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The map label for this gene is moaE [H]

Identifier: 222525283

GI number: 222525283

Start: 2563231

End: 2563644

Strand: Direct

Name: moaE [H]

Synonym: Chy400_2023

Alternate gene names: 222525283

Gene position: 2563231-2563644 (Clockwise)

Preceding gene: 222525282

Following gene: 222525284

Centisome position: 48.65

GC content: 59.9

Gene sequence:

>414_bases
ATGGTCGAACCGTTTGTCATTACCACAGAACCGCTTGATCCAGCGCCACTGGTAGCGGCAGTCCAGACGCCCAATGATGG
GGCTGTTGTCACCTTTAGCGGCGTGGTTCGCAACCACTTCGGTGGACGGCCTACGGCATTTCTGGTGTACGAAGCCTACA
CCGAAATGGCCGTGCCGGTGTTACGCCAGATTGCCGACGAGGCACGAGTGCGCTGGCCGATTGGGCGGGTCTGTGTCCAC
CACCGGGTCGGTCGGCTAGAGATTGGCGAGACGGCAGTGCTGGTTGTTGTTGCGGCTCCGCACCGCGACGCCGCCTTTGC
GGCTGCGGCCTACATTATGGATCGAATCAAAGAGATTGCGCCCATCTGGAAACAGGAGCATTGGGCCGATGGTGAAGCCG
AATGGCGTGAATAG

Upstream 100 bases:

>100_bases
CTTTGCCGTGAATCAACAGTTTGCCCAACCGACGACTGTGTTAGCCAACGGCGATGAGGTCGCCTTTATCCCGCCGGTAA
GTGGCGGACGGAGTTGATGT

Downstream 100 bases:

>100_bases
GTAACGTACTATGCCGGAACTTCCTGAAGTTGAAACTGTTGCCCGCTCCCTCGCCCCGCAGCTTCAGGGACGCACAATTA
CCGGGCTGGCCAAACTTGAC

Product: molybdopterin biosynthesis MoaE protein

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MVEPFVITTEPLDPAPLVAAVQTPNDGAVVTFSGVVRNHFGGRPTAFLVYEAYTEMAVPVLRQIADEARVRWPIGRVCVH
HRVGRLEIGETAVLVVVAAPHRDAAFAAAAYIMDRIKEIAPIWKQEHWADGEAEWRE

Sequences:

>Translated_137_residues
MVEPFVITTEPLDPAPLVAAVQTPNDGAVVTFSGVVRNHFGGRPTAFLVYEAYTEMAVPVLRQIADEARVRWPIGRVCVH
HRVGRLEIGETAVLVVVAAPHRDAAFAAAAYIMDRIKEIAPIWKQEHWADGEAEWRE
>Mature_137_residues
MVEPFVITTEPLDPAPLVAAVQTPNDGAVVTFSGVVRNHFGGRPTAFLVYEAYTEMAVPVLRQIADEARVRWPIGRVCVH
HRVGRLEIGETAVLVVVAAPHRDAAFAAAAYIMDRIKEIAPIWKQEHWADGEAEWRE

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=130, Percent_Identity=33.8461538461538, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1787003, Length=125, Percent_Identity=44.8, Blast_Score=101, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17509279, Length=133, Percent_Identity=36.0902255639098, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21356259, Length=133, Percent_Identity=30.0751879699248, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 15181; Mature: 15181

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEPFVITTEPLDPAPLVAAVQTPNDGAVVTFSGVVRNHFGGRPTAFLVYEAYTEMAVPV
CCCCEEEEECCCCCCCEEEEEECCCCCEEEEEHHHHHHCCCCCCEEEEEEHHHHHHHHHH
LRQIADEARVRWPIGRVCVHHRVGRLEIGETAVLVVVAAPHRDAAFAAAAYIMDRIKEIA
HHHHHHHHHCCCCHHHHHHHHCCCCEEECCEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
PIWKQEHWADGEAEWRE
HHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MVEPFVITTEPLDPAPLVAAVQTPNDGAVVTFSGVVRNHFGGRPTAFLVYEAYTEMAVPV
CCCCEEEEECCCCCCCEEEEEECCCCCEEEEEHHHHHHCCCCCCEEEEEEHHHHHHHHHH
LRQIADEARVRWPIGRVCVHHRVGRLEIGETAVLVVVAAPHRDAAFAAAAYIMDRIKEIA
HHHHHHHHHCCCCHHHHHHHHCCCCEEECCEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
PIWKQEHWADGEAEWRE
HHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]