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The map label for this gene is galE [C]

Identifier: 222525035

GI number: 222525035

Start: 2238729

End: 2239742

Strand: Direct

Name: galE [C]

Synonym: Chy400_1771

Alternate gene names: 222525035

Gene position: 2238729-2239742 (Clockwise)

Preceding gene: 222525034

Following gene: 222525036

Centisome position: 42.49

GC content: 56.41

Gene sequence:

>1014_bases
ATGACCGCAAAACGTATTTTGGTAACCGGAGGCGCGGGATTTATCGGTAGCGAACTGGTAACTCAACTGGCTGCTGCCGG
ACATCGGGTTGTCGTCGTTGACAATTTAGTCAATGGCAAGCGGGCGAATCTGGCCCATCTCGCCGATGCCGATGTAGAGC
TGGTCGAGGTTGATATTCGTCAGCGCGAGGTGATTGCTCGCTTAGTGCAGGGCGTGGAGATTGTCTACCACCTGGCTTGC
CTGGGTGTTCGCCATAGCCTGCACGATCCGTTTGAGAATCACGATGTCAATGCGACTGGTACCCTGATCTTGCTCGATCT
GGCCCGCCGTGCCGATGTCCCGCGCTTCGTCTATGTGTCAAGTTCGGAAGTGTACGGCACTGCCCGCTGGGTGCCCATGA
CGGAAGAGCATCCAACCTATCCGATGACGGTGTACGGTGGCGGAAAGCTGGCCGGTGAATGTTATACGCGCGCCTTCTGG
GAGAGCTATCGCTATCCGACGGTCGTGGTCAGACCCTTCAACAGCTTTGGGCCACGCAGTCATCACGAAGGCGACAGCGG
TGAAGTCATTCCCAAATTTATGTTGCGGGCAATGGCCGGTCTGCCAATGGTGATCTTTGGTGATGGGACGCAAACCCGCG
ATTTTACCTATGTCAGCGATACCGCTCGTGGCATCATGCTGGCCGGTATGGTCGATGCTGCCATCGGCGGAACGTTTAAT
CTGGGGCAGGGACGCGAAATCTCGATCAACGAGCTGGCCCGTACTGTGGCGACGGTTGTTGGCCGGCCTGATGCAGCGAT
TGTCTACGATATCCCACGTCCAGGTGATGTGTTACGCCTCTACGCCGATAGCACGCGCGCCCAACACGTTCTGGGCTTCA
CACCAACTGTTTCACTCCAGGAAGGGCTACAGCGGTTACAGGAATGGTACCTGAGCCGTGGCGTGGCCATTGCCGATCTA
TTGGCTGAAGAGCGCGTACACAACTGGAAAAAAGAGGAGAGTGTCAACCTATGA

Upstream 100 bases:

>100_bases
ATTGCAGGGATGGATGCAGCAGGTTGCTGCCGGTTGCTAGACAGTTATTGCTACACACAAACGATGTATACCAACAGCAA
GCATCTTTAGGGAAAAGACC

Downstream 100 bases:

>100_bases
CGACAACGGCAAAGCGGCATATTCCGCTCACCAAACCGGTGATGGGGCAGGCAGAAGCTGAGGCAGCCCAACGAGTGATT
TTATCGGGATGGATTACCCA

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MTAKRILVTGGAGFIGSELVTQLAAAGHRVVVVDNLVNGKRANLAHLADADVELVEVDIRQREVIARLVQGVEIVYHLAC
LGVRHSLHDPFENHDVNATGTLILLDLARRADVPRFVYVSSSEVYGTARWVPMTEEHPTYPMTVYGGGKLAGECYTRAFW
ESYRYPTVVVRPFNSFGPRSHHEGDSGEVIPKFMLRAMAGLPMVIFGDGTQTRDFTYVSDTARGIMLAGMVDAAIGGTFN
LGQGREISINELARTVATVVGRPDAAIVYDIPRPGDVLRLYADSTRAQHVLGFTPTVSLQEGLQRLQEWYLSRGVAIADL
LAEERVHNWKKEESVNL

Sequences:

>Translated_337_residues
MTAKRILVTGGAGFIGSELVTQLAAAGHRVVVVDNLVNGKRANLAHLADADVELVEVDIRQREVIARLVQGVEIVYHLAC
LGVRHSLHDPFENHDVNATGTLILLDLARRADVPRFVYVSSSEVYGTARWVPMTEEHPTYPMTVYGGGKLAGECYTRAFW
ESYRYPTVVVRPFNSFGPRSHHEGDSGEVIPKFMLRAMAGLPMVIFGDGTQTRDFTYVSDTARGIMLAGMVDAAIGGTFN
LGQGREISINELARTVATVVGRPDAAIVYDIPRPGDVLRLYADSTRAQHVLGFTPTVSLQEGLQRLQEWYLSRGVAIADL
LAEERVHNWKKEESVNL
>Mature_336_residues
TAKRILVTGGAGFIGSELVTQLAAAGHRVVVVDNLVNGKRANLAHLADADVELVEVDIRQREVIARLVQGVEIVYHLACL
GVRHSLHDPFENHDVNATGTLILLDLARRADVPRFVYVSSSEVYGTARWVPMTEEHPTYPMTVYGGGKLAGECYTRAFWE
SYRYPTVVVRPFNSFGPRSHHEGDSGEVIPKFMLRAMAGLPMVIFGDGTQTRDFTYVSDTARGIMLAGMVDAAIGGTFNL
GQGREISINELARTVATVVGRPDAAIVYDIPRPGDVLRLYADSTRAQHVLGFTPTVSLQEGLQRLQEWYLSRGVAIADLL
AEERVHNWKKEESVNL

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=314, Percent_Identity=34.3949044585987, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI7657641, Length=345, Percent_Identity=30.7246376811594, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI56237023, Length=340, Percent_Identity=31.1764705882353, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI56118217, Length=340, Percent_Identity=31.1764705882353, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI189083684, Length=340, Percent_Identity=31.1764705882353, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI239745448, Length=275, Percent_Identity=23.6363636363636, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI193211614, Length=242, Percent_Identity=26.8595041322314, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI8393516, Length=242, Percent_Identity=26.8595041322314, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI310132178, Length=275, Percent_Identity=23.2727272727273, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI310113012, Length=275, Percent_Identity=23.2727272727273, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1786974, Length=330, Percent_Identity=32.4242424242424, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI48994969, Length=337, Percent_Identity=30.2670623145401, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1788353, Length=340, Percent_Identity=31.1764705882353, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790049, Length=320, Percent_Identity=30.3125, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1788365, Length=231, Percent_Identity=30.3030303030303, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788366, Length=352, Percent_Identity=25, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539532, Length=319, Percent_Identity=31.3479623824451, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17568069, Length=340, Percent_Identity=30.2941176470588, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71982035, Length=345, Percent_Identity=29.8550724637681, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71982038, Length=347, Percent_Identity=29.6829971181556, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI115532424, Length=323, Percent_Identity=29.4117647058824, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI133901786, Length=342, Percent_Identity=23.3918128654971, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539424, Length=342, Percent_Identity=23.3918128654971, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI133901788, Length=342, Percent_Identity=23.3918128654971, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539422, Length=342, Percent_Identity=23.3918128654971, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI133901790, Length=342, Percent_Identity=23.3918128654971, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17507723, Length=342, Percent_Identity=22.8070175438596, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=347, Percent_Identity=30.835734870317, Blast_Score=123, Evalue=4e-29,
Organism=Drosophila melanogaster, GI21356223, Length=327, Percent_Identity=34.2507645259939, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI19923002, Length=342, Percent_Identity=31.2865497076023, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 37072; Mature: 36941

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKRILVTGGAGFIGSELVTQLAAAGHRVVVVDNLVNGKRANLAHLADADVELVEVDIR
CCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHCCCCEEEEEECHH
QREVIARLVQGVEIVYHLACLGVRHSLHDPFENHDVNATGTLILLDLARRADVPRFVYVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHHHCCCCEEEEEE
SSEVYGTARWVPMTEEHPTYPMTVYGGGKLAGECYTRAFWESYRYPTVVVRPFNSFGPRS
CCCEEEEEEEEECCCCCCCCCEEEECCCEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
HHEGDSGEVIPKFMLRAMAGLPMVIFGDGTQTRDFTYVSDTARGIMLAGMVDAAIGGTFN
CCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEEECCCCCCEEEHHHHHHHCCCCEE
LGQGREISINELARTVATVVGRPDAAIVYDIPRPGDVLRLYADSTRAQHVLGFTPTVSLQ
CCCCCEECHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCCCCEEECCCCCHHHH
EGLQRLQEWYLSRGVAIADLLAEERVHNWKKEESVNL
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TAKRILVTGGAGFIGSELVTQLAAAGHRVVVVDNLVNGKRANLAHLADADVELVEVDIR
CCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHCCCCEEEEEECHH
QREVIARLVQGVEIVYHLACLGVRHSLHDPFENHDVNATGTLILLDLARRADVPRFVYVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHHHCCCCEEEEEE
SSEVYGTARWVPMTEEHPTYPMTVYGGGKLAGECYTRAFWESYRYPTVVVRPFNSFGPRS
CCCEEEEEEEEECCCCCCCCCEEEECCCEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
HHEGDSGEVIPKFMLRAMAGLPMVIFGDGTQTRDFTYVSDTARGIMLAGMVDAAIGGTFN
CCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEEECCCCCCEEEHHHHHHHCCCCEE
LGQGREISINELARTVATVVGRPDAAIVYDIPRPGDVLRLYADSTRAQHVLGFTPTVSLQ
CCCCCEECHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCCCCEEECCCCCHHHH
EGLQRLQEWYLSRGVAIADLLAEERVHNWKKEESVNL
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]