Click here to switch to the map view.

The map label for this gene is degU [H]

Identifier: 222525011

GI number: 222525011

Start: 2206827

End: 2207486

Strand: Direct

Name: degU [H]

Synonym: Chy400_1746

Alternate gene names: 222525011

Gene position: 2206827-2207486 (Clockwise)

Preceding gene: 222525010

Following gene: 222525012

Centisome position: 41.88

GC content: 56.82

Gene sequence:

>660_bases
ATGAGCAATCCAATCACCATCCTTATTGCCGATGATCACACCATGTTTCGGCAAGGATTGCGCGAGATTTTAGAACGCAA
AGGTGGCTTTCAAGTGGTGGCTGAGGTGCGTGACGGGGCAGCCGCCGTTGAAGCGGCCAGCACTACCAAACCTGACATCG
CGCTGCTCGATGTCTCGATGCCGGTCATGACCGGTATCGAGGCAGCACGCCAGATTGCACAGGTCAGCCCGCAAACGCGC
TGTGTTGTGCTCACCATGCACCGCGATGAGCAAACCGTTCTCGAAGCACTCCGTGCCGGAGCCAATGCCTATCTGTTAAA
AGATGCCGACGCCACCGAGTTAATCGAAGCGATTCACGTCGTCTACCGTGGTGAAGCTGCCCTGGCCGGCAGTGCTGCTG
CCCGGGTACTCGATCTGCTGCGTCGTAACGATACCTCACCGGCGCTCAACGAAGTGCTTACCCCCAGAGAACGCGATATT
CTGGCCCTGCTCGCGCAAGGTGACGACAATCGGGCAATTGCGCTCAAGTTGAGTCTGGCCGAAAAGACGGTTGGTAATCG
CTTGAGCGAGATTTTTCAGAAACTCGGCGTGAGTAATCGTACTCAGGCGGCTATCGTCGCAGTTCAGCGTGGTCTGGTAC
CACCCCCAGATCTGCGTTAG

Upstream 100 bases:

>100_bases
CCTACGGTCAATCATCATCGTGCCTATCGTGTCATTCCTGCGACCGGGAAAGAGAGCGAGACCGATCACGCATCACCGAT
GTTCTTCCAATGGAGGATGT

Downstream 100 bases:

>100_bases
CACGCCTTAGCTAGAAAGTCATTTCAACGTTATGCTTCAACTCACAGGCATTCATCACGTCACTGCCATCTCTGCACGCA
TTCAACAGAACTACGATTTT

Product: LuxR family two component transcriptional regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MSNPITILIADDHTMFRQGLREILERKGGFQVVAEVRDGAAAVEAASTTKPDIALLDVSMPVMTGIEAARQIAQVSPQTR
CVVLTMHRDEQTVLEALRAGANAYLLKDADATELIEAIHVVYRGEAALAGSAAARVLDLLRRNDTSPALNEVLTPRERDI
LALLAQGDDNRAIALKLSLAEKTVGNRLSEIFQKLGVSNRTQAAIVAVQRGLVPPPDLR

Sequences:

>Translated_219_residues
MSNPITILIADDHTMFRQGLREILERKGGFQVVAEVRDGAAAVEAASTTKPDIALLDVSMPVMTGIEAARQIAQVSPQTR
CVVLTMHRDEQTVLEALRAGANAYLLKDADATELIEAIHVVYRGEAALAGSAAARVLDLLRRNDTSPALNEVLTPRERDI
LALLAQGDDNRAIALKLSLAEKTVGNRLSEIFQKLGVSNRTQAAIVAVQRGLVPPPDLR
>Mature_218_residues
SNPITILIADDHTMFRQGLREILERKGGFQVVAEVRDGAAAVEAASTTKPDIALLDVSMPVMTGIEAARQIAQVSPQTRC
VVLTMHRDEQTVLEALRAGANAYLLKDADATELIEAIHVVYRGEAALAGSAAARVLDLLRRNDTSPALNEVLTPRERDIL
ALLAQGDDNRAIALKLSLAEKTVGNRLSEIFQKLGVSNRTQAAIVAVQRGLVPPPDLR

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=212, Percent_Identity=34.9056603773585, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1788222, Length=211, Percent_Identity=33.175355450237, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787473, Length=213, Percent_Identity=37.5586854460094, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=33, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1786747, Length=196, Percent_Identity=26.0204081632653, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788546, Length=200, Percent_Identity=27.5, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788712, Length=188, Percent_Identity=26.063829787234, Blast_Score=68, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23605; Mature: 23473

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPITILIADDHTMFRQGLREILERKGGFQVVAEVRDGAAAVEAASTTKPDIALLDVSM
CCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEHHCCHHHHHHCCCCCCCEEEEECCC
PVMTGIEAARQIAQVSPQTRCVVLTMHRDEQTVLEALRAGANAYLLKDADATELIEAIHV
HHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHH
VYRGEAALAGSAAARVLDLLRRNDTSPALNEVLTPRERDILALLAQGDDNRAIALKLSLA
HHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCEEEEEECCCCCCEEEEEEEHH
EKTVGNRLSEIFQKLGVSNRTQAAIVAVQRGLVPPPDLR
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SNPITILIADDHTMFRQGLREILERKGGFQVVAEVRDGAAAVEAASTTKPDIALLDVSM
CCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEHHCCHHHHHHCCCCCCCEEEEECCC
PVMTGIEAARQIAQVSPQTRCVVLTMHRDEQTVLEALRAGANAYLLKDADATELIEAIHV
HHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHH
VYRGEAALAGSAAARVLDLLRRNDTSPALNEVLTPRERDILALLAQGDDNRAIALKLSLA
HHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCEEEEEECCCCCCEEEEEEEHH
EKTVGNRLSEIFQKLGVSNRTQAAIVAVQRGLVPPPDLR
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]