGFSVLGFDVSPMRVAQVNRGESYIGDVSSDALATLREAGRIEATT
DVRRMAECDILVICVPTPLNATREPDMRFVEAASENVAASIRPGQLVILESTTYPGTTRELIMPRIERSGLKVGEQIFLA
FSPERIDPGQTSSKGYSVENTPKVVGGVTPHCTELAGAFYGYITSRVVPVSSPDVAELTKLFENIFRAVNIALVNELALL
CDRMGIDVWEVIDAAATKPYGFMKFTPGPGLGGHCIPIDPFYLTWKARAYDLTTRFIELAGEINSQMPRHVHDLVVRALN
RARKPLNGSTILLLGIAYKPDVDDYRESPAFKVYDLLTADGATVIPCDPHITQFELHDGRCMQTVPLTDELLRQCDCAVI
ITNHRAFDYERIVTLAPAIVDTRNATRNIQGELRTKITVL
>Mature_440_residues
MFHELMNRIHGRTAKVGVIGLGYVGLPLAERAGRVGFSVLGFDVSPMRVAQVNRGESYIGDVSSDALATLREAGRIEATT
DVRRMAECDILVICVPTPLNATREPDMRFVEAASENVAASIRPGQLVILESTTYPGTTRELIMPRIERSGLKVGEQIFLA
FSPERIDPGQTSSKGYSVENTPKVVGGVTPHCTELAGAFYGYITSRVVPVSSPDVAELTKLFENIFRAVNIALVNELALL
CDRMGIDVWEVIDAAATKPYGFMKFTPGPGLGGHCIPIDPFYLTWKARAYDLTTRFIELAGEINSQMPRHVHDLVVRALN
RARKPLNGSTILLLGIAYKPDVDDYRESPAFKVYDLLTADGATVIPCDPHITQFELHDGRCMQTVPLTDELLRQCDCAVI
ITNHRAFDYERIVTLAPAIVDTRNATRNIQGELRTKITVL

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=464, Percent_Identity=25.6465517241379, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI296040438, Length=359, Percent_Identity=25.3481894150418, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI296040443, Length=443, Percent_Identity=24.3792325056433, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI48994968, Length=410, Percent_Identity=36.8292682926829, Blast_Score=217, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI17560350, Length=391, Percent_Identity=23.7851662404092, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17136908, Length=398, Percent_Identity=24.8743718592965, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 48401; Mature: 48401

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFHELMNRIHGRTAKVGVIGLGYVGLPLAERAGRVGFSVLGFDVSPMRVAQVNRGESYIG
CHHHHHHHHCCCCEEEEEEEECCCCCCHHHHCCCCCEEEEECCCCCEEEEECCCCCHHCC
DVSSDALATLREAGRIEATTDVRRMAECDILVICVPTPLNATREPDMRFVEAASENVAAS
CCCHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCEEE
IRPGQLVILESTTYPGTTRELIMPRIERSGLKVGEQIFLAFSPERIDPGQTSSKGYSVEN
ECCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
TPKVVGGVTPHCTELAGAFYGYITSRVVPVSSPDVAELTKLFENIFRAVNIALVNELALL
CCHHHCCCCHHHHHHHHHHHHHHHHCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
CDRMGIDVWEVIDAAATKPYGFMKFTPGPGLGGHCIPIDPFYLTWKARAYDLTTRFIELA
HHHHCCCHHHHHHHHCCCCCCEEEECCCCCCCCEEEECCCEEEEEEEEEHHHHHHHHHHH
GEINSQMPRHVHDLVVRALNRARKPLNGSTILLLGIAYKPDVDDYRESPAFKVYDLLTAD
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCHHHHHCCCCEEEEEEEECC
GATVIPCDPHITQFELHDGRCMQTVPLTDELLRQCDCAVIITNHRAFDYERIVTLAPAIV
CCEEEECCCCCEEEEECCCCEEEECCCHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHH
DTRNATRNIQGELRTKITVL
CCCCCCCCCCCCEEEEEEEC
>Mature Secondary Structure
MFHELMNRIHGRTAKVGVIGLGYVGLPLAERAGRVGFSVLGFDVSPMRVAQVNRGESYIG
CHHHHHHHHCCCCEEEEEEEECCCCCCHHHHCCCCCEEEEECCCCCEEEEECCCCCHHCC
DVSSDALATLREAGRIEATTDVRRMAECDILVICVPTPLNATREPDMRFVEAASENVAAS
CCCHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCEEE
IRPGQLVILESTTYPGTTRELIMPRIERSGLKVGEQIFLAFSPERIDPGQTSSKGYSVEN
ECCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
TPKVVGGVTPHCTELAGAFYGYITSRVVPVSSPDVAELTKLFENIFRAVNIALVNELALL
CCHHHCCCCHHHHHHHHHHHHHHHHCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
CDRMGIDVWEVIDAAATKPYGFMKFTPGPGLGGHCIPIDPFYLTWKARAYDLTTRFIELA
HHHHCCCHHHHHHHHCCCCCCEEEECCCCCCCCEEEECCCEEEEEEEEEHHHHHHHHHHH
GEINSQMPRHVHDLVVRALNRARKPLNGSTILLLGIAYKPDVDDYRESPAFKVYDLLTAD
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCHHHHHCCCCEEEEEEEECC
GATVIPCDPHITQFELHDGRCMQTVPLTDELLRQCDCAVIITNHRAFDYERIVTLAPAIV
CCEEEECCCCCEEEEECCCCEEEECCCHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHH
DTRNATRNIQGELRTKITVL
CCCCCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA