BacMap

Definition	Macrococcus caseolyticus JCSC5402, complete genome.
Accession	NC_011999
Length	2,102,324

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The map label for this gene is ppi [C]

Identifier: 222150830

GI number: 222150830

Start: 614912

End: 615502

Strand: Direct

Name: ppi [C]

Synonym: MCCL_0580

Alternate gene names: 222150830

Gene position: 614912-615502 (Clockwise)

Preceding gene: 222150821

Following gene: 222150831

Centisome position: 29.25

GC content: 39.42

Gene sequence:

>591_bases
ATGACTAATTTTCCTCAATTAAGTACAGAAATTTCTGAAAATGAAAAACTCGTAACAATGCATACAAATAAAGGTGTAAT
GAAGTTTAAGTTATTTCCTGAAATCGCACCAAAGACTGTAGAGAACTTTATTCAGTTATCACAAAAAGGATACTATGAAG
GCATCACGTTTCACCGTGTGATCAATGACTTTATGATTCAAGGTGGAGATCCAACGGGTACTGGTATGGGTGGAGAAAGT
ATTTACGGTGACAAATTCGAAGATGAATTTTCTATGGAAGCTTTCAATTTATATGGTGCATTATCGATGGCGAATGCAGG
TCCAGGTACAAACGGTTCACAATTCTTTATCGTACAGATGAAACAAGTGCCGGCACAAATGTTGTCACAGTTAAAGCAAG
GTGGCTGGCCTGAAGAAATTGTTGATGCGTATGCTGAACACGGAGGAACGCCATGGTTAGACCAGAAACATACGGTATTT
GGTCAGTTGGTTGAAGGTGCAGACACGTTAGAAACAATCGCTGCAGTAAAGGTTGGGGCGCAAGACAAACCTCTTGAAGA
TGTGATCATCGAACGTATTGAAGTACAATAA

Upstream 100 bases:

>100_bases
TATAAATTCCTGTTTTATGCATAAGTCTAAAATACATATTCATCATCCTTTATGTTAAAATAGTTTATTGTAAACATCAT
ATCATGAAGGAGAGAGAAAA

Downstream 100 bases:

>100_bases
GTAATCACTCATAAGTCATGAAATCGTCATGACTTATGATTTTTTTTTATGTCCATCATGTTATAATAATAAAAATTAGG
AGTGTGAAGTTATTATGATG

Product: cyclophilin-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MTNFPQLSTEISENEKLVTMHTNKGVMKFKLFPEIAPKTVENFIQLSQKGYYEGITFHRVINDFMIQGGDPTGTGMGGES
IYGDKFEDEFSMEAFNLYGALSMANAGPGTNGSQFFIVQMKQVPAQMLSQLKQGGWPEEIVDAYAEHGGTPWLDQKHTVF
GQLVEGADTLETIAAVKVGAQDKPLEDVIIERIEVQ

Sequences:

>Translated_196_residues
MTNFPQLSTEISENEKLVTMHTNKGVMKFKLFPEIAPKTVENFIQLSQKGYYEGITFHRVINDFMIQGGDPTGTGMGGES
IYGDKFEDEFSMEAFNLYGALSMANAGPGTNGSQFFIVQMKQVPAQMLSQLKQGGWPEEIVDAYAEHGGTPWLDQKHTVF
GQLVEGADTLETIAAVKVGAQDKPLEDVIIERIEVQ
>Mature_195_residues
TNFPQLSTEISENEKLVTMHTNKGVMKFKLFPEIAPKTVENFIQLSQKGYYEGITFHRVINDFMIQGGDPTGTGMGGESI
YGDKFEDEFSMEAFNLYGALSMANAGPGTNGSQFFIVQMKQVPAQMLSQLKQGGWPEEIVDAYAEHGGTPWLDQKHTVFG
QLVEGADTLETIAAVKVGAQDKPLEDVIIERIEVQ

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=179, Percent_Identity=50.2793296089386, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI7706339, Length=174, Percent_Identity=43.6781609195402, Blast_Score=147, Evalue=8e-36,
Organism=Homo sapiens, GI19557636, Length=181, Percent_Identity=43.646408839779, Blast_Score=143, Evalue=8e-35,
Organism=Homo sapiens, GI4758950, Length=180, Percent_Identity=43.8888888888889, Blast_Score=127, Evalue=6e-30,
Organism=Homo sapiens, GI4505991, Length=171, Percent_Identity=42.6900584795322, Blast_Score=117, Evalue=5e-27,
Organism=Homo sapiens, GI64276486, Length=182, Percent_Identity=37.3626373626374, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI22547212, Length=180, Percent_Identity=41.1111111111111, Blast_Score=110, Evalue=6e-25,
Organism=Homo sapiens, GI7657473, Length=180, Percent_Identity=41.1111111111111, Blast_Score=110, Evalue=6e-25,
Organism=Homo sapiens, GI22547215, Length=180, Percent_Identity=41.1111111111111, Blast_Score=110, Evalue=7e-25,
Organism=Homo sapiens, GI10863927, Length=153, Percent_Identity=45.0980392156863, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI5454154, Length=178, Percent_Identity=38.7640449438202, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI4826932, Length=178, Percent_Identity=40.4494382022472, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI5174637, Length=171, Percent_Identity=41.5204678362573, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI5031987, Length=154, Percent_Identity=43.5064935064935, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI6631100, Length=196, Percent_Identity=38.265306122449, Blast_Score=104, Evalue=4e-23,
Organism=Homo sapiens, GI310129267, Length=153, Percent_Identity=43.7908496732026, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI310120620, Length=153, Percent_Identity=43.7908496732026, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI256017253, Length=151, Percent_Identity=43.046357615894, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI221139811, Length=151, Percent_Identity=43.046357615894, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI256017251, Length=151, Percent_Identity=43.046357615894, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI42560244, Length=178, Percent_Identity=39.3258426966292, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI310110104, Length=153, Percent_Identity=43.1372549019608, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI178057341, Length=153, Percent_Identity=41.8300653594771, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI303305009, Length=153, Percent_Identity=41.1764705882353, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI209417936, Length=153, Percent_Identity=41.8300653594771, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI30102944, Length=153, Percent_Identity=41.8300653594771, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI219842199, Length=153, Percent_Identity=41.8300653594771, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI45439316, Length=153, Percent_Identity=41.1764705882353, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI310127646, Length=153, Percent_Identity=42.483660130719, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI310114371, Length=153, Percent_Identity=42.483660130719, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI310119221, Length=153, Percent_Identity=42.483660130719, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI169163387, Length=153, Percent_Identity=40.5228758169935, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI169164185, Length=153, Percent_Identity=39.8692810457516, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI169163623, Length=153, Percent_Identity=39.8692810457516, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI150418007, Length=155, Percent_Identity=41.9354838709677, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI310132444, Length=173, Percent_Identity=38.150289017341, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI310113152, Length=173, Percent_Identity=38.150289017341, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI27735045, Length=163, Percent_Identity=36.1963190184049, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI20911035, Length=181, Percent_Identity=32.5966850828729, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI310114540, Length=152, Percent_Identity=38.8157894736842, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI310127745, Length=152, Percent_Identity=38.8157894736842, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI310119290, Length=152, Percent_Identity=38.8157894736842, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI169214050, Length=153, Percent_Identity=38.562091503268, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI239751853, Length=153, Percent_Identity=38.562091503268, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI113428306, Length=153, Percent_Identity=38.562091503268, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI289803023, Length=189, Percent_Identity=31.2169312169312, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1786736, Length=188, Percent_Identity=33.5106382978723, Blast_Score=84, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71980594, Length=180, Percent_Identity=41.1111111111111, Blast_Score=135, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71980590, Length=169, Percent_Identity=43.1952662721894, Blast_Score=134, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17539496, Length=186, Percent_Identity=40.8602150537634, Blast_Score=132, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17552780, Length=165, Percent_Identity=47.2727272727273, Blast_Score=131, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17532641, Length=181, Percent_Identity=43.0939226519337, Blast_Score=131, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17506311, Length=195, Percent_Identity=40.5128205128205, Blast_Score=121, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17506307, Length=165, Percent_Identity=45.4545454545455, Blast_Score=120, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71997782, Length=148, Percent_Identity=41.8918918918919, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17559074, Length=178, Percent_Identity=40.4494382022472, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17566266, Length=160, Percent_Identity=43.125, Blast_Score=111, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17532643, Length=176, Percent_Identity=39.2045454545455, Blast_Score=106, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17552782, Length=162, Percent_Identity=39.5061728395062, Blast_Score=106, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17551284, Length=177, Percent_Identity=38.9830508474576, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17551282, Length=177, Percent_Identity=38.9830508474576, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17565860, Length=182, Percent_Identity=40.1098901098901, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17539498, Length=153, Percent_Identity=41.1764705882353, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17552784, Length=194, Percent_Identity=35.5670103092784, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI32563659, Length=182, Percent_Identity=30.7692307692308, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323562, Length=174, Percent_Identity=43.1034482758621, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321848, Length=169, Percent_Identity=43.7869822485207, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320359, Length=156, Percent_Identity=46.1538461538462, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320510, Length=166, Percent_Identity=41.566265060241, Blast_Score=108, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6323246, Length=182, Percent_Identity=39.010989010989, Blast_Score=104, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6322492, Length=202, Percent_Identity=35.6435643564356, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922376, Length=179, Percent_Identity=42.4581005586592, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI17986117, Length=181, Percent_Identity=40.8839779005525, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI20130249, Length=171, Percent_Identity=42.1052631578947, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17136360, Length=194, Percent_Identity=38.1443298969072, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI19922912, Length=181, Percent_Identity=43.646408839779, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24652460, Length=181, Percent_Identity=35.9116022099448, Blast_Score=113, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24664125, Length=172, Percent_Identity=43.6046511627907, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21357783, Length=172, Percent_Identity=43.6046511627907, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17647301, Length=165, Percent_Identity=40.6060606060606, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI45549139, Length=178, Percent_Identity=40.4494382022472, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24650807, Length=178, Percent_Identity=38.7640449438202, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21357249, Length=182, Percent_Identity=34.0659340659341, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24586038, Length=208, Percent_Identity=34.6153846153846, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24661775, Length=105, Percent_Identity=40, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21355237, Length=105, Percent_Identity=40, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24661771, Length=105, Percent_Identity=40, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21673; Mature: 21542

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNFPQLSTEISENEKLVTMHTNKGVMKFKLFPEIAPKTVENFIQLSQKGYYEGITFHRV
CCCCCCCHHHHCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHH
INDFMIQGGDPTGTGMGGESIYGDKFEDEFSMEAFNLYGALSMANAGPGTNGSQFFIVQM
HHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEH
KQVPAQMLSQLKQGGWPEEIVDAYAEHGGTPWLDQKHTVFGQLVEGADTLETIAAVKVGA
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCC
QDKPLEDVIIERIEVQ
CCCCHHHHHHHHHCCC
>Mature Secondary Structure 
TNFPQLSTEISENEKLVTMHTNKGVMKFKLFPEIAPKTVENFIQLSQKGYYEGITFHRV
CCCCCCHHHHCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHH
INDFMIQGGDPTGTGMGGESIYGDKFEDEFSMEAFNLYGALSMANAGPGTNGSQFFIVQM
HHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEH
KQVPAQMLSQLKQGGWPEEIVDAYAEHGGTPWLDQKHTVFGQLVEGADTLETIAAVKVGA
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCC
QDKPLEDVIIERIEVQ
CCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA