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The map label for this gene is cynR [H]

Identifier: 222524145

GI number: 222524145

Start: 1088021

End: 1088935

Strand: Direct

Name: cynR [H]

Synonym: Chy400_0861

Alternate gene names: 222524145

Gene position: 1088021-1088935 (Clockwise)

Preceding gene: 222524138

Following gene: 222524146

Centisome position: 20.65

GC content: 56.83

Gene sequence:

>915_bases
ATGGAACTTCGGCAATTACGCTACTTTCTGGCGGTAGCCGAGGAAGGACACATTACCCGTGCTGCCGAGAAGCTCTACAT
TTCTCAGCCGGCCCTCTCGCAACAGATCAAACTGCTTGAAGAAGAGATTGGGACGGTTTTGTTCGACCGTATCGGTCGGC
GCATCAGGCTGACAGCGGCGGGTGAGATTCTGGTTGCACACGCCCGGCGGGCATTGCAAGAGCTGAGCGAAGCCCAGGTT
GCCATCGATGAACTCAATGGCCTGCAACGTGGGATGCTCCGGATCGGTGTTGTGCAAACGGTCAACGCCTATCTTATGCC
CGATCTGGTAGCCGCTTTTACCAATGCTTACCCGGCGATTAGCTTGCAGATTGAAGAACTGGCGACCCGCGACATTGAGC
AACGACTCGCCGACGGCGATCTTCAGATCGGGATCGGCTTTGTGCCACCAGAGACGGCAGGTGTTACTGGCGAGGAACTA
TTCAGCGAAGATCTGGTTGTCGTTGTGTCCAGGCAGCATCCCTGGGCTGATCTGCCCCAATTACCGGTACAATCACTTCA
TCAGCAGCCACTTATTTTGCTCTCAACCACGTTCTGCACCCGTCGGCTTTGGGATCGTTGTACGCATATTGCCGGCATTC
AACCACGGGTTCAGATCGAGATGAATACTATCGGTAGTATTCTGGCGGCTGTACGGCAACTCACGCTAGCGACAGTGCTA
CCGGCAATGGTCTTGAGCGGTCAGCCCGACCTGGTTGGCATTCCCCTGGTCGATCCAACGCCACGGCGCACGGTGGGATT
GCTCTTCCGCCACAATGCCTACCGCTGCGCAGCGACACGGGCGTTTGTAGCCATGACCCGCGCAAAACTGAGGGTGTGGG
CCTCAAGGCAGGAGATAGCCCATAGCCCGGGGTGA

Upstream 100 bases:

>100_bases
AGAGTAGCCCTTTTCTGGTTGCAAGCTCAGTCTAAGCGCGCTATGATAATAAGTGAAATACGTTATTCTTATCTCAAGCA
TAAGTTAGACTTATCAAACA

Downstream 100 bases:

>100_bases
CGTGCGGTAGTAGCAAATCTTGACTGACAATGAGCATCGTAGCGAGCCGGAGGCTCGCGCTCCCAGTTTCCAGGGAATGC
CTGGGCAACACAACAACGCC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MELRQLRYFLAVAEEGHITRAAEKLYISQPALSQQIKLLEEEIGTVLFDRIGRRIRLTAAGEILVAHARRALQELSEAQV
AIDELNGLQRGMLRIGVVQTVNAYLMPDLVAAFTNAYPAISLQIEELATRDIEQRLADGDLQIGIGFVPPETAGVTGEEL
FSEDLVVVVSRQHPWADLPQLPVQSLHQQPLILLSTTFCTRRLWDRCTHIAGIQPRVQIEMNTIGSILAAVRQLTLATVL
PAMVLSGQPDLVGIPLVDPTPRRTVGLLFRHNAYRCAATRAFVAMTRAKLRVWASRQEIAHSPG

Sequences:

>Translated_304_residues
MELRQLRYFLAVAEEGHITRAAEKLYISQPALSQQIKLLEEEIGTVLFDRIGRRIRLTAAGEILVAHARRALQELSEAQV
AIDELNGLQRGMLRIGVVQTVNAYLMPDLVAAFTNAYPAISLQIEELATRDIEQRLADGDLQIGIGFVPPETAGVTGEEL
FSEDLVVVVSRQHPWADLPQLPVQSLHQQPLILLSTTFCTRRLWDRCTHIAGIQPRVQIEMNTIGSILAAVRQLTLATVL
PAMVLSGQPDLVGIPLVDPTPRRTVGLLFRHNAYRCAATRAFVAMTRAKLRVWASRQEIAHSPG
>Mature_304_residues
MELRQLRYFLAVAEEGHITRAAEKLYISQPALSQQIKLLEEEIGTVLFDRIGRRIRLTAAGEILVAHARRALQELSEAQV
AIDELNGLQRGMLRIGVVQTVNAYLMPDLVAAFTNAYPAISLQIEELATRDIEQRLADGDLQIGIGFVPPETAGVTGEEL
FSEDLVVVVSRQHPWADLPQLPVQSLHQQPLILLSTTFCTRRLWDRCTHIAGIQPRVQIEMNTIGSILAAVRQLTLATVL
PAMVLSGQPDLVGIPLVDPTPRRTVGLLFRHNAYRCAATRAFVAMTRAKLRVWASRQEIAHSPG

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=289, Percent_Identity=43.598615916955, Blast_Score=228, Evalue=3e-61,
Organism=Escherichia coli, GI1790399, Length=273, Percent_Identity=29.6703296703297, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI145693105, Length=301, Percent_Identity=27.2425249169435, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1787879, Length=203, Percent_Identity=35.4679802955665, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1787530, Length=297, Percent_Identity=26.5993265993266, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1788887, Length=176, Percent_Identity=38.0681818181818, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788297, Length=243, Percent_Identity=30.0411522633745, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI87081904, Length=176, Percent_Identity=34.6590909090909, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1788748, Length=289, Percent_Identity=28.3737024221453, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI2367136, Length=231, Percent_Identity=30.7359307359307, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1787601, Length=298, Percent_Identity=27.1812080536913, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788481, Length=290, Percent_Identity=28.2758620689655, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789204, Length=232, Percent_Identity=28.8793103448276, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787806, Length=290, Percent_Identity=26.2068965517241, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790208, Length=259, Percent_Identity=27.4131274131274, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789173, Length=168, Percent_Identity=31.547619047619, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87082132, Length=183, Percent_Identity=28.9617486338798, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786713, Length=186, Percent_Identity=32.7956989247312, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1790262, Length=225, Percent_Identity=25.7777777777778, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1788296, Length=195, Percent_Identity=27.1794871794872, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786401, Length=120, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789639, Length=122, Percent_Identity=32.7868852459016, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787128, Length=134, Percent_Identity=32.089552238806, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787589, Length=144, Percent_Identity=29.1666666666667, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33697; Mature: 33697

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRQLRYFLAVAEEGHITRAAEKLYISQPALSQQIKLLEEEIGTVLFDRIGRRIRLTAA
CCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GEILVAHARRALQELSEAQVAIDELNGLQRGMLRIGVVQTVNAYLMPDLVAAFTNAYPAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
SLQIEELATRDIEQRLADGDLQIGIGFVPPETAGVTGEELFSEDLVVVVSRQHPWADLPQ
EEEHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHCCCEEEEEECCCCCCCCCC
LPVQSLHQQPLILLSTTFCTRRLWDRCTHIAGIQPRVQIEMNTIGSILAAVRQLTLATVL
CCHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
PAMVLSGQPDLVGIPLVDPTPRRTVGLLFRHNAYRCAATRAFVAMTRAKLRVWASRQEIA
HHHHHCCCCCEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
HSPG
CCCC
>Mature Secondary Structure
MELRQLRYFLAVAEEGHITRAAEKLYISQPALSQQIKLLEEEIGTVLFDRIGRRIRLTAA
CCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GEILVAHARRALQELSEAQVAIDELNGLQRGMLRIGVVQTVNAYLMPDLVAAFTNAYPAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
SLQIEELATRDIEQRLADGDLQIGIGFVPPETAGVTGEELFSEDLVVVVSRQHPWADLPQ
EEEHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHCCCEEEEEECCCCCCCCCC
LPVQSLHQQPLILLSTTFCTRRLWDRCTHIAGIQPRVQIEMNTIGSILAAVRQLTLATVL
CCHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
PAMVLSGQPDLVGIPLVDPTPRRTVGLLFRHNAYRCAATRAFVAMTRAKLRVWASRQEIA
HHHHHCCCCCEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
HSPG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]