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The map label for this gene is degS [H]

Identifier: 222523996

GI number: 222523996

Start: 892202

End: 893602

Strand: Direct

Name: degS [H]

Synonym: Chy400_0711

Alternate gene names: 222523996

Gene position: 892202-893602 (Clockwise)

Preceding gene: 222523995

Following gene: 222523997

Centisome position: 16.93

GC content: 60.03

Gene sequence:

>1401_bases
ATGAAGACGCCACCCTCTGATACGATTGAATTGCTGGTACGCCTGCGCTGGCCGTTCGCGGCAGTGGTGGGGTTGCTGTT
TGCGCTGACCCGCCTGGTGGAAGGGTTGTATTTTGATGCCGCGATGGAGACACCTGCCGGACGAGCGCTTGATCCGATTG
TGTGGGGGCTGCTGGCGTTTGCCGCGATTTGGGGTGTGTTGAGCTGGGCCATCCATCAGGAACGGTTGCGGATCTCGAAT
GAAGCGCGTATGCTGGCCGCCCTGCGCGAGAGTAACGAGCGCCTCGAATTACTCTACGAGATCAATCAGCGGGTCGCGTC
GAGCGCCACGCTTGATGAGGTGCTCGATTATGCGATCACGCTGCCGGCCCGATTGGTGAATGCCGGTGCAGCCACAATTG
TGCTGATGGACGAGCAGGGTCAGCCGTACACGGCCCGCGTGACCGGGATCGACGCTGGAGAGCTGGAACGCGCCCGGACA
GCGTTTCTGTTGCGCTTGATGACGTCACCCCCCGATCAACCGGTGGTGTTGTCACCGCATTTAGGATGCAATTGGGCAGC
GTGCCTGGTGCTCCCATTGGTAGAGCACGATGCCCACCCGATTGGATGGATCGAAGCCTTCCTCAAAGAAGGTCCCGCCA
CATTACGCGAGACCCGTCAGCCGGTACTTCAGCCGTTGCTGGCGACGGTGGCCGGAGAGCTGACGGAGGCGGTGGTGAAT
AGCCGGCGCCGGGATCGGGCGATTGCCAGTATTGCTGCGGTTGAACGGGCAATTAGTGCTGAACGTACCCGCATTGCGCG
TGATCTGCACGATGGTGTTGCCCAGTCGCTGGCGTTTATGCGGATGCGGATTGATCTGTGGGAAGACTGGCTGACCCAGG
AACCAGAACGTTTACGCGAAGAGTTTGCTACGTTCAAAGCCAATCTGCGCCGTCAGATTGAAGAGTTGCGACGGGCAATC
TTTGCCCTGCGGCCGATTGAGATCGGGCAGTTGGGCTTTGCCGGCGCTCTACGCCGCTTCATTAACGAATTCGCCGAGCA
GCAAGACTGGGACGTTTCGATTGACTTCGCCGAACTGCCGCCCGATCTGCCTCCGGTGCTTGAGCTGGCAGCGTTTCGCT
TTGTGCAGGAAGCCCTGAACAACGTTGCCAAGCATGCGCAGGCCCGCCGGGTCTGGATCAAGCTGGGAGTGCGCGACCAG
GGGTTGATCATCCACGTGCGGGATGATGGGGTTGGCTTTAATCCTGGTGAGGAACCACCTGCCGGACATCTCGGCTTACG
GCAGATGCGCGAACGGGCAACTGCACTGGACGGTCAGTGTATGATTATGTCTCGTCCTGGCGACGGGACGGAAGTGCGGG
TCTGGCTGCCATTGCGCTACTCTGTCACCACCGTGAACTGA

Upstream 100 bases:

>100_bases
TGCCCGATGGGGCGCATACCTGGGCAGTGGCTGATCGTCATTTGGAACAGGCGCTGCCGTTGCACTACCGGGCGTTCGAG
CGTGTGATGAAGTCAGACCC

Downstream 100 bases:

>100_bases
ATCCATCTTCTGGCGTATCCACAACCGGGCCGGTGATCGGGTAAGATACCTCTACAAGAGAGTCACCACGCAGGCGTGGT
GTGAGTAGTGTGAGGAGTTA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MKTPPSDTIELLVRLRWPFAAVVGLLFALTRLVEGLYFDAAMETPAGRALDPIVWGLLAFAAIWGVLSWAIHQERLRISN
EARMLAALRESNERLELLYEINQRVASSATLDEVLDYAITLPARLVNAGAATIVLMDEQGQPYTARVTGIDAGELERART
AFLLRLMTSPPDQPVVLSPHLGCNWAACLVLPLVEHDAHPIGWIEAFLKEGPATLRETRQPVLQPLLATVAGELTEAVVN
SRRRDRAIASIAAVERAISAERTRIARDLHDGVAQSLAFMRMRIDLWEDWLTQEPERLREEFATFKANLRRQIEELRRAI
FALRPIEIGQLGFAGALRRFINEFAEQQDWDVSIDFAELPPDLPPVLELAAFRFVQEALNNVAKHAQARRVWIKLGVRDQ
GLIIHVRDDGVGFNPGEEPPAGHLGLRQMRERATALDGQCMIMSRPGDGTEVRVWLPLRYSVTTVN

Sequences:

>Translated_466_residues
MKTPPSDTIELLVRLRWPFAAVVGLLFALTRLVEGLYFDAAMETPAGRALDPIVWGLLAFAAIWGVLSWAIHQERLRISN
EARMLAALRESNERLELLYEINQRVASSATLDEVLDYAITLPARLVNAGAATIVLMDEQGQPYTARVTGIDAGELERART
AFLLRLMTSPPDQPVVLSPHLGCNWAACLVLPLVEHDAHPIGWIEAFLKEGPATLRETRQPVLQPLLATVAGELTEAVVN
SRRRDRAIASIAAVERAISAERTRIARDLHDGVAQSLAFMRMRIDLWEDWLTQEPERLREEFATFKANLRRQIEELRRAI
FALRPIEIGQLGFAGALRRFINEFAEQQDWDVSIDFAELPPDLPPVLELAAFRFVQEALNNVAKHAQARRVWIKLGVRDQ
GLIIHVRDDGVGFNPGEEPPAGHLGLRQMRERATALDGQCMIMSRPGDGTEVRVWLPLRYSVTTVN
>Mature_466_residues
MKTPPSDTIELLVRLRWPFAAVVGLLFALTRLVEGLYFDAAMETPAGRALDPIVWGLLAFAAIWGVLSWAIHQERLRISN
EARMLAALRESNERLELLYEINQRVASSATLDEVLDYAITLPARLVNAGAATIVLMDEQGQPYTARVTGIDAGELERART
AFLLRLMTSPPDQPVVLSPHLGCNWAACLVLPLVEHDAHPIGWIEAFLKEGPATLRETRQPVLQPLLATVAGELTEAVVN
SRRRDRAIASIAAVERAISAERTRIARDLHDGVAQSLAFMRMRIDLWEDWLTQEPERLREEFATFKANLRRQIEELRRAI
FALRPIEIGQLGFAGALRRFINEFAEQQDWDVSIDFAELPPDLPPVLELAAFRFVQEALNNVAKHAQARRVWIKLGVRDQ
GLIIHVRDDGVGFNPGEEPPAGHLGLRQMRERATALDGQCMIMSRPGDGTEVRVWLPLRYSVTTVN

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=398, Percent_Identity=26.8844221105528, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1788812, Length=196, Percent_Identity=29.0816326530612, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87082311, Length=244, Percent_Identity=30.327868852459, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52204; Mature: 52204

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTPPSDTIELLVRLRWPFAAVVGLLFALTRLVEGLYFDAAMETPAGRALDPIVWGLLAF
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
AAIWGVLSWAIHQERLRISNEARMLAALRESNERLELLYEINQRVASSATLDEVLDYAIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LPARLVNAGAATIVLMDEQGQPYTARVTGIDAGELERARTAFLLRLMTSPPDQPVVLSPH
HHHHHHCCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEECCC
LGCNWAACLVLPLVEHDAHPIGWIEAFLKEGPATLRETRQPVLQPLLATVAGELTEAVVN
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRRRDRAIASIAAVERAISAERTRIARDLHDGVAQSLAFMRMRIDLWEDWLTQEPERLRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EFATFKANLRRQIEELRRAIFALRPIEIGQLGFAGALRRFINEFAEQQDWDVSIDFAELP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHHHCC
PDLPPVLELAAFRFVQEALNNVAKHAQARRVWIKLGVRDQGLIIHVRDDGVGFNPGEEPP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEEEECCCCCCCCCCCCC
AGHLGLRQMRERATALDGQCMIMSRPGDGTEVRVWLPLRYSVTTVN
CCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEEEEEEEECC
>Mature Secondary Structure
MKTPPSDTIELLVRLRWPFAAVVGLLFALTRLVEGLYFDAAMETPAGRALDPIVWGLLAF
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
AAIWGVLSWAIHQERLRISNEARMLAALRESNERLELLYEINQRVASSATLDEVLDYAIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LPARLVNAGAATIVLMDEQGQPYTARVTGIDAGELERARTAFLLRLMTSPPDQPVVLSPH
HHHHHHCCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEECCC
LGCNWAACLVLPLVEHDAHPIGWIEAFLKEGPATLRETRQPVLQPLLATVAGELTEAVVN
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRRRDRAIASIAAVERAISAERTRIARDLHDGVAQSLAFMRMRIDLWEDWLTQEPERLRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EFATFKANLRRQIEELRRAIFALRPIEIGQLGFAGALRRFINEFAEQQDWDVSIDFAELP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHHHCC
PDLPPVLELAAFRFVQEALNNVAKHAQARRVWIKLGVRDQGLIIHVRDDGVGFNPGEEPP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEEEECCCCCCCCCCCCC
AGHLGLRQMRERATALDGQCMIMSRPGDGTEVRVWLPLRYSVTTVN
CCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]