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The map label for this gene is phr [H]

Identifier: 222525279

GI number: 222525279

Start: 2560902

End: 2561717

Strand: Direct

Name: phr [H]

Synonym: Chy400_2019

Alternate gene names: 222525279

Gene position: 2560902-2561717 (Clockwise)

Preceding gene: 222525278

Following gene: 222525280

Centisome position: 48.6

GC content: 58.95

Gene sequence:

>816_bases
ATGCAACTCCGTACCGATCTGACAACCCGTGAAGAGCAGGCCGCTTATCTGGCGGAAGCGCTGGCCGGCCTTTTTCAAGG
TCCGGCCCAACCGTCGCCGATTCGTGGCGGGCGGCGGGCAGCACTCCGTCGGCTGCGCGCATTTAACGTTCACCACTATG
CCCGTACTCGCAATGATGTGGTGCAACGCGGCGTTTCCATGCTCTCGCCATACCTGCGCCACGGGATGCTAAGCCTGGCC
GAAGTGCGCGATTCGATATTGGGCCGGTTTGGTATCACTCCAGACACCGAAAAATTTGTCAATGAGCTGGCCTGGCGGGC
ATTCTGGCAGCTTGTGTATGCCCATCTCGGCGACCGGATTCACCACGATATTGAGCCGGCAAAACACAAAGCTCGTGTGC
CTCGGCGTCGTCTACCACCAGACGTGACTGCGGCGACCACCGGTCTGGTCTGCATCGATGAATCGCTCCGCGAGCTGTAC
ACGGTCGGTTATATGCACAACCACGCCCGCATGTGGGTTGCGGCGTATCTCATTCACTGGTTAGGGGTTGACTGGCGTGA
GGGTGCCGATCTCTTCTACCGTCATCTGCTCGACGGAGATCCGGCCTCGAATAGCCTGTCGTGGCAATGGGTGAACAGCA
CGTTCAGCCATAAGCCTTACATCTTCAACCGGCAGAATGTCGAACGGTTTAGCGCCGGCACCTTCTGCGCTCGCTGCCCG
CTGGCAAAGGTGGGCTGTCCATTTGATGACAGTTATGAAAACCTGGCCTGGCGTCTGTTCGGGGTGACACTGGCCGAACT
GGAGGGAAGGCGATGA

Upstream 100 bases:

>100_bases
TCTCGTTGGGGTGAGAGGCCATCCAGCAGAAGGTGCCGGGCAATACTCGCCGTCATCCGAACTCGTGGTATACTCGATAA
GAGCAGTTGAGCTGAAACCA

Downstream 100 bases:

>100_bases
GCGGCGGGATTGTCTGGCTTCACGGCGATAGCCTCAGCCCAACCGATCCGGCGCTGGTCGCCAACCCAACGGCGCCGGCG
GTGTTTGTGTTCGATGAACC

Product: putative deoxyribodipyrimidine photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MQLRTDLTTREEQAAYLAEALAGLFQGPAQPSPIRGGRRAALRRLRAFNVHHYARTRNDVVQRGVSMLSPYLRHGMLSLA
EVRDSILGRFGITPDTEKFVNELAWRAFWQLVYAHLGDRIHHDIEPAKHKARVPRRRLPPDVTAATTGLVCIDESLRELY
TVGYMHNHARMWVAAYLIHWLGVDWREGADLFYRHLLDGDPASNSLSWQWVNSTFSHKPYIFNRQNVERFSAGTFCARCP
LAKVGCPFDDSYENLAWRLFGVTLAELEGRR

Sequences:

>Translated_271_residues
MQLRTDLTTREEQAAYLAEALAGLFQGPAQPSPIRGGRRAALRRLRAFNVHHYARTRNDVVQRGVSMLSPYLRHGMLSLA
EVRDSILGRFGITPDTEKFVNELAWRAFWQLVYAHLGDRIHHDIEPAKHKARVPRRRLPPDVTAATTGLVCIDESLRELY
TVGYMHNHARMWVAAYLIHWLGVDWREGADLFYRHLLDGDPASNSLSWQWVNSTFSHKPYIFNRQNVERFSAGTFCARCP
LAKVGCPFDDSYENLAWRLFGVTLAELEGRR
>Mature_271_residues
MQLRTDLTTREEQAAYLAEALAGLFQGPAQPSPIRGGRRAALRRLRAFNVHHYARTRNDVVQRGVSMLSPYLRHGMLSLA
EVRDSILGRFGITPDTEKFVNELAWRAFWQLVYAHLGDRIHHDIEPAKHKARVPRRRLPPDVTAATTGLVCIDESLRELY
TVGYMHNHARMWVAAYLIHWLGVDWREGADLFYRHLLDGDPASNSLSWQWVNSTFSHKPYIFNRQNVERFSAGTFCARCP
LAKVGCPFDDSYENLAWRLFGVTLAELEGRR

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Escherichia coli, GI1786926, Length=208, Percent_Identity=34.6153846153846, Blast_Score=84, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17137248, Length=233, Percent_Identity=27.4678111587983, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24585455, Length=233, Percent_Identity=27.4678111587983, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 31129; Mature: 31129

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLRTDLTTREEQAAYLAEALAGLFQGPAQPSPIRGGRRAALRRLRAFNVHHYARTRNDV
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VQRGVSMLSPYLRHGMLSLAEVRDSILGRFGITPDTEKFVNELAWRAFWQLVYAHLGDRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HHDIEPAKHKARVPRRRLPPDVTAATTGLVCIDESLRELYTVGYMHNHARMWVAAYLIHW
HHCCCHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGVDWREGADLFYRHLLDGDPASNSLSWQWVNSTFSHKPYIFNRQNVERFSAGTFCARCP
HCCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCEEECCCCHHHHHCCCHHHHCC
LAKVGCPFDDSYENLAWRLFGVTLAELEGRR
HHHCCCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQLRTDLTTREEQAAYLAEALAGLFQGPAQPSPIRGGRRAALRRLRAFNVHHYARTRNDV
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VQRGVSMLSPYLRHGMLSLAEVRDSILGRFGITPDTEKFVNELAWRAFWQLVYAHLGDRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HHDIEPAKHKARVPRRRLPPDVTAATTGLVCIDESLRELYTVGYMHNHARMWVAAYLIHW
HHCCCHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGVDWREGADLFYRHLLDGDPASNSLSWQWVNSTFSHKPYIFNRQNVERFSAGTFCARCP
HCCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCEEECCCCHHHHHCCCHHHHCC
LAKVGCPFDDSYENLAWRLFGVTLAELEGRR
HHHCCCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2501760 [H]