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The map label for this gene is tkt [H]

Identifier: 222525235

GI number: 222525235

Start: 2506867

End: 2508879

Strand: Reverse

Name: tkt [H]

Synonym: Chy400_1975

Alternate gene names: 222525235

Gene position: 2508879-2506867 (Counterclockwise)

Preceding gene: 222525239

Following gene: 222525233

Centisome position: 47.62

GC content: 60.61

Gene sequence:

>2013_bases
ATGAATAACCCGATGATCACCACGATTGACCAGTTATGTGCCAATGCTATTCGCGCGCTGGCGATTGATGCCGTTCAGCA
AGCTAACAGCGGCCATCCCGGTATGCCACTTGGGATGGCCGATGCTGCATACGTGCTCTGGACGCGCTTTCTGAAGCATA
ATCCGAGCGATCCACACTGGCCGAACCGGGATCGCTTTGTCCTGTCAGCCGGTCACGGTTCGATGTTACTCTACGCCCTG
CTCCACCTTACCGGTTACGATGTGTCGCTGGATGACCTGAAGCAATTTCGGCAATGGGGGAGTCGCACACCCGGCCATCC
TGAGTATCACGAAACGCCGGGGGTTGAGATGACGACCGGCCCGCTCGGTCAGGGGATTGCGACGGCGGTCGGGATGGCAA
TTGCCGAGCGCTGGCTGGCGACCAGATTTAATCGGGTAGGGTTTCCGGTCGTTGACCACTACACCTACGTCATTGCCAGC
GATGGTGATCTGATGGAGGGCATTTCCCACGAGGCGGCCAGTCTGGCCGGCCATTTACGGCTGGGGAAACTGATCGTCTT
GTACGATAGCAACGATATTTCGCTGGTGGGGCCAACCCGCCTGGCCTGGAGCGAACAGGTTGCTGATCGGTTTGCCGCTT
ACGGCTGGCAGGTGTTGTACGCCGATGGGCACAATATGTCTTCGGTAGCGCTGGCCCTGGCCGAAGCGATTGTCGATGGT
GAACGACCTTCCCTGATCATTACCCGCACCGTAATAGGGTATGCCAGTCCACGGGCCGGCAGCCATAAGGCCCACGGTGA
GCCGCTTGGCGTCGAAGGCGTGAAATTGACCAAAGAGGCGTTAGGCTGGCCGCAGGAACCGGCTTTCTACGTGCCCGATG
AGGTCTACGAACATATGCAGATGGCGGTCGAAGTTGGTGAGACCCGCCAGCGTGAATGGGAGGCGATGTTTCGGCGGTAT
CGAGCGTCGTACCCCGATCTGGCCGCGCAGTGGGATTTGATGCAGCAGGGCGGTTTACCGACAGGCTGGGAACAGGCCAT
CCCGACCTTTGCCCCCGATCCGAAAGCTAAAGGTACCCGTGTCGCGTCGGGAGCCGTGTTGCAGGCACTCGCTCCGATCA
TCCCCGGTCTGCTGGGAGGTTCAGCCGATCTGCACACCTCGGACTTTACCTATCTGGAAGGACTGGGTTCGATCAACGGT
GAGGATTTCAGTGCGCGCAACCTGCATTTCGGTGTGCGGGAGCACGCGATGGGTGCCATTCTCAACGGTATGGCGCTGCA
CGGTGGGATTATTCCTTACGGCGGCACCTTTCTCGTGTTCAGCGACTACATGCGCCCGGCCATCCGGCTGGCGGCCTTGA
TGCGGTTACGAGTGATTTACGTCTTTACGCACGACAGTATCGGTGTTGGCGAAGATGGGCCGACCCACCAGCCGGTAGAG
CATCTGCTGGCACTGCGGGCCATTCCCAACCTGCTGGTTGTGCGACCGGGTGATGCCAATGAGGTGGCAATGGCCTGGCG
TCTGGCACTGCAACGGAGCGATGGCCCAACCGCGATCATCCTCTCCCGGCAGAACGTGCCGACACTTGACCGGACGCAGC
TTGGTGCCGCCGATGGCACCCTGCGCGGTGGCTACGTGCTGCGTGATGCGGACGCGGCTCAGGCGTTGATCATTGCGACC
GGTTCGGAAGTGGCGCTGGCCCTGGCAGCCGCCGATCATCTGGCCGGGGAAGGCATTGCCACGCGCGTTGTCAGTATGCC
TTGTCGCGAACTGTTTGATCAACAAGATGCCGCCTACCGTGATCGGGTGCTGCCACCGCAGATCAGAGCGCGGGTGGCCG
TAGAGGCAGGGCGCTCAATCGGCTGGGAGCGCTATGTTGGCTGTGCAGGCGCGATTATCGGGGTGGATCGCTTCGGTGCC
TCTGCGCCATTCCAGCGCATTTACACCGAATTCGGTCTGACCGTCGAGCGGGTTGTGGCGGCGGTGAAAGATCAGCTCGT
GCGGCACGAATAG

Upstream 100 bases:

>100_bases
GAACAGTAAATAACGCATACAGTGGTATGATGGAGAGAAGTGGGGAATAACCGAACAGCGTTGAAGCTGGCGATGTTCGC
ATTAGAGGAGATTGTTGTGC

Downstream 100 bases:

>100_bases
GGTTGGCGTCACTAAGTGACTCACGGGTGGTGACATGAAGGCAACTGGATGTAGTTGCCTTCATGTTGCTCTGGGATTGA
GCCTATACCTGTTGGAGAAC

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 670; Mature: 670

Protein sequence:

>670_residues
MNNPMITTIDQLCANAIRALAIDAVQQANSGHPGMPLGMADAAYVLWTRFLKHNPSDPHWPNRDRFVLSAGHGSMLLYAL
LHLTGYDVSLDDLKQFRQWGSRTPGHPEYHETPGVEMTTGPLGQGIATAVGMAIAERWLATRFNRVGFPVVDHYTYVIAS
DGDLMEGISHEAASLAGHLRLGKLIVLYDSNDISLVGPTRLAWSEQVADRFAAYGWQVLYADGHNMSSVALALAEAIVDG
ERPSLIITRTVIGYASPRAGSHKAHGEPLGVEGVKLTKEALGWPQEPAFYVPDEVYEHMQMAVEVGETRQREWEAMFRRY
RASYPDLAAQWDLMQQGGLPTGWEQAIPTFAPDPKAKGTRVASGAVLQALAPIIPGLLGGSADLHTSDFTYLEGLGSING
EDFSARNLHFGVREHAMGAILNGMALHGGIIPYGGTFLVFSDYMRPAIRLAALMRLRVIYVFTHDSIGVGEDGPTHQPVE
HLLALRAIPNLLVVRPGDANEVAMAWRLALQRSDGPTAIILSRQNVPTLDRTQLGAADGTLRGGYVLRDADAAQALIIAT
GSEVALALAAADHLAGEGIATRVVSMPCRELFDQQDAAYRDRVLPPQIRARVAVEAGRSIGWERYVGCAGAIIGVDRFGA
SAPFQRIYTEFGLTVERVVAAVKDQLVRHE

Sequences:

>Translated_670_residues
MNNPMITTIDQLCANAIRALAIDAVQQANSGHPGMPLGMADAAYVLWTRFLKHNPSDPHWPNRDRFVLSAGHGSMLLYAL
LHLTGYDVSLDDLKQFRQWGSRTPGHPEYHETPGVEMTTGPLGQGIATAVGMAIAERWLATRFNRVGFPVVDHYTYVIAS
DGDLMEGISHEAASLAGHLRLGKLIVLYDSNDISLVGPTRLAWSEQVADRFAAYGWQVLYADGHNMSSVALALAEAIVDG
ERPSLIITRTVIGYASPRAGSHKAHGEPLGVEGVKLTKEALGWPQEPAFYVPDEVYEHMQMAVEVGETRQREWEAMFRRY
RASYPDLAAQWDLMQQGGLPTGWEQAIPTFAPDPKAKGTRVASGAVLQALAPIIPGLLGGSADLHTSDFTYLEGLGSING
EDFSARNLHFGVREHAMGAILNGMALHGGIIPYGGTFLVFSDYMRPAIRLAALMRLRVIYVFTHDSIGVGEDGPTHQPVE
HLLALRAIPNLLVVRPGDANEVAMAWRLALQRSDGPTAIILSRQNVPTLDRTQLGAADGTLRGGYVLRDADAAQALIIAT
GSEVALALAAADHLAGEGIATRVVSMPCRELFDQQDAAYRDRVLPPQIRARVAVEAGRSIGWERYVGCAGAIIGVDRFGA
SAPFQRIYTEFGLTVERVVAAVKDQLVRHE
>Mature_670_residues
MNNPMITTIDQLCANAIRALAIDAVQQANSGHPGMPLGMADAAYVLWTRFLKHNPSDPHWPNRDRFVLSAGHGSMLLYAL
LHLTGYDVSLDDLKQFRQWGSRTPGHPEYHETPGVEMTTGPLGQGIATAVGMAIAERWLATRFNRVGFPVVDHYTYVIAS
DGDLMEGISHEAASLAGHLRLGKLIVLYDSNDISLVGPTRLAWSEQVADRFAAYGWQVLYADGHNMSSVALALAEAIVDG
ERPSLIITRTVIGYASPRAGSHKAHGEPLGVEGVKLTKEALGWPQEPAFYVPDEVYEHMQMAVEVGETRQREWEAMFRRY
RASYPDLAAQWDLMQQGGLPTGWEQAIPTFAPDPKAKGTRVASGAVLQALAPIIPGLLGGSADLHTSDFTYLEGLGSING
EDFSARNLHFGVREHAMGAILNGMALHGGIIPYGGTFLVFSDYMRPAIRLAALMRLRVIYVFTHDSIGVGEDGPTHQPVE
HLLALRAIPNLLVVRPGDANEVAMAWRLALQRSDGPTAIILSRQNVPTLDRTQLGAADGTLRGGYVLRDADAAQALIIAT
GSEVALALAAADHLAGEGIATRVVSMPCRELFDQQDAAYRDRVLPPQIRARVAVEAGRSIGWERYVGCAGAIIGVDRFGA
SAPFQRIYTEFGLTVERVVAAVKDQLVRHE

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=580, Percent_Identity=26.7241379310345, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI4507521, Length=580, Percent_Identity=26.7241379310345, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI133778974, Length=597, Percent_Identity=25.963149078727, Blast_Score=150, Evalue=3e-36,
Organism=Escherichia coli, GI48994911, Length=660, Percent_Identity=52.5757575757576, Blast_Score=678, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=654, Percent_Identity=53.6697247706422, Blast_Score=666, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=577, Percent_Identity=26.8630849220104, Blast_Score=145, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6325331, Length=662, Percent_Identity=48.1873111782477, Blast_Score=602, Evalue=1e-173,
Organism=Saccharomyces cerevisiae, GI6319593, Length=665, Percent_Identity=44.3609022556391, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI45551847, Length=590, Percent_Identity=26.271186440678, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI45550715, Length=590, Percent_Identity=26.271186440678, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24666278, Length=581, Percent_Identity=26.3339070567986, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24645119, Length=545, Percent_Identity=26.0550458715596, Blast_Score=153, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72703; Mature: 72703

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNPMITTIDQLCANAIRALAIDAVQQANSGHPGMPLGMADAAYVLWTRFLKHNPSDPHW
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
PNRDRFVLSAGHGSMLLYALLHLTGYDVSLDDLKQFRQWGSRTPGHPEYHETPGVEMTTG
CCCCEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEECC
PLGQGIATAVGMAIAERWLATRFNRVGFPVVDHYTYVIASDGDLMEGISHEAASLAGHLR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCEEEEEECCCHHHHHHHHHHHHHHHHEE
LGKLIVLYDSNDISLVGPTRLAWSEQVADRFAAYGWQVLYADGHNMSSVALALAEAIVDG
ECEEEEEECCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCC
ERPSLIITRTVIGYASPRAGSHKAHGEPLGVEGVKLTKEALGWPQEPAFYVPDEVYEHMQ
CCCCEEEEEEEHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCEECCHHHHHHHH
MAVEVGETRQREWEAMFRRYRASYPDLAAQWDLMQQGGLPTGWEQAIPTFAPDPKAKGTR
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCE
VASGAVLQALAPIIPGLLGGSADLHTSDFTYLEGLGSINGEDFSARNLHFGVREHAMGAI
EHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
LNGMALHGGIIPYGGTFLVFSDYMRPAIRLAALMRLRVIYVFTHDSIGVGEDGPTHQPVE
HHCHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCHHHHH
HLLALRAIPNLLVVRPGDANEVAMAWRLALQRSDGPTAIILSRQNVPTLDRTQLGAADGT
HHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHCCCCCCC
LRGGYVLRDADAAQALIIATGSEVALALAAADHLAGEGIATRVVSMPCRELFDQQDAAYR
CCCCEEEEECCCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHH
DRVLPPQIRARVAVEAGRSIGWERYVGCAGAIIGVDRFGASAPFQRIYTEFGLTVERVVA
HCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHEEHHHCCCCCCHHHHHHHHCCHHHHHHH
AVKDQLVRHE
HHHHHHHCCC
>Mature Secondary Structure
MNNPMITTIDQLCANAIRALAIDAVQQANSGHPGMPLGMADAAYVLWTRFLKHNPSDPHW
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
PNRDRFVLSAGHGSMLLYALLHLTGYDVSLDDLKQFRQWGSRTPGHPEYHETPGVEMTTG
CCCCEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEECC
PLGQGIATAVGMAIAERWLATRFNRVGFPVVDHYTYVIASDGDLMEGISHEAASLAGHLR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCEEEEEECCCHHHHHHHHHHHHHHHHEE
LGKLIVLYDSNDISLVGPTRLAWSEQVADRFAAYGWQVLYADGHNMSSVALALAEAIVDG
ECEEEEEECCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCC
ERPSLIITRTVIGYASPRAGSHKAHGEPLGVEGVKLTKEALGWPQEPAFYVPDEVYEHMQ
CCCCEEEEEEEHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCEECCHHHHHHHH
MAVEVGETRQREWEAMFRRYRASYPDLAAQWDLMQQGGLPTGWEQAIPTFAPDPKAKGTR
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCE
VASGAVLQALAPIIPGLLGGSADLHTSDFTYLEGLGSINGEDFSARNLHFGVREHAMGAI
EHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
LNGMALHGGIIPYGGTFLVFSDYMRPAIRLAALMRLRVIYVFTHDSIGVGEDGPTHQPVE
HHCHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCHHHHH
HLLALRAIPNLLVVRPGDANEVAMAWRLALQRSDGPTAIILSRQNVPTLDRTQLGAADGT
HHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHCCCCCCC
LRGGYVLRDADAAQALIIATGSEVALALAAADHLAGEGIATRVVSMPCRELFDQQDAAYR
CCCCEEEEECCCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHH
DRVLPPQIRARVAVEAGRSIGWERYVGCAGAIIGVDRFGASAPFQRIYTEFGLTVERVVA
HCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHEEHHHCCCCCCHHHHHHHHCCHHHHHHH
AVKDQLVRHE
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]