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The map label for this gene is yfhQ [H]

Identifier: 222524837

GI number: 222524837

Start: 1988611

End: 1989561

Strand: Direct

Name: yfhQ [H]

Synonym: Chy400_1564

Alternate gene names: 222524837

Gene position: 1988611-1989561 (Clockwise)

Preceding gene: 222524836

Following gene: 222524838

Centisome position: 37.74

GC content: 54.68

Gene sequence:

>951_bases
ATGATCATTGATCGAAATCTGATGCTAGCGGCTCTTCGTTCTGCACTGCTTGAATGGTTTGCCGGTAACGCGCGCGATCT
GCCATGGCGACGTACTCGCGATCCATACGCGATTATGGTCGCCGAGATCATGCTTCAACAAACACAAGTTGACCGGGTTA
TTCCAAAATATCACGCCTTTTTAGCTACTTTCCCCACCCTGAAAGCACTGGCCTCCGCTCCAACTGCTGAAGTGATCCGG
TTGTGGGCCGGTCTTGGCTATAACCGGCGCGCAGTGAATCTGCAACGGGCAGCGCAGATTATTGTCGAACAATACGGTGG
TAAAGTGCCAGATTCGGTGGCGGTGTTGCGTACATTGCCCGGTATCGGCCCTTACACTGCCGGTGCGATTGCCTGTTTTG
CGTTCGAGCAGGATGTCGTGTTTCTCGATACTAATATTCGCCGCGTTGTACGTCGATTATGTGTCGGTTCTGACCTGCTT
CCGACACCATCCGATGCAGTGCTGCTGGTTCACGCCGAAACCTTATTGCCGGTCGGACAGGGCTGGATGTGGAATCAGGC
TATCATGGAATTGGGTGCCCTGATTTGCACAACGTCCAATCCGGCGTGCTGGCGTTGCCCTCTACGTCAGTATTGTCGGG
CTTACGCCGATGCGATTGTTGCGGATGGCGATCTGGTCAATACAATGATGTCACCAGTACCCCTGAAGCGGGTGGCTGAG
TCACGGTCTGGTGAGACGTTTGTCGGTTCGCGACGCTGGTACCGTGGGCGTATTATTGCCGTGCTCCGCGACTTGCCGGT
GGGAGATGTATTGCCGTTAGCCGAATTGGGTCAACGCTTACGCCCGGATTTCACTGCCGACCACGAGGACTGGTTACAAG
GGCTGGTGACCGATCTGGCGCGTGATGGATTACTGATTATCACCGATCAGGGAGTGCGTTTGCCAGAGTGA

Upstream 100 bases:

>100_bases
TGTTGAATGTCACGGTTTCGTTGCAATCGATGGCTCAACTGTCACCATTGATTGAAAAGCTTAATCGAATACCCGATGTC
ATTGATGTCTACCGTAAAAC

Downstream 100 bases:

>100_bases
AAGAGGGCATAACAGGAACCATTAACTGAACAACATATACAACGAGGAGTTGCCCCATCAACGTTCCGTTTTCCATCCTT
GCCCGGGCAATTTCGCCATC

Product: HhH-GPD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MIIDRNLMLAALRSALLEWFAGNARDLPWRRTRDPYAIMVAEIMLQQTQVDRVIPKYHAFLATFPTLKALASAPTAEVIR
LWAGLGYNRRAVNLQRAAQIIVEQYGGKVPDSVAVLRTLPGIGPYTAGAIACFAFEQDVVFLDTNIRRVVRRLCVGSDLL
PTPSDAVLLVHAETLLPVGQGWMWNQAIMELGALICTTSNPACWRCPLRQYCRAYADAIVADGDLVNTMMSPVPLKRVAE
SRSGETFVGSRRWYRGRIIAVLRDLPVGDVLPLAELGQRLRPDFTADHEDWLQGLVTDLARDGLLIITDQGVRLPE

Sequences:

>Translated_316_residues
MIIDRNLMLAALRSALLEWFAGNARDLPWRRTRDPYAIMVAEIMLQQTQVDRVIPKYHAFLATFPTLKALASAPTAEVIR
LWAGLGYNRRAVNLQRAAQIIVEQYGGKVPDSVAVLRTLPGIGPYTAGAIACFAFEQDVVFLDTNIRRVVRRLCVGSDLL
PTPSDAVLLVHAETLLPVGQGWMWNQAIMELGALICTTSNPACWRCPLRQYCRAYADAIVADGDLVNTMMSPVPLKRVAE
SRSGETFVGSRRWYRGRIIAVLRDLPVGDVLPLAELGQRLRPDFTADHEDWLQGLVTDLARDGLLIITDQGVRLPE
>Mature_316_residues
MIIDRNLMLAALRSALLEWFAGNARDLPWRRTRDPYAIMVAEIMLQQTQVDRVIPKYHAFLATFPTLKALASAPTAEVIR
LWAGLGYNRRAVNLQRAAQIIVEQYGGKVPDSVAVLRTLPGIGPYTAGAIACFAFEQDVVFLDTNIRRVVRRLCVGSDLL
PTPSDAVLLVHAETLLPVGQGWMWNQAIMELGALICTTSNPACWRCPLRQYCRAYADAIVADGDLVNTMMSPVPLKRVAE
SRSGETFVGSRRWYRGRIIAVLRDLPVGDVLPLAELGQRLRPDFTADHEDWLQGLVTDLARDGLLIITDQGVRLPE

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=234, Percent_Identity=41.8803418803419, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI115298654, Length=234, Percent_Identity=41.8803418803419, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI115298652, Length=234, Percent_Identity=41.8803418803419, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI115298650, Length=234, Percent_Identity=41.8803418803419, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI6912520, Length=234, Percent_Identity=41.8803418803419, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI190358497, Length=234, Percent_Identity=41.8803418803419, Blast_Score=164, Evalue=9e-41,
Organism=Escherichia coli, GI1789331, Length=214, Percent_Identity=40.1869158878505, Blast_Score=158, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17554540, Length=140, Percent_Identity=31.4285714285714, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 35130; Mature: 35130

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIDRNLMLAALRSALLEWFAGNARDLPWRRTRDPYAIMVAEIMLQQTQVDRVIPKYHAF
CEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LATFPTLKALASAPTAEVIRLWAGLGYNRRAVNLQRAAQIIVEQYGGKVPDSVAVLRTLP
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
GIGPYTAGAIACFAFEQDVVFLDTNIRRVVRRLCVGSDLLPTPSDAVLLVHAETLLPVGQ
CCCCHHHHHHHHEEECCCEEEECCCHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHCCCCC
GWMWNQAIMELGALICTTSNPACWRCPLRQYCRAYADAIVADGDLVNTMMSPVPLKRVAE
CCHHHHHHHHHHHEEEECCCCCEEECHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHH
SRSGETFVGSRRWYRGRIIAVLRDLPVGDVLPLAELGQRLRPDFTADHEDWLQGLVTDLA
CCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
RDGLLIITDQGVRLPE
CCCEEEEECCCCCCCC
>Mature Secondary Structure
MIIDRNLMLAALRSALLEWFAGNARDLPWRRTRDPYAIMVAEIMLQQTQVDRVIPKYHAF
CEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LATFPTLKALASAPTAEVIRLWAGLGYNRRAVNLQRAAQIIVEQYGGKVPDSVAVLRTLP
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
GIGPYTAGAIACFAFEQDVVFLDTNIRRVVRRLCVGSDLLPTPSDAVLLVHAETLLPVGQ
CCCCHHHHHHHHEEECCCEEEECCCHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHCCCCC
GWMWNQAIMELGALICTTSNPACWRCPLRQYCRAYADAIVADGDLVNTMMSPVPLKRVAE
CCHHHHHHHHHHHEEEECCCCCEEECHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHH
SRSGETFVGSRRWYRGRIIAVLRDLPVGDVLPLAELGQRLRPDFTADHEDWLQGLVTDLA
CCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
RDGLLIITDQGVRLPE
CCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]