Click here to switch to the map view.

The map label for this gene is pyc [H]

Identifier: 222150979

GI number: 222150979

Start: 787619

End: 791041

Strand: Direct

Name: pyc [H]

Synonym: MCCL_0729

Alternate gene names: 222150979

Gene position: 787619-791041 (Clockwise)

Preceding gene: 222150978

Following gene: 222150981

Centisome position: 37.46

GC content: 42.51

Gene sequence:

>3423_bases
ATGAAAACGATTAAGAAATTACTTGTTGCTAACCGTGGTGAGATTGCAATACGTATTTTTAGGGCTGCTACAGAACTACA
TATTCCAACTGTCGCAATCTATTCTAAAGAAGATAAAGGTGCGCTTCACCGATATAAGGCTGATGAAGCTTATCTCATTG
AAGGCGCAAGTCCATCTGATTGCTATCTTGACATCGAAGCGATTATAGAGACTGCAAAATCATGTGGTGCAAATGCAATT
CACCCAGGGTATGGTTTTTTAAGTGAAAATCAGCAGTTTGCAGTGCGCTGTGCACAAGAGGATATCATCTTCATCGGTCC
AGAGGTCCGTCACCTTGATATGTTTGGTGACAAGATAAAAGCACGTAATACAGCAATCCAGGCTGGACTTCCGGTGATAC
CTGGAACAAAGGATGCAATTAAAGGTTTAGATGAAGCGGTGCAGTTTGCACATGATAAGTATCCGGTTATGATAAAAGCA
CTGTCTGGTGGCGGTGGAAAGGGCATGCGTATCGTGCGCAATGCTGAAGAACTGGAAGAAGCCATTTCACGTGCGCAATC
AGAGGCAATGAAATCCTTTGGAAGCAGCGAAATTTATATTGAACAGTATATAGATGCGCCAAAGCATATTGAAGTTCAGA
TCATTGGAGATAAGTTCGGCAATATTGTTCATCTCTTTGAACGAGATTGTTCAGTACAACGTCGACACCAGAAAGTAGTT
GAAGTTGCACCATCAGTTGGGTTAAGTGATACCGTAAGAATGAACATCTGTAATGCTGCGGTTGATCTGATGCAGCAGAT
TTCATATGTCAACGCCGGAACGGTAGAATTTTTAGTTCAGGGAGAGGATTTTTATTTTATAGAAGTAAACCCGCGTGTTC
AAGTAGAACATACGATTACAGAGATGGTCACAGGGATAGATATCGTTAAGGCACAACTACTGATAGCTGATGGAGCACAG
CTAAGTGACGAACGTATTGCAATTCCGCAGCAGCACGAAATTGTGACCCATGGCTATGCGATTCAATGTCGAATTACGAC
AGAAGATCCTGCTAATAACTTTTTACCGGATACAGGTCGTATCACAGCGTATCGCTCAAGTGGTGGATTTGGTGTGCGCC
TTGACGCAGGCGATGGCTTCCAGGGCGCTGAAATCTCTCCTTACTATGATTCACTGCTCGTTAAATTATCTACGCATGCC
CTTACTTTCAAGCAGGCTGAAGAAAAGATGGTACGTTCATTAAAAGAAATGAGGATTCGTGGTATTAAGACGAACTTGCA
GTTTCTTCTGAATGTAGTTCAGCACCCTGTGTTTACTGCAGGTAATTACAATACGCGTTTCCTCGAACTTTATCCTGAAT
TATTTGACATAGAAGCCCCTAAAGATAGAGGGACGAAGACGTTAGCATATATCGCCGACATTACAGTGAACGGTTTTCCT
GGCATTAATAAGACCGAAAAGCCTGACTTTGAACTTCCGCTTACCAGGACCTTTAAAACCACTGGTTTATCTGGAACGAA
GCAGCTGCTGGACGAACATGGGCCATCTTATGTCAGCGACTGGATCAAAGCGCAGCACGAAGTACTGATTACTGATACAA
CATTTCGAGATGCGCATCAGTCATTGCTGGCGACGCGTGTACGTACAAAAGATATGCTTGCGATTGCATCACAGACCAAC
CATCATCGAATTGATAGCTTCTCATTAGAAATGTGGGGCGGTGCAACATTTGATGTAGCATATAACTTTCTGAAAGAAGA
TCCGTGGGAGAGGCTCACAAAGTTACGAACAGCTGTACCAAACATATTGTTTCAAATGCTCTTAAGGGCATCTAATGCTG
TCGGTTATAAGAACTATCCAGATAATGTTGTACAGCAGTTCATCCGAGCTGCAAGTGATAATGGCATCGATGTCTTTAGA
ATATTTGATTCGCTTAACTGGCTCGATCAGATGAAAGTAGCCAATGAAGCGGTACTGAACGCGGGTAAAATTTCTGAAGG
GACCATCTGTTATACCGGCGATATATTAAATCCAAAGCGTTCAGATGTTTATACGCTGGACTATTATTTAAAGATGGCTA
GAGCAATGGAACAAGAAGGGTTCCATATCCTGGCAATAAAAGATATGGCTGGCCTGTTGAAACCTGAAGCAGCTTATATA
TTAATTCAGGCATTAAAAGCAGAAGTATCACTGCCAATTCATCTGCATACGCATGATACGAGTGGCAATGGTATCATGAC
GTATAATAGAGCGATTGATGCAGGAGTTGATATTATTGATACTGCGATTTCCAGTATGAGTGGATTAACGAGTCAGCCTT
CGTTGAATAGTCTCTATTACAGTTTAGAAGGAAAAGAGAGACAGATCAGTGCAGATATAGAGGGACTTGAAGCACTATCG
CACTACTGGTCAGTGGTGCGCAAGTTCTATCATAACTTTGAAAGTGACATACAGTCGCCAAACACTGAAATATATCAGCA
TGAAATGCCCGGAGGACAATATTCAAATATTGAACAGCAAGCGAAAAGCTTAGGTCTTGGCGACCAGTTCGAAGCGGTTA
AAGATATGTATAAAAGAGTAAATATAATGTTCGGTGATATTGTTAAAGTCACGCCATCATCCAAAGTCGTCGGGGACATG
GCATTATACATGGTGCAGAACAACCTTGATGAACAGACAGTTATAGAACGAGGAGAAAATCTTGATTTCCCGGATTCTGT
CGTATCCTTCTTTAAAGGAGAGATTGGACAACCGGCAAATGGCTTCCCAAAAAGACTGCAGGACGTCGTATTAAAGGGAA
AAGCGCCGCTTACTGTTCGACCTGGCGAAGCGTTAGCACATGTAGATTTCAATGAACTGCAGCAGACGCTTACAGAACGT
TTTCAAGAAATCAATGAGGAAGATGTCCTCAGTTATGCATTGTATCCGAAAGTATTCGAAGTATATAAAGAGACAGAAGC
ACGATATGGCAACATTTCATTGCTCGACACACCGACATTCTTCTATGGCATGCGCAAAAACGAAACCGTAGAAATAGAGA
TCGATGCCGGCAAAACGCTGATCGTGAAACTGCTGAGTATCGGACATGTGCATGAAGATGGATATCGTACATTATATTTT
GAACTTAACGGGATGCCAAGGCAAGTGCGTGTGAAGGATAATGCAGCTGAAGTAAGTGTCAATACATTACTTAAAGCAGA
TGCTAAGAATAGCAAGCATATTGGAGCGCAGATGCCGGGAACCATCGGAGAAATTAAAGTGACAGCAGGAGCACACGTTC
GTGCGGGTGAAACATTGATGATCACTGAAGCGATGAAGATGGAGACGAGTGTGCAGGCACCTGTAGATGCAGTGGTGAAA
CATATCCATGTAACAACTGGAACGGCTATCCAGACAGGCGATTTGTTAGTCGAGTTTGAATAA

Upstream 100 bases:

>100_bases
CAATATGACGAGTTCGTGTCAATTATGGCTAAAAGCAGAATGTTCTTAACATTTATAATATAATATAATATAAATGAAAT
GAAATGATTGGAGGCTGTAT

Downstream 100 bases:

>100_bases
AATAAACAAGCGTTGGCAATAATTACATTGCCAACGCTTGTTTTTATGTGAAATCATTTATTTTGCTCTGCTAATAAGCA
GGATAAAGTAGCATAGAAGG

Product: pyruvate carboxylase

Products: NA

Alternate protein names: Pyruvic carboxylase; PYC [H]

Number of amino acids: Translated: 1140; Mature: 1140

Protein sequence:

>1140_residues
MKTIKKLLVANRGEIAIRIFRAATELHIPTVAIYSKEDKGALHRYKADEAYLIEGASPSDCYLDIEAIIETAKSCGANAI
HPGYGFLSENQQFAVRCAQEDIIFIGPEVRHLDMFGDKIKARNTAIQAGLPVIPGTKDAIKGLDEAVQFAHDKYPVMIKA
LSGGGGKGMRIVRNAEELEEAISRAQSEAMKSFGSSEIYIEQYIDAPKHIEVQIIGDKFGNIVHLFERDCSVQRRHQKVV
EVAPSVGLSDTVRMNICNAAVDLMQQISYVNAGTVEFLVQGEDFYFIEVNPRVQVEHTITEMVTGIDIVKAQLLIADGAQ
LSDERIAIPQQHEIVTHGYAIQCRITTEDPANNFLPDTGRITAYRSSGGFGVRLDAGDGFQGAEISPYYDSLLVKLSTHA
LTFKQAEEKMVRSLKEMRIRGIKTNLQFLLNVVQHPVFTAGNYNTRFLELYPELFDIEAPKDRGTKTLAYIADITVNGFP
GINKTEKPDFELPLTRTFKTTGLSGTKQLLDEHGPSYVSDWIKAQHEVLITDTTFRDAHQSLLATRVRTKDMLAIASQTN
HHRIDSFSLEMWGGATFDVAYNFLKEDPWERLTKLRTAVPNILFQMLLRASNAVGYKNYPDNVVQQFIRAASDNGIDVFR
IFDSLNWLDQMKVANEAVLNAGKISEGTICYTGDILNPKRSDVYTLDYYLKMARAMEQEGFHILAIKDMAGLLKPEAAYI
LIQALKAEVSLPIHLHTHDTSGNGIMTYNRAIDAGVDIIDTAISSMSGLTSQPSLNSLYYSLEGKERQISADIEGLEALS
HYWSVVRKFYHNFESDIQSPNTEIYQHEMPGGQYSNIEQQAKSLGLGDQFEAVKDMYKRVNIMFGDIVKVTPSSKVVGDM
ALYMVQNNLDEQTVIERGENLDFPDSVVSFFKGEIGQPANGFPKRLQDVVLKGKAPLTVRPGEALAHVDFNELQQTLTER
FQEINEEDVLSYALYPKVFEVYKETEARYGNISLLDTPTFFYGMRKNETVEIEIDAGKTLIVKLLSIGHVHEDGYRTLYF
ELNGMPRQVRVKDNAAEVSVNTLLKADAKNSKHIGAQMPGTIGEIKVTAGAHVRAGETLMITEAMKMETSVQAPVDAVVK
HIHVTTGTAIQTGDLLVEFE

Sequences:

>Translated_1140_residues
MKTIKKLLVANRGEIAIRIFRAATELHIPTVAIYSKEDKGALHRYKADEAYLIEGASPSDCYLDIEAIIETAKSCGANAI
HPGYGFLSENQQFAVRCAQEDIIFIGPEVRHLDMFGDKIKARNTAIQAGLPVIPGTKDAIKGLDEAVQFAHDKYPVMIKA
LSGGGGKGMRIVRNAEELEEAISRAQSEAMKSFGSSEIYIEQYIDAPKHIEVQIIGDKFGNIVHLFERDCSVQRRHQKVV
EVAPSVGLSDTVRMNICNAAVDLMQQISYVNAGTVEFLVQGEDFYFIEVNPRVQVEHTITEMVTGIDIVKAQLLIADGAQ
LSDERIAIPQQHEIVTHGYAIQCRITTEDPANNFLPDTGRITAYRSSGGFGVRLDAGDGFQGAEISPYYDSLLVKLSTHA
LTFKQAEEKMVRSLKEMRIRGIKTNLQFLLNVVQHPVFTAGNYNTRFLELYPELFDIEAPKDRGTKTLAYIADITVNGFP
GINKTEKPDFELPLTRTFKTTGLSGTKQLLDEHGPSYVSDWIKAQHEVLITDTTFRDAHQSLLATRVRTKDMLAIASQTN
HHRIDSFSLEMWGGATFDVAYNFLKEDPWERLTKLRTAVPNILFQMLLRASNAVGYKNYPDNVVQQFIRAASDNGIDVFR
IFDSLNWLDQMKVANEAVLNAGKISEGTICYTGDILNPKRSDVYTLDYYLKMARAMEQEGFHILAIKDMAGLLKPEAAYI
LIQALKAEVSLPIHLHTHDTSGNGIMTYNRAIDAGVDIIDTAISSMSGLTSQPSLNSLYYSLEGKERQISADIEGLEALS
HYWSVVRKFYHNFESDIQSPNTEIYQHEMPGGQYSNIEQQAKSLGLGDQFEAVKDMYKRVNIMFGDIVKVTPSSKVVGDM
ALYMVQNNLDEQTVIERGENLDFPDSVVSFFKGEIGQPANGFPKRLQDVVLKGKAPLTVRPGEALAHVDFNELQQTLTER
FQEINEEDVLSYALYPKVFEVYKETEARYGNISLLDTPTFFYGMRKNETVEIEIDAGKTLIVKLLSIGHVHEDGYRTLYF
ELNGMPRQVRVKDNAAEVSVNTLLKADAKNSKHIGAQMPGTIGEIKVTAGAHVRAGETLMITEAMKMETSVQAPVDAVVK
HIHVTTGTAIQTGDLLVEFE
>Mature_1140_residues
MKTIKKLLVANRGEIAIRIFRAATELHIPTVAIYSKEDKGALHRYKADEAYLIEGASPSDCYLDIEAIIETAKSCGANAI
HPGYGFLSENQQFAVRCAQEDIIFIGPEVRHLDMFGDKIKARNTAIQAGLPVIPGTKDAIKGLDEAVQFAHDKYPVMIKA
LSGGGGKGMRIVRNAEELEEAISRAQSEAMKSFGSSEIYIEQYIDAPKHIEVQIIGDKFGNIVHLFERDCSVQRRHQKVV
EVAPSVGLSDTVRMNICNAAVDLMQQISYVNAGTVEFLVQGEDFYFIEVNPRVQVEHTITEMVTGIDIVKAQLLIADGAQ
LSDERIAIPQQHEIVTHGYAIQCRITTEDPANNFLPDTGRITAYRSSGGFGVRLDAGDGFQGAEISPYYDSLLVKLSTHA
LTFKQAEEKMVRSLKEMRIRGIKTNLQFLLNVVQHPVFTAGNYNTRFLELYPELFDIEAPKDRGTKTLAYIADITVNGFP
GINKTEKPDFELPLTRTFKTTGLSGTKQLLDEHGPSYVSDWIKAQHEVLITDTTFRDAHQSLLATRVRTKDMLAIASQTN
HHRIDSFSLEMWGGATFDVAYNFLKEDPWERLTKLRTAVPNILFQMLLRASNAVGYKNYPDNVVQQFIRAASDNGIDVFR
IFDSLNWLDQMKVANEAVLNAGKISEGTICYTGDILNPKRSDVYTLDYYLKMARAMEQEGFHILAIKDMAGLLKPEAAYI
LIQALKAEVSLPIHLHTHDTSGNGIMTYNRAIDAGVDIIDTAISSMSGLTSQPSLNSLYYSLEGKERQISADIEGLEALS
HYWSVVRKFYHNFESDIQSPNTEIYQHEMPGGQYSNIEQQAKSLGLGDQFEAVKDMYKRVNIMFGDIVKVTPSSKVVGDM
ALYMVQNNLDEQTVIERGENLDFPDSVVSFFKGEIGQPANGFPKRLQDVVLKGKAPLTVRPGEALAHVDFNELQQTLTER
FQEINEEDVLSYALYPKVFEVYKETEARYGNISLLDTPTFFYGMRKNETVEIEIDAGKTLIVKLLSIGHVHEDGYRTLYF
ELNGMPRQVRVKDNAAEVSVNTLLKADAKNSKHIGAQMPGTIGEIKVTAGAHVRAGETLMITEAMKMETSVQAPVDAVVK
HIHVTTGTAIQTGDLLVEFE

Specific function: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second, leading to oxaloacetate production. Fulfills an anaplerotic functi

COG id: COG1038

COG function: function code C; Pyruvate carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=1150, Percent_Identity=47.3913043478261, Blast_Score=1037, Evalue=0.0,
Organism=Homo sapiens, GI106049295, Length=1150, Percent_Identity=47.3913043478261, Blast_Score=1037, Evalue=0.0,
Organism=Homo sapiens, GI106049292, Length=1150, Percent_Identity=47.3913043478261, Blast_Score=1037, Evalue=0.0,
Organism=Homo sapiens, GI116805327, Length=454, Percent_Identity=45.5947136563877, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI189095269, Length=460, Percent_Identity=43.695652173913, Blast_Score=360, Evalue=6e-99,
Organism=Homo sapiens, GI65506442, Length=459, Percent_Identity=43.7908496732026, Blast_Score=358, Evalue=1e-98,
Organism=Homo sapiens, GI295821183, Length=459, Percent_Identity=43.7908496732026, Blast_Score=358, Evalue=1e-98,
Organism=Homo sapiens, GI38679960, Length=522, Percent_Identity=32.3754789272031, Blast_Score=231, Evalue=3e-60,
Organism=Homo sapiens, GI38679974, Length=510, Percent_Identity=32.3529411764706, Blast_Score=231, Evalue=4e-60,
Organism=Homo sapiens, GI38679977, Length=510, Percent_Identity=32.3529411764706, Blast_Score=231, Evalue=4e-60,
Organism=Homo sapiens, GI38679967, Length=510, Percent_Identity=32.3529411764706, Blast_Score=231, Evalue=4e-60,
Organism=Homo sapiens, GI38679971, Length=522, Percent_Identity=32.3754789272031, Blast_Score=231, Evalue=4e-60,
Organism=Homo sapiens, GI134142062, Length=523, Percent_Identity=30.7839388145315, Blast_Score=218, Evalue=3e-56,
Organism=Escherichia coli, GI1789654, Length=449, Percent_Identity=44.3207126948775, Blast_Score=345, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI17562816, Length=1149, Percent_Identity=47.9547432550044, Blast_Score=1071, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71987519, Length=466, Percent_Identity=41.6309012875536, Blast_Score=339, Evalue=6e-93,
Organism=Caenorhabditis elegans, GI17567343, Length=455, Percent_Identity=42.4175824175824, Blast_Score=332, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI133931226, Length=496, Percent_Identity=29.2338709677419, Blast_Score=206, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=29.1585127201566, Blast_Score=204, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=512, Percent_Identity=29.296875, Blast_Score=203, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6319695, Length=1155, Percent_Identity=48.7445887445887, Blast_Score=1082, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321376, Length=1159, Percent_Identity=48.748921484038, Blast_Score=1068, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319685, Length=462, Percent_Identity=36.5800865800866, Blast_Score=296, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6324343, Length=545, Percent_Identity=30.2752293577982, Blast_Score=219, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6323863, Length=450, Percent_Identity=32.4444444444444, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24652212, Length=1153, Percent_Identity=46.9210754553339, Blast_Score=1039, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652210, Length=1153, Percent_Identity=46.9210754553339, Blast_Score=1039, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652214, Length=1153, Percent_Identity=46.9210754553339, Blast_Score=1039, Evalue=0.0,
Organism=Drosophila melanogaster, GI19921944, Length=1153, Percent_Identity=46.9210754553339, Blast_Score=1039, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652216, Length=1153, Percent_Identity=46.9210754553339, Blast_Score=1039, Evalue=0.0,
Organism=Drosophila melanogaster, GI281363050, Length=1165, Percent_Identity=46.2660944206009, Blast_Score=1034, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652224, Length=1165, Percent_Identity=46.2660944206009, Blast_Score=1034, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652222, Length=1165, Percent_Identity=46.2660944206009, Blast_Score=1034, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652220, Length=1165, Percent_Identity=46.2660944206009, Blast_Score=1034, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652218, Length=1165, Percent_Identity=46.2660944206009, Blast_Score=1034, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651757, Length=507, Percent_Identity=40.6311637080868, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24651759, Length=466, Percent_Identity=40.343347639485, Blast_Score=328, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24586458, Length=522, Percent_Identity=30.8429118773946, Blast_Score=222, Evalue=1e-57,
Organism=Drosophila melanogaster, GI161076407, Length=522, Percent_Identity=30.8429118773946, Blast_Score=222, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24586460, Length=522, Percent_Identity=30.8429118773946, Blast_Score=222, Evalue=1e-57,
Organism=Drosophila melanogaster, GI161076409, Length=522, Percent_Identity=30.8429118773946, Blast_Score=222, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR003379
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR000891
- InterPro:   IPR005930
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2; PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =6.4.1.1 [H]

Molecular weight: Translated: 127055; Mature: 127055

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50991 PYR_CT ; PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIKKLLVANRGEIAIRIFRAATELHIPTVAIYSKEDKGALHRYKADEAYLIEGASPSD
CCHHHHHHHCCCCCEEEEEEEHHHHHCCCEEEEEECCCCCCHHHCCCCCEEEEECCCCCC
CYLDIEAIIETAKSCGANAIHPGYGFLSENQQFAVRCAQEDIIFIGPEVRHLDMFGDKIK
CEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCEEEEHHHCCHHH
ARNTAIQAGLPVIPGTKDAIKGLDEAVQFAHDKYPVMIKALSGGGGKGMRIVRNAEELEE
HCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEECCHHHHHH
AISRAQSEAMKSFGSSEIYIEQYIDAPKHIEVQIIGDKFGNIVHLFERDCSVQRRHQKVV
HHHHHHHHHHHHCCCCEEEEEHHCCCCCEEEEEEECCCCCCCHHHHHHCCHHHHHHHHHH
EVAPSVGLSDTVRMNICNAAVDLMQQISYVNAGTVEFLVQGEDFYFIEVNPRVQVEHTIT
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEEEECCCEEEHHHHH
EMVTGIDIVKAQLLIADGAQLSDERIAIPQQHEIVTHGYAIQCRITTEDPANNFLPDTGR
HHHHHHHHHEEEEEEECCCCCCCCEECCCCCCEEEECCEEEEEEEECCCCCCCCCCCCCC
ITAYRSSGGFGVRLDAGDGFQGAEISPYYDSLLVKLSTHALTFKQAEEKMVRSLKEMRIR
EEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIKTNLQFLLNVVQHPVFTAGNYNTRFLELYPELFDIEAPKDRGTKTLAYIADITVNGFP
HHHHHHHHHHHHHHCCEEECCCCCCCCEEECHHHHCCCCCCCCCCEEEEEEEEEEECCCC
GINKTEKPDFELPLTRTFKTTGLSGTKQLLDEHGPSYVSDWIKAQHEVLITDTTFRDAHQ
CCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCHHHHHHHHCCCEEEEEECCHHHHHH
SLLATRVRTKDMLAIASQTNHHRIDSFSLEMWGGATFDVAYNFLKEDPWERLTKLRTAVP
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCEEHHHHHHHHHCCHHHHHHHHHHHHH
NILFQMLLRASNAVGYKNYPDNVVQQFIRAASDNGIDVFRIFDSLNWLDQMKVANEAVLN
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHC
AGKISEGTICYTGDILNPKRSDVYTLDYYLKMARAMEQEGFHILAIKDMAGLLKPEAAYI
CCCCCCCEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHCCCEEEEEHHHHHHCCCHHHHH
LIQALKAEVSLPIHLHTHDTSGNGIMTYNRAIDAGVDIIDTAISSMSGLTSQPSLNSLYY
HHHHHHHHCEEEEEEEECCCCCCEEEEECCHHHCCHHHHHHHHHHHCCCCCCCCCCCEEE
SLEGKERQISADIEGLEALSHYWSVVRKFYHNFESDIQSPNTEIYQHEMPGGQYSNIEQQ
EECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHH
AKSLGLGDQFEAVKDMYKRVNIMFGDIVKVTPSSKVVGDMALYMVQNNLDEQTVIERGEN
HHHCCCCCHHHHHHHHHHHHHEEECCEEEECCCCHHHHHHHHHHHHCCCCHHHHHHCCCC
LDFPDSVVSFFKGEIGQPANGFPKRLQDVVLKGKAPLTVRPGEALAHVDFNELQQTLTER
CCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCEEECCHHHHHHHHHHH
FQEINEEDVLSYALYPKVFEVYKETEARYGNISLLDTPTFFYGMRKNETVEIEIDAGKTL
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHEEECCCCCEEEEEECCCCHH
IVKLLSIGHVHEDGYRTLYFELNGMPRQVRVKDNAAEVSVNTLLKADAKNSKHIGAQMPG
HHHHHHHCCEECCCCEEEEEEECCCCCEEEEECCCHHEEHHHHHCCCCCCCCCCCCCCCC
TIGEIKVTAGAHVRAGETLMITEAMKMETSVQAPVDAVVKHIHVTTGTAIQTGDLLVEFE
CCCEEEEECCCEEECCCEEEEEHHHHHHCCCCCCHHHHHHHEEEECCCEEEECCEEEEEC
>Mature Secondary Structure
MKTIKKLLVANRGEIAIRIFRAATELHIPTVAIYSKEDKGALHRYKADEAYLIEGASPSD
CCHHHHHHHCCCCCEEEEEEEHHHHHCCCEEEEEECCCCCCHHHCCCCCEEEEECCCCCC
CYLDIEAIIETAKSCGANAIHPGYGFLSENQQFAVRCAQEDIIFIGPEVRHLDMFGDKIK
CEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCEEEEHHHCCHHH
ARNTAIQAGLPVIPGTKDAIKGLDEAVQFAHDKYPVMIKALSGGGGKGMRIVRNAEELEE
HCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEECCHHHHHH
AISRAQSEAMKSFGSSEIYIEQYIDAPKHIEVQIIGDKFGNIVHLFERDCSVQRRHQKVV
HHHHHHHHHHHHCCCCEEEEEHHCCCCCEEEEEEECCCCCCCHHHHHHCCHHHHHHHHHH
EVAPSVGLSDTVRMNICNAAVDLMQQISYVNAGTVEFLVQGEDFYFIEVNPRVQVEHTIT
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEEEECCCEEEHHHHH
EMVTGIDIVKAQLLIADGAQLSDERIAIPQQHEIVTHGYAIQCRITTEDPANNFLPDTGR
HHHHHHHHHEEEEEEECCCCCCCCEECCCCCCEEEECCEEEEEEEECCCCCCCCCCCCCC
ITAYRSSGGFGVRLDAGDGFQGAEISPYYDSLLVKLSTHALTFKQAEEKMVRSLKEMRIR
EEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIKTNLQFLLNVVQHPVFTAGNYNTRFLELYPELFDIEAPKDRGTKTLAYIADITVNGFP
HHHHHHHHHHHHHHCCEEECCCCCCCCEEECHHHHCCCCCCCCCCEEEEEEEEEEECCCC
GINKTEKPDFELPLTRTFKTTGLSGTKQLLDEHGPSYVSDWIKAQHEVLITDTTFRDAHQ
CCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCHHHHHHHHCCCEEEEEECCHHHHHH
SLLATRVRTKDMLAIASQTNHHRIDSFSLEMWGGATFDVAYNFLKEDPWERLTKLRTAVP
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCEEHHHHHHHHHCCHHHHHHHHHHHHH
NILFQMLLRASNAVGYKNYPDNVVQQFIRAASDNGIDVFRIFDSLNWLDQMKVANEAVLN
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHC
AGKISEGTICYTGDILNPKRSDVYTLDYYLKMARAMEQEGFHILAIKDMAGLLKPEAAYI
CCCCCCCEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHCCCEEEEEHHHHHHCCCHHHHH
LIQALKAEVSLPIHLHTHDTSGNGIMTYNRAIDAGVDIIDTAISSMSGLTSQPSLNSLYY
HHHHHHHHCEEEEEEEECCCCCCEEEEECCHHHCCHHHHHHHHHHHCCCCCCCCCCCEEE
SLEGKERQISADIEGLEALSHYWSVVRKFYHNFESDIQSPNTEIYQHEMPGGQYSNIEQQ
EECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHH
AKSLGLGDQFEAVKDMYKRVNIMFGDIVKVTPSSKVVGDMALYMVQNNLDEQTVIERGEN
HHHCCCCCHHHHHHHHHHHHHEEECCEEEECCCCHHHHHHHHHHHHCCCCHHHHHHCCCC
LDFPDSVVSFFKGEIGQPANGFPKRLQDVVLKGKAPLTVRPGEALAHVDFNELQQTLTER
CCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCEEECCHHHHHHHHHHH
FQEINEEDVLSYALYPKVFEVYKETEARYGNISLLDTPTFFYGMRKNETVEIEIDAGKTL
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHEEECCCCCEEEEEECCCCHH
IVKLLSIGHVHEDGYRTLYFELNGMPRQVRVKDNAAEVSVNTLLKADAKNSKHIGAQMPG
HHHHHHHCCEECCCCEEEEEEECCCCCEEEEECCCHHEEHHHHHCCCCCCCCCCCCCCCC
TIGEIKVTAGAHVRAGETLMITEAMKMETSVQAPVDAVVKHIHVTTGTAIQTGDLLVEFE
CCCEEEEECCCEEECCCEEEEEHHHHHHCCCCCCHHHHHHHEEEECCCEEEECCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]