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The map label for this gene is nuoH [H]

Identifier: 222525392

GI number: 222525392

Start: 2715583

End: 2716905

Strand: Reverse

Name: nuoH [H]

Synonym: Chy400_2137

Alternate gene names: 222525392

Gene position: 2716905-2715583 (Counterclockwise)

Preceding gene: 222525393

Following gene: 222525391

Centisome position: 51.56

GC content: 55.63

Gene sequence:

>1323_bases
ATGTACGACATCTTGCAGGGACTCATTAACGGTACCTTTGGCTGGGGATGGCCCGATTGGTTGATCAACCTGATCGGCTA
CATCATTATTGTGACGATTGTGCTGATTGTTGCCCCGTTACAGATGCTCTTCTTCACCTACTACGAGCGGCGGGTAATTG
CCCGCATGCAAGATCGGATCGGCCCCAACCGGGTTGGCCCAGAGGGCATCTGGCAGCCGATAGCTGATGGCGTCAAGATG
TTCACCAAAGAAGACATCGTACCGGCGGCAGCTGACCGGATCGTTCATTTTCTTGCCCCGTGTGTTGTCGTTGCGCCGAC
AGTCTTGATGTTTGCGGTTGTGCCCTGGGGGCCGGGTATGACACCGGTTGATTTGCCGACCGGTCTCCTCTTCTTCTTCG
CTGTCTCGTCAATCAGTGCGGTTGGATTGATGATGGCCGGTTGGGCCAGCAACAACAAGTTTTCGTTGCTGGGAGCGATG
CGGGCAGTGGCCCAGATGGTCTCTTACGAAATTCCGGCAGTCCTCTCGCTGATCGCCATCGTGATCATTGTCGGCTCACT
CTCGATCAACGACATCATCAATTATCAGTCTGGCCTGCTGATCAGCAATCGTGATCTGCCCGGCATTCCTGACCTTGGTC
TGGGCTGGTTCATCTTCACCCCGGTCGGTTTTGTTGCGTTTGTCGCCTTCTTCATCGCTGCCCTGGCCGAAGGTGAGCGC
ACTCCGTTCGACATTCCTGAAGCCGACTCAGAGATCGTGGCCGGCTACATGACCGAGTACAGCGGTATGAAATTCGGTCT
GTTCTACCTGGCTCAATACGTATTGAACTTCCTGCTCTGTGCTATCACGGCCATCATCTTTCTGGGTGGCTGGCAGGGGC
CGGGGGTGAACTGGCTCTACGCGCAGGCAATTACACCAACCAATCCTAATGGTAATGGCTTATTCAATGTACTGGCCGGC
ATGCTGGGCGTCTTCTACTTCCTGCTCAAGACCTACATCTTCTTCTTCGTGATGGTCTGGCTCCGTGGCGCCTTGCCCCG
CTTGCGGATCGATCAATTGATGGATTTTGGTTGGAAGTTTCTCATTCCATTAACACTGGTCAATCTGTTCAGCGCCGCGT
TGTGGGTTGCCTTCACACGCTGGGGGCCGGCAGAGGGGATGCTGCTGACAATGGGCTGGTCACCGGTGCTGCGCTGGCTG
GCGGCCTTTGTGATAACCCTTGCCATTAATCTGGGGGCCTACCTCTGGCTGACACAGGTCTACGCCGCATCGCAGGCCGA
ACGACGACGGGCAGAGCTAGAGGAATTGAGTGCCACGCTGTGA

Upstream 100 bases:

>100_bases
TAGCAGCCATCCGGGCCGCCAACGCAGCGAAGCGAAAACAGGCCGAGGAACAGGCACGTGACGGTTCGGGAGAGGAAGCA
TAACCCGACGGAGAACCTTC

Downstream 100 bases:

>100_bases
AAACAGCGAATCCGGCAATGAAAACAGCGAAGTGCTGGAGTAGGAAAGCGTGATGGAAATCGTTGTCCAAATTGTATTCG
GGGTGATAGCCCTCTTTATT

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MYDILQGLINGTFGWGWPDWLINLIGYIIIVTIVLIVAPLQMLFFTYYERRVIARMQDRIGPNRVGPEGIWQPIADGVKM
FTKEDIVPAAADRIVHFLAPCVVVAPTVLMFAVVPWGPGMTPVDLPTGLLFFFAVSSISAVGLMMAGWASNNKFSLLGAM
RAVAQMVSYEIPAVLSLIAIVIIVGSLSINDIINYQSGLLISNRDLPGIPDLGLGWFIFTPVGFVAFVAFFIAALAEGER
TPFDIPEADSEIVAGYMTEYSGMKFGLFYLAQYVLNFLLCAITAIIFLGGWQGPGVNWLYAQAITPTNPNGNGLFNVLAG
MLGVFYFLLKTYIFFFVMVWLRGALPRLRIDQLMDFGWKFLIPLTLVNLFSAALWVAFTRWGPAEGMLLTMGWSPVLRWL
AAFVITLAINLGAYLWLTQVYAASQAERRRAELEELSATL

Sequences:

>Translated_440_residues
MYDILQGLINGTFGWGWPDWLINLIGYIIIVTIVLIVAPLQMLFFTYYERRVIARMQDRIGPNRVGPEGIWQPIADGVKM
FTKEDIVPAAADRIVHFLAPCVVVAPTVLMFAVVPWGPGMTPVDLPTGLLFFFAVSSISAVGLMMAGWASNNKFSLLGAM
RAVAQMVSYEIPAVLSLIAIVIIVGSLSINDIINYQSGLLISNRDLPGIPDLGLGWFIFTPVGFVAFVAFFIAALAEGER
TPFDIPEADSEIVAGYMTEYSGMKFGLFYLAQYVLNFLLCAITAIIFLGGWQGPGVNWLYAQAITPTNPNGNGLFNVLAG
MLGVFYFLLKTYIFFFVMVWLRGALPRLRIDQLMDFGWKFLIPLTLVNLFSAALWVAFTRWGPAEGMLLTMGWSPVLRWL
AAFVITLAINLGAYLWLTQVYAASQAERRRAELEELSATL
>Mature_440_residues
MYDILQGLINGTFGWGWPDWLINLIGYIIIVTIVLIVAPLQMLFFTYYERRVIARMQDRIGPNRVGPEGIWQPIADGVKM
FTKEDIVPAAADRIVHFLAPCVVVAPTVLMFAVVPWGPGMTPVDLPTGLLFFFAVSSISAVGLMMAGWASNNKFSLLGAM
RAVAQMVSYEIPAVLSLIAIVIIVGSLSINDIINYQSGLLISNRDLPGIPDLGLGWFIFTPVGFVAFVAFFIAALAEGER
TPFDIPEADSEIVAGYMTEYSGMKFGLFYLAQYVLNFLLCAITAIIFLGGWQGPGVNWLYAQAITPTNPNGNGLFNVLAG
MLGVFYFLLKTYIFFFVMVWLRGALPRLRIDQLMDFGWKFLIPLTLVNLFSAALWVAFTRWGPAEGMLLTMGWSPVLRWL
AAFVITLAINLGAYLWLTQVYAASQAERRRAELEELSATL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=325, Percent_Identity=34.4615384615385, Blast_Score=184, Evalue=1e-46,
Organism=Escherichia coli, GI1788618, Length=367, Percent_Identity=38.6920980926431, Blast_Score=238, Evalue=8e-64,
Organism=Escherichia coli, GI87082115, Length=258, Percent_Identity=29.0697674418605, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 48707; Mature: 48707

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYDILQGLINGTFGWGWPDWLINLIGYIIIVTIVLIVAPLQMLFFTYYERRVIARMQDRI
CHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GPNRVGPEGIWQPIADGVKMFTKEDIVPAAADRIVHFLAPCVVVAPTVLMFAVVPWGPGM
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TPVDLPTGLLFFFAVSSISAVGLMMAGWASNNKFSLLGAMRAVAQMVSYEIPAVLSLIAI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIIVGSLSINDIINYQSGLLISNRDLPGIPDLGLGWFIFTPVGFVAFVAFFIAALAEGER
HHHHHCCCHHHHHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
TPFDIPEADSEIVAGYMTEYSGMKFGLFYLAQYVLNFLLCAITAIIFLGGWQGPGVNWLY
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
AQAITPTNPNGNGLFNVLAGMLGVFYFLLKTYIFFFVMVWLRGALPRLRIDQLMDFGWKF
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHH
LIPLTLVNLFSAALWVAFTRWGPAEGMLLTMGWSPVLRWLAAFVITLAINLGAYLWLTQV
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAASQAERRRAELEELSATL
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA