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The map label for this gene is dltA [H]

Identifier: 222150810

GI number: 222150810

Start: 596939

End: 598345

Strand: Direct

Name: dltA [H]

Synonym: MCCL_0560

Alternate gene names: 222150810

Gene position: 596939-598345 (Clockwise)

Preceding gene: 222150809

Following gene: 222150811

Centisome position: 28.39

GC content: 36.96

Gene sequence:

>1407_bases
ATGGATTTTTTAAAAAGGTTTGAACAAGTTGTAAATCAGCAGCCAGAAAAAATTGCTTTTATTCATAGAGAGGAAACGAT
GACATATCGTGCACTTGATTTATTAAGTGATGATCTCGGACAGAAGTTATTACATTCGAAAAAGCCACTTATCGTATACG
GACATATGTCAAAATGGATGCTAGTAGGTATGCTCGCATCACTTAAGGCTGGAATTGGTTATGTACCGATAGATGTTTCG
ATACCAAGGGAACGTATAGATAAAATAATCGACACAATTCAGCCGGAATTTATCTTTGCGACAGAAGTATTAGCAACACC
CATACAAACGATAACCCCCAGTGACGTTAAAGAAGAACCTTATAATTTACCAGGTCTTCAAGCGGATGATGTAGCCTATA
CAATATTCACAAGTGGATCGACAGGGATGCCAAAAGGGGTAACGATACTAAGTGAATCGTTAAATGAATTTACAGAGTGG
ATGACATCTTTATATGAGTTACAAGCAGAAAATTACTGGTTAAATCAAGCACCTTTATCTTTTGATCTTTCGGTAATGGC
TGTATATCCATCATTAGCGACAGGAAGTACATTAGTGATGATTGACAAAGATATGATCAAAAAACCGATCGACATTTATG
AAACTTTAAAACAGTATCCGATATCGGCATGGGTATCTACGCCTTCATTCATGGAAATGTGTTTAATGCTACCGGAATTT
GACGCAGTGCATCATAGTAATTTAAAGTATTTCTACTTCTGTGGTGAGGCACTCAAGCATAAGACAGCTGAAAGCTTAAA
GTCTAAGTTTAACGATAGTCACATTTATAATACTTACGGTCCTACTGAAGCAACTGTTGCAGTGACAGGATTAGAAATAA
CTGAAGAAGTACTGAGCAAATATAACCCTTTACCAGTTGGGTATGCGCGACCAGGTGTTACATTATCTATTAACGATGAT
GAGCTGCACATTCATGGTAATGCGGTAAGTACAGGTTATGTCAATGCACCGGATAAGACTGCAGCGCAATTCTATCAAGA
TAAAGAACGTAGTTACCGTACGGGAGATAAAGCTAGACTTGAAGATGAACTATTGTTTATCGATGGGCGTATTGACTTTC
AGATTAAACTGAATGGTTATCGTATGGAACTTGAAGAGATAGAACATGTGATTGCTGAGCAGGAAGGGATTAAGGCGTGT
ATTGTCACACCTGTTGAAAAACAAGGCAAAGTACAATACTTAATTGCACATATTGTTGAAATTAATTTTCAAGAAGCTCT
TGTTAGAGAAAAACTAAAGAATGAACTACCTGAGTATATGATTCCAAGAAAGTTTAATGTGATTGATCAAATTCCTATGA
CTGCAAATGGGAAAGTGGATCGTAAAGCACTATTGGGTGAACGATAA

Upstream 100 bases:

>100_bases
CTTTATATTTCAATACTGTTCATGTTGTTCTGGATATACGCTGGTGGAAGCGTTGAGAATAACTTTATATACAATGAATT
TTAAAGTAAGAGGTGGAAAA

Downstream 100 bases:

>100_bases
TGATACCTTATGGAGATTTTCAGTTTTTCTTTATAGCATTAGCACTATTGATTCCTGTCATAGTACTCGGTTTCTGTGGA
AGAAGGAATCATTATTATAA

Product: D-alanine--poly(phosphoribitol) ligase subunit 1

Products: NA

Alternate protein names: D-alanine-D-alanyl carrier protein ligase; DCL; D-alanine-activating enzyme; DAE [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MDFLKRFEQVVNQQPEKIAFIHREETMTYRALDLLSDDLGQKLLHSKKPLIVYGHMSKWMLVGMLASLKAGIGYVPIDVS
IPRERIDKIIDTIQPEFIFATEVLATPIQTITPSDVKEEPYNLPGLQADDVAYTIFTSGSTGMPKGVTILSESLNEFTEW
MTSLYELQAENYWLNQAPLSFDLSVMAVYPSLATGSTLVMIDKDMIKKPIDIYETLKQYPISAWVSTPSFMEMCLMLPEF
DAVHHSNLKYFYFCGEALKHKTAESLKSKFNDSHIYNTYGPTEATVAVTGLEITEEVLSKYNPLPVGYARPGVTLSINDD
ELHIHGNAVSTGYVNAPDKTAAQFYQDKERSYRTGDKARLEDELLFIDGRIDFQIKLNGYRMELEEIEHVIAEQEGIKAC
IVTPVEKQGKVQYLIAHIVEINFQEALVREKLKNELPEYMIPRKFNVIDQIPMTANGKVDRKALLGER

Sequences:

>Translated_468_residues
MDFLKRFEQVVNQQPEKIAFIHREETMTYRALDLLSDDLGQKLLHSKKPLIVYGHMSKWMLVGMLASLKAGIGYVPIDVS
IPRERIDKIIDTIQPEFIFATEVLATPIQTITPSDVKEEPYNLPGLQADDVAYTIFTSGSTGMPKGVTILSESLNEFTEW
MTSLYELQAENYWLNQAPLSFDLSVMAVYPSLATGSTLVMIDKDMIKKPIDIYETLKQYPISAWVSTPSFMEMCLMLPEF
DAVHHSNLKYFYFCGEALKHKTAESLKSKFNDSHIYNTYGPTEATVAVTGLEITEEVLSKYNPLPVGYARPGVTLSINDD
ELHIHGNAVSTGYVNAPDKTAAQFYQDKERSYRTGDKARLEDELLFIDGRIDFQIKLNGYRMELEEIEHVIAEQEGIKAC
IVTPVEKQGKVQYLIAHIVEINFQEALVREKLKNELPEYMIPRKFNVIDQIPMTANGKVDRKALLGER
>Mature_468_residues
MDFLKRFEQVVNQQPEKIAFIHREETMTYRALDLLSDDLGQKLLHSKKPLIVYGHMSKWMLVGMLASLKAGIGYVPIDVS
IPRERIDKIIDTIQPEFIFATEVLATPIQTITPSDVKEEPYNLPGLQADDVAYTIFTSGSTGMPKGVTILSESLNEFTEW
MTSLYELQAENYWLNQAPLSFDLSVMAVYPSLATGSTLVMIDKDMIKKPIDIYETLKQYPISAWVSTPSFMEMCLMLPEF
DAVHHSNLKYFYFCGEALKHKTAESLKSKFNDSHIYNTYGPTEATVAVTGLEITEEVLSKYNPLPVGYARPGVTLSINDD
ELHIHGNAVSTGYVNAPDKTAAQFYQDKERSYRTGDKARLEDELLFIDGRIDFQIKLNGYRMELEEIEHVIAEQEGIKAC
IVTPVEKQGKVQYLIAHIVEINFQEALVREKLKNELPEYMIPRKFNVIDQIPMTANGKVDRKALLGER

Specific function: Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp [H]

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=349, Percent_Identity=24.0687679083095, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI38505220, Length=375, Percent_Identity=25.0666666666667, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI187761345, Length=471, Percent_Identity=22.9299363057325, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI187761343, Length=471, Percent_Identity=22.9299363057325, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI58082049, Length=509, Percent_Identity=23.1827111984283, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI42544132, Length=513, Percent_Identity=21.2475633528265, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI13375727, Length=545, Percent_Identity=21.651376146789, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI157311624, Length=356, Percent_Identity=24.438202247191, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI157311622, Length=356, Percent_Identity=24.438202247191, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI122937307, Length=513, Percent_Identity=22.2222222222222, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI115511026, Length=523, Percent_Identity=22.7533460803059, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786801, Length=447, Percent_Identity=28.6353467561521, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI145693145, Length=513, Percent_Identity=22.2222222222222, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17556356, Length=447, Percent_Identity=27.9642058165548, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI32564422, Length=348, Percent_Identity=25.2873563218391, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI32564420, Length=348, Percent_Identity=25.2873563218391, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17550940, Length=412, Percent_Identity=24.0291262135922, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI32563687, Length=482, Percent_Identity=23.6514522821577, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17558820, Length=437, Percent_Identity=23.1121281464531, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71985884, Length=348, Percent_Identity=25.2873563218391, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17557194, Length=375, Percent_Identity=24.2666666666667, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17538037, Length=374, Percent_Identity=22.7272727272727, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6319591, Length=561, Percent_Identity=21.3903743315508, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319699, Length=374, Percent_Identity=25.9358288770053, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24648676, Length=455, Percent_Identity=27.6923076923077, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI281365686, Length=384, Percent_Identity=24.21875, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355181, Length=456, Percent_Identity=22.8070175438596, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356947, Length=398, Percent_Identity=25.1256281407035, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21358303, Length=479, Percent_Identity=22.1294363256785, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR000873
- InterPro:   IPR010072 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.1.1.13 [H]

Molecular weight: Translated: 53146; Mature: 53146

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFLKRFEQVVNQQPEKIAFIHREETMTYRALDLLSDDLGQKLLHSKKPLIVYGHMSKWM
CHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHH
LVGMLASLKAGIGYVPIDVSIPRERIDKIIDTIQPEFIFATEVLATPIQTITPSDVKEEP
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCEEHHHHHHCCHHCCCCCCCCCCC
YNLPGLQADDVAYTIFTSGSTGMPKGVTILSESLNEFTEWMTSLYELQAENYWLNQAPLS
CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCC
FDLSVMAVYPSLATGSTLVMIDKDMIKKPIDIYETLKQYPISAWVSTPSFMEMCLMLPEF
CCEEEEEEECCCCCCCEEEEECHHHHHCCHHHHHHHHHCCCHHCCCCHHHHHHHHHCCCC
DAVHHSNLKYFYFCGEALKHKTAESLKSKFNDSHIYNTYGPTEATVAVTGLEITEEVLSK
CCHHCCCCEEEEEECHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEECHHHHHHHHHH
YNPLPVGYARPGVTLSINDDELHIHGNAVSTGYVNAPDKTAAQFYQDKERSYRTGDKARL
CCCCCCCCCCCCEEEEECCCEEEEECCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
EDELLFIDGRIDFQIKLNGYRMELEEIEHVIAEQEGIKACIVTPVEKQGKVQYLIAHIVE
CCCEEEEECEEEEEEEECCEEECHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHH
INFQEALVREKLKNELPEYMIPRKFNVIDQIPMTANGKVDRKALLGER
CCHHHHHHHHHHHHCCHHHHCCCCCCHHHCCCCCCCCCCCHHHHCCCC
>Mature Secondary Structure
MDFLKRFEQVVNQQPEKIAFIHREETMTYRALDLLSDDLGQKLLHSKKPLIVYGHMSKWM
CHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHH
LVGMLASLKAGIGYVPIDVSIPRERIDKIIDTIQPEFIFATEVLATPIQTITPSDVKEEP
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCEEHHHHHHCCHHCCCCCCCCCCC
YNLPGLQADDVAYTIFTSGSTGMPKGVTILSESLNEFTEWMTSLYELQAENYWLNQAPLS
CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCC
FDLSVMAVYPSLATGSTLVMIDKDMIKKPIDIYETLKQYPISAWVSTPSFMEMCLMLPEF
CCEEEEEEECCCCCCCEEEEECHHHHHCCHHHHHHHHHCCCHHCCCCHHHHHHHHHCCCC
DAVHHSNLKYFYFCGEALKHKTAESLKSKFNDSHIYNTYGPTEATVAVTGLEITEEVLSK
CCHHCCCCEEEEEECHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEECHHHHHHHHHH
YNPLPVGYARPGVTLSINDDELHIHGNAVSTGYVNAPDKTAAQFYQDKERSYRTGDKARL
CCCCCCCCCCCCEEEEECCCEEEEECCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
EDELLFIDGRIDFQIKLNGYRMELEEIEHVIAEQEGIKACIVTPVEKQGKVQYLIAHIVE
CCCEEEEECEEEEEEEECCEEECHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHH
INFQEALVREKLKNELPEYMIPRKFNVIDQIPMTANGKVDRKALLGER
CCHHHHHHHHHHHHCCHHHHCCCCCCHHHCCCCCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA