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The map label for this gene is mre11 [H]

Identifier: 222525032

GI number: 222525032

Start: 2234647

End: 2235873

Strand: Direct

Name: mre11 [H]

Synonym: Chy400_1768

Alternate gene names: 222525032

Gene position: 2234647-2235873 (Clockwise)

Preceding gene: 222525031

Following gene: 222525033

Centisome position: 42.41

GC content: 56.32

Gene sequence:

>1227_bases
ATGATCCGCATGTTGCACCTGGCCGATCTTCATCTTGGGGTTGAAAATTACGGCGCTCTTGACCCACGACGCGGATTGCA
TTCGCGATTGATAGATTATCTCGACCGGCTTGATGAGGCGATTACTATCGGTCTCGATCATCAAATCGATCTTTGTCTGA
TCGCCGGTGACGTGTACAAAAACCGCTCGCCGAATCCAACCGTGCAGCGTGAATTTGCCACCCGGATTCGCCGCCTACGC
GACGCAGGGGTCGCTGTCGTGATCCTAACCGGTAACCACGATATTTCACCGGCGCAGGGTCGTGCGCATTCGGTCGAGAT
CTTTGCTACCCTGGCGTTAGAAGGGGTAACGGTGGCTGATCGACCACGAATGCATCGCATCGAGACGCGCAGCGGGCCGC
TCCAACTGATTGCAGTACCCTGGGTCACGCGCCAGATGTTGTTAACCCGCGACGAGATGGTTGGGGCGTCGTTTACAACC
ATCGAATATGAGATACGTCGTCGGCTTGAACAATTCATCGAACGCTCGGTTGCACAACGTGATCCCACGCTTCCCACTGT
GCTGGCGTTTCATGGTACCGTCGAAGGCGCCCAACTTGGCGCCGAGCGTGCGATGATTCTCGGTCATGATCTGAGTCTTC
CCAGTTCAGTTCTGGCGCAGCCGGGGATTGATTACGTTGCCCTTGGTCATATCCATCGCCATCAGGTGCTGACCAGACAG
CCACCAATGGTGTACCCTGGCAGTATCGAGCGGGTTGATTTTGGTGAACGTGACGAACCGAAGGGGTGTGTTCTGGTCGA
ACTGGCACCGGGGCAGGCAGACTGGCGATTTGTACCGTTAGCGGCGCGCCCCTTTGTCAGTATCGAACGTGATCTGCGAC
GGAGTAGTGATCCGGTGCAGGCACTGCAAACCGCCATCGAGCGCCATAACCTGCGCGATGCCGTGGTGCGGGTAGAGGTT
GAACTGACGCGCGAGCAGGCAGCTCTGTTGCGCGAAGAACAGGTACGCGAGTGGCTGCGGGCAGCAGATGCTGCGGTCAT
TGCAGCAATTGTGTTCAATGTTGAGCGACCGGCCCGGCAACGTTTCGCCGGTGTTGCCGAAGCTCTGGATGAAGGACTAA
CACCACTCAAAGCCTTAGAACTCTACCTCAAAAGTAAACAGGTGCCACCGCAGCGGATTACTCAATTGTTAGCTGCTGCT
CAGGAGTTGATGGATGGTGTTGAGTAG

Upstream 100 bases:

>100_bases
ACGGTAATGCCCTTCAGATACAATTATCTCTGATGCAGTTCGGGCAGATAAGCTCCGTTTATAATCTGCGGTGATGCTTC
GCTGGCAGAACGAGGTGGCT

Downstream 100 bases:

>100_bases
AACCTGTTTTAAACTCTTGAAGTTCCTTGCGTGACTGGCCGGGAAGACAGAAGCCGGTCTACGTGCTGTGTGTGCTTGTC
AGAGTCATGTGGGCGGCTAC

Product: nuclease SbcCD subunit D

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MIRMLHLADLHLGVENYGALDPRRGLHSRLIDYLDRLDEAITIGLDHQIDLCLIAGDVYKNRSPNPTVQREFATRIRRLR
DAGVAVVILTGNHDISPAQGRAHSVEIFATLALEGVTVADRPRMHRIETRSGPLQLIAVPWVTRQMLLTRDEMVGASFTT
IEYEIRRRLEQFIERSVAQRDPTLPTVLAFHGTVEGAQLGAERAMILGHDLSLPSSVLAQPGIDYVALGHIHRHQVLTRQ
PPMVYPGSIERVDFGERDEPKGCVLVELAPGQADWRFVPLAARPFVSIERDLRRSSDPVQALQTAIERHNLRDAVVRVEV
ELTREQAALLREEQVREWLRAADAAVIAAIVFNVERPARQRFAGVAEALDEGLTPLKALELYLKSKQVPPQRITQLLAAA
QELMDGVE

Sequences:

>Translated_408_residues
MIRMLHLADLHLGVENYGALDPRRGLHSRLIDYLDRLDEAITIGLDHQIDLCLIAGDVYKNRSPNPTVQREFATRIRRLR
DAGVAVVILTGNHDISPAQGRAHSVEIFATLALEGVTVADRPRMHRIETRSGPLQLIAVPWVTRQMLLTRDEMVGASFTT
IEYEIRRRLEQFIERSVAQRDPTLPTVLAFHGTVEGAQLGAERAMILGHDLSLPSSVLAQPGIDYVALGHIHRHQVLTRQ
PPMVYPGSIERVDFGERDEPKGCVLVELAPGQADWRFVPLAARPFVSIERDLRRSSDPVQALQTAIERHNLRDAVVRVEV
ELTREQAALLREEQVREWLRAADAAVIAAIVFNVERPARQRFAGVAEALDEGLTPLKALELYLKSKQVPPQRITQLLAAA
QELMDGVE
>Mature_408_residues
MIRMLHLADLHLGVENYGALDPRRGLHSRLIDYLDRLDEAITIGLDHQIDLCLIAGDVYKNRSPNPTVQREFATRIRRLR
DAGVAVVILTGNHDISPAQGRAHSVEIFATLALEGVTVADRPRMHRIETRSGPLQLIAVPWVTRQMLLTRDEMVGASFTT
IEYEIRRRLEQFIERSVAQRDPTLPTVLAFHGTVEGAQLGAERAMILGHDLSLPSSVLAQPGIDYVALGHIHRHQVLTRQ
PPMVYPGSIERVDFGERDEPKGCVLVELAPGQADWRFVPLAARPFVSIERDLRRSSDPVQALQTAIERHNLRDAVVRVEV
ELTREQAALLREEQVREWLRAADAAVIAAIVFNVERPARQRFAGVAEALDEGLTPLKALELYLKSKQVPPQRITQLLAAA
QELMDGVE

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity [H]

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MRE11/RAD32 family [H]

Homologues:

Organism=Escherichia coli, GI1786598, Length=280, Percent_Identity=27.8571428571429, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 45670; Mature: 45670

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRMLHLADLHLGVENYGALDPRRGLHSRLIDYLDRLDEAITIGLDHQIDLCLIAGDVYK
CEEEEEEHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCEEEEEEECHHHC
NRSPNPTVQREFATRIRRLRDAGVAVVILTGNHDISPAQGRAHSVEIFATLALEGVTVAD
CCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEEEEEHHCCCEECC
RPRMHRIETRSGPLQLIAVPWVTRQMLLTRDEMVGASFTTIEYEIRRRLEQFIERSVAQR
CCCCCEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHC
DPTLPTVLAFHGTVEGAQLGAERAMILGHDLSLPSSVLAQPGIDYVALGHIHRHQVLTRQ
CCCCCEEEEECCCCCHHHHCCCCEEEEECCCCCCHHHHHCCCCCEEEECCHHHHHHHHCC
PPMVYPGSIERVDFGERDEPKGCVLVELAPGQADWRFVPLAARPFVSIERDLRRSSDPVQ
CCEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHCCCCHHH
ALQTAIERHNLRDAVVRVEVELTREQAALLREEQVREWLRAADAAVIAAIVFNVERPARQ
HHHHHHHHCCCCHHEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
RFAGVAEALDEGLTPLKALELYLKSKQVPPQRITQLLAAAQELMDGVE
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIRMLHLADLHLGVENYGALDPRRGLHSRLIDYLDRLDEAITIGLDHQIDLCLIAGDVYK
CEEEEEEHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCEEEEEEECHHHC
NRSPNPTVQREFATRIRRLRDAGVAVVILTGNHDISPAQGRAHSVEIFATLALEGVTVAD
CCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEEEEEHHCCCEECC
RPRMHRIETRSGPLQLIAVPWVTRQMLLTRDEMVGASFTTIEYEIRRRLEQFIERSVAQR
CCCCCEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHC
DPTLPTVLAFHGTVEGAQLGAERAMILGHDLSLPSSVLAQPGIDYVALGHIHRHQVLTRQ
CCCCCEEEEECCCCCHHHHCCCCEEEEECCCCCCHHHHHCCCCCEEEECCHHHHHHHHCC
PPMVYPGSIERVDFGERDEPKGCVLVELAPGQADWRFVPLAARPFVSIERDLRRSSDPVQ
CCEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHCCCCHHH
ALQTAIERHNLRDAVVRVEVELTREQAALLREEQVREWLRAADAAVIAAIVFNVERPARQ
HHHHHHHHCCCCHHEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
RFAGVAEALDEGLTPLKALELYLKSKQVPPQRITQLLAAAQELMDGVE
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]