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The map label for this gene is lexA [H]

Identifier: 222523803

GI number: 222523803

Start: 610506

End: 611156

Strand: Direct

Name: lexA [H]

Synonym: Chy400_0511

Alternate gene names: 222523803

Gene position: 610506-611156 (Clockwise)

Preceding gene: 222523794

Following gene: 222523808

Centisome position: 11.59

GC content: 53.0

Gene sequence:

>651_bases
ATGAGAAGGCACGAGATGTCTGATCGACAGGCGGAAATCTATCAATACATTGTTCGTTTCATCAAAGAGCGTGGTATTTC
GCCGTCAATCCGCGACATCCAGCGCGATCTGCACATCTCATCGACTTCAGTTGTCTCCTACAATTTAGATGTTCTGGAGA
AGCTCGGCAAGATTGTACGTAACGATAAAATCTCGCGTGGTATCAGTCTGCCGGGGATGGTACCGGCGCTCCTGAGAAAT
GATGTTGGGCGGGTGCCATTGTTAGGTACGATTACTGCCGGTTCACCGCTCCCCGATCCAGAAGAGATCGACATCAATCG
AGCAGAGCAAGTGGTTGTGCCAGCCGATGTTGTTCCCCCAGAGCGATTGAACAATGTGTACGCATTGAAGGTGCGTGGGC
AATCAATGATCGATGCGCTGATCGATGACGGCGACATTGTCCTGCTCCGCCAGCAAGAGACAGCCGAGAATGGGCAGATG
GTGGCGGCCTGGTTGATTGACGAAAATGCGGTAACGCTCAAGAAGTTCTACCTTGAAGATGGCCGTGTCCGCCTGCAACC
GGCCAACTCCACGATGCAACCCATCTATACCTCGCCCGATAATGTTCGTATCCGTGGGCGGGTGATCGGGGTGTTGCGCA
GCCTGATGTAG

Upstream 100 bases:

>100_bases
TACTTGACAAAACAAGTGTTCGTTAGCTATAATTGCTACATAAGTTCTAATTTTTTCGCCGCAGCCCATCAAGGTCGCGG
CCAATGAAAGGAAAGCGGCC

Downstream 100 bases:

>100_bases
GACGCTATATTGTATGCCAGACAAGAAGGTGATGACAGGTATGTTCTTCCTGTCATCACCTCGATTTTTTTGTTCTCCCA
AGCACAATAACTCTGTGGCC

Product: SOS-response transcriptional repressor, LexA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MRRHEMSDRQAEIYQYIVRFIKERGISPSIRDIQRDLHISSTSVVSYNLDVLEKLGKIVRNDKISRGISLPGMVPALLRN
DVGRVPLLGTITAGSPLPDPEEIDINRAEQVVVPADVVPPERLNNVYALKVRGQSMIDALIDDGDIVLLRQQETAENGQM
VAAWLIDENAVTLKKFYLEDGRVRLQPANSTMQPIYTSPDNVRIRGRVIGVLRSLM

Sequences:

>Translated_216_residues
MRRHEMSDRQAEIYQYIVRFIKERGISPSIRDIQRDLHISSTSVVSYNLDVLEKLGKIVRNDKISRGISLPGMVPALLRN
DVGRVPLLGTITAGSPLPDPEEIDINRAEQVVVPADVVPPERLNNVYALKVRGQSMIDALIDDGDIVLLRQQETAENGQM
VAAWLIDENAVTLKKFYLEDGRVRLQPANSTMQPIYTSPDNVRIRGRVIGVLRSLM
>Mature_216_residues
MRRHEMSDRQAEIYQYIVRFIKERGISPSIRDIQRDLHISSTSVVSYNLDVLEKLGKIVRNDKISRGISLPGMVPALLRN
DVGRVPLLGTITAGSPLPDPEEIDINRAEQVVVPADVVPPERLNNVYALKVRGQSMIDALIDDGDIVLLRQQETAENGQM
VAAWLIDENAVTLKKFYLEDGRVRLQPANSTMQPIYTSPDNVRIRGRVIGVLRSLM

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=211, Percent_Identity=30.3317535545024, Blast_Score=78, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 24265; Mature: 24265

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRHEMSDRQAEIYQYIVRFIKERGISPSIRDIQRDLHISSTSVVSYNLDVLEKLGKIVR
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEECHHHHHHHHHHHH
NDKISRGISLPGMVPALLRNDVGRVPLLGTITAGSPLPDPEEIDINRAEQVVVPADVVPP
CCHHHCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCH
ERLNNVYALKVRGQSMIDALIDDGDIVLLRQQETAENGQMVAAWLIDENAVTLKKFYLED
HHHCCEEEEEECCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCCEEEEEEEECC
GRVRLQPANSTMQPIYTSPDNVRIRGRVIGVLRSLM
CEEEEEECCCCCCCEEECCCCEEEHHHHHHHHHHHC
>Mature Secondary Structure
MRRHEMSDRQAEIYQYIVRFIKERGISPSIRDIQRDLHISSTSVVSYNLDVLEKLGKIVR
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEECHHHHHHHHHHHH
NDKISRGISLPGMVPALLRNDVGRVPLLGTITAGSPLPDPEEIDINRAEQVVVPADVVPP
CCHHHCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCH
ERLNNVYALKVRGQSMIDALIDDGDIVLLRQQETAENGQMVAAWLIDENAVTLKKFYLED
HHHCCEEEEEECCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCCEEEEEEEECC
GRVRLQPANSTMQPIYTSPDNVRIRGRVIGVLRSLM
CEEEEEECCCCCCCEEECCCCEEEHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA