Click here to switch to the map view.

The map label for this gene is pyrC

Identifier: 222151020

GI number: 222151020

Start: 830148

End: 831431

Strand: Direct

Name: pyrC

Synonym: MCCL_0771

Alternate gene names: 222151020

Gene position: 830148-831431 (Clockwise)

Preceding gene: 222151019

Following gene: 222151021

Centisome position: 39.49

GC content: 41.51

Gene sequence:

>1284_bases
ATGTCAACTTTATTAAGAGGCGGAAAAGTATTAGTTAATGATGAACTTGTTTCAAAGGATATTCGAATAGAAGACGGAAA
AATAGTAGAGATGGGTGAAAAGTTAAACGTCTATAATTCAGAGATTATTGAACTTGATGGTAAGTTTGTATCACAAGGGT
TTGTTGATGTACACGTCCATCTACGTGAACCTGGTGGTGAACATAAGGAGACGATTGAAAGTGGAACACGTGCAGCAGCA
CGCGGTGGATTCACAACAGTATGTCCGATGCCGAATACACGACCAGTTCCTGACAGTGTGGAACATATTGAGGCATTAAA
TCAATCGATTAAACAGCATGCGAAAGTGCGTGTGTTACCGTACGCATCTATCACCGAAAGACAACTTGGAAAAGACTTAG
TCGATTTCAAGGCACTCAAAGAACACGGTGCATTTGCTTTTACAGATGATGGGGTCGGTGTACAGACAGCATCCATCATG
TATGAAGCGATGCAGCAGGCTGCACAACTTAATATGGCGATTGTCGCCCACTGTGAAGATAATTCACTCATTTACGGTGG
TGCAATGCATGAAGGGAAAGTATCAAAAGCCCTTAATATCCCTGGTATTCCTTCAATCTGTGAAGCTGTACAGATTGCCC
GAGATGTACTGTTAGCTGAAGCAGCGGATTGTCACTATCATGTGTGCCACGTATCGAGTAAAGAAAGTGTGCGTGTCATA
CGTGATGCAAAACGTGCAGGTATTAAGGTAACGGCAGAAGTGACGCCACATCATCTGTTGTTAAATGAAACTGCAATTAC
AGAAGATGATGCGATTCTTAAGATGAATCCACCGCTTCGTAGTGAGGAAGATCATCAGGCTTTAATAGAAGCATTACTTG
ACGGCACAATCGACTTTATCGCAACAGACCATGCACCTCATGCCGCAGATGAGAAGAATCAGCCGATGACAAAAGCACCG
TTCGGTATTGTTGGCAGTGAAACAGCATTTCCGTTGCTGTACACAAGATTCGTTAAAAATGGGGATTGGACATTAGGTCA
GCTTATTGATTATTTAGCACTAAAACCAGGACAAGTATTTGGATTGCCATACGGAAAATCTTTAGAAGTTGGCAGTATTG
CAGATATCACAGTTATTGATCTGGACGAGAAATATGAAATTAAATCAGAAGACTTCTTATCAAAATCAAGTAATACACCA
TTTATTGGAGAACATGTCTACGGCAATGTGAAGCTAACACTTGTAGAAGGACAAATCGCTTATCAGGAGGGGCAACATGC
GTAA

Upstream 100 bases:

>100_bases
CGCCGAAGTCACGTATTTTTAAGCAGATGGAAAACGGTGTCTACACACGTATGAGTATTTTAAGTCAAGTCATTGAAAAT
AATCGATAGGAGTGTTGAAT

Downstream 100 bases:

>100_bases
ACAAAGATATCTTGTATTAGAAGATGGCACTACATTTAAAGGATATAGATTTGGAAGTGACAAAGAGGTAGTAGGGGAAA
TCGTATTTAATACTGCGATG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSTLLRGGKVLVNDELVSKDIRIEDGKIVEMGEKLNVYNSEIIELDGKFVSQGFVDVHVHLREPGGEHKETIESGTRAAA
RGGFTTVCPMPNTRPVPDSVEHIEALNQSIKQHAKVRVLPYASITERQLGKDLVDFKALKEHGAFAFTDDGVGVQTASIM
YEAMQQAAQLNMAIVAHCEDNSLIYGGAMHEGKVSKALNIPGIPSICEAVQIARDVLLAEAADCHYHVCHVSSKESVRVI
RDAKRAGIKVTAEVTPHHLLLNETAITEDDAILKMNPPLRSEEDHQALIEALLDGTIDFIATDHAPHAADEKNQPMTKAP
FGIVGSETAFPLLYTRFVKNGDWTLGQLIDYLALKPGQVFGLPYGKSLEVGSIADITVIDLDEKYEIKSEDFLSKSSNTP
FIGEHVYGNVKLTLVEGQIAYQEGQHA

Sequences:

>Translated_427_residues
MSTLLRGGKVLVNDELVSKDIRIEDGKIVEMGEKLNVYNSEIIELDGKFVSQGFVDVHVHLREPGGEHKETIESGTRAAA
RGGFTTVCPMPNTRPVPDSVEHIEALNQSIKQHAKVRVLPYASITERQLGKDLVDFKALKEHGAFAFTDDGVGVQTASIM
YEAMQQAAQLNMAIVAHCEDNSLIYGGAMHEGKVSKALNIPGIPSICEAVQIARDVLLAEAADCHYHVCHVSSKESVRVI
RDAKRAGIKVTAEVTPHHLLLNETAITEDDAILKMNPPLRSEEDHQALIEALLDGTIDFIATDHAPHAADEKNQPMTKAP
FGIVGSETAFPLLYTRFVKNGDWTLGQLIDYLALKPGQVFGLPYGKSLEVGSIADITVIDLDEKYEIKSEDFLSKSSNTP
FIGEHVYGNVKLTLVEGQIAYQEGQHA
>Mature_426_residues
STLLRGGKVLVNDELVSKDIRIEDGKIVEMGEKLNVYNSEIIELDGKFVSQGFVDVHVHLREPGGEHKETIESGTRAAAR
GGFTTVCPMPNTRPVPDSVEHIEALNQSIKQHAKVRVLPYASITERQLGKDLVDFKALKEHGAFAFTDDGVGVQTASIMY
EAMQQAAQLNMAIVAHCEDNSLIYGGAMHEGKVSKALNIPGIPSICEAVQIARDVLLAEAADCHYHVCHVSSKESVRVIR
DAKRAGIKVTAEVTPHHLLLNETAITEDDAILKMNPPLRSEEDHQALIEALLDGTIDFIATDHAPHAADEKNQPMTKAPF
GIVGSETAFPLLYTRFVKNGDWTLGQLIDYLALKPGQVFGLPYGKSLEVGSIADITVIDLDEKYEIKSEDFLSKSSNTPF
IGEHVYGNVKLTLVEGQIAYQEGQHA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=379, Percent_Identity=32.1899736147757, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4503051, Length=446, Percent_Identity=23.9910313901345, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI62422571, Length=446, Percent_Identity=23.9910313901345, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI4503375, Length=450, Percent_Identity=24.6666666666667, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4503379, Length=444, Percent_Identity=22.972972972973, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4503377, Length=450, Percent_Identity=25.1111111111111, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI19923821, Length=447, Percent_Identity=23.9373601789709, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI190194363, Length=454, Percent_Identity=22.9074889867841, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786722, Length=434, Percent_Identity=28.110599078341, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI87082175, Length=449, Percent_Identity=25.3897550111359, Blast_Score=119, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI193204318, Length=412, Percent_Identity=31.0679611650485, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17539558, Length=449, Percent_Identity=23.8307349665924, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71989490, Length=453, Percent_Identity=22.9580573951435, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI86575075, Length=445, Percent_Identity=25.1685393258427, Blast_Score=81, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6322218, Length=389, Percent_Identity=26.9922879177378, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24642586, Length=376, Percent_Identity=33.2446808510638, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI18859883, Length=418, Percent_Identity=23.444976076555, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_MACCJ (B9EB67)

Other databases:

- EMBL:   AP009484
- RefSeq:   YP_002560174.1
- ProteinModelPortal:   B9EB67
- GeneID:   7389860
- GenomeReviews:   AP009484_GR
- KEGG:   mcl:MCCL_0771
- OMA:   PRVAEES
- ProtClustDB:   PRK09357
- HAMAP:   MF_00220_B
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 46666; Mature: 46534

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLLRGGKVLVNDELVSKDIRIEDGKIVEMGEKLNVYNSEIIELDGKFVSQGFVDVHVH
CCCCCCCCEEEEEHHHHCCCCEECCCCEEECCCCCCCCCCEEEEECCHHHCCCEEEEEEE
LREPGGEHKETIESGTRAAARGGFTTVCPMPNTRPVPDSVEHIEALNQSIKQHAKVRVLP
EECCCCCHHHHHHHCCHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEE
YASITERQLGKDLVDFKALKEHGAFAFTDDGVGVQTASIMYEAMQQAAQLNMAIVAHCED
CCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEEEECC
NSLIYGGAMHEGKVSKALNIPGIPSICEAVQIARDVLLAEAADCHYHVCHVSSKESVRVI
CCEEEECCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHH
RDAKRAGIKVTAEVTPHHLLLNETAITEDDAILKMNPPLRSEEDHQALIEALLDGTIDFI
HHHHHCCEEEEEECCCCEEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCEEEE
ATDHAPHAADEKNQPMTKAPFGIVGSETAFPLLYTRFVKNGDWTLGQLIDYLALKPGQVF
EECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEE
GLPYGKSLEVGSIADITVIDLDEKYEIKSEDFLSKSSNTPFIGEHVYGNVKLTLVEGQIA
ECCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHCCCCCCEEEEEEECCEEEEEEECEEE
YQEGQHA
CCCCCCC
>Mature Secondary Structure 
STLLRGGKVLVNDELVSKDIRIEDGKIVEMGEKLNVYNSEIIELDGKFVSQGFVDVHVH
CCCCCCCEEEEEHHHHCCCCEECCCCEEECCCCCCCCCCEEEEECCHHHCCCEEEEEEE
LREPGGEHKETIESGTRAAARGGFTTVCPMPNTRPVPDSVEHIEALNQSIKQHAKVRVLP
EECCCCCHHHHHHHCCHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEE
YASITERQLGKDLVDFKALKEHGAFAFTDDGVGVQTASIMYEAMQQAAQLNMAIVAHCED
CCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEEEECC
NSLIYGGAMHEGKVSKALNIPGIPSICEAVQIARDVLLAEAADCHYHVCHVSSKESVRVI
CCEEEECCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHH
RDAKRAGIKVTAEVTPHHLLLNETAITEDDAILKMNPPLRSEEDHQALIEALLDGTIDFI
HHHHHCCEEEEEECCCCEEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCEEEE
ATDHAPHAADEKNQPMTKAPFGIVGSETAFPLLYTRFVKNGDWTLGQLIDYLALKPGQVF
EECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEE
GLPYGKSLEVGSIADITVIDLDEKYEIKSEDFLSKSSNTPFIGEHVYGNVKLTLVEGQIA
ECCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHCCCCCCEEEEEEECCEEEEEEECEEE
YQEGQHA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA