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The map label for this gene is htrA [H]

Identifier: 222151650

GI number: 222151650

Start: 1519501

End: 1520751

Strand: Direct

Name: htrA [H]

Synonym: MCCL_1403

Alternate gene names: 222151650

Gene position: 1519501-1520751 (Clockwise)

Preceding gene: 222151647

Following gene: 222151654

Centisome position: 72.28

GC content: 39.33

Gene sequence:

>1251_bases
TTGAACTCTGATTTTAATAAGATTATACTTTTTGTATCACAGCAAATGGAGGTAGCTATGGAACAAAATAATGAATATTA
CAATGAAAACTCTCATCTAAAAGCACAACACCCAAAGCAACAAAAAGCCGGTTTCTTAAAGATGGTGCTTGCTGGTGTCG
TTGGATCTGTACTCACGCTTGGTGTGACCGAACTACCAGAGTATTTCTCACACGATGAAACAGAAACAATTTCTCCAGTC
ACAGTTGATAATACGACAACTTCCAAATCAACTTCAAATCTCTCTCAAATGCTAGAACAAGTTTCTCCTGCAATTGTCGG
CGTTATCAATATACAGCAGGCGCCTAGCAGTATCTATGATATCTTGTCCGGTAACCGTTCTACCGATACCACACCTGCAG
GAACGGGTTCAGGTGTGATCTATCAAGTTGACGGGAACAATACATATATTGTTACAAACAACCACGTTGTTGAAGGCGCT
AAAGAATTGAAGGTTAAATTATCTAACGGGAAAACGATAGATGCTGAACTTATGGGCACAGATGCTTTGACCGATATCGC
TGTACTCAAAGTAACAGGTCAGCTAAATATTAAACCCGTTGCCTTTGCCGACTCTTCTAAGATTCGAATTGGAGAACCTG
TCTATGCGATTGGTAATCCGTTAGGTCTTGAACTTGCTGGTACAGTAACAGAAGGAATCGTGAGTTCAAAGGAACGCACA
ATGAAAGTAGAAACTTCAGCCGGTAATGCAAGCGTGAAAGTTATTCAGACGGATGCTGCAATTAATCCCGGGAATTCTGG
TGGTGCTTTAATCAATACAAGTGGACAATTGATTGGTATCAACAGCATGAAGATATCTGCTAATCAAGTGGAAGGAATCG
GCTTTGCCATTCCATCGAATGACACTAAGACGATTATCGAACAGCTTGTTAAGAACGGGAAAGTTGAACGTCCATATATA
GGTCTTGGACTCGTAGGAATTAGCGATGTTCCTGCTGATTATTTGAAAGAACTTAAAATAACACAAACTAAAGGTGTAGT
GGTAGCACAAACTGACAGTGTTTCTCGTACGAAGTTCAATAAAGGCGATGTCATCACTGCTATCAATGGACATAAGGTCG
AAAGTGACAGCGACGTCAGAAATTATATTTATACACATCATAAAGCAGGCGATAATGTGAAATTTACTGTTTACAGAGGA
GACAAAAAAACAGAAGTTACAATGACTTTAAGAAGTACCAATAACAAATAA

Upstream 100 bases:

>100_bases
AGAAGATGATACGAGAAATGAATTGATACATGTGGCACTCCTTTTATATAGAATATTTATATTTTATCATAACCTAATAT
ATTTTGAAGAGTGCATTTGC

Downstream 100 bases:

>100_bases
AAAAATCCGGAAATGTACTGTCCCCTAAAGTTCGATTTATTAGGATTCATGTCATTTCCGAATTTTTTTATTTAGAAGCT
ACGACCAGCGCCACCGCCGT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MNSDFNKIILFVSQQMEVAMEQNNEYYNENSHLKAQHPKQQKAGFLKMVLAGVVGSVLTLGVTELPEYFSHDETETISPV
TVDNTTTSKSTSNLSQMLEQVSPAIVGVINIQQAPSSIYDILSGNRSTDTTPAGTGSGVIYQVDGNNTYIVTNNHVVEGA
KELKVKLSNGKTIDAELMGTDALTDIAVLKVTGQLNIKPVAFADSSKIRIGEPVYAIGNPLGLELAGTVTEGIVSSKERT
MKVETSAGNASVKVIQTDAAINPGNSGGALINTSGQLIGINSMKISANQVEGIGFAIPSNDTKTIIEQLVKNGKVERPYI
GLGLVGISDVPADYLKELKITQTKGVVVAQTDSVSRTKFNKGDVITAINGHKVESDSDVRNYIYTHHKAGDNVKFTVYRG
DKKTEVTMTLRSTNNK

Sequences:

>Translated_416_residues
MNSDFNKIILFVSQQMEVAMEQNNEYYNENSHLKAQHPKQQKAGFLKMVLAGVVGSVLTLGVTELPEYFSHDETETISPV
TVDNTTTSKSTSNLSQMLEQVSPAIVGVINIQQAPSSIYDILSGNRSTDTTPAGTGSGVIYQVDGNNTYIVTNNHVVEGA
KELKVKLSNGKTIDAELMGTDALTDIAVLKVTGQLNIKPVAFADSSKIRIGEPVYAIGNPLGLELAGTVTEGIVSSKERT
MKVETSAGNASVKVIQTDAAINPGNSGGALINTSGQLIGINSMKISANQVEGIGFAIPSNDTKTIIEQLVKNGKVERPYI
GLGLVGISDVPADYLKELKITQTKGVVVAQTDSVSRTKFNKGDVITAINGHKVESDSDVRNYIYTHHKAGDNVKFTVYRG
DKKTEVTMTLRSTNNK
>Mature_416_residues
MNSDFNKIILFVSQQMEVAMEQNNEYYNENSHLKAQHPKQQKAGFLKMVLAGVVGSVLTLGVTELPEYFSHDETETISPV
TVDNTTTSKSTSNLSQMLEQVSPAIVGVINIQQAPSSIYDILSGNRSTDTTPAGTGSGVIYQVDGNNTYIVTNNHVVEGA
KELKVKLSNGKTIDAELMGTDALTDIAVLKVTGQLNIKPVAFADSSKIRIGEPVYAIGNPLGLELAGTVTEGIVSSKERT
MKVETSAGNASVKVIQTDAAINPGNSGGALINTSGQLIGINSMKISANQVEGIGFAIPSNDTKTIIEQLVKNGKVERPYI
GLGLVGISDVPADYLKELKITQTKGVVVAQTDSVSRTKFNKGDVITAINGHKVESDSDVRNYIYTHHKAGDNVKFTVYRG
DKKTEVTMTLRSTNNK

Specific function: May be involved in processing, maturation, or secretion of extracellular enzymes [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=326, Percent_Identity=33.4355828220859, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI22129776, Length=344, Percent_Identity=28.7790697674419, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI24308541, Length=336, Percent_Identity=30.0595238095238, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI7019477, Length=316, Percent_Identity=30.379746835443, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1789629, Length=335, Percent_Identity=36.7164179104478, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1786356, Length=364, Percent_Identity=33.5164835164835, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1789630, Length=377, Percent_Identity=31.5649867374005, Blast_Score=138, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24646839, Length=417, Percent_Identity=29.4964028776978, Blast_Score=135, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 44553; Mature: 44553

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSDFNKIILFVSQQMEVAMEQNNEYYNENSHLKAQHPKQQKAGFLKMVLAGVVGSVLTL
CCCCCCEEEEEEEHHHHHHHHCCCCEECCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHH
GVTELPEYFSHDETETISPVTVDNTTTSKSTSNLSQMLEQVSPAIVGVINIQQAPSSIYD
CHHHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCHHHHH
ILSGNRSTDTTPAGTGSGVIYQVDGNNTYIVTNNHVVEGAKELKVKLSNGKTIDAELMGT
HHCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCEECCCEEEEEEECCCCEEEEEEECC
DALTDIAVLKVTGQLNIKPVAFADSSKIRIGEPVYAIGNPLGLELAGTVTEGIVSSKERT
CHHCEEEEEEEECCEEEEEEEEECCCCEEECCCEEECCCCCCEEEECHHHHHHHCCCCCE
MKVETSAGNASVKVIQTDAAINPGNSGGALINTSGQLIGINSMKISANQVEGIGFAIPSN
EEEEECCCCCEEEEEEECCEECCCCCCCEEEECCCCEEEEEEEEEECCCCCCEEEEECCC
DTKTIIEQLVKNGKVERPYIGLGLVGISDVPADYLKELKITQTKGVVVAQTDSVSRTKFN
CHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHEEEEECCCEEEEECCCCCCCCCC
KGDVITAINGHKVESDSDVRNYIYTHHKAGDNVKFTVYRGDKKTEVTMTLRSTNNK
CCCEEEEECCCEECCCCHHHHHEEEEECCCCCEEEEEEECCCCEEEEEEEECCCCC
>Mature Secondary Structure
MNSDFNKIILFVSQQMEVAMEQNNEYYNENSHLKAQHPKQQKAGFLKMVLAGVVGSVLTL
CCCCCCEEEEEEEHHHHHHHHCCCCEECCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHH
GVTELPEYFSHDETETISPVTVDNTTTSKSTSNLSQMLEQVSPAIVGVINIQQAPSSIYD
CHHHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCHHHHH
ILSGNRSTDTTPAGTGSGVIYQVDGNNTYIVTNNHVVEGAKELKVKLSNGKTIDAELMGT
HHCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCEECCCEEEEEEECCCCEEEEEEECC
DALTDIAVLKVTGQLNIKPVAFADSSKIRIGEPVYAIGNPLGLELAGTVTEGIVSSKERT
CHHCEEEEEEEECCEEEEEEEEECCCCEEECCCEEECCCCCCEEEECHHHHHHHCCCCCE
MKVETSAGNASVKVIQTDAAINPGNSGGALINTSGQLIGINSMKISANQVEGIGFAIPSN
EEEEECCCCCEEEEEEECCEECCCCCCCEEEECCCCEEEEEEEEEECCCCCCEEEEECCC
DTKTIIEQLVKNGKVERPYIGLGLVGISDVPADYLKELKITQTKGVVVAQTDSVSRTKFN
CHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHEEEEECCCEEEEECCCCCCCCCC
KGDVITAINGHKVESDSDVRNYIYTHHKAGDNVKFTVYRGDKKTEVTMTLRSTNNK
CCCEEEEECCCEECCCCHHHHHEEEEECCCCCEEEEEEECCCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 10692364; 11133960; 11555295 [H]