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The map label for this gene is crp [H]

Identifier: 222524968

GI number: 222524968

Start: 2149671

End: 2150345

Strand: Direct

Name: crp [H]

Synonym: Chy400_1703

Alternate gene names: 222524968

Gene position: 2149671-2150345 (Clockwise)

Preceding gene: 222524966

Following gene: 222524971

Centisome position: 40.8

GC content: 58.37

Gene sequence:

>675_bases
TTGGACAACGAACGCATCGCTCAATTGCGCCGGGTGAGTTTTTGCACTCACCTCCCTGATACAGTATTGCAGGCACTGGC
AGCCACGGCCTTCCCACGCTCGTACCCCGCCAGTGCATTGATTGTCCTTGCCGGTGAGCCACCACAGGCAATGTACGCCG
TGGTAGCGGGACGGGTCAAGCTAACCCGCATTGCGCCGAGTGGCCGCGAACAGATCGTGAATGTCATGGGGCCGGGTCAG
CACTTCAATGCGGTACCGATTTTCGATGAAGGGCCTTGCCCGGTGAATGTGGAAGCGATTACTGATGTTGAGGTGCTGGA
ATTCTCCATCACAGCAATGCGGCAACTGGTGCATGAACACCCGGCGCTGGCGATGGCCCTGCTCCGGGAGTTTGCCACTC
GCCTGCGCCACATGGTCAATCTGATCGATAACATTGCGCTACACAGTGTACAAGGCCGTCTGGCGCAGTTGCTACTCAAT
CGGGCAATTGCTTCGGAAAAGGGTGAGTTGATGGCACCGTTGACACAGGCCGAAATGGCTGCCATGATCGGTACCGTGCG
CGAGATGGTGAGTCGGACACTGCACCAGTTTGAGATGCAGGGGATGATCCGTATCGAACGCGGCGCAATCGCGATTTGCG
ACCGCGCCGCGCTGGCTGCCTGTGCTGAGACCTAG

Upstream 100 bases:

>100_bases
TTGTGTTCATAGTATTTCTCCGGTTCATCATCTTCTGCAATCCACTATAATGAGAACGACGGTACGGTTGCAGTGACAAT
CGTCACAGCGCAGGTGGTCA

Downstream 100 bases:

>100_bases
ATTCAGATTAGCCGCTTACACGCTGTAATGCCGCGATTGCCCCCCGACTGATCAGATCACTGTCGTTGACAATCGTGATG
AACCGAAAGCCAAGCGCCGC

Product: Crp/Fnr family transcriptional regulator

Products: NA

Alternate protein names: cAMP receptor protein; cAMP regulatory protein [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MDNERIAQLRRVSFCTHLPDTVLQALAATAFPRSYPASALIVLAGEPPQAMYAVVAGRVKLTRIAPSGREQIVNVMGPGQ
HFNAVPIFDEGPCPVNVEAITDVEVLEFSITAMRQLVHEHPALAMALLREFATRLRHMVNLIDNIALHSVQGRLAQLLLN
RAIASEKGELMAPLTQAEMAAMIGTVREMVSRTLHQFEMQGMIRIERGAIAICDRAALAACAET

Sequences:

>Translated_224_residues
MDNERIAQLRRVSFCTHLPDTVLQALAATAFPRSYPASALIVLAGEPPQAMYAVVAGRVKLTRIAPSGREQIVNVMGPGQ
HFNAVPIFDEGPCPVNVEAITDVEVLEFSITAMRQLVHEHPALAMALLREFATRLRHMVNLIDNIALHSVQGRLAQLLLN
RAIASEKGELMAPLTQAEMAAMIGTVREMVSRTLHQFEMQGMIRIERGAIAICDRAALAACAET
>Mature_224_residues
MDNERIAQLRRVSFCTHLPDTVLQALAATAFPRSYPASALIVLAGEPPQAMYAVVAGRVKLTRIAPSGREQIVNVMGPGQ
HFNAVPIFDEGPCPVNVEAITDVEVLEFSITAMRQLVHEHPALAMALLREFATRLRHMVNLIDNIALHSVQGRLAQLLLN
RAIASEKGELMAPLTQAEMAAMIGTVREMVSRTLHQFEMQGMIRIERGAIAICDRAALAACAET

Specific function: This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of one or more genes involved in the induction of competence [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789756, Length=191, Percent_Identity=29.3193717277487, Blast_Score=84, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR018488
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 24457; Mature: 24457

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNERIAQLRRVSFCTHLPDTVLQALAATAFPRSYPASALIVLAGEPPQAMYAVVAGRVK
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHCCEE
LTRIAPSGREQIVNVMGPGQHFNAVPIFDEGPCPVNVEAITDVEVLEFSITAMRQLVHEH
EEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEHHHHCCHHHHHHHHHHHHHHHHHC
PALAMALLREFATRLRHMVNLIDNIALHSVQGRLAQLLLNRAIASEKGELMAPLTQAEMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHH
AMIGTVREMVSRTLHQFEMQGMIRIERGAIAICDRAALAACAET
HHHHHHHHHHHHHHHHHHHHCCEEEECCCEEHHHHHHHHHHCCC
>Mature Secondary Structure
MDNERIAQLRRVSFCTHLPDTVLQALAATAFPRSYPASALIVLAGEPPQAMYAVVAGRVK
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHCCEE
LTRIAPSGREQIVNVMGPGQHFNAVPIFDEGPCPVNVEAITDVEVLEFSITAMRQLVHEH
EEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEHHHHCCHHHHHHHHHHHHHHHHHC
PALAMALLREFATRLRHMVNLIDNIALHSVQGRLAQLLLNRAIASEKGELMAPLTQAEMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHH
AMIGTVREMVSRTLHQFEMQGMIRIERGAIAICDRAALAACAET
HHHHHHHHHHHHHHHHHHHHCCEEEECCCEEHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1542653; 7542800 [H]