Click here to switch to the map view.

The map label for this gene is lysA [H]

Identifier: 222151302

GI number: 222151302

Start: 1163620

End: 1164891

Strand: Direct

Name: lysA [H]

Synonym: MCCL_1055

Alternate gene names: 222151302

Gene position: 1163620-1164891 (Clockwise)

Preceding gene: 222151301

Following gene: 222151304

Centisome position: 55.35

GC content: 36.64

Gene sequence:

>1272_bases
ATGACATTAACATATATTAATAATCAACTTACTATTAACGGCCATAATATTCGACAAATCGCTGAACAATATGGTACACC
ATTATTTATTTACGATGAGGATGAGATACGCAATCAGTGCAGAAGATTTCATCGTGCATTAAAAGCTTCTGGATTAAATT
ATACGATTTCATATGCCTCTAAAGCTTTTACATCTGTGCAATTATTTAATTTGATGCACGAAGAGGATATGGGACTTGAT
GTGGTTAGCGAAGGAGAACTGTATACAGCACTTAAGTCTAAAGTTTCTGCTTCAAAAATGCATTTTCATGGAAACAATAA
AACGGATCGAGAAATTAAATACGCGATCGAGTCAGGTGTTGAGTATTTTGTTATCGATAGTCTTGATGAAATTGAACGCA
TCAATGATATTGCGCATTCATTAGGTCAAACTGTAAAAGCAGTACTGCGCATCAATCCTGGTGTTGAAGCTCACACGCAC
GAATTTATTCAGACCGGCCAGGAAGATAGCAAATTTGGCTTAAGTATCAGACATGGACTCGCAATAGAAGGTGTAAGACA
AATTGAAGCTGCGTCTCACATCGAATTCAAAGGTGTTCATTTCCACATCGGATCACAAATATTTGAGTCTACAGGCACAA
TCAAGACGATTGAACTGGTCATAAACTGGCTTACACAACACAAAATTGACATTGATATTTTAAATATTGGTGGTGGTTTC
AGCATCAAATATACTTCAGAAGATATCAGCTACCCTATCGAAGAAGGCATTAAAAGGATAGCCGAAACACTAAAAAATGA
ATGTAAGAAACATTCCTATCCTGTACCAGAAATATCATTAGAACCTGGGCGTTCAATCGTTGGTGAAGCTGGTATTACAG
TCTATGAGGTTGGTACTGTCAAAGAGATTCCTGATACAAACTGTTATGTATCCATAGACGGTGGTATGAGCGATCATATT
CGCACAGCATTGTATAACGCGAAATATGAATTACTACTTGCAGATCGATATGAAATACACGATAAAGAAGTAACCGTCGC
CGGTAAATTATGCGAATCTGGAGACATTATTATGCGCAATATAATGCTCCCCTCGTCAATTAAACGTGGTGATTTGCTAG
TGGTTAAAGCTACAGGTGCGTACCATTATAGTATGAGCTCTAATTATAATCAGATGTTAAAGCCAGCAGTAGTCTTTGTC
ACTAAAGATAACGTACGAGAAGTAATAAAAAGGCAATCTTTAGAACATCTGATTGCAAACGAAATTTATTAA

Upstream 100 bases:

>100_bases
GATGAGATTCGTATCGATGAATTTACCTTTAAGGGCATCGGAGCAAATTCAGAACAACTCAGCGCCTTGAACCATCAATC
ACTAATAAAGGAGTATATCA

Downstream 100 bases:

>100_bases
CCCCCCTTTGTAATTCTTGGGGGTTTTTTTAAATACATTTAAGGTTTACATAACATTATTATAATTATTTTTTATAATAA
AAAATATCAACCCCCAACAA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MTLTYINNQLTINGHNIRQIAEQYGTPLFIYDEDEIRNQCRRFHRALKASGLNYTISYASKAFTSVQLFNLMHEEDMGLD
VVSEGELYTALKSKVSASKMHFHGNNKTDREIKYAIESGVEYFVIDSLDEIERINDIAHSLGQTVKAVLRINPGVEAHTH
EFIQTGQEDSKFGLSIRHGLAIEGVRQIEAASHIEFKGVHFHIGSQIFESTGTIKTIELVINWLTQHKIDIDILNIGGGF
SIKYTSEDISYPIEEGIKRIAETLKNECKKHSYPVPEISLEPGRSIVGEAGITVYEVGTVKEIPDTNCYVSIDGGMSDHI
RTALYNAKYELLLADRYEIHDKEVTVAGKLCESGDIIMRNIMLPSSIKRGDLLVVKATGAYHYSMSSNYNQMLKPAVVFV
TKDNVREVIKRQSLEHLIANEIY

Sequences:

>Translated_423_residues
MTLTYINNQLTINGHNIRQIAEQYGTPLFIYDEDEIRNQCRRFHRALKASGLNYTISYASKAFTSVQLFNLMHEEDMGLD
VVSEGELYTALKSKVSASKMHFHGNNKTDREIKYAIESGVEYFVIDSLDEIERINDIAHSLGQTVKAVLRINPGVEAHTH
EFIQTGQEDSKFGLSIRHGLAIEGVRQIEAASHIEFKGVHFHIGSQIFESTGTIKTIELVINWLTQHKIDIDILNIGGGF
SIKYTSEDISYPIEEGIKRIAETLKNECKKHSYPVPEISLEPGRSIVGEAGITVYEVGTVKEIPDTNCYVSIDGGMSDHI
RTALYNAKYELLLADRYEIHDKEVTVAGKLCESGDIIMRNIMLPSSIKRGDLLVVKATGAYHYSMSSNYNQMLKPAVVFV
TKDNVREVIKRQSLEHLIANEIY
>Mature_422_residues
TLTYINNQLTINGHNIRQIAEQYGTPLFIYDEDEIRNQCRRFHRALKASGLNYTISYASKAFTSVQLFNLMHEEDMGLDV
VSEGELYTALKSKVSASKMHFHGNNKTDREIKYAIESGVEYFVIDSLDEIERINDIAHSLGQTVKAVLRINPGVEAHTHE
FIQTGQEDSKFGLSIRHGLAIEGVRQIEAASHIEFKGVHFHIGSQIFESTGTIKTIELVINWLTQHKIDIDILNIGGGFS
IKYTSEDISYPIEEGIKRIAETLKNECKKHSYPVPEISLEPGRSIVGEAGITVYEVGTVKEIPDTNCYVSIDGGMSDHIR
TALYNAKYELLLADRYEIHDKEVTVAGKLCESGDIIMRNIMLPSSIKRGDLLVVKATGAYHYSMSSNYNQMLKPAVVFVT
KDNVREVIKRQSLEHLIANEIY

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=441, Percent_Identity=28.7981859410431, Blast_Score=135, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24586472, Length=407, Percent_Identity=23.0958230958231, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47649; Mature: 47518

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTYINNQLTINGHNIRQIAEQYGTPLFIYDEDEIRNQCRRFHRALKASGLNYTISYAS
CEEEEECCEEEECCCHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHCCCCEEEEHHH
KAFTSVQLFNLMHEEDMGLDVVSEGELYTALKSKVSASKMHFHGNNKTDREIKYAIESGV
HHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCHHEEEECCCCCCCHHHHHHHHCCC
EYFVIDSLDEIERINDIAHSLGQTVKAVLRINPGVEAHTHEFIQTGQEDSKFGLSIRHGL
EEEEECCHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHCCCCCCCCCEEEECCC
AIEGVRQIEAASHIEFKGVHFHIGSQIFESTGTIKTIELVINWLTQHKIDIDILNIGGGF
CHHHHHHHHHHCCEEEEEEEEEECHHHHHCCCCEEHHHHHHHHHHHCCEEEEEEEECCCE
SIKYTSEDISYPIEEGIKRIAETLKNECKKHSYPVPEISLEPGRSIVGEAGITVYEVGTV
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHCCCCEEEEEECCC
KEIPDTNCYVSIDGGMSDHIRTALYNAKYELLLADRYEIHDKEVTVAGKLCESGDIIMRN
CCCCCCCEEEEECCCCHHHHHHHHHCCEEEEEEECCEEECCCEEEEEEHHCCCCCEEEEE
IMLPSSIKRGDLLVVKATGAYHYSMSSNYNQMLKPAVVFVTKDNVREVIKRQSLEHLIAN
EECCCCCCCCCEEEEEECCEEEEECCCCHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHH
EIY
CCC
>Mature Secondary Structure 
TLTYINNQLTINGHNIRQIAEQYGTPLFIYDEDEIRNQCRRFHRALKASGLNYTISYAS
EEEEECCEEEECCCHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHCCCCEEEEHHH
KAFTSVQLFNLMHEEDMGLDVVSEGELYTALKSKVSASKMHFHGNNKTDREIKYAIESGV
HHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCHHEEEECCCCCCCHHHHHHHHCCC
EYFVIDSLDEIERINDIAHSLGQTVKAVLRINPGVEAHTHEFIQTGQEDSKFGLSIRHGL
EEEEECCHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHCCCCCCCCCEEEECCC
AIEGVRQIEAASHIEFKGVHFHIGSQIFESTGTIKTIELVINWLTQHKIDIDILNIGGGF
CHHHHHHHHHHCCEEEEEEEEEECHHHHHCCCCEEHHHHHHHHHHHCCEEEEEEEECCCE
SIKYTSEDISYPIEEGIKRIAETLKNECKKHSYPVPEISLEPGRSIVGEAGITVYEVGTV
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHCCCCEEEEEECCC
KEIPDTNCYVSIDGGMSDHIRTALYNAKYELLLADRYEIHDKEVTVAGKLCESGDIIMRN
CCCCCCCEEEEECCCCHHHHHHHHHCCEEEEEEECCEEECCCEEEEEEHHCCCCCEEEEE
IMLPSSIKRGDLLVVKATGAYHYSMSSNYNQMLKPAVVFVTKDNVREVIKRQSLEHLIAN
EECCCCCCCCCEEEEEECCEEEEECCCCHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHH
EIY
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2513554; 7934829; 1368705; 8969508; 9384377 [H]