Click here to switch to the map view.

The map label for this gene is ctaB

Identifier: 222523332

GI number: 222523332

Start: 34581

End: 36344

Strand: Reverse

Name: ctaB

Synonym: Chy400_0033

Alternate gene names: 222523332

Gene position: 36344-34581 (Counterclockwise)

Preceding gene: 222523333

Following gene: 222523331

Centisome position: 0.69

GC content: 60.09

Gene sequence:

>1764_bases
ATGGCAGCGCGTTCTCTAATGCGAATCTTGCTTGTTGGTTTAGGCTTAACGCTGGCCACAATCATCTCAGGTGCACTGGT
CACTATCTCGGCCAGTGCGACCGTCTGTTCGTCGTGGCCTTTGTGTCTGGAAGAACTGGTACAGAGCCAGAATCCATTGG
TCTGGATATCACTCTTGCACCGACTGTTCGTCGCGCTGGCACTACTGGCTGTGTTCGCCGGTCTGGTAGCTGTCTGGCGG
TCATCGGACACTGCCGGGTTACCGCGCATAACGGCAGGTATAGCTGCCGCATTCTTTCTCTTACAGGCTCTGGCAGGCGC
GTTGCTGGTCTGGGGCGTTCCGGCGATGGTGGCTGATGTATGGCACCTGAGTGGCGCGCTACTGGCGTTCGGGGCGCAAA
GCCTCACCATTGCCCTCATCGCCGTGCCAACGCCGGCCACACCAGAGCGACTGGCCGGGCGAGCGGCACAGATGCAGCGC
CGTCTGCGCAGTCTGGCGTGGTGGTCAGCAGCCGCTGCCGGGGTTGCGGCCCTGGCTATCGGCGCACGCAGTGTCGTTCC
CGGCTTTGGGATGATGACGGCGGTGCCGACAAACAGCGTCAGTGCAGTCGGCTTTGCCGCTTTGCTGTCGGTGTGGATGG
CCCTGGAAGCGCGACGGCGGCTACGACCCGTCGCTGAAACTCCAGCACTGGCGCTGGCGTTGCCGCGCTACAGTCTGTTC
CTGCCGGCGCTGGCCTTACTTGCCCTTCTTGGCGCCTTCATCCCGGTGGCTGGACATCTGATCAGTCTGACCGCCATTGC
GCTCCTCTGGGCCGCTACGATCATCGCTGCCGTGATCCTGCAACGGGTACCATTCTCATTTGCAACCGCTACCGCAGGTG
TGCGTTCGCAGCCGGCCTGGCGAACAGTTGTAGCCGACTATATTAGCCTGACCAAGCCCAAAGTTATTTCGCTGCTCCTG
GTAACCACTCTGACCACCATGTTCATCACCGAAGCCGGGCTACCATCGTGGTGGCTGGTGATCTGGACAATGATCGGTGG
CTATCTGGCTGCCGGCGGTGCGGGGGCGATCAATTGTGCCTTCGACAGCGATATTGACATCAACATGGGGCGCACCAGCC
GGCGTCCGGTACCGAGTGGTCGCATCTCGCGGCGGGCGGCGTTCATCTTTGGTTTGATTTTGAGCGTGCTATCGATCATT
GTGCTCTGGGTCTTCACCACACCGCTGGCGGCCTTCTTCGCCTTGCTGGGCATCATCTACTACGCCTGGTTCTATACGGG
CTGGCTCAAACGATCAACCTGGCAAAACATCATCATTGGTGGTGGGGCCGGCGCCATTCCGCCACTCGTAGGCTGGACGG
CAGTAACCGGTTCGGTTAGCCTGATGGCAGTCGTGCTGTTTGCAATCATTTTCTACTGGACTCCACCCCATTTCTGGGCG
TTAGCCCTGGTGAAGCAGAAGGATTATGCGCGGGCCGGCGTGCCAATGTTACCGGTTGTGGCCGGTGAAGCCGAAACGCG
CTGGCAGATTCTGGTCTACTCGGCAATCATGGTGGCGGTATCATTGTTGCCGGTAGCGATAGGGGCCATGAGCTGGATAT
ATCTCATCGGGGCAGTCGTCCTGGGTCTACGCTTCATGCGCGATGCCTGGGCCGTGTGGCGCGTGGGCGATCAGGCAGCG
ATCTGGGGTCTATACAAATACTCGTTGCTCTACCTGGCGCTCGTATTTGCCGCGATGGTGGCCGACCGCCTGATCATCGG
CTAA

Upstream 100 bases:

>100_bases
TGGTCGGGCAGATTTGGGGTGGACAATTCTCACTGCGCTGGCGACGCTGGCGCTGTTTGGTGCTGCGTATCTGGCTTTGC
CGTAAGAGCGTGAGGAGTGT

Downstream 100 bases:

>100_bases
CCTGGCCCAGTGATGACTTTTGAAAGATAGTACTAGCATTTTCGGCCAACATCGTGTATACTGCACATATTGAAGGAGGC
AGGCGCTTCGGCGACTGTAC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 587; Mature: 586

Protein sequence:

>587_residues
MAARSLMRILLVGLGLTLATIISGALVTISASATVCSSWPLCLEELVQSQNPLVWISLLHRLFVALALLAVFAGLVAVWR
SSDTAGLPRITAGIAAAFFLLQALAGALLVWGVPAMVADVWHLSGALLAFGAQSLTIALIAVPTPATPERLAGRAAQMQR
RLRSLAWWSAAAAGVAALAIGARSVVPGFGMMTAVPTNSVSAVGFAALLSVWMALEARRRLRPVAETPALALALPRYSLF
LPALALLALLGAFIPVAGHLISLTAIALLWAATIIAAVILQRVPFSFATATAGVRSQPAWRTVVADYISLTKPKVISLLL
VTTLTTMFITEAGLPSWWLVIWTMIGGYLAAGGAGAINCAFDSDIDINMGRTSRRPVPSGRISRRAAFIFGLILSVLSII
VLWVFTTPLAAFFALLGIIYYAWFYTGWLKRSTWQNIIIGGGAGAIPPLVGWTAVTGSVSLMAVVLFAIIFYWTPPHFWA
LALVKQKDYARAGVPMLPVVAGEAETRWQILVYSAIMVAVSLLPVAIGAMSWIYLIGAVVLGLRFMRDAWAVWRVGDQAA
IWGLYKYSLLYLALVFAAMVADRLIIG

Sequences:

>Translated_587_residues
MAARSLMRILLVGLGLTLATIISGALVTISASATVCSSWPLCLEELVQSQNPLVWISLLHRLFVALALLAVFAGLVAVWR
SSDTAGLPRITAGIAAAFFLLQALAGALLVWGVPAMVADVWHLSGALLAFGAQSLTIALIAVPTPATPERLAGRAAQMQR
RLRSLAWWSAAAAGVAALAIGARSVVPGFGMMTAVPTNSVSAVGFAALLSVWMALEARRRLRPVAETPALALALPRYSLF
LPALALLALLGAFIPVAGHLISLTAIALLWAATIIAAVILQRVPFSFATATAGVRSQPAWRTVVADYISLTKPKVISLLL
VTTLTTMFITEAGLPSWWLVIWTMIGGYLAAGGAGAINCAFDSDIDINMGRTSRRPVPSGRISRRAAFIFGLILSVLSII
VLWVFTTPLAAFFALLGIIYYAWFYTGWLKRSTWQNIIIGGGAGAIPPLVGWTAVTGSVSLMAVVLFAIIFYWTPPHFWA
LALVKQKDYARAGVPMLPVVAGEAETRWQILVYSAIMVAVSLLPVAIGAMSWIYLIGAVVLGLRFMRDAWAVWRVGDQAA
IWGLYKYSLLYLALVFAAMVADRLIIG
>Mature_586_residues
AARSLMRILLVGLGLTLATIISGALVTISASATVCSSWPLCLEELVQSQNPLVWISLLHRLFVALALLAVFAGLVAVWRS
SDTAGLPRITAGIAAAFFLLQALAGALLVWGVPAMVADVWHLSGALLAFGAQSLTIALIAVPTPATPERLAGRAAQMQRR
LRSLAWWSAAAAGVAALAIGARSVVPGFGMMTAVPTNSVSAVGFAALLSVWMALEARRRLRPVAETPALALALPRYSLFL
PALALLALLGAFIPVAGHLISLTAIALLWAATIIAAVILQRVPFSFATATAGVRSQPAWRTVVADYISLTKPKVISLLLV
TTLTTMFITEAGLPSWWLVIWTMIGGYLAAGGAGAINCAFDSDIDINMGRTSRRPVPSGRISRRAAFIFGLILSVLSIIV
LWVFTTPLAAFFALLGIIYYAWFYTGWLKRSTWQNIIIGGGAGAIPPLVGWTAVTGSVSLMAVVLFAIIFYWTPPHFWAL
ALVKQKDYARAGVPMLPVVAGEAETRWQILVYSAIMVAVSLLPVAIGAMSWIYLIGAVVLGLRFMRDAWAVWRVGDQAAI
WGLYKYSLLYLALVFAAMVADRLIIG

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=241, Percent_Identity=33.6099585062241, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1786631, Length=283, Percent_Identity=29.6819787985866, Blast_Score=126, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71998235, Length=218, Percent_Identity=32.1100917431193, Blast_Score=80, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6325085, Length=227, Percent_Identity=27.7533039647577, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI19921064, Length=270, Percent_Identity=25.9259259259259, Blast_Score=91, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_CHLAA (A9WAQ6)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001633673.1
- GeneID:   5828179
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_0029
- HOGENOM:   HBG656003
- OMA:   PSANERL
- ProtClustDB:   CLSK926546
- HAMAP:   MF_00154
- InterPro:   IPR003780
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF02628 COX15-CtaA; PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 62575; Mature: 62443

Theoretical pI: Translated: 10.98; Mature: 10.98

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1a146f28)-; HASH(0x1e2857ec)-; HASH(0x1e28221c)-; HASH(0x1e2859c0)-; HASH(0x1e2805fc)-; HASH(0x1e277dc4)-; HASH(0x1e287b60)-; HASH(0x1e28462c)-; HASH(0x1e2815f8)-; HASH(0x1e2835ac)-; HASH(0x1e282540)-; HASH(0x1e287adc)-; HASH(0x1e2859b4)-; HASH(0x1e285744)-; HASH(0x1e2803e0)-; HASH(0x1e283534)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARSLMRILLVGLGLTLATIISGALVTISASATVCSSWPLCLEELVQSQNPLVWISLLH
CCHHHHHHHHHHHHHHHHHHHHCCHHEEEECCHHHHCCCHHHHHHHHCCCCCEEHHHHHH
RLFVALALLAVFAGLVAVWRSSDTAGLPRITAGIAAAFFLLQALAGALLVWGVPAMVADV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WHLSGALLAFGAQSLTIALIAVPTPATPERLAGRAAQMQRRLRSLAWWSAAAAGVAALAI
HHHHHHHHHHCCCHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GARSVVPGFGMMTAVPTNSVSAVGFAALLSVWMALEARRRLRPVAETPALALALPRYSLF
HHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LPALALLALLGAFIPVAGHLISLTAIALLWAATIIAAVILQRVPFSFATATAGVRSQPAW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHH
RTVVADYISLTKPKVISLLLVTTLTTMFITEAGLPSWWLVIWTMIGGYLAAGGAGAINCA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEE
FDSDIDINMGRTSRRPVPSGRISRRAAFIFGLILSVLSIIVLWVFTTPLAAFFALLGIIY
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAWFYTGWLKRSTWQNIIIGGGAGAIPPLVGWTAVTGSVSLMAVVLFAIIFYWTPPHFWA
HHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LALVKQKDYARAGVPMLPVVAGEAETRWQILVYSAIMVAVSLLPVAIGAMSWIYLIGAVV
HHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLRFMRDAWAVWRVGDQAAIWGLYKYSLLYLALVFAAMVADRLIIG
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
AARSLMRILLVGLGLTLATIISGALVTISASATVCSSWPLCLEELVQSQNPLVWISLLH
CHHHHHHHHHHHHHHHHHHHHCCHHEEEECCHHHHCCCHHHHHHHHCCCCCEEHHHHHH
RLFVALALLAVFAGLVAVWRSSDTAGLPRITAGIAAAFFLLQALAGALLVWGVPAMVADV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WHLSGALLAFGAQSLTIALIAVPTPATPERLAGRAAQMQRRLRSLAWWSAAAAGVAALAI
HHHHHHHHHHCCCHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GARSVVPGFGMMTAVPTNSVSAVGFAALLSVWMALEARRRLRPVAETPALALALPRYSLF
HHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LPALALLALLGAFIPVAGHLISLTAIALLWAATIIAAVILQRVPFSFATATAGVRSQPAW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHH
RTVVADYISLTKPKVISLLLVTTLTTMFITEAGLPSWWLVIWTMIGGYLAAGGAGAINCA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEE
FDSDIDINMGRTSRRPVPSGRISRRAAFIFGLILSVLSIIVLWVFTTPLAAFFALLGIIY
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAWFYTGWLKRSTWQNIIIGGGAGAIPPLVGWTAVTGSVSLMAVVLFAIIFYWTPPHFWA
HHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LALVKQKDYARAGVPMLPVVAGEAETRWQILVYSAIMVAVSLLPVAIGAMSWIYLIGAVV
HHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLRFMRDAWAVWRVGDQAAIWGLYKYSLLYLALVFAAMVADRLIIG
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA