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The map label for this gene is glmU [H]

Identifier: 222525166

GI number: 222525166

Start: 2409648

End: 2410622

Strand: Direct

Name: glmU [H]

Synonym: Chy400_1904

Alternate gene names: 222525166

Gene position: 2409648-2410622 (Clockwise)

Preceding gene: 222525165

Following gene: 222525167

Centisome position: 45.73

GC content: 53.13

Gene sequence:

>975_bases
ATGCGCGTTATGATCCTGACAGCCGGCCTCGGTACTCGCCTGCGCCCACATACCTTTGTGCGTCCCAAGCCATTGGTGAG
TGTTGCCGGAAAGACGGTGTTGGCTCACATTATCGATTATCTGGCCCCCCTTCAGATCGACGAACTGATCTGTGTGGTTG
GTTATCTGGGTAACCAGATCGAAGAGTTTATGCGGGCCAACTACACCTATCCAATGCGCTTCCTTGAACAGAAGGTAATG
CGCGGGCAGGCCGATGCTATTGCTCTCGCCCGCGAGCTGACCGGGCCGCTGCTGGTGGTGTTCGGCGACGGGTTGCTGGA
GTTTGATATTGAACAGCTCAATCAGCATCCCAATTACGGCATTATCTACTGCAAGGAAGTTGACGATCCGCGCCGTTTCG
GTGTTGTGGTGGTCGAACAAGGCCGTATCGTGCGGCTGGTGGAGAAGCCGAGTGAGCCGATTTCCAATCTGGCTGTGGCC
GGTATCTATTATGTACCAGAGGCTGCCCGGCTGATGTCAGCGATCGACTACATTATGCAGAACAACATTCAAACCAAGGG
CGAGTTCTATCTGGCAGATGCTCTTCAGGTAATGATCGACCGCGGTGAGGAATTACGTGCTGAAACGGTGCGAACCTGGT
ACGATTGCGGTACGATAGAGGCATTACTCGATACCAATCGTTATCTGCTCGATCACGGGCACAATCAGGCTGCTGAGTAT
CCCAATGCCGTTATTGTGCCGCCGGTGAATATTGCTCCGACAGCAGTCATCGAACATGCAGTCATTGGCCCGTATGTCTC
GATTGCTGATGGTGCCGTCGTGCGGCATGCGATTGTCCGCGACTCGATTATTAACGCAGGCGCACAAATTCAGTCGGTTA
TTCTCAATCGCAGCCTGATCGGTGACCGTGCTTCCGTTAATGGTGTCAGTCAGGAGTTAAACGTCGGCGATTTATCTGAT
ATTCGTTTCAGGTGA

Upstream 100 bases:

>100_bases
GACGCAGAGCCGCGGTGATGCAGCCGTTGCGGCGACGACGACGACAACTGGTGGCGGGTGCGGTTGCAGTGGCTGTAGTT
GTGGCTCAAGGAGCTAAAGT

Downstream 100 bases:

>100_bases
ACAACTATGATTGCTTACAACTTCCATGCTGCAAGCAATGGCGCTCGCGGCGAGGCCGAGGATGGCCGTTGGGAGTTGGC
TTCGCCTGGTAACAGGCATA

Product: nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MRVMILTAGLGTRLRPHTFVRPKPLVSVAGKTVLAHIIDYLAPLQIDELICVVGYLGNQIEEFMRANYTYPMRFLEQKVM
RGQADAIALARELTGPLLVVFGDGLLEFDIEQLNQHPNYGIIYCKEVDDPRRFGVVVVEQGRIVRLVEKPSEPISNLAVA
GIYYVPEAARLMSAIDYIMQNNIQTKGEFYLADALQVMIDRGEELRAETVRTWYDCGTIEALLDTNRYLLDHGHNQAAEY
PNAVIVPPVNIAPTAVIEHAVIGPYVSIADGAVVRHAIVRDSIINAGAQIQSVILNRSLIGDRASVNGVSQELNVGDLSD
IRFR

Sequences:

>Translated_324_residues
MRVMILTAGLGTRLRPHTFVRPKPLVSVAGKTVLAHIIDYLAPLQIDELICVVGYLGNQIEEFMRANYTYPMRFLEQKVM
RGQADAIALARELTGPLLVVFGDGLLEFDIEQLNQHPNYGIIYCKEVDDPRRFGVVVVEQGRIVRLVEKPSEPISNLAVA
GIYYVPEAARLMSAIDYIMQNNIQTKGEFYLADALQVMIDRGEELRAETVRTWYDCGTIEALLDTNRYLLDHGHNQAAEY
PNAVIVPPVNIAPTAVIEHAVIGPYVSIADGAVVRHAIVRDSIINAGAQIQSVILNRSLIGDRASVNGVSQELNVGDLSD
IRFR
>Mature_324_residues
MRVMILTAGLGTRLRPHTFVRPKPLVSVAGKTVLAHIIDYLAPLQIDELICVVGYLGNQIEEFMRANYTYPMRFLEQKVM
RGQADAIALARELTGPLLVVFGDGLLEFDIEQLNQHPNYGIIYCKEVDDPRRFGVVVVEQGRIVRLVEKPSEPISNLAVA
GIYYVPEAARLMSAIDYIMQNNIQTKGEFYLADALQVMIDRGEELRAETVRTWYDCGTIEALLDTNRYLLDHGHNQAAEY
PNAVIVPPVNIAPTAVIEHAVIGPYVSIADGAVVRHAIVRDSIINAGAQIQSVILNRSLIGDRASVNGVSQELNVGDLSD
IRFR

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=332, Percent_Identity=30.1204819277108, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI11761621, Length=336, Percent_Identity=29.7619047619048, Blast_Score=112, Evalue=4e-25,
Organism=Escherichia coli, GI1790224, Length=245, Percent_Identity=25.3061224489796, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=342, Percent_Identity=29.5321637426901, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17509979, Length=358, Percent_Identity=26.536312849162, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17509981, Length=345, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=336, Percent_Identity=27.3809523809524, Blast_Score=99, Evalue=9e-22,
Organism=Drosophila melanogaster, GI21355443, Length=333, Percent_Identity=29.1291291291291, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24644084, Length=333, Percent_Identity=29.1291291291291, Blast_Score=104, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 35949; Mature: 35949

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVMILTAGLGTRLRPHTFVRPKPLVSVAGKTVLAHIIDYLAPLQIDELICVVGYLGNQI
CEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
EEFMRANYTYPMRFLEQKVMRGQADAIALARELTGPLLVVFGDGLLEFDIEQLNQHPNYG
HHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCHHEEEHHHHCCCCCCC
IIYCKEVDDPRRFGVVVVEQGRIVRLVEKPSEPISNLAVAGIYYVPEAARLMSAIDYIMQ
EEEEECCCCCCCEEEEEEECCCEEEEECCCCCHHHHHHHHHEEECCHHHHHHHHHHHHHH
NNIQTKGEFYLADALQVMIDRGEELRAETVRTWYDCGTIEALLDTNRYLLDHGHNQAAEY
CCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHCCCHHEEECCCCCHHHC
PNAVIVPPVNIAPTAVIEHAVIGPYVSIADGAVVRHAIVRDSIINAGAQIQSVILNRSLI
CCEEEECCCCCCHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
GDRASVNGVSQELNVGDLSDIRFR
CCCCCCCCCHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRVMILTAGLGTRLRPHTFVRPKPLVSVAGKTVLAHIIDYLAPLQIDELICVVGYLGNQI
CEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
EEFMRANYTYPMRFLEQKVMRGQADAIALARELTGPLLVVFGDGLLEFDIEQLNQHPNYG
HHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCHHEEEHHHHCCCCCCC
IIYCKEVDDPRRFGVVVVEQGRIVRLVEKPSEPISNLAVAGIYYVPEAARLMSAIDYIMQ
EEEEECCCCCCCEEEEEEECCCEEEEECCCCCHHHHHHHHHEEECCHHHHHHHHHHHHHH
NNIQTKGEFYLADALQVMIDRGEELRAETVRTWYDCGTIEALLDTNRYLLDHGHNQAAEY
CCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHCCCHHEEECCCCCHHHC
PNAVIVPPVNIAPTAVIEHAVIGPYVSIADGAVVRHAIVRDSIINAGAQIQSVILNRSLI
CCEEEECCCCCCHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
GDRASVNGVSQELNVGDLSDIRFR
CCCCCCCCCHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]