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The map label for this gene is thlA [H]

Identifier: 222524938

GI number: 222524938

Start: 2111723

End: 2112904

Strand: Reverse

Name: thlA [H]

Synonym: Chy400_1673

Alternate gene names: 222524938

Gene position: 2112904-2111723 (Counterclockwise)

Preceding gene: 222524939

Following gene: 222524935

Centisome position: 40.1

GC content: 62.61

Gene sequence:

>1182_bases
ATGGACGATGTCGTCATTGTTGGTGCAGCGCGTACCCCAATCGGGCGCTTCAACAGCGCCTACAGCGGATTGAGTGCCAT
CGATTTAGGTGCAGCCGCCGTGCAAGCGGCTGTCCAACGGGCCGGAATTGAGGCAGACTCCATCGATGAATGCATTATGG
GCTGCGTAGTCACCGCCGGCCTGGGACAATCACCGGCACGCCAGGCAGCTCTGCGTGCGGGCTTGCCGCATACAATTGGC
GGCCTGACCATCAACAAGGTCTGTGGCAGTGGCCTCAAGGCAGTCATGATCGGCACCGCCCTGATCAAAGCCGGCGAAGC
TGATGTCATTGTCGCCGGCGGTATGGAGCACATGAGCGGTGCGCCATACCTGCTTCCCCAGGCCCGCCACGGCTACCGGC
TCGGCCACGGCCAGATCATCGACGCTGTCGTTCACGATGGTCTGTGGTGCGCTTTTGAGCATCATCACATGGGAGTGGCC
GCTGAATGGATTGCGCGCACCTTCAATGTCACTCGCGAACAGCAAGATGCTTACGCATTGCAATCACACCAACGCGCAGT
AGCCGCTCAGGACAGCGGCGCCTTCCAGGCCGAAATTGCACCGGTAACCGTCCCAGGGCCGAAAGGCCAGGTCAATCTGG
TGACGACTGACGAAGGCCCCAGACGCGACACCTCGCTGGCTGCACTGGCAAAGCTCAAACCGGCATTTGTCACCGACGGC
ACCGTCACTGCCGGCAATGCCCCCGGCATTACCGACGGCGCGGCAGCAGTCGTACTAATGCGAGCCAGCCGGGCAGCCCA
ATTGGGGGTGCAACCCTTAGCCCGCATCGGCACAGCCGCCCAGGCCGCCGTCAAGCCGCTTGAACTCTTCACCGCACCGG
CGTTTGCCATCGAACGGCTGATGAAGCGGGCAGGCCGTACCCTCGACGACTACGACCTGTTCGAGATCAACGAAGCCTTT
GCCGCCCAGGTCATTGCGAACCTGCGTGCCCTGGCCCTCGATGCAGACCGGGTCAATGTCCACGGTGGCGCGATTGCTCT
CGGCCATCCGATAGGAGCCAGCGGAGCACGTGTCCTGGTGACACTCATCTCAGCGTTACGCCAGCGCGGCGGCCAGCGCG
GGATTGCCGCACTGTGTCTGGGAGGTGGTGAAGCGGTCGCCCTCGAAGTCGAGGTCGTCTAA

Upstream 100 bases:

>100_bases
GGCTTCTAAGAGACACCTCAAGCTGCCTGTTATGAAACCCGTTATAATAGTCAACATCTTATAGAGTGTCACCAGTCTAA
GCCAAACGAGGAAACAAACT

Downstream 100 bases:

>100_bases
CCAAGGCCCGTCTCTGCCAGCCCTGCCGGTCATAGCGAGAGTGATTCAGCGCAGTGAGTCGTCAGGTGCGACCACCACGC
AATTACCGCATATGGTTGGG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MDDVVIVGAARTPIGRFNSAYSGLSAIDLGAAAVQAAVQRAGIEADSIDECIMGCVVTAGLGQSPARQAALRAGLPHTIG
GLTINKVCGSGLKAVMIGTALIKAGEADVIVAGGMEHMSGAPYLLPQARHGYRLGHGQIIDAVVHDGLWCAFEHHHMGVA
AEWIARTFNVTREQQDAYALQSHQRAVAAQDSGAFQAEIAPVTVPGPKGQVNLVTTDEGPRRDTSLAALAKLKPAFVTDG
TVTAGNAPGITDGAAAVVLMRASRAAQLGVQPLARIGTAAQAAVKPLELFTAPAFAIERLMKRAGRTLDDYDLFEINEAF
AAQVIANLRALALDADRVNVHGGAIALGHPIGASGARVLVTLISALRQRGGQRGIAALCLGGGEAVALEVEVV

Sequences:

>Translated_393_residues
MDDVVIVGAARTPIGRFNSAYSGLSAIDLGAAAVQAAVQRAGIEADSIDECIMGCVVTAGLGQSPARQAALRAGLPHTIG
GLTINKVCGSGLKAVMIGTALIKAGEADVIVAGGMEHMSGAPYLLPQARHGYRLGHGQIIDAVVHDGLWCAFEHHHMGVA
AEWIARTFNVTREQQDAYALQSHQRAVAAQDSGAFQAEIAPVTVPGPKGQVNLVTTDEGPRRDTSLAALAKLKPAFVTDG
TVTAGNAPGITDGAAAVVLMRASRAAQLGVQPLARIGTAAQAAVKPLELFTAPAFAIERLMKRAGRTLDDYDLFEINEAF
AAQVIANLRALALDADRVNVHGGAIALGHPIGASGARVLVTLISALRQRGGQRGIAALCLGGGEAVALEVEVV
>Mature_393_residues
MDDVVIVGAARTPIGRFNSAYSGLSAIDLGAAAVQAAVQRAGIEADSIDECIMGCVVTAGLGQSPARQAALRAGLPHTIG
GLTINKVCGSGLKAVMIGTALIKAGEADVIVAGGMEHMSGAPYLLPQARHGYRLGHGQIIDAVVHDGLWCAFEHHHMGVA
AEWIARTFNVTREQQDAYALQSHQRAVAAQDSGAFQAEIAPVTVPGPKGQVNLVTTDEGPRRDTSLAALAKLKPAFVTDG
TVTAGNAPGITDGAAAVVLMRASRAAQLGVQPLARIGTAAQAAVKPLELFTAPAFAIERLMKRAGRTLDDYDLFEINEAF
AAQVIANLRALALDADRVNVHGGAIALGHPIGASGARVLVTLISALRQRGGQRGIAALCLGGGEAVALEVEVV

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=392, Percent_Identity=46.9387755102041, Blast_Score=345, Evalue=5e-95,
Organism=Homo sapiens, GI4557237, Length=392, Percent_Identity=44.3877551020408, Blast_Score=321, Evalue=8e-88,
Organism=Homo sapiens, GI167614485, Length=393, Percent_Identity=40.2035623409669, Blast_Score=283, Evalue=3e-76,
Organism=Homo sapiens, GI4501853, Length=388, Percent_Identity=37.3711340206186, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=33.4905660377358, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI194353979, Length=383, Percent_Identity=27.9373368146214, Blast_Score=135, Evalue=9e-32,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=51.4066496163683, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=52.5510204081633, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=40.0497512437811, Blast_Score=267, Evalue=9e-73,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=38, Blast_Score=241, Evalue=8e-65,
Organism=Escherichia coli, GI1788683, Length=411, Percent_Identity=32.8467153284672, Blast_Score=185, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI25147385, Length=386, Percent_Identity=39.8963730569948, Blast_Score=285, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=40.4092071611253, Blast_Score=284, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=40.253164556962, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=33.8028169014084, Blast_Score=214, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=33.8422391857506, Blast_Score=191, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=45.3400503778337, Blast_Score=323, Evalue=3e-89,
Organism=Saccharomyces cerevisiae, GI6322031, Length=390, Percent_Identity=34.6153846153846, Blast_Score=213, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=48.5933503836317, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=46.4102564102564, Blast_Score=338, Evalue=4e-93,
Organism=Drosophila melanogaster, GI17648125, Length=392, Percent_Identity=36.9897959183673, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=33.7264150943396, Blast_Score=210, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40391; Mature: 40391

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDVVIVGAARTPIGRFNSAYSGLSAIDLGAAAVQAAVQRAGIEADSIDECIMGCVVTAG
CCCEEEEECCCCCCHHCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCC
LGQSPARQAALRAGLPHTIGGLTINKVCGSGLKAVMIGTALIKAGEADVIVAGGMEHMSG
CCCCHHHHHHHHCCCCCHHCCEEHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCHHHHCC
APYLLPQARHGYRLGHGQIIDAVVHDGLWCAFEHHHMGVAAEWIARTFNVTREQQDAYAL
CCEECCCCCCCEECCCCHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
QSHQRAVAAQDSGAFQAEIAPVTVPGPKGQVNLVTTDEGPRRDTSLAALAKLKPAFVTDG
HHHHHHHHCCCCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCEEECC
TVTAGNAPGITDGAAAVVLMRASRAAQLGVQPLARIGTAAQAAVKPLELFTAPAFAIERL
EEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHCCHHHHHHHH
MKRAGRTLDDYDLFEINEAFAAQVIANLRALALDADRVNVHGGAIALGHPIGASGARVLV
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCEEEECCCEEEECCCCCCCHHHHHH
TLISALRQRGGQRGIAALCLGGGEAVALEVEVV
HHHHHHHHCCCCCCEEEEEECCCCEEEEEEEEC
>Mature Secondary Structure
MDDVVIVGAARTPIGRFNSAYSGLSAIDLGAAAVQAAVQRAGIEADSIDECIMGCVVTAG
CCCEEEEECCCCCCHHCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCC
LGQSPARQAALRAGLPHTIGGLTINKVCGSGLKAVMIGTALIKAGEADVIVAGGMEHMSG
CCCCHHHHHHHHCCCCCHHCCEEHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCHHHHCC
APYLLPQARHGYRLGHGQIIDAVVHDGLWCAFEHHHMGVAAEWIARTFNVTREQQDAYAL
CCEECCCCCCCEECCCCHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
QSHQRAVAAQDSGAFQAEIAPVTVPGPKGQVNLVTTDEGPRRDTSLAALAKLKPAFVTDG
HHHHHHHHCCCCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCEEECC
TVTAGNAPGITDGAAAVVLMRASRAAQLGVQPLARIGTAAQAAVKPLELFTAPAFAIERL
EEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHCCHHHHHHHH
MKRAGRTLDDYDLFEINEAFAAQVIANLRALALDADRVNVHGGAIALGHPIGASGARVLV
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCEEEECCCEEEECCCCCCCHHHHHH
TLISALRQRGGQRGIAALCLGGGEAVALEVEVV
HHHHHHHHCCCCCCEEEEEECCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]