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The map label for this gene is ctpB [H]

Identifier: 222525247

GI number: 222525247

Start: 2521902

End: 2523266

Strand: Reverse

Name: ctpB [H]

Synonym: Chy400_1987

Alternate gene names: 222525247

Gene position: 2523266-2521902 (Counterclockwise)

Preceding gene: 222525248

Following gene: 222525246

Centisome position: 47.89

GC content: 58.83

Gene sequence:

>1365_bases
ATGCACTTCAATACTAGAAAAGATACTGCTATGGAACGGGTGTGGGCAATTATCGGCAAAATCGTGCAATGGCTGGCTGT
CGTGACCGTGGCGTTTCTCGGCGGGTGGATTACCGGCCGTATCGTCGGCGTCTCGCCGATTGATGTCTTTATTACCGGCG
TTTCCAATGCTGACGCCCGCCTGCTGACCCCCGGTGACCGCCGGCAATACGCTGCCGTGTTCTGGGATGTATGGGACCTG
GTGGAAGGCAATTTCTACCGTCCTGAGAGTATTGATCGGCAGCGCATGATCTACGGTGCCATCCGTGGCATGCTGGCCAC
CCTCGACGATCCCTACACCTTCTTCCAGGAGCCAGAGGAGGCACAGCAGAATCGCGAGTCAATGGAAGGCCGTTACGAAG
GGATCGGTGCCTACCTGCGGGTCGAGGATGGGATGATTGTGATTGACCGCCCCATCCCCAACTCGCCGGCAGCACAGGCC
GGCCTGCAACCGGGTGACATTATCCTGGCCGTCGATGATCAGGAACTGGCTGAACTGATCGCTGGCCTGAACGAGAACGA
CGCCAGTGCCCGTGCCGTCAGCCTGATCCGTGGCCCGGCCGGATCCGTCGTTCGCCTGACCCTGCGTCGCCCGGCAGAGG
ATCGCGTCTTTACCGTTGCCATTACTCGTGCCGCCATCCCGTTGATCACCGTTAACAGCACCATGCTGCCGAATGGCATT
GCCTACATCCAGATCACCGAATTCAAAGCCACCACCACCGAGTTGCTTGATGCCGCAATTGCCGAACTGCGGCCGCAACA
GCCACGCGCCATTGTGCTTGATCTGAGAAACAATTCCGGCGGCTTTTTAACCACTGCGCAAGAAGTCCTGGGTCGTTTTT
ACGACGGCATCGCCCTTTACGAAGAGGAACGAAGCGGGGTCAAAAAGGAGCTGCGTACTATCACTGCCGTACCCGACCGC
CGGCTCTACGACATACCAATGGTTGTCCTGGTGAATGGTGGATCGGCCAGTGCGGCCGAGGTCGTGGCCGGCGCCTTACG
CGATCAACGGCCCAACACCGTACTGCTCGGTGAGCGCACCTTCGGCAAGGGATCGGTGCAAAACATCTACACGTTACGCG
ACGGGAGTAGTGTACGCATCACCATTGCCCGCTGGTTAACCCCTGCTGGCGAAGCCATTAACGGTGTCGGCATTACCCCC
CAGCACGTGGTACCGGCCTCGAATGAGGCGACTTACCCTGTCCCCTGCGTCCCTGATCGTCCCGCCGATACGAGCTGTGC
TGATGCTCAACTCTACTGGGCTTTACAGTTATTAGAGAACGGAACCGCACCACCACCGCCGGCAGAAACAGAAACGGCCC
CCTAA

Upstream 100 bases:

>100_bases
CGAACGGCGGCGCATCAGCACGGCATTCAATCGGTGTCACTGGGACCACGCATTTTACGGGCCGAAACGGCACCGCTGGT
AGCACTGGCCATGCTTCAAT

Downstream 100 bases:

>100_bases
GGGGCCGTAGACCGGACGGCGGGCAAAGGGGCAAGCGCGAGGAAACGGCGTGCAGGGCGCCGTGGAGGTTGAATTGGGGA
GGCAGAGATCCTGGCTGACA

Product: carboxyl-terminal protease

Products: NA

Alternate protein names: C-terminal processing protease [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MHFNTRKDTAMERVWAIIGKIVQWLAVVTVAFLGGWITGRIVGVSPIDVFITGVSNADARLLTPGDRRQYAAVFWDVWDL
VEGNFYRPESIDRQRMIYGAIRGMLATLDDPYTFFQEPEEAQQNRESMEGRYEGIGAYLRVEDGMIVIDRPIPNSPAAQA
GLQPGDIILAVDDQELAELIAGLNENDASARAVSLIRGPAGSVVRLTLRRPAEDRVFTVAITRAAIPLITVNSTMLPNGI
AYIQITEFKATTTELLDAAIAELRPQQPRAIVLDLRNNSGGFLTTAQEVLGRFYDGIALYEEERSGVKKELRTITAVPDR
RLYDIPMVVLVNGGSASAAEVVAGALRDQRPNTVLLGERTFGKGSVQNIYTLRDGSSVRITIARWLTPAGEAINGVGITP
QHVVPASNEATYPVPCVPDRPADTSCADAQLYWALQLLENGTAPPPPAETETAP

Sequences:

>Translated_454_residues
MHFNTRKDTAMERVWAIIGKIVQWLAVVTVAFLGGWITGRIVGVSPIDVFITGVSNADARLLTPGDRRQYAAVFWDVWDL
VEGNFYRPESIDRQRMIYGAIRGMLATLDDPYTFFQEPEEAQQNRESMEGRYEGIGAYLRVEDGMIVIDRPIPNSPAAQA
GLQPGDIILAVDDQELAELIAGLNENDASARAVSLIRGPAGSVVRLTLRRPAEDRVFTVAITRAAIPLITVNSTMLPNGI
AYIQITEFKATTTELLDAAIAELRPQQPRAIVLDLRNNSGGFLTTAQEVLGRFYDGIALYEEERSGVKKELRTITAVPDR
RLYDIPMVVLVNGGSASAAEVVAGALRDQRPNTVLLGERTFGKGSVQNIYTLRDGSSVRITIARWLTPAGEAINGVGITP
QHVVPASNEATYPVPCVPDRPADTSCADAQLYWALQLLENGTAPPPPAETETAP
>Mature_454_residues
MHFNTRKDTAMERVWAIIGKIVQWLAVVTVAFLGGWITGRIVGVSPIDVFITGVSNADARLLTPGDRRQYAAVFWDVWDL
VEGNFYRPESIDRQRMIYGAIRGMLATLDDPYTFFQEPEEAQQNRESMEGRYEGIGAYLRVEDGMIVIDRPIPNSPAAQA
GLQPGDIILAVDDQELAELIAGLNENDASARAVSLIRGPAGSVVRLTLRRPAEDRVFTVAITRAAIPLITVNSTMLPNGI
AYIQITEFKATTTELLDAAIAELRPQQPRAIVLDLRNNSGGFLTTAQEVLGRFYDGIALYEEERSGVKKELRTITAVPDR
RLYDIPMVVLVNGGSASAAEVVAGALRDQRPNTVLLGERTFGKGSVQNIYTLRDGSSVRITIARWLTPAGEAINGVGITP
QHVVPASNEATYPVPCVPDRPADTSCADAQLYWALQLLENGTAPPPPAETETAP

Specific function: Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the regulatory protein

COG id: COG0793

COG function: function code M; Periplasmic protease

Gene ontology:

Cell location: Forespore intermembrane space. Note=Is expressed in both the mother cell and forespore compartments but that synthesis in the forespore is both necessary and sufficient for the proper timing of pro-sigma-K processing [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Escherichia coli, GI1788134, Length=348, Percent_Identity=30.1724137931034, Blast_Score=107, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR005151
- InterPro:   IPR004447
- InterPro:   IPR002477 [H]

Pfam domain/function: PF00595 PDZ; PF03572 Peptidase_S41; PF01471 PG_binding_1 [H]

EC number: =3.4.21.102 [H]

Molecular weight: Translated: 49495; Mature: 49495

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFNTRKDTAMERVWAIIGKIVQWLAVVTVAFLGGWITGRIVGVSPIDVFITGVSNADAR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCEEEEEEEECCCCCCE
LLTPGDRRQYAAVFWDVWDLVEGNFYRPESIDRQRMIYGAIRGMLATLDDPYTFFQEPEE
EECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCHHH
AQQNRESMEGRYEGIGAYLRVEDGMIVIDRPIPNSPAAQAGLQPGDIILAVDDQELAELI
HHHHHHHHCCHHCCCEEEEEEECCEEEEECCCCCCCHHHCCCCCCCEEEEECCHHHHHHH
AGLNENDASARAVSLIRGPAGSVVRLTLRRPAEDRVFTVAITRAAIPLITVNSTMLPNGI
HCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEECCCEEEEEECCEECCCCE
AYIQITEFKATTTELLDAAIAELRPQQPRAIVLDLRNNSGGFLTTAQEVLGRFYDGIALY
EEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHCCCEEE
EEERSGVKKELRTITAVPDRRLYDIPMVVLVNGGSASAAEVVAGALRDQRPNTVLLGERT
HHHHHHHHHHHHHHHCCCCCEEECCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCC
FGKGSVQNIYTLRDGSSVRITIARWLTPAGEAINGVGITPQHVVPASNEATYPVPCVPDR
CCCCCCCEEEEEECCCEEEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCC
PADTSCADAQLYWALQLLENGTAPPPPAETETAP
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHFNTRKDTAMERVWAIIGKIVQWLAVVTVAFLGGWITGRIVGVSPIDVFITGVSNADAR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCEEEEEEEECCCCCCE
LLTPGDRRQYAAVFWDVWDLVEGNFYRPESIDRQRMIYGAIRGMLATLDDPYTFFQEPEE
EECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCHHH
AQQNRESMEGRYEGIGAYLRVEDGMIVIDRPIPNSPAAQAGLQPGDIILAVDDQELAELI
HHHHHHHHCCHHCCCEEEEEEECCEEEEECCCCCCCHHHCCCCCCCEEEEECCHHHHHHH
AGLNENDASARAVSLIRGPAGSVVRLTLRRPAEDRVFTVAITRAAIPLITVNSTMLPNGI
HCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEECCCEEEEEECCEECCCCE
AYIQITEFKATTTELLDAAIAELRPQQPRAIVLDLRNNSGGFLTTAQEVLGRFYDGIALY
EEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHCCCEEE
EEERSGVKKELRTITAVPDRRLYDIPMVVLVNGGSASAAEVVAGALRDQRPNTVLLGERT
HHHHHHHHHHHHHHHCCCCCEEECCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCC
FGKGSVQNIYTLRDGSSVRITIARWLTPAGEAINGVGITPQHVVPASNEATYPVPCVPDR
CCCCCCCEEEEEECCCEEEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCC
PADTSCADAQLYWALQLLENGTAPPPPAETETAP
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9570401; 9384377 [H]