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The map label for this gene is gltT [H]

Identifier: 222151639

GI number: 222151639

Start: 1507704

End: 1509014

Strand: Direct

Name: gltT [H]

Synonym: MCCL_1392

Alternate gene names: 222151639

Gene position: 1507704-1509014 (Clockwise)

Preceding gene: 222151638

Following gene: 222151641

Centisome position: 71.72

GC content: 36.92

Gene sequence:

>1311_bases
ATGAGTTCAGTTACAGAAATTAAAAAACCAAAAAAGAAAAAGTTTATAAGTTTACCGATGCAAATTTTAATTGCATTAAT
ATTAGGCGTTGTCGTCGGCGCTCTACTTAATGGTCAGAAAGAATACGTTAACTACTTTCAGCCATTAGGTGATATCTTCT
TACACCTTATTAAAATGATTGTTGTACCGATCGTATTCTGTTCACTTGTAATTTCCATTGCCGGTACAGGTGACATGAAA
ACTGTCGGCCGTTACGGCTGGAAAACGTTACTGTACTTTGAAATTATTACGACATTAGCAATTGGTTTAGGGATTATATT
TGCAAATGTCTTTAAACCAGGTGCCGGTATCAACAAAGATCTATTACCTAAAGGTGATGTAACGAAGTATACGACAAATG
CAGAAGCTGCTGCAGAGTCCACATATGGTAATCATATGATTGATACAATCGTTAATATTATTCCGACGAACATTATTGAT
TCTATGGCACAGGGTCAATTATTACCGGTTATCTTCTTCTCGGTATTCTTCGGTCTTGGTTTAGCTGCAATTGGTAAAAA
AGGTGATCCAGTACGTGCTTTCTTTGATGGCTTCTTAGATGTTATCTTCTGGATGACGAATCAAATCATGAAATATGCAC
CAATTGGTGTATTTGCATTTATGGCAGTAACAATCATCAATTTAGGGTTAGGTGCATTAATTCCACTTGGAAAGTTAGCA
CTTGTTGTTGCAGGGTCAATGGTATTTTTCATTATCGTCGTGCTCGGTGCTGTTGCAGCAATGTGTAAGATCAATATCTT
TCACCTATTGCGCATATTAAAGGACGAGTTACTGCTTGCATTCTCAACGTCAAGTTCAGAGACTGTATTGCCTGTCATCA
TGGACAAGATGGAGAAATTTGGTGCACCGAAAGAAATTGTGTCTTTTGTTATACCGACAGGTTATACATTCAACCTTGAT
GGTTCAGCATTGTATCAATCTATTGCAGCACTTACAATCGCTCAAATGTATGGTGTTCATTTATCAGTGACCGAACAACT
TGTATTATTATTAACATTGATGCTGACATCTAAAGGTATGGCTGCTGTACCAGGTACATCAATCGTCGTTCTGATTACGA
CTTTAACAGCAATGAATATTCACCCTGAAGGACTAGCATTGATCATTGGTATTGACCGTATCTTAGATATGATGCGTACA
GTTGTCAACGTAGTCGGCAACTCTTTATCAACACTAGTCATTGCAAGATGGGAAAACCGTCTTGATTATGAAAAAAGTCG
TAAGTATTACGAAACATATGTAAATAAATAA

Upstream 100 bases:

>100_bases
TAATGACTACTTAAATTTTCTGACAATTAGTGAATAATTAAATTGACAGACTTATCAATAACAAATAAAATACATTAGTA
CGAAAGAAAAGAGGGATGAT

Downstream 100 bases:

>100_bases
AAATTTAATGTTATTTCGTTTGTCAAAATAAGCTAGACAATTTCTCATCTTCGATGAAACTCATAAATACTTCCAATGGT
GTTTTATAGCCCAGTGATTT

Product: proton/sodium-glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSSVTEIKKPKKKKFISLPMQILIALILGVVVGALLNGQKEYVNYFQPLGDIFLHLIKMIVVPIVFCSLVISIAGTGDMK
TVGRYGWKTLLYFEIITTLAIGLGIIFANVFKPGAGINKDLLPKGDVTKYTTNAEAAAESTYGNHMIDTIVNIIPTNIID
SMAQGQLLPVIFFSVFFGLGLAAIGKKGDPVRAFFDGFLDVIFWMTNQIMKYAPIGVFAFMAVTIINLGLGALIPLGKLA
LVVAGSMVFFIIVVLGAVAAMCKINIFHLLRILKDELLLAFSTSSSETVLPVIMDKMEKFGAPKEIVSFVIPTGYTFNLD
GSALYQSIAALTIAQMYGVHLSVTEQLVLLLTLMLTSKGMAAVPGTSIVVLITTLTAMNIHPEGLALIIGIDRILDMMRT
VVNVVGNSLSTLVIARWENRLDYEKSRKYYETYVNK

Sequences:

>Translated_436_residues
MSSVTEIKKPKKKKFISLPMQILIALILGVVVGALLNGQKEYVNYFQPLGDIFLHLIKMIVVPIVFCSLVISIAGTGDMK
TVGRYGWKTLLYFEIITTLAIGLGIIFANVFKPGAGINKDLLPKGDVTKYTTNAEAAAESTYGNHMIDTIVNIIPTNIID
SMAQGQLLPVIFFSVFFGLGLAAIGKKGDPVRAFFDGFLDVIFWMTNQIMKYAPIGVFAFMAVTIINLGLGALIPLGKLA
LVVAGSMVFFIIVVLGAVAAMCKINIFHLLRILKDELLLAFSTSSSETVLPVIMDKMEKFGAPKEIVSFVIPTGYTFNLD
GSALYQSIAALTIAQMYGVHLSVTEQLVLLLTLMLTSKGMAAVPGTSIVVLITTLTAMNIHPEGLALIIGIDRILDMMRT
VVNVVGNSLSTLVIARWENRLDYEKSRKYYETYVNK
>Mature_435_residues
SSVTEIKKPKKKKFISLPMQILIALILGVVVGALLNGQKEYVNYFQPLGDIFLHLIKMIVVPIVFCSLVISIAGTGDMKT
VGRYGWKTLLYFEIITTLAIGLGIIFANVFKPGAGINKDLLPKGDVTKYTTNAEAAAESTYGNHMIDTIVNIIPTNIIDS
MAQGQLLPVIFFSVFFGLGLAAIGKKGDPVRAFFDGFLDVIFWMTNQIMKYAPIGVFAFMAVTIINLGLGALIPLGKLAL
VVAGSMVFFIIVVLGAVAAMCKINIFHLLRILKDELLLAFSTSSSETVLPVIMDKMEKFGAPKEIVSFVIPTGYTFNLDG
SALYQSIAALTIAQMYGVHLSVTEQLVLLLTLMLTSKGMAAVPGTSIVVLITTLTAMNIHPEGLALIIGIDRILDMMRTV
VNVVGNSLSTLVIARWENRLDYEKSRKYYETYVNK

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=435, Percent_Identity=27.1264367816092, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI4827012, Length=477, Percent_Identity=26.4150943396226, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI21314632, Length=434, Percent_Identity=27.6497695852535, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI40254478, Length=452, Percent_Identity=26.3274336283186, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI5032093, Length=434, Percent_Identity=29.4930875576037, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI66773030, Length=464, Percent_Identity=26.0775862068966, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI194239697, Length=468, Percent_Identity=24.5726495726496, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI223468566, Length=272, Percent_Identity=30.1470588235294, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI223468564, Length=272, Percent_Identity=30.1470588235294, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI262359914, Length=395, Percent_Identity=25.8227848101266, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI301601644, Length=146, Percent_Identity=32.1917808219178, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1790514, Length=432, Percent_Identity=53.0092592592593, Blast_Score=454, Evalue=1e-129,
Organism=Escherichia coli, GI1789947, Length=421, Percent_Identity=41.3301662707838, Blast_Score=324, Evalue=9e-90,
Organism=Escherichia coli, GI1788024, Length=403, Percent_Identity=24.8138957816377, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789473, Length=285, Percent_Identity=25.6140350877193, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71996953, Length=467, Percent_Identity=26.9807280513919, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17537407, Length=425, Percent_Identity=27.7647058823529, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71983106, Length=466, Percent_Identity=24.4635193133047, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71983099, Length=466, Percent_Identity=24.4635193133047, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI193206505, Length=454, Percent_Identity=27.5330396475771, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI193206654, Length=425, Percent_Identity=23.0588235294118, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17541374, Length=402, Percent_Identity=26.865671641791, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24583025, Length=457, Percent_Identity=25.164113785558, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI17137668, Length=457, Percent_Identity=25.164113785558, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24583023, Length=457, Percent_Identity=25.164113785558, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI281360483, Length=484, Percent_Identity=25.6198347107438, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17137666, Length=484, Percent_Identity=25.6198347107438, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281360481, Length=484, Percent_Identity=25.6198347107438, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 47538; Mature: 47407

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVTEIKKPKKKKFISLPMQILIALILGVVVGALLNGQKEYVNYFQPLGDIFLHLIKMI
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
VVPIVFCSLVISIAGTGDMKTVGRYGWKTLLYFEIITTLAIGLGIIFANVFKPGAGINKD
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LLPKGDVTKYTTNAEAAAESTYGNHMIDTIVNIIPTNIIDSMAQGQLLPVIFFSVFFGLG
CCCCCCCCEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LAAIGKKGDPVRAFFDGFLDVIFWMTNQIMKYAPIGVFAFMAVTIINLGLGALIPLGKLA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVVAGSMVFFIIVVLGAVAAMCKINIFHLLRILKDELLLAFSTSSSETVLPVIMDKMEKF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHH
GAPKEIVSFVIPTGYTFNLDGSALYQSIAALTIAQMYGVHLSVTEQLVLLLTLMLTSKGM
CCCHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
AAVPGTSIVVLITTLTAMNIHPEGLALIIGIDRILDMMRTVVNVVGNSLSTLVIARWENR
CCCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LDYEKSRKYYETYVNK
CCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSVTEIKKPKKKKFISLPMQILIALILGVVVGALLNGQKEYVNYFQPLGDIFLHLIKMI
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH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CCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1359385 [H]