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The map label for this gene is ddn [H]

Identifier: 222524991

GI number: 222524991

Start: 2178785

End: 2179270

Strand: Reverse

Name: ddn [H]

Synonym: Chy400_1726

Alternate gene names: 222524991

Gene position: 2179270-2178785 (Counterclockwise)

Preceding gene: 222524995

Following gene: 222524988

Centisome position: 41.36

GC content: 57.41

Gene sequence:

>486_bases
ATGCGAATCTTTCGCCGTTTTCAATTGATCGTCGCCCGTCTTTCGGCTACCCGCCCCGGTGCCTGGTTTGTCCGCACGTG
TATCCAACCATTTGACCGCTTTCTGCTCCGGATCAGCGGTGGCCGCTTCGGTGTCGTCTCCCTCGTCTACCCTACCCTCA
CCCTGATCACTACCGGTGCGCGTAGTGGTGTGCAACGTCGCACACCACTGCTGTTCTTTCCCGATGGCAATCGAGTAGTG
CTGATCGCCTCGAATTTTGGTCGGCGGCAACATCCGGCCTGGTACTACAACTTGCAGAAGAATCCGGTCGCTCAGGTGAA
CATTTATGGACGCACCTTCACCTGCCGGGCATACGAGGTTTCCGGTATCGAGTATCTGGAGCTGTGGGAGCGGGCAGTCC
GCTATTACCCCGGCTTCGCTGCGTATGCGCAACGGGCCGGGCGTACCATACCGATAGTAGTGCTTGATCTCAATATACCA
GCCTGA

Upstream 100 bases:

>100_bases
CGTGTTAAAGTCATCACAGTGTATCGCAACAGCGGTAACTACGTTGTTCACTTAACGCATACACTGTTATCCTCACCTGA
TCAAAAACCTGTGATATACG

Downstream 100 bases:

>100_bases
TCACCAGCGGGGTTACCAGTCCTTCAACAATAGCCGCAACCAGGACCAGTGGGGTAATCAGCAAGAGCCAGACCTTCGCG
GTCTGGGCTGCTGCCCAAAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MRIFRRFQLIVARLSATRPGAWFVRTCIQPFDRFLLRISGGRFGVVSLVYPTLTLITTGARSGVQRRTPLLFFPDGNRVV
LIASNFGRRQHPAWYYNLQKNPVAQVNIYGRTFTCRAYEVSGIEYLELWERAVRYYPGFAAYAQRAGRTIPIVVLDLNIP
A

Sequences:

>Translated_161_residues
MRIFRRFQLIVARLSATRPGAWFVRTCIQPFDRFLLRISGGRFGVVSLVYPTLTLITTGARSGVQRRTPLLFFPDGNRVV
LIASNFGRRQHPAWYYNLQKNPVAQVNIYGRTFTCRAYEVSGIEYLELWERAVRYYPGFAAYAQRAGRTIPIVVLDLNIP
A
>Mature_161_residues
MRIFRRFQLIVARLSATRPGAWFVRTCIQPFDRFLLRISGGRFGVVSLVYPTLTLITTGARSGVQRRTPLLFFPDGNRVV
LIASNFGRRQHPAWYYNLQKNPVAQVNIYGRTFTCRAYEVSGIEYLELWERAVRYYPGFAAYAQRAGRTIPIVVLDLNIP
A

Specific function: Nitroreductase involved in the bioreductive activation of the antitubercular prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It converts PA-824 into three primary metabolites;

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deazaflavin-dependent nitroreductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012349
- InterPro:   IPR009002
- InterPro:   IPR004378 [H]

Pfam domain/function: PF04075 DUF385 [H]

EC number: NA

Molecular weight: Translated: 18505; Mature: 18505

Theoretical pI: Translated: 11.61; Mature: 11.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIFRRFQLIVARLSATRPGAWFVRTCIQPFDRFLLRISGGRFGVVSLVYPTLTLITTGA
CHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEECCCCEEEHHHHHHHHHEEECCC
RSGVQRRTPLLFFPDGNRVVLIASNFGRRQHPAWYYNLQKNPVAQVNIYGRTFTCRAYEV
CCCCCCCCCEEEECCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEEEECCEEEEEEEEE
SGIEYLELWERAVRYYPGFAAYAQRAGRTIPIVVLDLNIPA
CCCHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEEEEECCCC
>Mature Secondary Structure
MRIFRRFQLIVARLSATRPGAWFVRTCIQPFDRFLLRISGGRFGVVSLVYPTLTLITTGA
CHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEECCCCEEEHHHHHHHHHEEECCC
RSGVQRRTPLLFFPDGNRVVLIASNFGRRQHPAWYYNLQKNPVAQVNIYGRTFTCRAYEV
CCCCCCCCCEEEECCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEEEECCEEEEEEEEE
SGIEYLELWERAVRYYPGFAAYAQRAGRTIPIVVLDLNIPA
CCCHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]