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The map label for this gene is hisI [H]

Identifier: 222525470

GI number: 222525470

Start: 2811596

End: 2812213

Strand: Reverse

Name: hisI [H]

Synonym: Chy400_2218

Alternate gene names: 222525470

Gene position: 2812213-2811596 (Counterclockwise)

Preceding gene: 222525471

Following gene: 222525469

Centisome position: 53.37

GC content: 55.83

Gene sequence:

>618_bases
ATGGTGTCCATAAGTGATACAGAACTACTACCAGCTATCGTACAACATGCCCGCAGCGGCGAAGTATTGATGCTGGGATA
TATGAATAAAGAGGCGCTAACGGCTACCCTCACCAGCGGCTTTGTCACGTTTTATAGCCGCTCGCGCCAGCGCCTGTGGC
GTAAAGGTGAAACCAGTGGCAACACCTTACGTCTCGTCGAGATTCGACAGGATTGTGATGGTGATGCCTTGTTAGTCCTG
GCAGAACCGGCCGGCCCAACCTGTCATACGGGCCGGCCAGGTTGTTTCTTCCGCGATCTTGATGAAACGGAAGTTTCTGG
ACCAGTACCGCCAGTCGCCATTCTGGCGCGTCTGGCGGATCGTATCCAGGCCCGCCGCGATTCTACGCCAGGCGAGTCCT
ACACCGCTAAGCTACTCCACGGCGGTGTTGATCGGATCGGCAAGAAGATCGGCGAGGAAGCAGCCGAAGTGATTATTGCC
GCCAAAAATGGGAACCCGGCAGAGATCGCCTACGAATTGGCCGATCTCATCTACCATAGCCTGGTGTTGCTGGAACAGCA
AGGTATGACAGCAGAGGCGGTGTGGGCTGAACTGGCCCGTCGCTATAGCTCCTCGTAA

Upstream 100 bases:

>100_bases
GCGGCGATGGTCTTTACCGGACGCCGCCATTTCCGCCATTAGATACACTGACAACCGTTACATAGCTGCCTTACAGAATA
TAAGGAGGTACACCGGACGC

Downstream 100 bases:

>100_bases
TCACTGGAGATTGCGGGATAACCGTATGAGCAGTTGGGCTGGCCACGTATTGGTTGTCGATGACGATCCGCAGTTACGCG
ACCTGTGTCGGCAAACGCTG

Product: phosphoribosyl-ATP diphosphatase

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MVSISDTELLPAIVQHARSGEVLMLGYMNKEALTATLTSGFVTFYSRSRQRLWRKGETSGNTLRLVEIRQDCDGDALLVL
AEPAGPTCHTGRPGCFFRDLDETEVSGPVPPVAILARLADRIQARRDSTPGESYTAKLLHGGVDRIGKKIGEEAAEVIIA
AKNGNPAEIAYELADLIYHSLVLLEQQGMTAEAVWAELARRYSSS

Sequences:

>Translated_205_residues
MVSISDTELLPAIVQHARSGEVLMLGYMNKEALTATLTSGFVTFYSRSRQRLWRKGETSGNTLRLVEIRQDCDGDALLVL
AEPAGPTCHTGRPGCFFRDLDETEVSGPVPPVAILARLADRIQARRDSTPGESYTAKLLHGGVDRIGKKIGEEAAEVIIA
AKNGNPAEIAYELADLIYHSLVLLEQQGMTAEAVWAELARRYSSS
>Mature_205_residues
MVSISDTELLPAIVQHARSGEVLMLGYMNKEALTATLTSGFVTFYSRSRQRLWRKGETSGNTLRLVEIRQDCDGDALLVL
AEPAGPTCHTGRPGCFFRDLDETEVSGPVPPVAILARLADRIQARRDSTPGESYTAKLLHGGVDRIGKKIGEEAAEVIIA
AKNGNPAEIAYELADLIYHSLVLLEQQGMTAEAVWAELARRYSSS

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=194, Percent_Identity=50, Blast_Score=186, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319819, Length=183, Percent_Identity=31.6939890710383, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 22329; Mature: 22329

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSISDTELLPAIVQHARSGEVLMLGYMNKEALTATLTSGFVTFYSRSRQRLWRKGETSG
CCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NTLRLVEIRQDCDGDALLVLAEPAGPTCHTGRPGCFFRDLDETEVSGPVPPVAILARLAD
CEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHH
RIQARRDSTPGESYTAKLLHGGVDRIGKKIGEEAAEVIIAAKNGNPAEIAYELADLIYHS
HHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHH
LVLLEQQGMTAEAVWAELARRYSSS
HHHHHCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVSISDTELLPAIVQHARSGEVLMLGYMNKEALTATLTSGFVTFYSRSRQRLWRKGETSG
CCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NTLRLVEIRQDCDGDALLVLAEPAGPTCHTGRPGCFFRDLDETEVSGPVPPVAILARLAD
CEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHH
RIQARRDSTPGESYTAKLLHGGVDRIGKKIGEEAAEVIIAAKNGNPAEIAYELADLIYHS
HHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHH
LVLLEQQGMTAEAVWAELARRYSSS
HHHHHCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]