Click here to switch to the map view.

The map label for this gene is cytR [H]

Identifier: 222525437

GI number: 222525437

Start: 2765035

End: 2766060

Strand: Reverse

Name: cytR [H]

Synonym: Chy400_2182

Alternate gene names: 222525437

Gene position: 2766060-2765035 (Counterclockwise)

Preceding gene: 222525444

Following gene: 222525436

Centisome position: 52.5

GC content: 54.19

Gene sequence:

>1026_bases
ATGCCTATGACAGCCTCGAAAGTCACGCTCAAAGATGTAGCGGCGCGCGCCGGTGTCAGTTATCAAACTGTGTCTAAGGT
GCTGAACGGCGATATGCAGGTCGCGCCCGAAACGATGGAGCGGATTCAGGCGGCAGTTCAGGAATTAGGCTATCGGCCAA
ACCGCATTGCGCGCAACATGCGCGCCGGGCGTAGCTTTATGATTGGGTATTCGTGGACGCAAACCGAACCCGGTCAGGTC
AACCACATTCTTGACCAGTTTCTGAGCAGTATGGTGCGTGAAGCGAGTGCGGTTGGCTATTACGTTTTGCCATTTCCATT
TTCCGAAGGTAAATCGCAGATTGACTCGTACCGCGATTTGATCCGAAGCGGCAATGTAGACGGATTTGTTCTTTCGAGTG
TGAATTATCACGATCCGCGGATTCAATATTTACTGAAACAAAAATTTCCCTTCGTCGCCTTCGGTCGCTCTAACCCGGAG
TGGGATTTTGCCTGGGTAGATATTGACGGCGCTGCCGGGACGCGACAGGCTATCGAGTATCTGATCGGGCGTGGTCATCG
GCGCATTGCTATCCTGGCCTGGCCGGAAGAATCACGGGTCGGTAATGACCGGTTGCAGGGATACCTTGACGCTATGCGCG
CCGCAGAGATTGATATCGAACCAGGCTATCTGTTACGGGGGGAAGGAACGTTCGAGGTTGGACGGGCAATGACCCTGCAT
CTGCTAGAGTTGCCACCCGAACGACGACCGACGGCAATTATGGCGCTTAACGACACGATGGCAATTGGGGCAATGGCCGC
AGCCCGTGAATGCGGTCTGGAGATTGGCACCGACCTGGCGATTATCGGTTTTGACGATGCACCTATGGTGCAATACCTGT
TTCCTCCGCTCACCAGTGTGCGCCAACCGATTGCCGAGGCCGGTCATAAATGCGTTGAGCTGCTGGTATCACTAGTAGAA
GGACGCCCAATCGAGCAACATCACATCTTACTATCACCATCCCTGATCATCCGCGCTTCTGCCTGA

Upstream 100 bases:

>100_bases
GTTCGCCAGATAATTCCCAGGCGAACGTTCGCTTTTTCCTCTTGACAAGTCACCAGGTGGGGTGTATGATAAAAGCGAAC
GTTCGCCTAGGAAACTTGTG

Downstream 100 bases:

>100_bases
CAACAATCGATAATGTTCGTTCCTGATCATCGGCTGGCGATGATCGGGTAGTGGGTTATTGTGCTACGCGAGGAGGGTAA
AAAATGGTCTGAAATCGCAT

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MPMTASKVTLKDVAARAGVSYQTVSKVLNGDMQVAPETMERIQAAVQELGYRPNRIARNMRAGRSFMIGYSWTQTEPGQV
NHILDQFLSSMVREASAVGYYVLPFPFSEGKSQIDSYRDLIRSGNVDGFVLSSVNYHDPRIQYLLKQKFPFVAFGRSNPE
WDFAWVDIDGAAGTRQAIEYLIGRGHRRIAILAWPEESRVGNDRLQGYLDAMRAAEIDIEPGYLLRGEGTFEVGRAMTLH
LLELPPERRPTAIMALNDTMAIGAMAAARECGLEIGTDLAIIGFDDAPMVQYLFPPLTSVRQPIAEAGHKCVELLVSLVE
GRPIEQHHILLSPSLIIRASA

Sequences:

>Translated_341_residues
MPMTASKVTLKDVAARAGVSYQTVSKVLNGDMQVAPETMERIQAAVQELGYRPNRIARNMRAGRSFMIGYSWTQTEPGQV
NHILDQFLSSMVREASAVGYYVLPFPFSEGKSQIDSYRDLIRSGNVDGFVLSSVNYHDPRIQYLLKQKFPFVAFGRSNPE
WDFAWVDIDGAAGTRQAIEYLIGRGHRRIAILAWPEESRVGNDRLQGYLDAMRAAEIDIEPGYLLRGEGTFEVGRAMTLH
LLELPPERRPTAIMALNDTMAIGAMAAARECGLEIGTDLAIIGFDDAPMVQYLFPPLTSVRQPIAEAGHKCVELLVSLVE
GRPIEQHHILLSPSLIIRASA
>Mature_340_residues
PMTASKVTLKDVAARAGVSYQTVSKVLNGDMQVAPETMERIQAAVQELGYRPNRIARNMRAGRSFMIGYSWTQTEPGQVN
HILDQFLSSMVREASAVGYYVLPFPFSEGKSQIDSYRDLIRSGNVDGFVLSSVNYHDPRIQYLLKQKFPFVAFGRSNPEW
DFAWVDIDGAAGTRQAIEYLIGRGHRRIAILAWPEESRVGNDRLQGYLDAMRAAEIDIEPGYLLRGEGTFEVGRAMTLHL
LELPPERRPTAIMALNDTMAIGAMAAARECGLEIGTDLAIIGFDDAPMVQYLFPPLTSVRQPIAEAGHKCVELLVSLVEG
RPIEQHHILLSPSLIIRASA

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=341, Percent_Identity=34.8973607038123, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1790194, Length=347, Percent_Identity=31.700288184438, Blast_Score=160, Evalue=8e-41,
Organism=Escherichia coli, GI1787948, Length=334, Percent_Identity=31.437125748503, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1786540, Length=342, Percent_Identity=30.1169590643275, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1788474, Length=342, Percent_Identity=31.2865497076023, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1789202, Length=337, Percent_Identity=29.673590504451, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1787580, Length=321, Percent_Identity=26.791277258567, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1789068, Length=321, Percent_Identity=31.1526479750779, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI48994940, Length=326, Percent_Identity=27.6073619631902, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787906, Length=345, Percent_Identity=25.5072463768116, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790689, Length=329, Percent_Identity=25.8358662613982, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1790715, Length=329, Percent_Identity=26.1398176291793, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789456, Length=320, Percent_Identity=27.1875, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786268, Length=329, Percent_Identity=26.4437689969605, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37837; Mature: 37706

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMTASKVTLKDVAARAGVSYQTVSKVLNGDMQVAPETMERIQAAVQELGYRPNRIARNM
CCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCEECHHHHHHHHHHHHHHCCCHHHHHHHH
RAGRSFMIGYSWTQTEPGQVNHILDQFLSSMVREASAVGYYVLPFPFSEGKSQIDSYRDL
HCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHH
IRSGNVDGFVLSSVNYHDPRIQYLLKQKFPFVAFGRSNPEWDFAWVDIDGAAGTRQAIEY
HHCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCCHHHHHHH
LIGRGHRRIAILAWPEESRVGNDRLQGYLDAMRAAEIDIEPGYLLRGEGTFEVGRAMTLH
HHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHEEECCCCEEEECCCCHHHCCCEEEE
LLELPPERRPTAIMALNDTMAIGAMAAARECGLEIGTDLAIIGFDDAPMVQYLFPPLTSV
EEECCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHCCHHHH
RQPIAEAGHKCVELLVSLVEGRPIEQHHILLSPSLIIRASA
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEECC
>Mature Secondary Structure 
PMTASKVTLKDVAARAGVSYQTVSKVLNGDMQVAPETMERIQAAVQELGYRPNRIARNM
CCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCEECHHHHHHHHHHHHHHCCCHHHHHHHH
RAGRSFMIGYSWTQTEPGQVNHILDQFLSSMVREASAVGYYVLPFPFSEGKSQIDSYRDL
HCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHH
IRSGNVDGFVLSSVNYHDPRIQYLLKQKFPFVAFGRSNPEWDFAWVDIDGAAGTRQAIEY
HHCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCCHHHHHHH
LIGRGHRRIAILAWPEESRVGNDRLQGYLDAMRAAEIDIEPGYLLRGEGTFEVGRAMTLH
HHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHEEECCCCEEEECCCCHHHCCCEEEE
LLELPPERRPTAIMALNDTMAIGAMAAARECGLEIGTDLAIIGFDDAPMVQYLFPPLTSV
EEECCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHCCHHHH
RQPIAEAGHKCVELLVSLVEGRPIEQHHILLSPSLIIRASA
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]