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The map label for this gene is sdhA [H]

Identifier: 222525290

GI number: 222525290

Start: 2572945

End: 2574918

Strand: Reverse

Name: sdhA [H]

Synonym: Chy400_2032

Alternate gene names: 222525290

Gene position: 2574918-2572945 (Counterclockwise)

Preceding gene: 222525291

Following gene: 222525289

Centisome position: 48.87

GC content: 58.36

Gene sequence:

>1974_bases
ATGAGCGAGACGAAGAACGAGACGACTGTTCGTACCGGGACGCGGCAGGTTGAGTATGTCAGTGTCCTTGACTCGAAAGT
CCCGACTGGCCCGATTGAGCAGCGCTGGGATAAGCATCGCTTTGAGATGAAGCTGGTCAATCCGGCCAACCGCCGAAAAT
ACACGATTATTGTGGTCGGTTCTGGACTGGCCGGAGCGTCGGCAGCCGCTACGCTGGGTGAAGCCGGGTACAACGTGCTT
TGCTTCTGCTATCAAGATAGTCCGCGTCGCGCGCACAGCATTGCCGCTCAGGGTGGTATCAACGCAGCCAAGAATTACCG
CAACGACGGCGATAGCATTTATCGCCTCTTCTACGATACCGTGAAAGGTGGCGATTTCCGGGCACGTGAGAGTAATGTCT
ACCGCCTGGCCCAGGTCTCCGTCAATATTATCGACCAGTGCGTGGCCCAGGGTGTGCCGTTTGCCCGTGAGTACGGTGGC
TTGCTTGATAACCGCTCGTTCGGTGGTGCCCAGGTGGCGCGCACGTTCTACGCCCGTGGTCAGACCGGCCAGCAGTTGCT
GCTCGGCGCGTACCAGGCCCTGAGTCGCCAGATCGCCGCCGGTACCGTGAAGATGTTCCCCCGTACCGAGATGCTTGATC
TGGTGGTAGTTGATGGGCGAGCGCGAGGGATCATTACCCGCGATATGGTAACCGGCAAGATCACGCGCTACGCTGCCGAT
GCGGTTGTGCTGGCGACCGGTGGCTACGGCAATGTCTTCTATCTGAGCACAAACGCCAAAGGGTGTAACGCCACAGCGAT
CTGGCGCGCTCATCGCCGGGGGGCGTTTTTCGGTAATCCCTGCTTTACCCAGATTCACCCAACCTGTATTCCGGTCAGTG
GTGAATACCAGAGCAAGCTGACCCTGATGTCGGAGTCGTTACGTAACGACGGCCGAATTTGGGTACCGAAGAAGAAGGGA
GATACCCGCCGCCCGCAGGATATTCCCGAATCAGAGCGCGATTACTATCTCGAAGAGCGCTATCCCAGCTTCGGTAATCT
GGTGCCGCGTGATATTGCCTCTCGTGCTGCCAAGCAGGTGTGTGATGAGGGGCGCGGTGTTGGTCCTGGCGGTCTGGGGG
TTTATCTTGACTTCGCCGATGCGATCAAGCGCCTGGGCCGACAGAAGATTGCCGAACGCTACGGTAATCTCTTCGATATG
TACAAGCAGATTACCGGCGAAGACCCGTATGAAACGCCGATGCGGATTTATCCCGCCGTCCACTATACGATGGGTGGGCT
GTGGGTTGATTATAACCTCCAGAGCACGATCCCCGGCCTGTTCGTGATCGGTGAGGCGAACTTCTCGGATCACGGTGCCA
ATCGGTTGGGTGCATCGGCGCTGATGCAGGGTCTGGCCGACGGTTACTTCATTCTGCCTTACACTATCGCCAATTTCCTG
GCCCAGGTTAAGCCCGGTGGTGTCAGCATCGACCGTCCTGAGTTCGCTGAGGCCGAAGCCGAAATCAACCAGCGTATTCA
ACGCCTGCTCAGCATTCGCGGCAAGCGAACCGTCGATTCGTTCCACCGCGAGTTGGGCAAGCTGATGTGGGATAAGTGCG
GTATGGCACGCAATGCGGCCGGCCTGCGCGAGGCGTTGCAGCGCATCCCTGAGATTCGCGCCGAGTTCTGGGAGAATGTG
AATGTGCCCGGCGAGGCCAACGATCTCAATCAGGCGCTGGAAAAGGCCGGACGAGTAGCCGATTTCCTCGAACTGGCCGA
GTTGATGTGTCTGGATGCGCTGCACCGTGAAGAGTCGTGTGGCGGCCACTTCCGCGAAGAATACCAGACACCCGACGGCG
AAGCACTCCGCAACGACGAGCAGTTCTCGTATGTGGCTGCGTGGGAGTTTACCGGCGATCTGGCGAAACCTCGCCTGCAC
AAAGAGCCGCTCGTCTTCGAGTATGTCAAGCCGACCCAGCGCAGTTATAAGTGA

Upstream 100 bases:

>100_bases
CAGCCGTTTTCATTGGCAATATCTCATTCCCGTTGGCGGTCTATTTCGGCTTTGTCGCGTAGATGGTCCCGACCAACGCT
AGAAGAGCGAGGAAATTCGC

Downstream 100 bases:

>100_bases
TCCGGTTGGATGCTGGCGATGTTCGGACAGGTTCCTGTTGCTATCAGTTTAACTGCTGCCGGTTGATATAAGCAATCGGT
GGCCGGAGATAGAGTATGAA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 657; Mature: 656

Protein sequence:

>657_residues
MSETKNETTVRTGTRQVEYVSVLDSKVPTGPIEQRWDKHRFEMKLVNPANRRKYTIIVVGSGLAGASAAATLGEAGYNVL
CFCYQDSPRRAHSIAAQGGINAAKNYRNDGDSIYRLFYDTVKGGDFRARESNVYRLAQVSVNIIDQCVAQGVPFAREYGG
LLDNRSFGGAQVARTFYARGQTGQQLLLGAYQALSRQIAAGTVKMFPRTEMLDLVVVDGRARGIITRDMVTGKITRYAAD
AVVLATGGYGNVFYLSTNAKGCNATAIWRAHRRGAFFGNPCFTQIHPTCIPVSGEYQSKLTLMSESLRNDGRIWVPKKKG
DTRRPQDIPESERDYYLEERYPSFGNLVPRDIASRAAKQVCDEGRGVGPGGLGVYLDFADAIKRLGRQKIAERYGNLFDM
YKQITGEDPYETPMRIYPAVHYTMGGLWVDYNLQSTIPGLFVIGEANFSDHGANRLGASALMQGLADGYFILPYTIANFL
AQVKPGGVSIDRPEFAEAEAEINQRIQRLLSIRGKRTVDSFHRELGKLMWDKCGMARNAAGLREALQRIPEIRAEFWENV
NVPGEANDLNQALEKAGRVADFLELAELMCLDALHREESCGGHFREEYQTPDGEALRNDEQFSYVAAWEFTGDLAKPRLH
KEPLVFEYVKPTQRSYK

Sequences:

>Translated_657_residues
MSETKNETTVRTGTRQVEYVSVLDSKVPTGPIEQRWDKHRFEMKLVNPANRRKYTIIVVGSGLAGASAAATLGEAGYNVL
CFCYQDSPRRAHSIAAQGGINAAKNYRNDGDSIYRLFYDTVKGGDFRARESNVYRLAQVSVNIIDQCVAQGVPFAREYGG
LLDNRSFGGAQVARTFYARGQTGQQLLLGAYQALSRQIAAGTVKMFPRTEMLDLVVVDGRARGIITRDMVTGKITRYAAD
AVVLATGGYGNVFYLSTNAKGCNATAIWRAHRRGAFFGNPCFTQIHPTCIPVSGEYQSKLTLMSESLRNDGRIWVPKKKG
DTRRPQDIPESERDYYLEERYPSFGNLVPRDIASRAAKQVCDEGRGVGPGGLGVYLDFADAIKRLGRQKIAERYGNLFDM
YKQITGEDPYETPMRIYPAVHYTMGGLWVDYNLQSTIPGLFVIGEANFSDHGANRLGASALMQGLADGYFILPYTIANFL
AQVKPGGVSIDRPEFAEAEAEINQRIQRLLSIRGKRTVDSFHRELGKLMWDKCGMARNAAGLREALQRIPEIRAEFWENV
NVPGEANDLNQALEKAGRVADFLELAELMCLDALHREESCGGHFREEYQTPDGEALRNDEQFSYVAAWEFTGDLAKPRLH
KEPLVFEYVKPTQRSYK
>Mature_656_residues
SETKNETTVRTGTRQVEYVSVLDSKVPTGPIEQRWDKHRFEMKLVNPANRRKYTIIVVGSGLAGASAAATLGEAGYNVLC
FCYQDSPRRAHSIAAQGGINAAKNYRNDGDSIYRLFYDTVKGGDFRARESNVYRLAQVSVNIIDQCVAQGVPFAREYGGL
LDNRSFGGAQVARTFYARGQTGQQLLLGAYQALSRQIAAGTVKMFPRTEMLDLVVVDGRARGIITRDMVTGKITRYAADA
VVLATGGYGNVFYLSTNAKGCNATAIWRAHRRGAFFGNPCFTQIHPTCIPVSGEYQSKLTLMSESLRNDGRIWVPKKKGD
TRRPQDIPESERDYYLEERYPSFGNLVPRDIASRAAKQVCDEGRGVGPGGLGVYLDFADAIKRLGRQKIAERYGNLFDMY
KQITGEDPYETPMRIYPAVHYTMGGLWVDYNLQSTIPGLFVIGEANFSDHGANRLGASALMQGLADGYFILPYTIANFLA
QVKPGGVSIDRPEFAEAEAEINQRIQRLLSIRGKRTVDSFHRELGKLMWDKCGMARNAAGLREALQRIPEIRAEFWENVN
VPGEANDLNQALEKAGRVADFLELAELMCLDALHREESCGGHFREEYQTPDGEALRNDEQFSYVAAWEFTGDLAKPRLHK
EPLVFEYVKPTQRSYK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=572, Percent_Identity=28.8461538461538, Blast_Score=170, Evalue=4e-42,
Organism=Escherichia coli, GI1790597, Length=541, Percent_Identity=30.1293900184843, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1786942, Length=592, Percent_Identity=26.3513513513513, Blast_Score=145, Evalue=1e-35,
Organism=Escherichia coli, GI1788928, Length=570, Percent_Identity=26.6666666666667, Blast_Score=133, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17505833, Length=543, Percent_Identity=29.097605893186, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17550100, Length=545, Percent_Identity=28.4403669724771, Blast_Score=179, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6322701, Length=635, Percent_Identity=28.6614173228346, Blast_Score=204, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6322416, Length=582, Percent_Identity=28.6941580756014, Blast_Score=188, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17137288, Length=549, Percent_Identity=28.5974499089253, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24655642, Length=549, Percent_Identity=28.5974499089253, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24655647, Length=549, Percent_Identity=28.5974499089253, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24663005, Length=580, Percent_Identity=26.0344827586207, Blast_Score=153, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 73282; Mature: 73151

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETKNETTVRTGTRQVEYVSVLDSKVPTGPIEQRWDKHRFEMKLVNPANRRKYTIIVVG
CCCCCCCCEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHCEEEEEECCCCCCEEEEEEEE
SGLAGASAAATLGEAGYNVLCFCYQDSPRRAHSIAAQGGINAAKNYRNDGDSIYRLFYDT
CCCCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHH
VKGGDFRARESNVYRLAQVSVNIIDQCVAQGVPFAREYGGLLDNRSFGGAQVARTFYARG
HCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCHHHHHHHHHHCC
QTGQQLLLGAYQALSRQIAAGTVKMFPRTEMLDLVVVDGRARGIITRDMVTGKITRYAAD
CCCHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEEECCCCCCEEEHHHHHHHHHHHCCC
AVVLATGGYGNVFYLSTNAKGCNATAIWRAHRRGAFFGNPCFTQIHPTCIPVSGEYQSKL
EEEEEECCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHH
TLMSESLRNDGRIWVPKKKGDTRRPQDIPESERDYYLEERYPSFGNLVPRDIASRAAKQV
HHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHCCCHHHCCCCCCCCCCHHHHHHHHHHH
CDEGRGVGPGGLGVYLDFADAIKRLGRQKIAERYGNLFDMYKQITGEDPYETPMRIYPAV
HHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCC
HYTMGGLWVDYNLQSTIPGLFVIGEANFSDHGANRLGASALMQGLADGYFILPYTIANFL
EEEECCEEEEECHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHH
AQVKPGGVSIDRPEFAEAEAEINQRIQRLLSIRGKRTVDSFHRELGKLMWDKCGMARNAA
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHH
GLREALQRIPEIRAEFWENVNVPGEANDLNQALEKAGRVADFLELAELMCLDALHREESC
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGHFREEYQTPDGEALRNDEQFSYVAAWEFTGDLAKPRLHKEPLVFEYVKPTQRSYK
CCHHHHHCCCCCCHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCEEEECCCCCCCCC
>Mature Secondary Structure 
SETKNETTVRTGTRQVEYVSVLDSKVPTGPIEQRWDKHRFEMKLVNPANRRKYTIIVVG
CCCCCCCEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHCEEEEEECCCCCCEEEEEEEE
SGLAGASAAATLGEAGYNVLCFCYQDSPRRAHSIAAQGGINAAKNYRNDGDSIYRLFYDT
CCCCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHH
VKGGDFRARESNVYRLAQVSVNIIDQCVAQGVPFAREYGGLLDNRSFGGAQVARTFYARG
HCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCHHHHHHHHHHCC
QTGQQLLLGAYQALSRQIAAGTVKMFPRTEMLDLVVVDGRARGIITRDMVTGKITRYAAD
CCCHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEEECCCCCCEEEHHHHHHHHHHHCCC
AVVLATGGYGNVFYLSTNAKGCNATAIWRAHRRGAFFGNPCFTQIHPTCIPVSGEYQSKL
EEEEEECCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHH
TLMSESLRNDGRIWVPKKKGDTRRPQDIPESERDYYLEERYPSFGNLVPRDIASRAAKQV
HHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHCCCHHHCCCCCCCCCCHHHHHHHHHHH
CDEGRGVGPGGLGVYLDFADAIKRLGRQKIAERYGNLFDMYKQITGEDPYETPMRIYPAV
HHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCC
HYTMGGLWVDYNLQSTIPGLFVIGEANFSDHGANRLGASALMQGLADGYFILPYTIANFL
EEEECCEEEEECHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHH
AQVKPGGVSIDRPEFAEAEAEINQRIQRLLSIRGKRTVDSFHRELGKLMWDKCGMARNAA
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHH
GLREALQRIPEIRAEFWENVNVPGEANDLNQALEKAGRVADFLELAELMCLDALHREESC
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGHFREEYQTPDGEALRNDEQFSYVAAWEFTGDLAKPRLHKEPLVFEYVKPTQRSYK
CCHHHHHCCCCCCHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]