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The map label for this gene is fabF [H]

Identifier: 222525340

GI number: 222525340

Start: 2656571

End: 2657986

Strand: Reverse

Name: fabF [H]

Synonym: Chy400_2085

Alternate gene names: 222525340

Gene position: 2657986-2656571 (Counterclockwise)

Preceding gene: 222525346

Following gene: 222525339

Centisome position: 50.45

GC content: 59.53

Gene sequence:

>1416_bases
ATGACCCCACGAGCACTGGATCGGCGCGCAGCGTTGCGGGCCGAACTGCTCGGTCTCGTGCGAGAGCATGTGCCCGACGA
AGCTATTGAAGCGCAGATCGAAGCACTGTTGGCCGAGGTATTGGCTGAAGAACCCGTTGTCGAACCACAGCCGGTTGTAA
CCGATCATCTCCCCCCTGACCAGCGCATTGTGGTGACCGGTCTGGGCGTTATCTCGCCGTTTGGGGTTGGTGTTGAGCCA
TTTTGGGCTGGTCTCGTTGCCGGGCGCAGTGCGATTGGTCGCATCACCTTTTTCGATCCGAGTGATTATCCCTGTCAACT
GGCAGGCCAGGTAAACGATTTTCATCCACAGGAGTTCATGGATGCGAAAGAGGCGCGCCGGATGTCCCGCGCCAGTCAGA
TGGCCGTAGCCGCTGCCCGGATGGCCCTTGACCACGCTCGCCTGCCTCTCGAACGTATGGCACGCGATGAGATCGGTGTT
CTGATCGCCAGCGGGACTACCTCGATGCCCGATGTAGAACAGGCAGTCACCACACTGATCCAGCGTGGTGGCATGAAAAT
TAGTCCTTTCTTCATTCCGGCAGCCCTGCCGAATATGCCATCCAGCCAGGTCGCCATTCACTTCGGTTTACGCGGCTACA
CAACTGCGATCTGTACCGCATGTGCTGCCGGCGCGCAGGCAATCGGTGAGGCGGCAGAGATCATTCGGCGCGGCGATGCC
GAAGTGATGCTGGCCGGTGGCGCCGAAGCTCCCATTACTGCCCTCAGCCTGGGTGCATTCTGTGTCATGCGCGCTTTGAG
TACGCGCAGTAACCACGAGCCGACACGGGCATCGCGTCCGTTTGATGCGCTGCGCGATGGCTTTGTTCCCGGCGAAGGGG
CAGCCGTGCTGGTGCTTGAACGTCTGAGCAGTGCCCAGCGACGTGGCGCGCCAATCCTGGCTGAGTTGATCGGGTATGGC
GTCTCTGCCGATGCCTATCACGTTACTGCTCCCGATCCAGATGGTGAAGGGGCGGCGCTGGCAATCCGGCGGGCATTGCA
ACAAGCCCGACTGGCACCGCAACAGGTTGATTACATCAATGCCCACGCCACCAGTACACCGGCAGGTGACATTGCGGAAA
CCAGAGCGATTAAGCAGGTGTTCGGTGAATATGCATACAGTGTGCCGATCAGTTCGATCAAATCGATGATCGGGCATCTC
ACCGGTGCTGCCGGCGCAGTTGAGGCAGCAGCCACCATCCTGGCACTGCACCACGGTCAGATTCCACCCACCATCAACCT
CGAACATCCCGATCCCGAATGCGATCTCGATTATGTGCCGAATGTTGCCCGTCAGGCAGCCATTCAGGTCGCAATCTCGA
ATTCGTTCGGGTTTGGCGGGGTGAATGCGGTGCTGGCCTTCCGCAAAATGCCGTGA

Upstream 100 bases:

>100_bases
ATAGTGACGAGGGAGCGCATACCAGCGAGTATGATACCACAGACACAACAGCTACGTGGTATAATTCAAGCCTTGAATAG
TTGAATTGAGGGAGGAAGCA

Downstream 100 bases:

>100_bases
GCGGATACAATGGTATGGATGGATCACGGCATCCGCTTGCCGTGCGATCTGTTGCCAGCCGCCTGCAAACGATGATTACC
TGATATGTGGCATGTGTACG

Product: 3-oxoacyl-(acyl-carrier-protein) synthase 2

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTPRALDRRAALRAELLGLVREHVPDEAIEAQIEALLAEVLAEEPVVEPQPVVTDHLPPDQRIVVTGLGVISPFGVGVEP
FWAGLVAGRSAIGRITFFDPSDYPCQLAGQVNDFHPQEFMDAKEARRMSRASQMAVAAARMALDHARLPLERMARDEIGV
LIASGTTSMPDVEQAVTTLIQRGGMKISPFFIPAALPNMPSSQVAIHFGLRGYTTAICTACAAGAQAIGEAAEIIRRGDA
EVMLAGGAEAPITALSLGAFCVMRALSTRSNHEPTRASRPFDALRDGFVPGEGAAVLVLERLSSAQRRGAPILAELIGYG
VSADAYHVTAPDPDGEGAALAIRRALQQARLAPQQVDYINAHATSTPAGDIAETRAIKQVFGEYAYSVPISSIKSMIGHL
TGAAGAVEAAATILALHHGQIPPTINLEHPDPECDLDYVPNVARQAAIQVAISNSFGFGGVNAVLAFRKMP

Sequences:

>Translated_471_residues
MTPRALDRRAALRAELLGLVREHVPDEAIEAQIEALLAEVLAEEPVVEPQPVVTDHLPPDQRIVVTGLGVISPFGVGVEP
FWAGLVAGRSAIGRITFFDPSDYPCQLAGQVNDFHPQEFMDAKEARRMSRASQMAVAAARMALDHARLPLERMARDEIGV
LIASGTTSMPDVEQAVTTLIQRGGMKISPFFIPAALPNMPSSQVAIHFGLRGYTTAICTACAAGAQAIGEAAEIIRRGDA
EVMLAGGAEAPITALSLGAFCVMRALSTRSNHEPTRASRPFDALRDGFVPGEGAAVLVLERLSSAQRRGAPILAELIGYG
VSADAYHVTAPDPDGEGAALAIRRALQQARLAPQQVDYINAHATSTPAGDIAETRAIKQVFGEYAYSVPISSIKSMIGHL
TGAAGAVEAAATILALHHGQIPPTINLEHPDPECDLDYVPNVARQAAIQVAISNSFGFGGVNAVLAFRKMP
>Mature_470_residues
TPRALDRRAALRAELLGLVREHVPDEAIEAQIEALLAEVLAEEPVVEPQPVVTDHLPPDQRIVVTGLGVISPFGVGVEPF
WAGLVAGRSAIGRITFFDPSDYPCQLAGQVNDFHPQEFMDAKEARRMSRASQMAVAAARMALDHARLPLERMARDEIGVL
IASGTTSMPDVEQAVTTLIQRGGMKISPFFIPAALPNMPSSQVAIHFGLRGYTTAICTACAAGAQAIGEAAEIIRRGDAE
VMLAGGAEAPITALSLGAFCVMRALSTRSNHEPTRASRPFDALRDGFVPGEGAAVLVLERLSSAQRRGAPILAELIGYGV
SADAYHVTAPDPDGEGAALAIRRALQQARLAPQQVDYINAHATSTPAGDIAETRAIKQVFGEYAYSVPISSIKSMIGHLT
GAAGAVEAAATILALHHGQIPPTINLEHPDPECDLDYVPNVARQAAIQVAISNSFGFGGVNAVLAFRKMP

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=44.4711538461538, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI223972627, Length=168, Percent_Identity=48.2142857142857, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI41872631, Length=278, Percent_Identity=28.7769784172662, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1787337, Length=411, Percent_Identity=49.3917274939173, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI1788663, Length=415, Percent_Identity=36.6265060240964, Blast_Score=220, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71983541, Length=417, Percent_Identity=38.3693045563549, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=43.609022556391, Blast_Score=214, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI212642053, Length=289, Percent_Identity=26.2975778546713, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=271, Percent_Identity=28.4132841328413, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=451, Percent_Identity=37.0288248337029, Blast_Score=261, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24644341, Length=415, Percent_Identity=46.0240963855422, Blast_Score=349, Evalue=3e-96,
Organism=Drosophila melanogaster, GI19920632, Length=463, Percent_Identity=24.4060475161987, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221330659, Length=463, Percent_Identity=24.4060475161987, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24581345, Length=434, Percent_Identity=24.6543778801843, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 49784; Mature: 49652

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00099 THIOLASE_3 ; PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPRALDRRAALRAELLGLVREHVPDEAIEAQIEALLAEVLAEEPVVEPQPVVTDHLPPD
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
QRIVVTGLGVISPFGVGVEPFWAGLVAGRSAIGRITFFDPSDYPCQLAGQVNDFHPQEFM
CEEEEECCCHHCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCEEECCCCCCCCHHHHH
DAKEARRMSRASQMAVAAARMALDHARLPLERMARDEIGVLIASGTTSMPDVEQAVTTLI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHCEEEECCCCCCCCHHHHHHHHH
QRGGMKISPFFIPAALPNMPSSQVAIHFGLRGYTTAICTACAAGAQAIGEAAEIIRRGDA
HHCCCEECCEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EVMLAGGAEAPITALSLGAFCVMRALSTRSNHEPTRASRPFDALRDGFVPGEGAAVLVLE
CEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHH
RLSSAQRRGAPILAELIGYGVSADAYHVTAPDPDGEGAALAIRRALQQARLAPQQVDYIN
HHHHHHHCCCHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHEE
AHATSTPAGDIAETRAIKQVFGEYAYSVPISSIKSMIGHLTGAAGAVEAAATILALHHGQ
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
IPPTINLEHPDPECDLDYVPNVARQAAIQVAISNSFGFGGVNAVLAFRKMP
CCCEEECCCCCCCCCCCCCCCHHHHHHEEEEEECCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
TPRALDRRAALRAELLGLVREHVPDEAIEAQIEALLAEVLAEEPVVEPQPVVTDHLPPD
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
QRIVVTGLGVISPFGVGVEPFWAGLVAGRSAIGRITFFDPSDYPCQLAGQVNDFHPQEFM
CEEEEECCCHHCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCEEECCCCCCCCHHHHH
DAKEARRMSRASQMAVAAARMALDHARLPLERMARDEIGVLIASGTTSMPDVEQAVTTLI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHCEEEECCCCCCCCHHHHHHHHH
QRGGMKISPFFIPAALPNMPSSQVAIHFGLRGYTTAICTACAAGAQAIGEAAEIIRRGDA
HHCCCEECCEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EVMLAGGAEAPITALSLGAFCVMRALSTRSNHEPTRASRPFDALRDGFVPGEGAAVLVLE
CEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHH
RLSSAQRRGAPILAELIGYGVSADAYHVTAPDPDGEGAALAIRRALQQARLAPQQVDYIN
HHHHHHHCCCHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHEE
AHATSTPAGDIAETRAIKQVFGEYAYSVPISSIKSMIGHLTGAAGAVEAAATILALHHGQ
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
IPPTINLEHPDPECDLDYVPNVARQAAIQVAISNSFGFGGVNAVLAFRKMP
CCCEEECCCCCCCCCCCCCCCHHHHHHEEEEEECCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]