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The map label for this gene is aapA [H]

Identifier: 222151610

GI number: 222151610

Start: 1477178

End: 1478587

Strand: Direct

Name: aapA [H]

Synonym: MCCL_1363

Alternate gene names: 222151610

Gene position: 1477178-1478587 (Clockwise)

Preceding gene: 222151598

Following gene: 222151618

Centisome position: 70.26

GC content: 36.81

Gene sequence:

>1410_bases
GTGGATACTCAGTTAAATAACAACAGTAACAACGATTTACAACGCGCGCTCTCAAACAGACATATTCAGCTTATTGCAAT
TGGTGGAGCTATAGGTACTGGACTATTTTTAGGAGCTGGTAAATCTATCAATTTTGCAGGACCTTCAATATTGCTGACAT
ACCTCGTCATAGGATTGTTCTTATTCTTATTTATGCGAGGGCTTGGTGAATTATTATTATCCAATACGAATTATCATTCC
TTTACTGATATTGCAAGAGATTATCTTGGAGATTTCATGGGGTATGTTACAGGTTGGACATATTGGTTCTGCTGGGTTGT
GACTGGGATGGCAGAAGTGACTGCCGTTGCGAAGTACGTTCAGTTTTGGTGGCCGGACTTCCCGACATGGGCATCTTCTT
TAATCTGTATCGTTGTGCTGATGGGGTTGAACTTACTTACAGCAAAGCTCTTTGGAGAACTTGAATTCTGGTTTGCTATC
ATTAAAGTAGTTACAATCATTGCGCTTATACTTGTTGGTGTTATCCTAATTGTAATCGGATTTGAAACGAAGTTTGGACA
TGCATCACTTACTAATCTATGGTCACATAACGGTATTTTTCCGAATGGTATGAATGGTTTTCTGCTAAGTTTCCAGATGG
CAATATTTAGTTTCGTGGGAATTGAGCTTATCGGTGTTACAGCAGGAGAAGCACAAGATCCAGAGAAAACATTACCTCGT
GCAATAAATAGTGTACCTATTCGTATCGTTTTATTTTATATTGGCTCATTAATCATCATCATGAGTGTTACACCATGGGA
TAAAATCGATCCGAACGAAAGTCCATTCGTTAAGTTCTTTGGACTGATTGGTATTGGATTTGCAGCAAGTTTAATCAATT
TTGTTGTTATAACTTCTGCATCATCATCTTGTAACAGTGGTATATTCTCAAACAGCCGTATGCTATTCGGATTAAGTAAA
AACTTCTCAAAAGGAGATAACAGCTTCTTTCAAAGAACGAATAGAGCTGGCGTACCAGCGAATGCAGTTGTGTTCTCAAG
TGTACTGCTGTTAATCTCTGTATTATTGAACTATATTATTCCGAATGCAAATGCGGTATTTACACTCGTAACTACAGTTG
CTACTGTATTCTTTATCGTTGTATGGTCAATTATTATGTTCGCTTATCTGAAGTATTTAAAAACACGACCAGAACTTCAT
GAACATAGTACCTATAAAATGCCTGGTGGCAAAATAGCAGCCTACATTGTACTTGCATTCTTTGCCTTTGTATTCATGCT
CTTATTTATAGCAGAAGATACACGTTTAGGATTATTCGTTTCACCATTATGGTTTATTCTATTAGCAGTTATGTATTATG
TACAGGGTGGATTTAAGAAAGACAACTTCGAAAAACATAATTATAGATAA

Upstream 100 bases:

>100_bases
GCGTGATAAGTTTTAGTTATAACTATATTTTAAAATATAGTTTGAGTTTTTCGATAATTCATAACATAATAGAAAAATAC
TAAGGAAAGAAGGTAAAAAT

Downstream 100 bases:

>100_bases
AGAAATTATCAAGGGCATTTAGCTTCAAGTATATTCAAAAAAATTTATAGAAATTAAAAATAAGGATGAGCAAATGCTCA
TCCTTATTTTAGTTTACTTT

Product: D-serine D-alanine glycine transporter

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MDTQLNNNSNNDLQRALSNRHIQLIAIGGAIGTGLFLGAGKSINFAGPSILLTYLVIGLFLFLFMRGLGELLLSNTNYHS
FTDIARDYLGDFMGYVTGWTYWFCWVVTGMAEVTAVAKYVQFWWPDFPTWASSLICIVVLMGLNLLTAKLFGELEFWFAI
IKVVTIIALILVGVILIVIGFETKFGHASLTNLWSHNGIFPNGMNGFLLSFQMAIFSFVGIELIGVTAGEAQDPEKTLPR
AINSVPIRIVLFYIGSLIIIMSVTPWDKIDPNESPFVKFFGLIGIGFAASLINFVVITSASSSCNSGIFSNSRMLFGLSK
NFSKGDNSFFQRTNRAGVPANAVVFSSVLLLISVLLNYIIPNANAVFTLVTTVATVFFIVVWSIIMFAYLKYLKTRPELH
EHSTYKMPGGKIAAYIVLAFFAFVFMLLFIAEDTRLGLFVSPLWFILLAVMYYVQGGFKKDNFEKHNYR

Sequences:

>Translated_469_residues
MDTQLNNNSNNDLQRALSNRHIQLIAIGGAIGTGLFLGAGKSINFAGPSILLTYLVIGLFLFLFMRGLGELLLSNTNYHS
FTDIARDYLGDFMGYVTGWTYWFCWVVTGMAEVTAVAKYVQFWWPDFPTWASSLICIVVLMGLNLLTAKLFGELEFWFAI
IKVVTIIALILVGVILIVIGFETKFGHASLTNLWSHNGIFPNGMNGFLLSFQMAIFSFVGIELIGVTAGEAQDPEKTLPR
AINSVPIRIVLFYIGSLIIIMSVTPWDKIDPNESPFVKFFGLIGIGFAASLINFVVITSASSSCNSGIFSNSRMLFGLSK
NFSKGDNSFFQRTNRAGVPANAVVFSSVLLLISVLLNYIIPNANAVFTLVTTVATVFFIVVWSIIMFAYLKYLKTRPELH
EHSTYKMPGGKIAAYIVLAFFAFVFMLLFIAEDTRLGLFVSPLWFILLAVMYYVQGGFKKDNFEKHNYR
>Mature_469_residues
MDTQLNNNSNNDLQRALSNRHIQLIAIGGAIGTGLFLGAGKSINFAGPSILLTYLVIGLFLFLFMRGLGELLLSNTNYHS
FTDIARDYLGDFMGYVTGWTYWFCWVVTGMAEVTAVAKYVQFWWPDFPTWASSLICIVVLMGLNLLTAKLFGELEFWFAI
IKVVTIIALILVGVILIVIGFETKFGHASLTNLWSHNGIFPNGMNGFLLSFQMAIFSFVGIELIGVTAGEAQDPEKTLPR
AINSVPIRIVLFYIGSLIIIMSVTPWDKIDPNESPFVKFFGLIGIGFAASLINFVVITSASSSCNSGIFSNSRMLFGLSK
NFSKGDNSFFQRTNRAGVPANAVVFSSVLLLISVLLNYIIPNANAVFTLVTTVATVFFIVVWSIIMFAYLKYLKTRPELH
EHSTYKMPGGKIAAYIVLAFFAFVFMLLFIAEDTRLGLFVSPLWFILLAVMYYVQGGFKKDNFEKHNYR

Specific function: Probable amino-acid or metabolite transport protein [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=357, Percent_Identity=22.4089635854342, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1790653, Length=458, Percent_Identity=54.1484716157205, Blast_Score=519, Evalue=1e-148,
Organism=Escherichia coli, GI1786789, Length=442, Percent_Identity=41.4027149321267, Blast_Score=355, Evalue=3e-99,
Organism=Escherichia coli, GI48994972, Length=462, Percent_Identity=40.6926406926407, Blast_Score=354, Evalue=8e-99,
Organism=Escherichia coli, GI1786302, Length=447, Percent_Identity=38.9261744966443, Blast_Score=348, Evalue=6e-97,
Organism=Escherichia coli, GI1786602, Length=444, Percent_Identity=41.8918918918919, Blast_Score=338, Evalue=6e-94,
Organism=Escherichia coli, GI87081915, Length=412, Percent_Identity=36.6504854368932, Blast_Score=291, Evalue=4e-80,
Organism=Escherichia coli, GI87081708, Length=413, Percent_Identity=32.6876513317191, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1789017, Length=470, Percent_Identity=29.7872340425532, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1788480, Length=417, Percent_Identity=33.8129496402878, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI2367353, Length=328, Percent_Identity=25.9146341463415, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17532491, Length=335, Percent_Identity=21.7910447761194, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=453, Percent_Identity=33.112582781457, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6324061, Length=408, Percent_Identity=31.1274509803922, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6324924, Length=431, Percent_Identity=29.0023201856148, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324990, Length=453, Percent_Identity=30.0220750551876, Blast_Score=166, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6322892, Length=480, Percent_Identity=28.5416666666667, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321053, Length=399, Percent_Identity=28.5714285714286, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324059, Length=446, Percent_Identity=29.372197309417, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319608, Length=429, Percent_Identity=25.8741258741259, Blast_Score=140, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6324553, Length=392, Percent_Identity=29.8469387755102, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6321629, Length=426, Percent_Identity=25.8215962441315, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322967, Length=426, Percent_Identity=26.9953051643192, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6319824, Length=409, Percent_Identity=23.960880195599, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6320251, Length=496, Percent_Identity=23.1854838709677, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319542, Length=404, Percent_Identity=23.5148514851485, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6319543, Length=335, Percent_Identity=25.9701492537313, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320717, Length=417, Percent_Identity=22.5419664268585, Blast_Score=116, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6324981, Length=413, Percent_Identity=26.1501210653753, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6320364, Length=483, Percent_Identity=24.4306418219462, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52185; Mature: 52185

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTQLNNNSNNDLQRALSNRHIQLIAIGGAIGTGLFLGAGKSINFAGPSILLTYLVIGLF
CCCCCCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LFLFMRGLGELLLSNTNYHSFTDIARDYLGDFMGYVTGWTYWFCWVVTGMAEVTAVAKYV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFWWPDFPTWASSLICIVVLMGLNLLTAKLFGELEFWFAIIKVVTIIALILVGVILIVIG
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FETKFGHASLTNLWSHNGIFPNGMNGFLLSFQMAIFSFVGIELIGVTAGEAQDPEKTLPR
CCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHH
AINSVPIRIVLFYIGSLIIIMSVTPWDKIDPNESPFVKFFGLIGIGFAASLINFVVITSA
HHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
SSSCNSGIFSNSRMLFGLSKNFSKGDNSFFQRTNRAGVPANAVVFSSVLLLISVLLNYII
CCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHC
PNANAVFTLVTTVATVFFIVVWSIIMFAYLKYLKTRPELHEHSTYKMPGGKIAAYIVLAF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCHHHHHHHHHH
FAFVFMLLFIAEDTRLGLFVSPLWFILLAVMYYVQGGFKKDNFEKHNYR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDTQLNNNSNNDLQRALSNRHIQLIAIGGAIGTGLFLGAGKSINFAGPSILLTYLVIGLF
CCCCCCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LFLFMRGLGELLLSNTNYHSFTDIARDYLGDFMGYVTGWTYWFCWVVTGMAEVTAVAKYV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFWWPDFPTWASSLICIVVLMGLNLLTAKLFGELEFWFAIIKVVTIIALILVGVILIVIG
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FETKFGHASLTNLWSHNGIFPNGMNGFLLSFQMAIFSFVGIELIGVTAGEAQDPEKTLPR
CCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHH
AINSVPIRIVLFYIGSLIIIMSVTPWDKIDPNESPFVKFFGLIGIGFAASLINFVVITSA
HHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
SSSCNSGIFSNSRMLFGLSKNFSKGDNSFFQRTNRAGVPANAVVFSSVLLLISVLLNYII
CCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHC
PNANAVFTLVTTVATVFFIVVWSIIMFAYLKYLKTRPELHEHSTYKMPGGKIAAYIVLAF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCHHHHHHHHHH
FAFVFMLLFIAEDTRLGLFVSPLWFILLAVMYYVQGGFKKDNFEKHNYR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]