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The map label for this gene is dnaA

Identifier: 222523303

GI number: 222523303

Start: 294

End: 1733

Strand: Direct

Name: dnaA

Synonym: Chy400_0001

Alternate gene names: 222523303

Gene position: 294-1733 (Clockwise)

Preceding gene: NA

Following gene: 222523304

Centisome position: 0.01

GC content: 54.58

Gene sequence:

>1440_bases
GTGAATCTAACACAAATCTGGAAAGCAACACTATCGGCCCTTCAAACACAGACCTCGCGTCACGATTACGAGGCGCTGTT
GCGACCGGCTACGCTCTTATCTCTCGATAATGGTGCAGCCTTCATTGGAGTTTCCTCACCAGGGCAGAAGGAAGGGCTGG
AGAATCGTTTGCTCATGCCACTGCGTAATGCTCTCGCCCGTGTCGTAGGGTATCCGGTACAGGTGCAGGTGTTGATTGCC
AACCTGAACTCGCGTACTGAGCCTTCACCTTCACTTACCCTGAGCAATGGTTCACGCCTGATGAGTGATCCAGAGCCGGT
CGTTGCCGAGACTCCGGCACCAGCACTTACGCCGGGTAACGGCACCGGCGAGCGTGTGGTTCAGCTCGACCTGGCCAGCG
CCATGCGATCGGGTATGCTGAACCCTCGCTATACATTTTCCAGTTTCATCGTCGGTTCGAGCAACCGACTGGCCCACGCG
GCCTGCCTGGCTGTTGCCGATAATCCCGGTCAGGCGTATAATCCGCTCTTCCTGTACGGCGGTGTAGGATTGGGCAAGAC
CCACCTGCTGCACGCTATCGGCAATCGCGTCCTCGACCGCGATCCGGAAATCAATGTTCTGTATGTGTCGTCAGAAAAAT
TCACAAATGATTTGATTAACGCCATTCGTCGGCAGCAGACTGAAGAGTTTCGGATGCGCTATCGCAACATCGATGTCTTG
CTGATTGACGATATTCAATTTATTGCTGGCAAAGATGCGACCCAGGAAGAGTTTTTTCACACGTTTAATACCCTTCATTC
AGCAGCCAAGCACATTGTGATTAGTTCTGATCGTCCACCGAAGGCCATTTTAACTCTCGAAGAGCGGTTGCGTTCTCGCT
TTGAATGGGGTCTGATTGTTGATGTGCAACCCCCTGATCTGGAAACGCGCACCGCCATTCTCCGCGCCAAAGCGGAGCAG
ATGAGTGTCCATGTGCCCGATGAGGTGATCGACTTTCTGGCCCACAAGATTCAGAGCAATATCCGTGAGCTGGAAGGTAG
CCTCAATCGGGTTGCGGCCTACGCCGAACTTAACCGTGCGCCGATCACCATCGAGACGGCAACCGCTGCCCTGGCCGATT
TGCTCGGCAATCAGCGTCGCCGGCGGATCAGCGCCGAAGCCATTCTCCAGATTGTGAGCGAGCACTACGGGATTGAAGTA
GAGCAACTCCGGGCGCGCAATCGCTCGCGCCACGTAGTTGTGCCACGACAGGTAGCGATGTATCTGCTTCGCGAAGAGAC
GGAAAGCTCGCTGGTCGATATTGGCAATCTCCTCGGTGGGCGTGACCATACTACGGTAATGTACGGTTGCGAAAAGATTG
CCGAAGAGATCAACAGTGATAGCCGTTTACGTAGCGAAGTAATGGCGATCCGCGAACGCATTCAGATGCTGCGCGGGTAG

Upstream 100 bases:

>100_bases
GCACTGCAAACACCAACAATGATGTTGCCCTCCCCGCGTCCCGGCGCGGGTCATTCATTATGTGTGCGAAGGCGAAGCGC
GGCTCGCAAGGAGGCGCAGG

Downstream 100 bases:

>100_bases
AAAAACTGTACCATAAACGAACGCCACCCCGTCAGAGCACTGTTGGACAGTGCTCTGTCTGTTTTATCAGGCTAATATCA
CATCTGTGACTCGATAATGC

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MNLTQIWKATLSALQTQTSRHDYEALLRPATLLSLDNGAAFIGVSSPGQKEGLENRLLMPLRNALARVVGYPVQVQVLIA
NLNSRTEPSPSLTLSNGSRLMSDPEPVVAETPAPALTPGNGTGERVVQLDLASAMRSGMLNPRYTFSSFIVGSSNRLAHA
ACLAVADNPGQAYNPLFLYGGVGLGKTHLLHAIGNRVLDRDPEINVLYVSSEKFTNDLINAIRRQQTEEFRMRYRNIDVL
LIDDIQFIAGKDATQEEFFHTFNTLHSAAKHIVISSDRPPKAILTLEERLRSRFEWGLIVDVQPPDLETRTAILRAKAEQ
MSVHVPDEVIDFLAHKIQSNIRELEGSLNRVAAYAELNRAPITIETATAALADLLGNQRRRRISAEAILQIVSEHYGIEV
EQLRARNRSRHVVVPRQVAMYLLREETESSLVDIGNLLGGRDHTTVMYGCEKIAEEINSDSRLRSEVMAIRERIQMLRG

Sequences:

>Translated_479_residues
MNLTQIWKATLSALQTQTSRHDYEALLRPATLLSLDNGAAFIGVSSPGQKEGLENRLLMPLRNALARVVGYPVQVQVLIA
NLNSRTEPSPSLTLSNGSRLMSDPEPVVAETPAPALTPGNGTGERVVQLDLASAMRSGMLNPRYTFSSFIVGSSNRLAHA
ACLAVADNPGQAYNPLFLYGGVGLGKTHLLHAIGNRVLDRDPEINVLYVSSEKFTNDLINAIRRQQTEEFRMRYRNIDVL
LIDDIQFIAGKDATQEEFFHTFNTLHSAAKHIVISSDRPPKAILTLEERLRSRFEWGLIVDVQPPDLETRTAILRAKAEQ
MSVHVPDEVIDFLAHKIQSNIRELEGSLNRVAAYAELNRAPITIETATAALADLLGNQRRRRISAEAILQIVSEHYGIEV
EQLRARNRSRHVVVPRQVAMYLLREETESSLVDIGNLLGGRDHTTVMYGCEKIAEEINSDSRLRSEVMAIRERIQMLRG
>Mature_479_residues
MNLTQIWKATLSALQTQTSRHDYEALLRPATLLSLDNGAAFIGVSSPGQKEGLENRLLMPLRNALARVVGYPVQVQVLIA
NLNSRTEPSPSLTLSNGSRLMSDPEPVVAETPAPALTPGNGTGERVVQLDLASAMRSGMLNPRYTFSSFIVGSSNRLAHA
ACLAVADNPGQAYNPLFLYGGVGLGKTHLLHAIGNRVLDRDPEINVLYVSSEKFTNDLINAIRRQQTEEFRMRYRNIDVL
LIDDIQFIAGKDATQEEFFHTFNTLHSAAKHIVISSDRPPKAILTLEERLRSRFEWGLIVDVQPPDLETRTAILRAKAEQ
MSVHVPDEVIDFLAHKIQSNIRELEGSLNRVAAYAELNRAPITIETATAALADLLGNQRRRRISAEAILQIVSEHYGIEV
EQLRARNRSRHVVVPRQVAMYLLREETESSLVDIGNLLGGRDHTTVMYGCEKIAEEINSDSRLRSEVMAIRERIQMLRG

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=387, Percent_Identity=46.5116279069767, Blast_Score=340, Evalue=9e-95,
Organism=Escherichia coli, GI226510964, Length=225, Percent_Identity=27.1111111111111, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_CHLAA (A9WAN1)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001633648.1
- ProteinModelPortal:   A9WAN1
- SMR:   A9WAN1
- GeneID:   5825775
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_0001
- HOGENOM:   HBG695666
- OMA:   FNELHAN
- ProtClustDB:   PRK00149
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 53291; Mature: 53291

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLTQIWKATLSALQTQTSRHDYEALLRPATLLSLDNGAAFIGVSSPGQKEGLENRLLMP
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCEEEEEECCCCHHCCCHHHHHHH
LRNALARVVGYPVQVQVLIANLNSRTEPSPSLTLSNGSRLMSDPEPVVAETPAPALTPGN
HHHHHHHHHCCCEEEEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCEECCCCCCCCCCC
GTGERVVQLDLASAMRSGMLNPRYTFSSFIVGSSNRLAHAACLAVADNPGQAYNPLFLYG
CCCCCEEEHHHHHHHHHCCCCCCEEHHHEEECCCCCHHHEEEEEEECCCCCCCCCEEEEC
GVGLGKTHLLHAIGNRVLDRDPEINVLYVSSEKFTNDLINAIRRQQTEEFRMRYRNIDVL
CCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LIDDIQFIAGKDATQEEFFHTFNTLHSAAKHIVISSDRPPKAILTLEERLRSRFEWGLIV
EECCCHHHCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHCCCCEEE
DVQPPDLETRTAILRAKAEQMSVHVPDEVIDFLAHKIQSNIRELEGSLNRVAAYAELNRA
ECCCCCCHHHHHHHHHHHHHCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PITIETATAALADLLGNQRRRRISAEAILQIVSEHYGIEVEQLRARNRSRHVVVPRQVAM
CEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEECHHHHHH
YLLREETESSLVDIGNLLGGRDHTTVMYGCEKIAEEINSDSRLRSEVMAIRERIQMLRG
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLTQIWKATLSALQTQTSRHDYEALLRPATLLSLDNGAAFIGVSSPGQKEGLENRLLMP
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCEEEEEECCCCHHCCCHHHHHHH
LRNALARVVGYPVQVQVLIANLNSRTEPSPSLTLSNGSRLMSDPEPVVAETPAPALTPGN
HHHHHHHHHCCCEEEEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCEECCCCCCCCCCC
GTGERVVQLDLASAMRSGMLNPRYTFSSFIVGSSNRLAHAACLAVADNPGQAYNPLFLYG
CCCCCEEEHHHHHHHHHCCCCCCEEHHHEEECCCCCHHHEEEEEEECCCCCCCCCEEEEC
GVGLGKTHLLHAIGNRVLDRDPEINVLYVSSEKFTNDLINAIRRQQTEEFRMRYRNIDVL
CCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LIDDIQFIAGKDATQEEFFHTFNTLHSAAKHIVISSDRPPKAILTLEERLRSRFEWGLIV
EECCCHHHCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHCCCCEEE
DVQPPDLETRTAILRAKAEQMSVHVPDEVIDFLAHKIQSNIRELEGSLNRVAAYAELNRA
ECCCCCCHHHHHHHHHHHHHCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PITIETATAALADLLGNQRRRRISAEAILQIVSEHYGIEVEQLRARNRSRHVVVPRQVAM
CEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEECHHHHHH
YLLREETESSLVDIGNLLGGRDHTTVMYGCEKIAEEINSDSRLRSEVMAIRERIQMLRG
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA